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Entry version 124 (03 Jul 2019)
Sequence version 3 (01 Sep 2009)
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Protein

CUB and sushi domain-containing protein 3

Gene

Csmd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in dendrite development.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • regulation of dendrite development Source: UniProtKB

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CUB and sushi domain-containing protein 3
Alternative name(s):
CUB and sushi multiple domains protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Csmd3
Synonyms:Kiaa1894
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2386403 Csmd3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 42CytoplasmicSequence analysisAdd BLAST42
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Topological domaini64 – 3630ExtracellularSequence analysisAdd BLAST3567
Transmembranei3631 – 3651HelicalSequence analysisAdd BLAST21
Topological domaini3652 – 3707CytoplasmicSequence analysisAdd BLAST56

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000794061 – 3707CUB and sushi domain-containing protein 3Add BLAST3707

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi65 ↔ 91By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi73N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi178 ↔ 218By similarity
Disulfide bondi204 ↔ 235By similarity
Disulfide bondi241 ↔ 267By similarity
Disulfide bondi486 ↔ 526By similarity
Disulfide bondi512 ↔ 543By similarity
Disulfide bondi548 ↔ 574By similarity
Disulfide bondi664 ↔ 704By similarity
Disulfide bondi690 ↔ 717By similarity
Disulfide bondi721 ↔ 747By similarity
Glycosylationi724N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi823N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi834 ↔ 875By similarity
Disulfide bondi860 ↔ 891By similarity
Disulfide bondi895 ↔ 921By similarity
Glycosylationi966N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1010 ↔ 1050By similarity
Disulfide bondi1036 ↔ 1063By similarity
Disulfide bondi1067 ↔ 1093By similarity
Glycosylationi1092N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1126N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1171N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1182 ↔ 1222By similarity
Disulfide bondi1208 ↔ 1237By similarity
Disulfide bondi1241 ↔ 1267By similarity
Glycosylationi1280N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1354 ↔ 1395By similarity
Disulfide bondi1381 ↔ 1410By similarity
Disulfide bondi1414 ↔ 1441By similarity
Disulfide bondi1528 ↔ 1568By similarity
Glycosylationi1536N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1554 ↔ 1584By similarity
Disulfide bondi1588 ↔ 1614By similarity
Glycosylationi1591N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1701 ↔ 1741By similarity
Glycosylationi1709N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1727 ↔ 1758By similarity
Disulfide bondi1762 ↔ 1788By similarity
Glycosylationi1781N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1878 ↔ 1918By similarity
Disulfide bondi1904 ↔ 1935By similarity
Glycosylationi1929N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1939 ↔ 1965By similarity
Glycosylationi2019N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2052 ↔ 2092By similarity
Disulfide bondi2078 ↔ 2107By similarity
Disulfide bondi2111 ↔ 2137By similarity
Glycosylationi2155N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2224 ↔ 2264By similarity
Disulfide bondi2250 ↔ 2279By similarity
Disulfide bondi2283 ↔ 2309By similarity
Glycosylationi2286N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2291N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2395 ↔ 2437By similarity
Disulfide bondi2423 ↔ 2452By similarity
Disulfide bondi2456 ↔ 2484By similarity
Disulfide bondi2569 ↔ 2610By similarity
Disulfide bondi2596 ↔ 2627By similarity
Disulfide bondi2632 ↔ 2674By similarity
Disulfide bondi2658 ↔ 2689By similarity
Disulfide bondi2694 ↔ 2739By similarity
Disulfide bondi2725 ↔ 2754By similarity
Disulfide bondi2759 ↔ 2799By similarity
Disulfide bondi2785 ↔ 2812By similarity
Disulfide bondi2817 ↔ 2857By similarity
Disulfide bondi2843 ↔ 2870By similarity
Disulfide bondi2875 ↔ 2915By similarity
Disulfide bondi2901 ↔ 2928By similarity
Disulfide bondi2933 ↔ 2977By similarity
Disulfide bondi2963 ↔ 2990By similarity
Disulfide bondi2995 ↔ 3035By similarity
Disulfide bondi3021 ↔ 3048By similarity
Disulfide bondi3056 ↔ 3096By similarity
Disulfide bondi3082 ↔ 3109By similarity
Disulfide bondi3114 ↔ 3155By similarity
Disulfide bondi3141 ↔ 3168By similarity
Disulfide bondi3173 ↔ 3215By similarity
Disulfide bondi3199 ↔ 3228By similarity
Disulfide bondi3233 ↔ 3273By similarity
Disulfide bondi3259 ↔ 3286By similarity
Disulfide bondi3291 ↔ 3331By similarity
Disulfide bondi3317 ↔ 3344By similarity
Disulfide bondi3352 ↔ 3393By similarity
Disulfide bondi3379 ↔ 3406By similarity
Disulfide bondi3411 ↔ 3453By similarity
Disulfide bondi3438 ↔ 3466By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q80T79

