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UniProtKB - Q80T41 (GABR2_MOUSE)

Entry version 124 (25 May 2022)
Sequence version 2 (02 Oct 2007)
Previous versions | rss
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Protein

Gamma-aminobutyric acid type B receptor subunit 2

Gene

Gabbr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:10075644).

Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (By similarity).

Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644).

Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644).

Plays a critical role in the fine-tuning of inhibitory synaptic transmission (By similarity).

Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:10075644).

Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (By similarity).

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-1296041, Activation of G protein gated Potassium channels
R-MMU-418594, G alpha (i) signalling events
R-MMU-420499, Class C/3 (Metabotropic glutamate/pheromone receptors)
R-MMU-977444, GABA B receptor activation
R-MMU-997272, Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gamma-aminobutyric acid type B receptor subunit 2
Short name:
GABA-B receptor 2
Short name:
GABA-B-R2
Short name:
GABA-BR2
Short name:
GABABR2
Short name:
Gb2
Alternative name(s):
G-protein coupled receptor 51
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Gabbr2
Synonyms:Gm425, Gpr51
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2386030, Gabbr2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000039809

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini41 – 482ExtracellularSequence analysisAdd BLAST442
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei483 – 503Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini504 – 521CytoplasmicSequence analysisAdd BLAST18
Transmembranei522 – 542Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini543 – 550ExtracellularSequence analysis8
Transmembranei551 – 571Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini572 – 596CytoplasmicSequence analysisAdd BLAST25
Transmembranei597 – 617Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini618 – 653ExtracellularSequence analysisAdd BLAST36
Transmembranei654 – 674Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini675 – 690CytoplasmicSequence analysisAdd BLAST16
Transmembranei691 – 711Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini712 – 719ExtracellularSequence analysis8
Transmembranei720 – 740Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini741 – 940CytoplasmicSequence analysisAdd BLAST200

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 40Sequence analysisAdd BLAST40
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000030625041 – 940Gamma-aminobutyric acid type B receptor subunit 2Add BLAST900

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi107 ↔ 134By similarity
Disulfide bondi236 ↔ 265By similarity
Disulfide bondi264 ↔ 301By similarity
Glycosylationi297N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi388N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi403N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi452N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei775PhosphoserineCombined sources1
Modified residuei778PhosphoserineCombined sources1
Modified residuei818PhosphothreonineCombined sources1
Modified residuei883PhosphoserineCombined sources1
Modified residuei892PhosphoserineCombined sources1
Modified residuei912PhosphoserineCombined sources1
Modified residuei915PhosphoserineCombined sources1
Modified residuei919PhosphoserineCombined sources1
Modified residuei923PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q80T41

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q80T41

PeptideAtlas

More...PeptideAtlasi		Q80T41

PRoteomics IDEntifications database

More...PRIDEi		Q80T41

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		268837

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2329, 3 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q80T41, 5 sites, 3 N-linked glycans (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q80T41

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q80T41

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000039809, Expressed in dentate gyrus of hippocampal formation granule cell and 64 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q80T41, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of GABBR1 and GABBR2 (PubMed:10075644). Homodimers may form, but are inactive (By similarity).

Interacts (via C-terminus) with ATF4 (via leucine zipper domain) (By similarity).

By similarity1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		232404, 7 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-2990, GABA-B receptor complex

Protein interaction database and analysis system

More...IntActi		Q80T41, 4 interactors

Molecular INTeraction database

More...MINTi		Q80T41

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000103378

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q80T41, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q80T41

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q80T41

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni762 – 789DisorderedSequence analysisAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili781 – 818Sequence analysisAdd BLAST38

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABBR1.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.Curated

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1055, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155783

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005240_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q80T41

Identification of Orthologs from Complete Genome Data

More...OMAi		LLKHYHW

Database of Orthologous Groups

More...OrthoDBi		590810at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q80T41

