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Entry version 84 (08 May 2019)
Sequence version 1 (01 Jun 2003)
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Protein

Mucin-6

Gene

Muc6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-913709 O-linked glycosylation of mucins
R-MMU-977068 Termination of O-glycan biosynthesis

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I08.952

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mucin-6
Short name:
MUC-6
Alternative name(s):
Gastric mucin-6
Secreted gel-forming mucin-6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Muc6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2663233 Muc6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000025949723 – 2850Mucin-6Add BLAST2828

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi? ↔ 2848By similarity
Disulfide bondi67 ↔ 75By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi310N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi528N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi701N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1017N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1221N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2760 ↔ 2807By similarity
Disulfide bondi2774 ↔ 2821By similarity
Disulfide bondi2783 ↔ 2841By similarity
Disulfide bondi2787 ↔ 2843By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q80T03

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q80T03

PRoteomics IDEntifications database

More...
PRIDEi
Q80T03

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q80T03

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q80T03

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in stomach, duodenum and small intestine.2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Multimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000140483

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q80T03

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini44 – 288VWFD 1PROSITE-ProRule annotationAdd BLAST245
Domaini344 – 399TIL 1Add BLAST56
Domaini438 – 650VWFD 2PROSITE-ProRule annotationAdd BLAST213
Domaini806 – 869TIL 2Add BLAST64
Domaini909 – 1117VWFD 3PROSITE-ProRule annotationAdd BLAST209
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1440 – 15551Add BLAST116
Repeati1556 – 17122Add BLAST157
Repeati1713 – 18853Add BLAST173
Repeati1886 – 20544Add BLAST169
Repeati2055 – 22275Add BLAST173
Repeati2228 – 23966Add BLAST169
Repeati2397 – 25637Add BLAST167
Repeati2564 – 26718Add BLAST108
Domaini2760 – 2849CTCKPROSITE-ProRule annotationAdd BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1440 – 2671Approximate repeatsBy similarityAdd BLAST1232

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2291 – 2755Ser-richAdd BLAST465

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1216 Eukaryota
ENOG410XNSK LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000170714

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q80T03

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q80T03

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006207 Cys_knot_C
IPR030124 MUC6
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR014853 Unchr_dom_Cys-rich
IPR001007 VWF_dom
IPR001846 VWF_type-D