PRoteomics IDEntifications database

More...
PRIDEi
Q80T79

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2242

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q80T79

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q80T79

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the apical dendrites of postnatal hippocampal neurons (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000022311 Expressed in 125 organ(s), highest expression level in embryo

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q80T79 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q80T79 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000098235

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q80T79

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini65 – 173CUB 1PROSITE-ProRule annotationAdd BLAST109
Domaini176 – 237Sushi 1PROSITE-ProRule annotationAdd BLAST62
Domaini241 – 345CUB 2PROSITE-ProRule annotationAdd BLAST105
Domaini484 – 545Sushi 2PROSITE-ProRule annotationAdd BLAST62
Domaini548 – 659CUB 3PROSITE-ProRule annotationAdd BLAST112
Domaini662 – 719Sushi 3PROSITE-ProRule annotationAdd BLAST58
Domaini721 – 829CUB 4PROSITE-ProRule annotationAdd BLAST109
Domaini832 – 893Sushi 4PROSITE-ProRule annotationAdd BLAST62
Domaini895 – 1003CUB 5PROSITE-ProRule annotationAdd BLAST109
Domaini1008 – 1065Sushi 5PROSITE-ProRule annotationAdd BLAST58
Domaini1067 – 1177CUB 6PROSITE-ProRule annotationAdd BLAST111
Domaini1180 – 1239Sushi 6PROSITE-ProRule annotationAdd BLAST60
Domaini1241 – 1349CUB 7PROSITE-ProRule annotationAdd BLAST109
Domaini1352 – 1412Sushi 7PROSITE-ProRule annotationAdd BLAST61
Domaini1414 – 1523CUB 8PROSITE-ProRule annotationAdd BLAST110
Domaini1526 – 1586Sushi 8PROSITE-ProRule annotationAdd BLAST61
Domaini1588 – 1696CUB 9PROSITE-ProRule annotationAdd BLAST109
Domaini1699 – 1760Sushi 9PROSITE-ProRule annotationAdd BLAST62
Domaini1762 – 1870CUB 10PROSITE-ProRule annotationAdd BLAST109
Domaini1876 – 1937Sushi 10PROSITE-ProRule annotationAdd BLAST62
Domaini1939 – 2047CUB 11PROSITE-ProRule annotationAdd BLAST109
Domaini2050 – 2109Sushi 11PROSITE-ProRule annotationAdd BLAST60
Domaini2111 – 2219CUB 12PROSITE-ProRule annotationAdd BLAST109
Domaini2222 – 2281Sushi 12PROSITE-ProRule annotationAdd BLAST60
Domaini2283 – 2394CUB 13PROSITE-ProRule annotationAdd BLAST112
Domaini2393 – 2454Sushi 13PROSITE-ProRule annotationAdd BLAST62
Domaini2456 – 2567CUB 14PROSITE-ProRule annotationAdd BLAST112
Domaini2567 – 2629Sushi 14PROSITE-ProRule annotationAdd BLAST63
Domaini2630 – 2691Sushi 15PROSITE-ProRule annotationAdd BLAST62
Domaini2692 – 2756Sushi 16PROSITE-ProRule annotationAdd BLAST65
Domaini2757 – 2814Sushi 17PROSITE-ProRule annotationAdd BLAST58
Domaini2815 – 2872Sushi 18PROSITE-ProRule annotationAdd BLAST58
Domaini2873 – 2930Sushi 19PROSITE-ProRule annotationAdd BLAST58
Domaini2931 – 2992Sushi 20PROSITE-ProRule annotationAdd BLAST62
Domaini2993 – 3050Sushi 21PROSITE-ProRule annotationAdd BLAST58
Domaini3054 – 3111Sushi 22PROSITE-ProRule annotationAdd BLAST58
Domaini3112 – 3170Sushi 23PROSITE-ProRule annotationAdd BLAST59
Domaini3171 – 3230Sushi 24PROSITE-ProRule annotationAdd BLAST60
Domaini3231 – 3288Sushi 25PROSITE-ProRule annotationAdd BLAST58
Domaini3289 – 3346Sushi 26PROSITE-ProRule annotationAdd BLAST58
Domaini3350 – 3408Sushi 27PROSITE-ProRule annotationAdd BLAST59
Domaini3409 – 3468Sushi 28PROSITE-ProRule annotationAdd BLAST60

