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Entry version 138 (07 Apr 2021)
Sequence version 2 (27 Jul 2011)
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Protein

Extracellular matrix organizing protein FRAS1

Gene

Fras1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in extracellular matrix organization (PubMed:32333816). Required for the regulation of epidermal-basement membrane adhesion responsible for proper organogenesis during embryonic development (PubMed:12766769). Involved in brain organization and function (PubMed:32333816).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Extracellular matrix organizing protein FRAS11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fras1Imported
Synonyms:Kiaa1500
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2385368, Fras1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 3903ExtracellularSequence analysisAdd BLAST3878
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3904 – 3924HelicalSequence analysisAdd BLAST21
Topological domaini3925 – 4010CytoplasmicSequence analysisAdd BLAST86

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in Fras1 are the cause of blebbed (bl) phenotype, which is characterized by blister formation, syndactyly, eyelid fusion and renal agenesis. Subepidermal blisters are predominantly formed in the head region around the eyes and at the distal part of the limbs. As development proceeds blisters that are initially transparent gradually become hemorrhagic and embryos die between 14.5 dpc and 16.5 dpc.3 Publications

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Homozygous adult knockout mice display impaired performance in various types of learning and memory tasks as well as reduced anxiety.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001012126 – 4010Extracellular matrix organizing protein FRAS1Add BLAST3985

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei343PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi727N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1094N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1107N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1506N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1779N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1950N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1980N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2565N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2666N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2684N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2910N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2987N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3072N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3220N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3678N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3877N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q80T14

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q80T14

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q80T14

PeptideAtlas

More...
PeptideAtlasi
Q80T14

PRoteomics IDEntifications database

More...
PRIDEi
Q80T14

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
267408

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2307, 1 N-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q80T14, 16 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q80T14

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q80T14

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Highly expressed in the apical ectodermal ridge of the limb buds from 10.5-12.5 dpc and expression was also detected in the interdigital spaces at 14.5 dpc. Found in cells just underlying the surface epithelium of the entire embryo and in the linings of the peritoneal cavity and dorsal aorta. At 12 dpc, detected in the mesonephric duct and in the lens (PubMed:12766769). Found in a linear fashion underlying the epidermis and the basal surface of other epithelia in embryos (PubMed:12766770). Found in meningeal and choroidal epidermal-basement membranes in embryos and neonates (PubMed:32333816).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000034687, Expressed in medulla oblongata part of 4th ventricle choroid plexus (mouse) and 225 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q80T14, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
231125, 1 interactor

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q80T14

Database of interacting proteins

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DIPi
DIP-61242N

Protein interaction database and analysis system

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IntActi
Q80T14, 2 interactors

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000043250

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q80T14, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q80T14

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 87VWFC 1PROSITE-ProRule annotationAdd BLAST62
Domaini92 – 152VWFC 2PROSITE-ProRule annotationAdd BLAST61
Domaini156 – 216VWFC 3PROSITE-ProRule annotationAdd BLAST61
Domaini218 – 278VWFC 4PROSITE-ProRule annotationAdd BLAST61
Domaini282 – 342VWFC 5PROSITE-ProRule annotationAdd BLAST61
Domaini358 – 416VWFC 6PROSITE-ProRule annotationAdd BLAST59
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati408 – 459FU 1Add BLAST52
Repeati461 – 504FU 2Add BLAST44
Repeati506 – 552FU 3Add BLAST47
Repeati554 – 598FU 4Add BLAST45
Repeati601 – 646FU 5Add BLAST46
Repeati648 – 704FU 6Add BLAST57
Repeati707 – 752FU 7Add BLAST46
Repeati754 – 799FU 8Add BLAST46
Repeati802 – 851FU 9Add BLAST50
Repeati853 – 899FU 10Add BLAST47
Repeati902 – 947FU 11Add BLAST46
Repeati951 – 996FU 12Add BLAST46
Repeati998 – 1041FU 13Add BLAST44
Repeati1045 – 1088FU 14Add BLAST44
Repeati1101 – 1196CSPG 1PROSITE-ProRule annotationAdd BLAST96
Repeati1216 – 1307CSPG 2PROSITE-ProRule annotationAdd BLAST92
Repeati1328 – 1440CSPG 3PROSITE-ProRule annotationAdd BLAST113
Repeati1465 – 1561CSPG 4PROSITE-ProRule annotationAdd BLAST97
Repeati1597 – 1691CSPG 5PROSITE-ProRule annotationAdd BLAST95
Repeati1712 – 1812CSPG 6PROSITE-ProRule annotationAdd BLAST101
Repeati1834 – 1938CSPG 7PROSITE-ProRule annotationAdd BLAST105
Repeati1959 – 2059CSPG 8PROSITE-ProRule annotationAdd BLAST101
Repeati2080 – 2179CSPG 9PROSITE-ProRule annotationAdd BLAST100
Repeati2201 – 2293CSPG 10PROSITE-ProRule annotationAdd BLAST93
Repeati2313 – 2406CSPG 11PROSITE-ProRule annotationAdd BLAST94
Repeati2441 – 2538CSPG 12PROSITE-ProRule annotationAdd BLAST98
Domaini2545 – 2648Calx-beta 1Add BLAST104
Domaini2661 – 2772Calx-beta 2Add BLAST112
Domaini2786 – 2892Calx-beta 3Add BLAST107
Domaini2907 – 3009Calx-beta 4Add BLAST103
Domaini3027 – 3131Calx-beta 5Add BLAST105

