UniProtKB - Q80T41 (GABR2_MOUSE)
Gamma-aminobutyric acid type B receptor subunit 2
Gabbr2
Functioni
Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:10075644).
Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (By similarity).
Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644).
Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644).
Plays a critical role in the fine-tuning of inhibitory synaptic transmission (By similarity).
Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:10075644).
Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (By similarity).
By similarity1 PublicationGO - Molecular functioni
- G protein-coupled GABA receptor activity Source: MGI
- protein heterodimerization activity Source: MGI
- transmembrane signaling receptor activity Source: GO_Central
GO - Biological processi
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: MGI
- gamma-aminobutyric acid signaling pathway Source: UniProtKB
- neuron-glial cell signaling Source: MGI
- synaptic transmission, GABAergic Source: ComplexPortal
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-MMU-1296041, Activation of G protein gated Potassium channels R-MMU-418594, G alpha (i) signalling events R-MMU-420499, Class C/3 (Metabotropic glutamate/pheromone receptors) R-MMU-977444, GABA B receptor activation R-MMU-997272, Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
Names & Taxonomyi
Protein namesi | Recommended name: Gamma-aminobutyric acid type B receptor subunit 2Short name: GABA-B receptor 2 Short name: GABA-B-R2 Short name: GABA-BR2 Short name: GABABR2 Short name: Gb2 Alternative name(s): G-protein coupled receptor 51 |
Gene namesi | Name:Gabbr2 Synonyms:Gm425, Gpr51 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2386030, Gabbr2 |
VEuPathDBi | HostDB:ENSMUSG00000039809 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
- postsynaptic cell membrane By similarity; Multi-pass membrane protein By similarity
Note: Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane. In contrast, GABBR2 does not depend on GABBR1 for transport to the cell membrane (By similarity).By similarity
Plasma Membrane
- G protein-coupled GABA receptor complex Source: MGI
- G protein-coupled receptor heterodimeric complex Source: UniProtKB
- integral component of plasma membrane Source: UniProtKB
- integral component of postsynaptic membrane Source: MGI
- integral component of presynaptic membrane Source: MGI
Other locations
- cytoplasm Source: MGI
- GABA receptor complex Source: MGI
- GABA-ergic synapse Source: MGI
- glutamatergic synapse Source: MGI
- neuron projection Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 41 – 482 | ExtracellularSequence analysisAdd BLAST | 442 | |
Transmembranei | 483 – 503 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 504 – 521 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 522 – 542 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 543 – 550 | ExtracellularSequence analysis | 8 | |
Transmembranei | 551 – 571 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 572 – 596 | CytoplasmicSequence analysisAdd BLAST | 25 | |
Transmembranei | 597 – 617 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 618 – 653 | ExtracellularSequence analysisAdd BLAST | 36 | |
Transmembranei | 654 – 674 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 675 – 690 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 691 – 711 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 712 – 719 | ExtracellularSequence analysis | 8 | |
Transmembranei | 720 – 740 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 741 – 940 | CytoplasmicSequence analysisAdd BLAST | 200 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 40 | Sequence analysisAdd BLAST | 40 | |
ChainiPRO_0000306250 | 41 – 940 | Gamma-aminobutyric acid type B receptor subunit 2Add BLAST | 900 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 89 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 107 ↔ 134 | By similarity | ||
Disulfide bondi | 236 ↔ 265 | By similarity | ||
Disulfide bondi | 264 ↔ 301 | By similarity | ||
Glycosylationi | 297 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 388 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 403 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 452 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 775 | PhosphoserineCombined sources | 1 | |
Modified residuei | 778 | PhosphoserineCombined sources | 1 | |
Modified residuei | 818 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 883 | PhosphoserineCombined sources | 1 | |
Modified residuei | 892 | PhosphoserineCombined sources | 1 | |
Modified residuei | 912 | PhosphoserineCombined sources | 1 | |
Modified residuei | 915 | PhosphoserineCombined sources | 1 | |
Modified residuei | 919 | PhosphoserineCombined sources | 1 | |
Modified residuei | 923 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
MaxQBi | Q80T41 |
PaxDbi | Q80T41 |
PeptideAtlasi | Q80T41 |
PRIDEi | Q80T41 |
ProteomicsDBi | 268837 |
PTM databases
GlyConnecti | 2329, 3 N-Linked glycans (1 site) |
GlyGeni | Q80T41, 5 sites, 3 N-linked glycans (1 site) |
iPTMneti | Q80T41 |
PhosphoSitePlusi | Q80T41 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000039809, Expressed in dentate gyrus of hippocampal formation granule cell and 64 other tissues |
ExpressionAtlasi | Q80T41, baseline and differential |
Interactioni
Subunit structurei
Heterodimer of GABBR1 and GABBR2 (PubMed:10075644). Homodimers may form, but are inactive (By similarity).