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The intracellular region is dispensable for its function.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CSMD family.Curated

Keywords - Domaini

Repeat, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4297 Eukaryota
ENOG410XPJ1 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155549

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000112015

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q80T79

KEGG Orthology (KO)

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KOi
K17495

Identification of Orthologs from Complete Genome Data

More...
OMAi
SADHGTN

Database of Orthologous Groups

More...
OrthoDBi
2377at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q80T79

TreeFam database of animal gene trees

More...
TreeFami
TF316872

Family and domain databases

Conserved Domains Database

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CDDi
cd00033 CCP, 28 hits
cd00041 CUB, 14 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.290, 14 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000859 CUB_dom
IPR035914 Sperma_CUB_dom_sf
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00431 CUB, 14 hits
PF00084 Sushi, 28 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00032 CCP, 28 hits
SM00042 CUB, 14 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49854 SSF49854, 14 hits
SSF57535 SSF57535, 28 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01180 CUB, 14 hits
PS50923 SUSHI, 28 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q80T79-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKGSRKGESR AKESKPREPG TRRCAKCGRL DFILKKKMGI KSGFTFWNLV
60 70 80 90 100
FLLTLSCVKG FIYTCGGTLK GLNGTIESPG FPYGYPNGAN CTWVIIAEER
110 120 130 140 150
NRIQIVFQSF ALEEEYDYLS LYDGHPHPTN FRTRLTGFHL PPPVTSTKSV
160 170 180 190 200
FSLRLTSDFA VSAHGFKVYY EELQSSSCGN PGVPPKGVLY GTRFDVGDKI
210 220 230 240 250
RYSCVTGYIL DGHPQLTCIA NSVNTASWDF PVPICRAEDA CGGTMRGSSG
260 270 280 290 300
IISSPGFPNE YHNNADCTWT IVAEPGDTIS LIFTDFQMEE KYDYLEIEGS
310 320 330 340 350
EPPTIWLSGM NIPPPIISNK NWLRLHFVTD SNHRYRGFSA PYQGSSPLTL
360 370 380 390 400
TASIGELEEH IRTATGAIDV ASTPADVTVS SVTAVTSHRL SEEQRVQVRS
410 420 430 440 450
LSDSGLDPNT PEDQLSPHQA DTQSTSRRPR NAEQIERTKE LAVVTHRVKK
460 470 480 490 500
AIDFKSRGFK LFPGKDNSNK FSLLNEGGIK TASNLCPDPG EPENGKRFGS
510 520 530 540 550
DFSLGSTVQF SCDEDYVLQG AKSITCQRIA EVFAAWSDHR PVCKVKTCGS
560 570 580 590 600
NLQGPSGTFT SPNFPFQYDS NAQCVWVITA VNTNKVIQIN FEEFDLEIGY