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon binding.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FRAS1 family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1025, Eukaryota
KOG1216, Eukaryota
KOG1306, Eukaryota
KOG3525, Eukaryota
KOG3597, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162130

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000244_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q80T14

Identification of Orthologs from Complete Genome Data

More...
OMAi
CGPSHVL

Database of Orthologous Groups

More...
OrthoDBi
13258at2759

TreeFam database of animal gene trees

More...
TreeFami
TF316876

Family and domain databases

Conserved Domains Database

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CDDi
cd00064, FU, 12 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.2030, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038081, CalX-like_sf
IPR003644, Calx_beta
IPR039005, CSPG_rpt
IPR000742, EGF-like_dom
IPR006212, Furin_repeat
IPR009030, Growth_fac_rcpt_cys_sf
IPR001007, VWF_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03160, Calx-beta, 5 hits
PF00093, VWC, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00237, Calx_beta, 5 hits
SM00181, EGF, 10 hits
SM00261, FU, 14 hits
SM00214, VWC, 6 hits
SM00215, VWC_out, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF141072, SSF141072, 5 hits
SSF57184, SSF57184, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51854, CSPG, 12 hits
PS01208, VWFC_1, 6 hits
PS50184, VWFC_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q80T14-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGVLKAWLGV ALALAEFAVL PNCEGACLYQ GSFLADATIW KPDSCQNCRC
60 70 80 90 100
HGDIVICKPV VCKNPRCAFE KGEVLWIAPN QCCPQCAPRT PGSCHHEGKI
110 120 130 140 150
HEHGTEWASA PCTVCSCTHG EVRCSHQQCT PLSCGPQELE FLAEGRCCPI
160 170 180 190 200
CVGTGKPCSY DGHVFQDGED WQLSRCAKCV CRNGLTQCFA AQCQPLFCNQ
210 220 230 240 250
DEIVVRVPGK CCSQCSARSC STAGQVYEHG EQWKEDACTL CMCDQGQVRC
260 270 280 290 300
HKQVCPPLRC AKGQGRARHH GQCCEECATP DRSCSSGGVL RYQDEMWKGS
310 320 330 340 350
ACEFCMCDQG QVTCQTGECA KVACALGEEL VHLEGKCCPE CISRNGYCIY
360 370 380 390 400
EQKAETMSSS AREIKHVPDG EKWEEGPCKL CECREAQVTC YEPSCPPCPV
410 420 430 440 450
ATLALVVKGQ CCPDCTPVHC HPDCLTCSHS PDHCDLCQDP TKLLQNGRCV
460 470 480 490 500
HSCGLGFYQA GSLCLACQPQ CSTCTNGLEC SSCLPPLLMQ QGQCVSTCGD
510 520 530 540 550
GFYQDHHSCA VCHESCAGCW GPTEKHCMAC RDPLQVLRDS SCENTCGNGF
560 570 580 590 600
YNRQGTCVAC DQSCKSCGPS SPRCLSCAEK TILHDGKCIS ECPHGYYADS
610 620 630 640 650
TGSCKVCHSS CASCSGPTAA HCIACIHPQT LRQGHCLPSC GEGFYPDHGI