TreeFam database of animal gene trees

More...TreeFami		TF313965

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001828, ANF_lig-bd_rcpt
IPR041689, GBR2_CC
IPR002455, GPCR3_GABA-B
IPR000337, GPCR_3
IPR017978, GPCR_3_C
IPR017979, GPCR_3_CS
IPR002457, GPCR_3_GABA_rcpt_B2
IPR028082, Peripla_BP_I

The PANTHER Classification System

More...PANTHERi		PTHR10519, PTHR10519, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00003, 7tm_3, 1 hit
PF01094, ANF_receptor, 1 hit
PF18455, GBR2_CC, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01178, GABAB2RECPTR
PR00248, GPCRMGR

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53822, SSF53822, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00981, G_PROTEIN_RECEP_F3_3, 1 hit
PS50259, G_PROTEIN_RECEP_F3_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q80T41-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASPPSSGQP RPPPPPPPPA RLLLPLLLSL LLSLAPGAWG WARGAPRPPP 
        60         70         80         90        100
SSPPLSIMGL MPLTKEVAKG SIGRGVLPAV ELAIEQIRNE SLLRPYFLDL 
       110        120        130        140        150
RLYDTECDNA KGLKAFYDAI KYGPNHLMVF GGVCPSVTSI IAESLQGWNL 
       160        170        180        190        200
VQLSFAATTP VLADKKKYPY FFRTVPSDNA VNPAILKLLK HFRWRRVGTL 
       210        220        230        240        250
TQDVQRFSEV RNDLTGVLYG EDIEISDTES FSNDPCTSVK KLKGNDVRII 
       260        270        280        290        300
LGQFDQNMAA KVFCCAFEES MFGSKYQWII PGWYEPAWWE QVHVEANSSR 
       310        320        330        340        350
CLRRSLLAAM EGYIGVDFEP LSSKQIKTIS GKTPQQYERE YNSKRSGVGP 
       360        370        380        390        400
SKFHGYAYDG IWVIAKTLQR AMETLHASSR HQRIQDFNYT DHTLGRIILN 
       410        420        430        440        450
AMNETNFFGV TGQVVFRNGE RMGTIKFTQF QDSREVKVGE YNAVADTLEI 
       460        470        480        490        500
INDTIRFQGS EPPKDKTIIL EQLRKISLPL YSILSALTIL GMIMASAFLF 
       510        520        530        540        550
FNIKNRNQKL IKMSSPYMNN LIILGGMLSY ASIFLFGLDG SFVSEKTFET 
       560        570        580        590        600
LCTVRTWILT VGYTTAFGAM FAKTWRVHAI FKNVKMKKKI IKDQKLLVIV 
       610        620        630        640        650
GGMLLIDLCI LICWQAVDPL RRTVERYSME PDPAGRDISI RPLLEHCENT 
       660        670        680        690        700
HMTIWLGIVY AYKGLLMLFG CFLAWETRNV SIPALNDSKY IGMSVYNVGI 
       710        720        730        740        750
MCIIGAAVSF LTRDQPNVQF CIVALVIIFC STITLCLVFV PKLITLRTNP 
       760        770        780        790        800
DAATQNRRFQ FTQNQKKEDS KTSTSVTSVN QASTSRLEGL QSENHRLRMK 
       810        820        830        840        850
ITELDKDLEE VTMQLQDTPE KTTYIKQNHY QELNDILSLG NFTESTDGGK 
       860        870        880        890        900
AILKNHLDQN PQLQWNTTEP SRTCKDPIED INSPEHIQRR LSLQLPILHH 
       910        920        930        940
AYLPSIGGVD ASCVSPCVSP TASPRHRHVP PSFRVMVSGL
Length:940
Mass (Da):105,666
Last modified:October 2, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB364DC0A54EE9206
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RQ90A0A0U1RQ90_MOUSE
Gamma-aminobutyric acid type B rece...
Gabbr2
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL772399 Genomic DNA No translation available.
AL831741 Genomic DNA No translation available.
AL844224 Genomic DNA No translation available.
BX005247 Genomic DNA No translation available.
BX571848 Genomic DNA No translation available.
AY255605 mRNA Translation: AAO85117.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS38758.1