610 620 630 640 650
DTLTIGDGGE VGDPRTVLQV LTGSFVPDLI VSMRSQMWLH LQTDESVGSV
660 670 680 690 700
GFKVNYKEIE KESCGDPGTP LYGIREGDGF SNRDVLRFEC QFGFELIGEK
710 720 730 740 750
SIVCQENNQW SANIPICIFP CLSNFTAPMG TVLSPDYPEG YGNNLNCIWT
760 770 780 790 800
IISDPGSRIH LSFNDFDLES QFDFLAVKDG DSPDSPILGT FTGAEVPSHL
810 820 830 840 850
TSNSHILRLE FQADHSMSGR GFNITYNTFG HNECPDPGIP INARRFGDNF
860 870 880 890 900
QLGSSISVIC EEGFIKTQGT ETITCILMDG KVMWSGPIPR CGAPCGGHFS
910 920 930 940 950
APSGVILSPG WPGYYKDSLN CEWVIEAEPG HSIKITFERF QTELNYDVLE
960 970 980 990 1000
VHDGPNLLSP LLGSYNGTQV PQFLFSSSNF IYLLFTTDNS RSNNGFKIHY
1010 1020 1030 1040 1050
ESVTVNTYSC LDPGIPVHGR RYGHDFSIGS TVSFSCDPGY RLSHEEPLLC
1060 1070 1080 1090 1100
EKNHWWSHPL PTCDALCGGD VRGPSGTILS PGYPEFYPNS LNCTWTVDVT
1110 1120 1130 1140 1150
HGKGVQFNFH TFHLEDHHDY LLITENGSFT QPLARLTGSE LPSTINAGLY
1160 1170 1180 1190 1200
GNFRAQLRFI SDFSISYEGF NITFSEYNLE PCEDPGIPQY GSRVGFSFGV
1210 1220 1230 1240 1250
GDTLTFSCSL GYRLEGSSEI ICLGGGRRVW SAPLPRCVAE CGASATNNEG
1260 1270 1280 1290 1300
ILLSPNYPLN YENNHECIYS LQVQAGKGIN ISARTFHLAQ GDVLKIYDGK
1310 1320 1330 1340 1350
DKTTHLLGAF TGASMRGLTL SSTSNQLWLE FNSDSEGTDE GFQLVYTSFE
1360 1370 1380 1390 1400
LSHCEDPGIP QFGYKISDQG HFAGSTIIYG CNPGYTLHGS SLLKCMTGER
1410 1420 1430 1440 1450
RAWDYPLPSC IAECGGRFKG ESSGRILSPG YPFPYDNNLR CMWMIEVDPG
1460 1470 1480 1490 1500
NIVSLQFLAF DTEASHDILR VWDGPPENEM LLKEVSGSLI PDGIHSTLNI
1510 1520 1530 1540 1550
VTIQFDTDFY ISKSGFAIQF SSSVATACRD PGVPMNGTRN GDGREPGDTV
1560 1570 1580 1590 1600
VFQCDPGYEL QGQERITCIQ VENRYFWQPS PPVCIAPCGG NLTGSSGFIL
1610 1620 1630 1640 1650
SPNFPHPYPH SRDCDWTISV NTDYVISLAF ISFSIEPNYD FLYIYDGPDS
1660 1670 1680 1690 1700
NSPLIGSFQD SKLPERIESS SNTMHLAFRS DGSVSYTGFH LEYKAKLRES
1710 1720 1730 1740 1750
CFDPGNIMNG TRLGMDYKLG STVTYYCDAG YVLQGYSTLT CIMGDDGRPG
1760 1770 1780 1790 1800
WNRVLPSCHA PCGSRSTGSE GTVLSPNYPK NYSVDHNCVY SIAVPKEFVV
1810 1820 1830 1840 1850
FGQFVFFQTS LHDVVEVFDG PTQQSPLLSS LSGSHSGESL PLSSGNQITI
1860 1870 1880 1890 1900
RFTSVGPITA KGFHFVYQAV PRTSSTQCSS VPEPRFGRRI GNDFAVGSLV
1910 1920 1930 1940 1950
LFECNPGYIL HGSRAIRCET VPNSLAQWND SLPTCIVPCG GILTKRKGTI
1960 1970 1980 1990 2000
LSPGYPEPYD NNLNCVWKIT VPEGAGIQVQ VVSFATEHNW DSLDFYDGGD
2010 2020 2030 2040 2050
NNAPRLGSYS GTTIPHLLNS TSNNLYLNFQ SDISVSAAGF HLEYTAIGLD
2060 2070 2080 2090 2100
SCPEPQTPSS GIKVGDRYMV GDVVSFQCDQ GYSLQGHSHI TCMPGPVRRW
2110 2120 2130 2140 2150
NYPIPICLAQ CGGAMSDFSG VILSPGFPGN YPSSLDCTWT IKLPIGFGVH