660 670 680 690 700
CEACHASCHT CVGPQPSHCT QCKKPEAGLL VEQHSGENVP YGKCVSRCGT
710 720 730 740 750
HFYLESTGLC EVCHPSCLTC EGKSPHNCTG CESTHALLAG CCVSQCPETH
760 770 780 790 800
FNLEGTCTEC HPSCRQCHGP LESDCVSCHP HLTLTSGHCK TSCKEEQFLN
810 820 830 840 850
LVGYCADCHP LCQHCVANLQ DTGSICLKCQ HARHLLLGDH CVPECPPGHY
860 870 880 890 900
KERGTCKTCH SSCRSCQNGG PFSCSSCDTG LVLTHIGTCS TACFPGHYLD
910 920 930 940 950
DNQVCQPCNR HCRSCDSQGS CTSCRDPSKV LLFGECQYES CTPQYYLDIA
960 970 980 990 1000
TKTCKECDWS CNACTGPLRT DCLQCMDGYV LQDGVCVEQC SPQHYRDSGS
1010 1020 1030 1040 1050
CKRCDSHCVE CQGPHECTRC EEPFLLFQAQ CVQECGKGYF ADHAKHRCIA
1060 1070 1080 1090 1100
CPQGCLRCSH KDRCHLCDHS FFLKSGLCMP TCVPGFSGHS SNENCTDKMY
1110 1120 1130 1140 1150
TPSLHVNGSL TLGIGSMKPL DFSLLNIQHQ DGRVEDLLFH VVSTPTNGQL
1160 1170 1180 1190 1200
LLSRNGKEVQ LEKAGHFSWK DVNEKKVRFV HSKEKLRKGY FSLKISDQQF
1210 1220 1230 1240 1250
FSEPQLINIQ AFSTQAPYVL RNEVLHVSKG ERATITTQLL DIRDDDNPQD
1260 1270 1280 1290 1300
VVVNVLDPPL HGQLLQMPPA PAASIYQFHL DELSRGLLLY AHDGSDSTSD
1310 1320 1330 1340 1350
IIVFQANDGH SFQNILFHVK NIPKNDRALR LVTNSMVWVP EGGMLKITNR
1360 1370 1380 1390 1400
ILKAQAPGVR ADDIIYKITH SRPQFGEVVL LMNLPADSPA GPAEEGHHLP
1410 1420 1430 1440 1450
DGRMATPIST FTQQDIDDGV VWYRHLGAPT QSDSFRFQVS SATSAQEHLE
1460 1470 1480 1490 1500
SHMFNIAILP QAPEAPKLSL GTSLHMTARE DGLSVIQPQS LSFVKAESPS
1510 1520 1530 1540 1550
GKIIYNITVP LHPNQGIIEH RDRPHSPIQY FTQEDINQGQ IMYRPPVAPP
1560 1570 1580 1590 1600
HLQEIMAFSF AGLPESVKFY FTVSDGQHTS PEMALTIHLL HSDLQPPAFQ
1610 1620 1630 1640 1650
VKAPLLEVSP GGRTSLGLQL LVRDAQVVPE ELFFQLQKSP QHGMLVKYTA
1660 1670 1680 1690 1700
KSSVTMAAGD TFTYDEVERN VLQYVHDGSS AWEDSLEISV TDGLTVTTSE
1710 1720 1730 1740 1750
VKVEVSPSEN RGPRLAPGSS LSMTVASQHT AIITRSHLAY VDDSSSDPEI
1760 1770 1780 1790 1800
WIRLSSLPLY GVLFRSSGPD MDELSGDSNF TMEDINKKNI RYSAVFETDG
1810 1820 1830 1840 1850
HSVTDGFHFS VSDMDGNHVD NQVFTITVTP AENPPHIIAF ADLITVDEGG
1860 1870 1880 1890 1900
RAPLSLHHFF ATEDQDNLQD DAVIKLSALP KYGCIENTGT GDRFGPGANS
1910 1920 1930 1940 1950
ELEASFPIQD VLENYIYYFQ SVHESIEPTH DVFSFYVSDG SGRSEIHSIN
1960 1970 1980 1990 2000
ITIERKNDEP PRMTLRPLGV RLSSGVAISN SSLSLQDLDT PDNELIFVLM
2010 2020 2030 2040 2050
KKPDHGHLLR RSTASDPLEN GTVLDQGSSF TYQDVLAGLV GYLPGDIYMA
2060 2070 2080 2090 2100
VDEFRFSLTD GLHVDTGRME IYIELPSTNI PHLAINRGLQ LSAGSVARIT
2110 2120 2130 2140 2150
EQHLKATDTD SEAGQVVYIM KEDPGAGRLL MAKADNLEQI SVRGPIRSFT
2160 2170 2180 2190 2200
QADVSQGQIE YSHGPGEPGG SFAFKFDVVD GEGNKLADQS FSIGVLEDKS
2210 2220 2230 2240 2250
PPVVITNRGL VLDENSVEKI TTAQLSATDQ DSKPTELIYR ITTQPQLGHL
2260 2270 2280 2290 2300