Interacts (via C-terminus) with ATF4 (via leucine zipper domain) (By similarity).
By similarity1 PublicationGO - Molecular functioni
- protein heterodimerization activity Source: MGI
Protein-protein interaction databases
BioGRIDi | 232404, 7 interactors |
ComplexPortali | CPX-2990, GABA-B receptor complex |
IntActi | Q80T41, 4 interactors |
MINTi | Q80T41 |
STRINGi | 10090.ENSMUSP00000103378 |
Miscellaneous databases
RNActi | Q80T41, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 762 – 789 | DisorderedSequence analysisAdd BLAST | 28 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 781 – 818 | Sequence analysisAdd BLAST | 38 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coil, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1055, Eukaryota |
GeneTreei | ENSGT00940000155783 |
HOGENOMi | CLU_005240_0_0_1 |
InParanoidi | Q80T41 |
OMAi | LLKHYHW |
OrthoDBi | 590810at2759 |
PhylomeDBi | Q80T41 |
TreeFami | TF313965 |
Family and domain databases
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR041689, GBR2_CC IPR002455, GPCR3_GABA-B IPR000337, GPCR_3 IPR017978, GPCR_3_C IPR017979, GPCR_3_CS IPR002457, GPCR_3_GABA_rcpt_B2 IPR028082, Peripla_BP_I |
PANTHERi | PTHR10519, PTHR10519, 1 hit |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit PF01094, ANF_receptor, 1 hit PF18455, GBR2_CC, 1 hit |
PRINTSi | PR01178, GABAB2RECPTR PR00248, GPCRMGR |
SUPFAMi | SSF53822, SSF53822, 1 hit |
PROSITEi | View protein in PROSITE PS00981, G_PROTEIN_RECEP_F3_3, 1 hit PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MASPPSSGQP RPPPPPPPPA RLLLPLLLSL LLSLAPGAWG WARGAPRPPP
60 70 80 90 100
SSPPLSIMGL MPLTKEVAKG SIGRGVLPAV ELAIEQIRNE SLLRPYFLDL
110 120 130 140 150
RLYDTECDNA KGLKAFYDAI KYGPNHLMVF GGVCPSVTSI IAESLQGWNL
160 170 180 190 200
VQLSFAATTP VLADKKKYPY FFRTVPSDNA VNPAILKLLK HFRWRRVGTL
210 220 230 240 250
TQDVQRFSEV RNDLTGVLYG EDIEISDTES FSNDPCTSVK KLKGNDVRII
260 270 280 290 300
LGQFDQNMAA KVFCCAFEES MFGSKYQWII PGWYEPAWWE QVHVEANSSR
310 320 330 340 350
CLRRSLLAAM EGYIGVDFEP LSSKQIKTIS GKTPQQYERE YNSKRSGVGP
360 370 380 390 400
SKFHGYAYDG IWVIAKTLQR AMETLHASSR HQRIQDFNYT DHTLGRIILN
410 420 430 440 450
AMNETNFFGV TGQVVFRNGE RMGTIKFTQF QDSREVKVGE YNAVADTLEI
460 470 480 490 500
INDTIRFQGS EPPKDKTIIL EQLRKISLPL YSILSALTIL GMIMASAFLF
510 520 530 540 550
FNIKNRNQKL IKMSSPYMNN LIILGGMLSY ASIFLFGLDG SFVSEKTFET
560 570 580 590 600
LCTVRTWILT VGYTTAFGAM FAKTWRVHAI FKNVKMKKKI IKDQKLLVIV
610 620 630 640 650
GGMLLIDLCI LICWQAVDPL RRTVERYSME PDPAGRDISI RPLLEHCENT
660 670 680 690 700
HMTIWLGIVY AYKGLLMLFG CFLAWETRNV SIPALNDSKY IGMSVYNVGI
710 720 730 740 750
MCIIGAAVSF LTRDQPNVQF CIVALVIIFC STITLCLVFV PKLITLRTNP
760 770 780 790 800
DAATQNRRFQ FTQNQKKEDS KTSTSVTSVN QASTSRLEGL QSENHRLRMK
810 820 830 840 850
ITELDKDLEE VTMQLQDTPE KTTYIKQNHY QELNDILSLG NFTESTDGGK
860 870 880 890 900
AILKNHLDQN PQLQWNTTEP SRTCKDPIED INSPEHIQRR LSLQLPILHH
910 920 930 940
AYLPSIGGVD ASCVSPCVSP TASPRHRHVP PSFRVMVSGL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0U1RQ90 | A0A0U1RQ90_MOUSE | Gamma-aminobutyric acid type B rece... | Gabbr2 | 183 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL772399 Genomic DNA No translation available. AL831741 Genomic DNA No translation available. AL844224 Genomic DNA No translation available. BX005247 Genomic DNA No translation available. BX571848 Genomic DNA No translation available. AY255605 mRNA Translation: AAO85117.1 |