2160 2170 2180 2190 2200
LQFVNFSTET IHDYLEVRSG SSEISTVIGR LSGPQIPSSL FSTTHETSLY
2210 2220 2230 2240 2250
FHSDYSQNKQ GFHIVYQAYQ LQSCPDPRPF RNGFVIGNDF TVGQTISFEC
2260 2270 2280 2290 2300
FPGYTLIGNS ALTCLHGVSR NWNHPLPRCE ALCGGNITAM NGTIYSPGYP
2310 2320 2330 2340 2350
DEYPNFQDCF WLVRVPPGNG IYINFTVLQT EPIYDFITVW DGPDQNSPQI
2360 2370 2380 2390 2400
GQFSGNTALE SVYSTSNQIL IKFHSDFTTS GFFVLSYHAY QLRVCQPPPP
2410 2420 2430 2440 2450
VPNAEILTED DEFEIGDIIR YQCLPGFTLV GNAILTCRLG ERLQMDGAPP
2460 2470 2480 2490 2500
VCQVLCPANE LRLDSTGVIL SPGYPDSYPN LQMCAWSISV EKGYNISMFV
2510 2520 2530 2540 2550
EFFQTEKEFD VLQVYDGPNI QSPVLISLSG DYSAAFNVTS NGHEVFLQWS
2560 2570 2580 2590 2600
ADHGNNKKGF RIRYIAFYCS TPESPPHGYI ISQTGGQLNS VVRWACDRGF
2610 2620 2630 2640 2650
RLVGKSSAVC RKSSYGYHSW DAPVPACQAI SCGIPKAPTN GGILTTDYLV
2660 2670 2680 2690 2700
GTRVTYFCND GYRLSSKELT TATCQSDGTW SNHNKTPRCV VVTCPSINSF
2710 2720 2730 2740 2750
TLDHGRWRIV NGSHYEYKTK VVFSCDPGYH GLGPASIECL PNGTWSWRTE
2760 2770 2780 2790 2800
RPYCQIISCG ELPTPPNGNK IGTQTSYGST AIFTCDLGFM LVGSAVRECL
2810 2820 2830 2840 2850
SSGLWSGSET RCLAGHCGIP ELIVNGQVIG ENYGYRDTVV YQCNPGFRLI
2860 2870 2880 2890 2900
GSSVRICQQD HNWSGQLPSC VPVSCGHPGS PIYGRTSGNG FNFNDVVTFS
2910 2920 2930 2940 2950
CNIGYLMQGP TKAQCQANRQ WSHPPPVCKV VNCSDPGIPA NSKRESKIEH
2960 2970 2980 2990 3000
GNFTYGTVVF YDCNPGYFLF GSSVLICQPN GQWDKPLPEC IMIDCGHPGI
3010 3020 3030 3040 3050
PPNAVLSGEK YTFGSTVHYS CTGKRSLLGQ ASRTCQLNGH WSGSQPHCSG
3060 3070 3080 3090 3100
DTTGTCGDPG TPGHGSRQES DFRTKSTVRF ACDTGYILYG SEERTCLSNG
3110 3120 3130 3140 3150
SWTGRQPECK AVQCGNPGTT ANGKVFRIDG TTFSSSVIYS CLEGYILSGP
3160 3170 3180 3190 3200
SVRQCTANGT WSGSLPNCTI ISCGDPGIPA NGLRYGDDFV VGQNVSYMCQ
3210 3220 3230 3240 3250
PGYTIELNGS RVRTCTTNGT WSGVMPTCRA VTCSTPPQIS NGRLEGTNFD
3260 3270 3280 3290 3300
WGFSISYICS AGYELSFPAV LTCVGNGTWS GEVPQCLPKF CGDPGIPSQG
3310 3320 3330 3340 3350
KREGKSFIYQ SEVSFSCNSP FILVGSSTRL CQTDGTWSGS SPHCIEPTRT
3360 3370 3380 3390 3400
SCENPGVPRH GSQNNTFGFQ VGSVVQFHCK KGHLLQGSTT RTCLPDLTWS
3410 3420 3430 3440 3450
GIQPECIPHS CKQPESPAHA NVVGMDLPSH GYTLIYTCQP GFFLAGGTEH
3460 3470 3480 3490 3500
RVCRSDNTWT GKVPVCEAGS KILVKDPRPA LGTPSPKLSV PDDVFAQNYI
3510 3520 3530 3540 3550
WKGSYNFKGR KQPMTLTVTS FNASTGRVNA TLSNSDMELL LSGVYKSQEA
3560 3570 3580 3590 3600
RLMLHIYLIK VPAHASVKKM KEENWAMDGF VSAEPDGATY VFQGFIKGKD
3610 3620 3630 3640 3650
YGQFGLQRLG LNTSEGSNSS NQPHGTNSSS VAIAILVPFF ALIFAGFGFY
3660 3670 3680 3690 3700
LYKQRTAPKT QYTGCSVHEN NNGQAAFENP MYDTNAKSVE GKAVRFDPNL