EHVASPGIQI SSFTQADLAS RNVQYVRSSG TGKQSDAFSF VLSDGLHEVT
2310 2320 2330 2340 2350
QTFPITIHPV DDARPLVQNR GMRVQEGVRK TITEFELKAV DVDTEAESIT
2360 2370 2380 2390 2400
FTIVQPPRHG TIERTARGQR FHQTSSFTME DIYQNRVSYS HDGSNSLKDR
2410 2420 2430 2440 2450
FTFTVSDGTN PFFIIEEGGE EIMTAAPQQF HVDILPVDDG TPRIVTNLGL
2460 2470 2480 2490 2500
QWLEYMDGKA TNLITKKELL TVDPDTEDSQ LIYEVTTGPM HGYLENKLQP
2510 2520 2530 2540 2550
GRAAATFTQE HVNLGLIRYV LYEEKIQKVM DSFQFLVKDS KPNVVSDNVF
2560 2570 2580 2590 2600
HIQWSLISFK YTSYNVSEKA GSVSVTVQRT GNLNQYAIVL CRTEQGTASS
2610 2620 2630 2640 2650
SSHPGQQDYM EYAGQVQFDE GEGTKSCTVI INDDDVFENI ESFTVGLSMP
2660 2670 2680 2690 2700
AYALLGEFTQ AKVVINDTED EPTLEFDKKT YRVNESAGFL FAPIKRQGDS
2710 2720 2730 2740 2750
SSTVSAVCYT VPKSAMGSSL YALESGSDFK SRGRSAESRV IFGPGVTVST
2760 2770 2780 2790 2800
CDVMVIDDSE YEEEEEFEIA LADASNNARI GRQAVAKVLI SGPNDASTVS
2810 2820 2830 2840 2850
LGNTAFTISE DAGTVKIPVI RHGTDLSTFT SVWCATRPSD PASATPGVDY
2860 2870 2880 2890 2900
VPSSRKVEFG PGITEQYCTL TILDDTQYPV IEGLETFVVF LSSAQGAELT
2910 2920 2930 2940 2950
KPSQAVIAIN DTFQDVPSMQ FSKDLLLVKE KEGVLHIPII RSGDLSYESS
2960 2970 2980 2990 3000
VRCYTQGHSA QVMEDFEERR NADSSRITFL KGQKTKNCTV YIHDDSMFEP
3010 3020 3030 3040 3050
EEQFRVYLGH PLGNHWSGAR IGKNSVATVT ISNDEDAPTI EFEEAAYQVR
3060 3070 3080 3090 3100
EPAGPEAIAV LSIKVIRRGD QNRTSKIRCS TRDGSAQSGV DYYPKSRVLK
3110 3120 3130 3140 3150
FSPGVDHIFF KVEILSNEDR EWHESFSLVL GPDDLVEAVL GDVTTATVTI
3160 3170 3180 3190 3200
LDQEAAGSLI LPAPPIVVTL ADYDHVEELA KEGVKKAPSP GYPLVCVTPC
3210 3220 3230 3240 3250
DPRYPRYAVM KERCSEAGIN QTSVQFSWEV AAPTDGNGAR SPFETITDNT
3260 3270 3280 3290 3300
PFTSVNHKVL DSIYFSRRFH VRCVAKAVDK VGHVGTPLRS NVVTIGTDSA
3310 3320 3330 3340 3350
ICHTPVVAGT ARGFQAQSFI ATLKYLDVKH KEHPNRIHIS VQIPHQDGML
3360 3370 3380 3390 3400
PLISTMPLHN LHFLLSESIY RHQHVCSNLV TAQDLRGLAE AGFLNDAGFH
3410 3420 3430 3440 3450
STALGPGYDR PFQFDSSVRE PKTIQLYRHL NLKSCVWTFD AYYDMTELID
3460 3470 3480 3490 3500
VCGGSVTADF QVRDSAQSFL TVHVPLYVSY IYVTAPRGWA SLEHHTEMEF
3510 3520 3530 3540 3550
SFFYDTVLWR TGIQTDSVLS ARLQIIRIYI REDGRLVIEF KTHAKFRGQF
3560 3570 3580 3590 3600
VIEHHTLPDV KSFILTPDHL GGIQFDLQLL WSAQTFDSPH QLWRATSSYN
3610 3620 3630 3640 3650
RKDYSGEYTI YLIPCTVQPT QPWVDPGEKA LACTAHAPER FLIPIAFQQT
3660 3670 3680 3690 3700
NRPVPVVYSL NTEFQLCNNE KVFLMDPNTS DMSLAEMDYK GAFSKGQILY
3710 3720 3730 3740 3750
GRVLWNPEQN LHSAYKLQLE KVYLCTGKDG YVPFFDPTGT IYNEGPQYGC
3760 3770 3780 3790 3800
IQPNKHLKHR FLLLDRSQPE VTDKYFHDVP FEAHFASELP DFQVVSSMPG
3810 3820 3830 3840 3850
VDGFTLKVDA LYKVEAGHQW YLQVIYIIGP DSTSRPRVQR SLTVSLRRHQ
3860 3870 3880 3890 3900