NCBI Reference Sequences

More...RefSeqi		NP_001074610.1, NM_001081141.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000107749; ENSMUSP00000103378; ENSMUSG00000039809

Database of genes from NCBI RefSeq genomes

More...GeneIDi		242425

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:242425

UCSC genome browser

More...UCSCi		uc008sug.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772399 Genomic DNA No translation available.
AL831741 Genomic DNA No translation available.
AL844224 Genomic DNA No translation available.
BX005247 Genomic DNA No translation available.
BX571848 Genomic DNA No translation available.
AY255605 mRNA Translation: AAO85117.1
CCDSiCCDS38758.1
RefSeqiNP_001074610.1, NM_001081141.1

3D structure databases

AlphaFoldDBiQ80T41
SMRiQ80T41
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi232404, 7 interactors
ComplexPortaliCPX-2990, GABA-B receptor complex
IntActiQ80T41, 4 interactors
MINTiQ80T41
STRINGi10090.ENSMUSP00000103378

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyConnecti2329, 3 N-Linked glycans (1 site)
GlyGeniQ80T41, 5 sites, 3 N-linked glycans (1 site)
iPTMnetiQ80T41
PhosphoSitePlusiQ80T41

Proteomic databases

MaxQBiQ80T41
PaxDbiQ80T41
PeptideAtlasiQ80T41
PRIDEiQ80T41
ProteomicsDBi268837

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q80T41, 2 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2939, 575 antibodies from 41 providers

Genome annotation databases

EnsembliENSMUST00000107749; ENSMUSP00000103378; ENSMUSG00000039809
GeneIDi242425
KEGGimmu:242425
UCSCiuc008sug.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9568
MGIiMGI:2386030, Gabbr2
VEuPathDBiHostDB:ENSMUSG00000039809

Phylogenomic databases

eggNOGiKOG1055, Eukaryota
GeneTreeiENSGT00940000155783
HOGENOMiCLU_005240_0_0_1
InParanoidiQ80T41
OMAiLLKHYHW
OrthoDBi590810at2759
PhylomeDBiQ80T41
TreeFamiTF313965

Enzyme and pathway databases

ReactomeiR-MMU-1296041, Activation of G protein gated Potassium channels
R-MMU-418594, G alpha (i) signalling events
R-MMU-420499, Class C/3 (Metabotropic glutamate/pheromone receptors)
R-MMU-977444, GABA B receptor activation
R-MMU-997272, Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		242425, 2 hits in 76 CRISPR screens

Protein Ontology

More...PROi		PR:Q80T41
RNActiQ80T41, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000039809, Expressed in dentate gyrus of hippocampal formation granule cell and 64 other tissues
ExpressionAtlasiQ80T41, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR001828, ANF_lig-bd_rcpt
IPR041689, GBR2_CC
IPR002455, GPCR3_GABA-B
IPR000337, GPCR_3
IPR017978, GPCR_3_C
IPR017979, GPCR_3_CS
IPR002457, GPCR_3_GABA_rcpt_B2
IPR028082, Peripla_BP_I
PANTHERiPTHR10519, PTHR10519, 1 hit
PfamiView protein in Pfam
PF00003, 7tm_3, 1 hit
PF01094, ANF_receptor, 1 hit
PF18455, GBR2_CC, 1 hit
PRINTSiPR01178, GABAB2RECPTR
PR00248, GPCRMGR
SUPFAMiSSF53822, SSF53822, 1 hit
PROSITEiView protein in PROSITE
PS00981, G_PROTEIN_RECEP_F3_3, 1 hit
PS50259, G_PROTEIN_RECEP_F3_4, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGABR2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80T41
Secondary accession number(s): A2AL05
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: May 25, 2022
This is version 124 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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