NTVCTMV
Length:3,707
Mass (Da):405,762
Last modified:September 1, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAA185621A294A0DF
GO
Isoform 2 (identifier: Q80T79-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1799-1868: Missing.

Note: No experimental confirmation available.
Show »
Length:3,637
Mass (Da):398,221
Checksum:i43C08B1DFD075137
GO
Isoform 3 (identifier: Q80T79-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1061: Missing.
     1062-1064: TCD → MAK
     1239-1250: AECGASATNNEG → GTWSAAFICLYV
     1251-3707: Missing.

Note: No experimental confirmation available.
Show »
Length:189
Mass (Da):20,720
Checksum:i36B038EBDAB462B3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PWJ0E9PWJ0_MOUSE
CUB and sushi domain-containing pro...
Csmd3
3,538Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6TRD7F6TRD7_MOUSE
CUB and sushi domain-containing pro...
Csmd3
2,797Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti545 – 578VKTCG…CVWVI → GLSLSLSLSLCVCVCVCLCD CVLICVYLCSYSNF in BAE24305 (PubMed:16141072).CuratedAdd BLAST34
Sequence conflicti1183E → G in BAB29924 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0090531 – 1061Missing in isoform 3. 1 PublicationAdd BLAST1061
Alternative sequenceiVSP_0090541062 – 1064TCD → MAK in isoform 3. 1 Publication3
Alternative sequenceiVSP_0090551239 – 1250AECGA…TNNEG → GTWSAAFICLYV in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_0090561251 – 3707Missing in isoform 3. 1 PublicationAdd BLAST2457
Alternative sequenceiVSP_0270091799 – 1868Missing in isoform 2. 1 PublicationAdd BLAST70