RDLVDPSGWL SLDDSLIYDN EGDQVKNGTN MKSLNLEMQE PVIAASLSQT
3910 3920 3930 3940 3950
GASIGSALAA IMLLLLLFLV ACFVTRKCQK QKKKQPPEDT LEEYPLNTKV
3960 3970 3980 3990 4000
DVAKRNADKV EKNANRQYCT VRNVNILSDN EGYYTFKGAK VKKLNLEVRV
4010
HNNLQDGTEV
Length:4,010
Mass (Da):442,369
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C1DDED1C8ACEC04
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC34788 differs from that shown. Reason: Frameshift.Curated
The sequence BAC34788 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti22N → H in CAD33519 (PubMed:12766770).Curated1
Sequence conflicti1026L → F in CAD33519 (PubMed:12766770).Curated1
Sequence conflicti1063R → Q in CAD33519 (PubMed:12766770).Curated1
Sequence conflicti1466P → H in CAD33519 (PubMed:12766770).Curated1
Sequence conflicti2020N → H in CAD33519 (PubMed:12766770).Curated1
Sequence conflicti2208R → K in CAD33519 (PubMed:12766770).Curated1
Sequence conflicti2310V → L in CAD33519 (PubMed:12766770).Curated1
Sequence conflicti2310V → L in BAC65800 (PubMed:12693553).Curated1
Sequence conflicti2314R → Q in CAD33519 (PubMed:12766770).Curated1
Sequence conflicti2314R → Q in BAC65800 (PubMed:12693553).Curated1
Sequence conflicti2623G → S in CAD33519 (PubMed:12766770).Curated1
Sequence conflicti2623G → S in BAC65800 (PubMed:12693553).Curated1
Sequence conflicti2646G → W in BAC34788 (PubMed:16141072).Curated1
Sequence conflicti2664V → I in CAD33519 (PubMed:12766770).Curated1
Sequence conflicti2664V → I in BAC65800 (PubMed:12693553).Curated1
Sequence conflicti3135L → P in CAD33519 (PubMed:12766770).Curated1
Sequence conflicti3135L → P in BAC65800 (PubMed:12693553).Curated1
Sequence conflicti3172D → G in BAC34788 (PubMed:16141072).Curated1
Sequence conflicti3383Q → R in CAD33519 (PubMed:12766770).Curated1
Sequence conflicti3383Q → R in BAC65800 (PubMed:12693553).Curated1
Sequence conflicti3383Q → R in AAH44881 (PubMed:15489334).Curated1
Sequence conflicti3395N → D in CAD33519 (PubMed:12766770).Curated1
Sequence conflicti3395N → D in BAC65800 (PubMed:12693553).Curated1
Sequence conflicti3395N → D in AAH44881 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ489280 mRNA Translation: CAD33519.1
AC101391 Genomic DNA No translation available.
AC121829 Genomic DNA No translation available.
AC122007 Genomic DNA No translation available.
AC151985 Genomic DNA No translation available.
AK122518 mRNA Translation: BAC65800.1
AK051850 mRNA Translation: BAC34788.1 Sequence problems.
BC044881 mRNA Translation: AAH44881.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS19450.1