CCDSi | CCDS38758.1 |
RefSeqi | NP_001074610.1, NM_001081141.1 |
Genome annotation databases
Ensembli | ENSMUST00000107749; ENSMUSP00000103378; ENSMUSG00000039809 |
GeneIDi | 242425 |
KEGGi | mmu:242425 |
UCSCi | uc008sug.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL772399 Genomic DNA No translation available. AL831741 Genomic DNA No translation available. AL844224 Genomic DNA No translation available. BX005247 Genomic DNA No translation available. BX571848 Genomic DNA No translation available. AY255605 mRNA Translation: AAO85117.1 |
CCDSi | CCDS38758.1 |
RefSeqi | NP_001074610.1, NM_001081141.1 |
3D structure databases
AlphaFoldDBi | Q80T41 |
SMRi | Q80T41 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 232404, 7 interactors |
ComplexPortali | CPX-2990, GABA-B receptor complex |
IntActi | Q80T41, 4 interactors |
MINTi | Q80T41 |
STRINGi | 10090.ENSMUSP00000103378 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyConnecti | 2329, 3 N-Linked glycans (1 site) |
GlyGeni | Q80T41, 5 sites, 3 N-linked glycans (1 site) |
iPTMneti | Q80T41 |
PhosphoSitePlusi | Q80T41 |
Proteomic databases
MaxQBi | Q80T41 |
PaxDbi | Q80T41 |
PeptideAtlasi | Q80T41 |
PRIDEi | Q80T41 |
ProteomicsDBi | 268837 |
Protocols and materials databases
ABCDi | Q80T41, 2 sequenced antibodies |
Antibodypediai | 2939, 575 antibodies from 41 providers |
Genome annotation databases
Ensembli | ENSMUST00000107749; ENSMUSP00000103378; ENSMUSG00000039809 |
GeneIDi | 242425 |
KEGGi | mmu:242425 |
UCSCi | uc008sug.1, mouse |
Organism-specific databases
CTDi | 9568 |
MGIi | MGI:2386030, Gabbr2 |
VEuPathDBi | HostDB:ENSMUSG00000039809 |
Phylogenomic databases
eggNOGi | KOG1055, Eukaryota |
GeneTreei | ENSGT00940000155783 |
HOGENOMi | CLU_005240_0_0_1 |
InParanoidi | Q80T41 |
OMAi | LLKHYHW |
OrthoDBi | 590810at2759 |
PhylomeDBi | Q80T41 |
TreeFami | TF313965 |
Enzyme and pathway databases
Reactomei | R-MMU-1296041, Activation of G protein gated Potassium channels R-MMU-418594, G alpha (i) signalling events R-MMU-420499, Class C/3 (Metabotropic glutamate/pheromone receptors) R-MMU-977444, GABA B receptor activation R-MMU-997272, Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
Miscellaneous databases
BioGRID-ORCSi | 242425, 2 hits in 76 CRISPR screens |
PROi | PR:Q80T41 |
RNActi | Q80T41, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000039809, Expressed in dentate gyrus of hippocampal formation granule cell and 64 other tissues |
ExpressionAtlasi | Q80T41, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR041689, GBR2_CC IPR002455, GPCR3_GABA-B IPR000337, GPCR_3 IPR017978, GPCR_3_C IPR017979, GPCR_3_CS IPR002457, GPCR_3_GABA_rcpt_B2 IPR028082, Peripla_BP_I |
PANTHERi | PTHR10519, PTHR10519, 1 hit |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit PF01094, ANF_receptor, 1 hit PF18455, GBR2_CC, 1 hit |
PRINTSi | PR01178, GABAB2RECPTR PR00248, GPCRMGR |
SUPFAMi | SSF53822, SSF53822, 1 hit |
PROSITEi | View protein in PROSITE PS00981, G_PROTEIN_RECEP_F3_3, 1 hit PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GABR2_MOUSE | |
Accessioni | Q80T41Primary (citable) accession number: Q80T41 Secondary accession number(s): A2AL05 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | October 2, 2007 | |
Last modified: | May 25, 2022 | |
This is version 124 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families