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK140264 mRNA Translation: BAE24305.1
AK015672 mRNA Translation: BAB29924.1
AC099596 Genomic DNA No translation available.
AC099600 Genomic DNA No translation available.
AC099711 Genomic DNA No translation available.
AC101706 Genomic DNA No translation available.
AC101771 Genomic DNA No translation available.
AC129189 Genomic DNA No translation available.
AC130669 Genomic DNA No translation available.
AC137905 Genomic DNA No translation available.
AC154881 Genomic DNA No translation available.
AC157584 Genomic DNA No translation available.
AC158907 Genomic DNA No translation available.
AK122567 mRNA Translation: BAC65849.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS49602.1 [Q80T79-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001074860.2, NM_001081391.2 [Q80T79-3]
XP_011243913.1, XM_011245611.2 [Q80T79-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000100670; ENSMUSP00000098235; ENSMUSG00000022311 [Q80T79-3]
ENSMUST00000162830; ENSMUSP00000124775; ENSMUSG00000022311 [Q80T79-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
239420

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:239420

UCSC genome browser

More...
UCSCi
uc007vqt.1 mouse [Q80T79-2]
uc007vqu.2 mouse [Q80T79-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK140264 mRNA Translation: BAE24305.1
AK015672 mRNA Translation: BAB29924.1
AC099596 Genomic DNA No translation available.
AC099600 Genomic DNA No translation available.
AC099711 Genomic DNA No translation available.
AC101706 Genomic DNA No translation available.
AC101771 Genomic DNA No translation available.
AC129189 Genomic DNA No translation available.
AC130669 Genomic DNA No translation available.
AC137905 Genomic DNA No translation available.
AC154881 Genomic DNA No translation available.
AC157584 Genomic DNA No translation available.
AC158907 Genomic DNA No translation available.
AK122567 mRNA Translation: BAC65849.1
CCDSiCCDS49602.1 [Q80T79-3]
RefSeqiNP_001074860.2, NM_001081391.2 [Q80T79-3]
XP_011243913.1, XM_011245611.2 [Q80T79-1]

3D structure databases

SMRiQ80T79
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098235

PTM databases

GlyConnecti2242
iPTMnetiQ80T79
PhosphoSitePlusiQ80T79

Proteomic databases

PaxDbiQ80T79
PRIDEiQ80T79

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000100670; ENSMUSP00000098235; ENSMUSG00000022311 [Q80T79-3]
ENSMUST00000162830; ENSMUSP00000124775; ENSMUSG00000022311 [Q80T79-3]
GeneIDi239420
KEGGimmu:239420
UCSCiuc007vqt.1 mouse [Q80T79-2]
uc007vqu.2 mouse [Q80T79-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
114788
MGIiMGI:2386403 Csmd3

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00940000155549
HOGENOMiHOG000112015
InParanoidiQ80T79
KOiK17495
OMAiSADHGTN
OrthoDBi2377at2759
PhylomeDBiQ80T79
TreeFamiTF316872

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Csmd3 mouse

Protein Ontology

More...
PROi
PR:Q80T79

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000022311 Expressed in 125 organ(s), highest expression level in embryo
ExpressionAtlasiQ80T79 baseline and differential
GenevisibleiQ80T79 MM

Family and domain databases

CDDicd00033 CCP, 28 hits
cd00041 CUB, 14 hits
Gene3Di2.60.120.290, 14 hits
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR035914 Sperma_CUB_dom_sf
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00431 CUB, 14 hits
PF00084 Sushi, 28 hits
SMARTiView protein in SMART
SM00032 CCP, 28 hits
SM00042 CUB, 14 hits
SUPFAMiSSF49854 SSF49854, 14 hits
SSF57535 SSF57535, 28 hits
PROSITEiView protein in PROSITE
PS01180 CUB, 14 hits
PS50923 SUSHI, 28 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSMD3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80T79
Secondary accession number(s): Q3USM6, Q8BVJ0, Q9D588
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: September 1, 2009
Last modified: July 3, 2019
This is version 124 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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