NCBI Reference Sequences

More...
RefSeqi
NP_780682.3, NM_175473.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000036019; ENSMUSP00000043250; ENSMUSG00000034687

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
231470

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:231470

UCSC genome browser

More...
UCSCi
uc008yfk.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ489280 mRNA Translation: CAD33519.1
AC101391 Genomic DNA No translation available.
AC121829 Genomic DNA No translation available.
AC122007 Genomic DNA No translation available.
AC151985 Genomic DNA No translation available.
AK122518 mRNA Translation: BAC65800.1
AK051850 mRNA Translation: BAC34788.1 Sequence problems.
BC044881 mRNA Translation: AAH44881.1
CCDSiCCDS19450.1
RefSeqiNP_780682.3, NM_175473.3

3D structure databases

SMRiQ80T14
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi231125, 1 interactor
CORUMiQ80T14
DIPiDIP-61242N
IntActiQ80T14, 2 interactors
STRINGi10090.ENSMUSP00000043250

PTM databases

GlyConnecti2307, 1 N-Linked glycan (1 site)
GlyGeniQ80T14, 16 sites
iPTMnetiQ80T14
PhosphoSitePlusiQ80T14

Proteomic databases

EPDiQ80T14
MaxQBiQ80T14
PaxDbiQ80T14
PeptideAtlasiQ80T14
PRIDEiQ80T14
ProteomicsDBi267408

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2470, 31 antibodies

Genome annotation databases

EnsembliENSMUST00000036019; ENSMUSP00000043250; ENSMUSG00000034687
GeneIDi231470
KEGGimmu:231470
UCSCiuc008yfk.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80144
MGIiMGI:2385368, Fras1

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG1025, Eukaryota
KOG1216, Eukaryota
KOG1306, Eukaryota
KOG3525, Eukaryota
KOG3597, Eukaryota
GeneTreeiENSGT00940000162130
HOGENOMiCLU_000244_0_0_1
InParanoidiQ80T14
OMAiCGPSHVL
OrthoDBi13258at2759
TreeFamiTF316876

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
231470, 1 hit in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Fras1, mouse

Protein Ontology

More...
PROi
PR:Q80T14
RNActiQ80T14, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000034687, Expressed in medulla oblongata part of 4th ventricle choroid plexus (mouse) and 225 other tissues
GenevisibleiQ80T14, MM

Family and domain databases

CDDicd00064, FU, 12 hits
Gene3Di2.60.40.2030, 5 hits
InterProiView protein in InterPro
IPR038081, CalX-like_sf
IPR003644, Calx_beta
IPR039005, CSPG_rpt
IPR000742, EGF-like_dom
IPR006212, Furin_repeat
IPR009030, Growth_fac_rcpt_cys_sf
IPR001007, VWF_dom
PfamiView protein in Pfam
PF03160, Calx-beta, 5 hits
PF00093, VWC, 5 hits
SMARTiView protein in SMART
SM00237, Calx_beta, 5 hits
SM00181, EGF, 10 hits
SM00261, FU, 14 hits
SM00214, VWC, 6 hits
SM00215, VWC_out, 3 hits
SUPFAMiSSF141072, SSF141072, 5 hits
SSF57184, SSF57184, 5 hits
PROSITEiView protein in PROSITE
PS51854, CSPG, 12 hits
PS01208, VWFC_1, 6 hits
PS50184, VWFC_2, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFRAS1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80T14
Secondary accession number(s): E9QPG9
, Q80TC7, Q811H8, Q8BPZ4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 27, 2011
Last modified: April 7, 2021
This is version 138 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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