The PANTHER Classification System

More...
PANTHERi
PTHR11339:SF264 PTHR11339:SF264, 8 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08742 C8, 3 hits
PF01826 TIL, 2 hits
PF00094 VWD, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00832 C8, 3 hits
SM00215 VWC_out, 2 hits
SM00216 VWD, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57567 SSF57567, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01225 CTCK_2, 1 hit
PS51233 VWFD, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q80T03-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRVRQLLLL LLFRGPLIDA GAWTGDVTDS DTEDNLQSSP EKGWCSTWGA
60 70 80 90 100
GHFSTFDGHE YNFQGMCNYI FTATCGDDVP ATFSIQLRRD MEGNISRIIM
110 120 130 140 150
ELGASVVTVN KETISVRDIG VVSLPYTSNG LQITPYGQSV QLVAKQLELE
160 170 180 190 200
LVITWGPDAH LTEGQGGDEV GTPGTLKQES KGSPAWAGSS LCIPTETNST
210 220 230 240 250
TPQVQVETKY MGKLCGLCGN FDGKIDNEFL SEDGKLLEAH KYATLQKLDD
260 270 280 290 300
PNEICAHEAI PSTIILKTRY AQICNQLLTL VSPGCDVPKE TLMLSCQADM
310 320 330 340 350
AACARPGQPN CSCATLSEYS RRCSMTGQPV RNWRTPALCP MSQCPANQVY
360 370 380 390 400
QECGEVCIKT CSNPQHSCSS PCTFGCFCPH GTLLDDISGN QSCVPVNQCP
410 420 430 440 450
CMLNGMVYGP GEITKTACQT CQCTMGRWTC TKQPCPGHCS LEGGSFVTTF
460 470 480 490 500
DARPYRFHGT CTYTLLQSPQ LPNEGTLMAV YDKSGYSHSE TSLVAIMYLS
510 520 530 540 550
KKDKIVISED EVITNNGDTK LLPYKTHNIT IFRQTSTHLQ MATTFGLELV
560 570 580 590 600
FQMQPVFQVY ITVGPQFKGQ TRGLCGNFNG DTTDDFTTSM GIDEGTASLF
610 620 630 640 650
VDSWRAGNCP AALEREMDPC SMSQLNKVCA ETHCSMLLKK GSVFEKCHSV
660 670 680 690 700
VNPQPFYKRC VYQACNYEET FPHICSALGA YAHACSARGI LLWGWRNSVD
710 720 730 740 750
NCTVPCTGNR TFSYDSQACD RTCLSLSDRE TECHVSPVPV DGCNCPEGTY
760 770 780 790 800
LNHKAECVHK AQCPCLLDDY KFVQADQSTM INGVICHCIN GRLSCPRQAE
810 820 830 840 850
MFFASCPEPK TFQSCSQSSE DKFGAACAPT CQMLATGIDC VPTKCESGCV
860 870 880 890 900
CPKGLYENSD GQCVPAEECP CDYAGVSYPG GFELHTDCKT CTCSQGRWTC
910 920 930 940 950
QLSTQCPSTC VLYGEGHIIT FDGQRFVFDG DCEYMLATDD CGANSSQPTF
960 970 980 990 1000
KVLTENVICG KSGVTCSRAI KISLGGLFIT MADSNYTVSG EEPLVHLKVK
1010 1020 1030 1040 1050
PSPLNLVLDI DIPGRLNLTL VWNKHMSVSI KIRRATQDAL CGLCGNANGN
1060 1070 1080 1090 1100
MKDDFETRSK YVASNELEFV NSWKESPLCG DASYAVDPCS LNTFRRSWAE
1110 1120 1130 1140 1150
RKCNIINSQT FAACHSKVYH LPYYEACVRD ACGCDTGGDC ECLCDAVAAY
1160 1170 1180 1190 1200
AKACLDKGVC VDWRTPDFCP IYCDFYNTHT LVGENEYQYA QESNCTWHYQ
1210 1220 1230 1240 1250
PCLCPGSLGS FPDTNTEGCY NCSQNEYFDH SEGTCVPCAP PTTTLPPTTT
1260 1270 1280 1290 1300
GSQPTTETTI STEFHSSTSA NTPVAPSYLP GLPTPPPSAP SSTEELTVWT
1310 1320 1330 1340 1350
TPKESTVSSG EYPQTTMAAT PPTSPWPPTS IPKSTPTELP VTQATSKPTA
1360 1370 1380 1390 1400
SSLSSSTKTT AELTESTTVT LLTLMPGMST SQEGTPTSKI PVTQTTTHRV
1410 1420 1430 1440 1450
PSRCITNQST TMFQTTTVQE AEITQTLAPS TYTTNDITKT QNLFSTAPHL
1460 1470 1480 1490 1500
SETSAVTAHQ STPTAVSANS IKPTMSSTGT PVVHTTSGTS SSPQTPRTTH
1510 1520 1530 1540 1550
PSTTVAVSGT VHTTGLPSGT SVHTTTNFPT HSGPQSSLST HLPLFSTLSV
1560 1570 1580 1590 1600
TPTTEGLNTQ STPIPAITNS LMTTGGLTGT PPVHTTSGTT SSPQTPRTTH
1610 1620 1630 1640 1650
PFSTVAVSNT KHTTGVSLET SVQTTIASPT PSAPQTSLAT HLPFSSTSSV
1660 1670 1680 1690 1700
TPTSEVIITP TPQHTLSSAS TSTTTGNILP TTIGKTGSPH TSVPVIYTTS
1710 1720 1730 1740 1750
AITQTKTSFS TDRTSTSTSA PHLSETSAVT AHQSTPTAVS ANSIKPTMSS
1760 1770 1780 1790 1800
TGTPVVHTTS GTTSSPQTPR TTHPSTTVAV SGTVHTTGLP SGTSVHTTTN
1810 1820 1830 1840 1850
FPTHSGPQSS LSTHLPLFST LSVTPTTEGL NTPTSPHSLS VASTSMPLMT
1860 1870 1880 1890 1900
VLPTTLEGTR PPHTSVPVTY TTTAATQTKS SFSTDRTSAP HLSQPSTVTP
1910 1920 1930 1940 1950
TQSTPIPATT NSLMTTGGLT GTPPVHTTSG TTSSPQTPRT THPFSTVAVS
1960 1970 1980 1990 2000
NTKHTTGVSL ETSVQTTIAS PTPSAPQTSL ATHLPFSSTS SVTPTSEVII
2010 2020 2030 2040 2050
TPTPQHTLSS ASTSTTTGNI LPTTIGQTGS PHTSVPVIYT TSAITQTKTS
2060 2070 2080 2090 2100
FSTDRTSTST SAPHLSETSA VTAHQSTPTA VSANSIKPTM SSTGTPVVHT
2110 2120 2130 2140 2150
TSGTTSSPQT PRTTHPSTTV AVSGTVHTTG LPSGTSVHTT TNFPTHSGPQ
2160 2170 2180 2190 2200
SSLSTHLPLF STLSVTPTTE GLNTPTSPHS LSAASTSMPL MTVLPTTLEG
2210 2220 2230 2240 2250
TRPPHTSVPV TYTTTAATQT KSSFSTDRTS TPHLSQSSTV TPTQPTPIPA
2260 2270 2280 2290 2300
TTNSPMTTVG LTGTPVVHTP SGTSSIAHTP HTTHSLPTAA SSSTTLSTAP
2310 2320 2330 2340 2350
QFRTSEQSTT TFPTPSAPQT SLVTSLPPFS TSSVSPTDEI HITSTNPHTV
2360 2370 2380 2390 2400
SSVSMSRPVS TILQTTIEVT TPPNTSTPVT HSTSATTEAQ GSFSTERTST
2410 2420 2430 2440 2450
SYLSHPSSTT VHQSTAGPVI TSIKSTMGVT GTPPVHTTSG TTSSPQTPHS
2460 2470 2480 2490 2500
THPISTAAIS RTTGISGTPF RTPMKTTITF PTPSSLQTSM ATLFPPFSTS
2510 2520 2530 2540 2550
VMSSTEIFNT PTNPHSVSSA STSRPLSTSL PTTIKGTGTP QTPVSDINTT
2560 2570 2580 2590 2600
SATTQAHSSF PTTRTSTSHL SLPSSMTSTL TPASRSASTL QYTPTPSSVS
2610 2620 2630 2640 2650
HSPLLTTPTA SPPSSAPTFV SPTAASTVIS SALPTIHMTP TPSSRPTSST
2660 2670 2680 2690 2700
GLLSTSKTTS HVPTFSSFSS KSTTAHLTSL TTQAATSGLL SSTMGMTNLP
2710 2720 2730 2740 2750
SSGSPDINHT TRPPGSSPLP TSAFLSRSTS PTGSSSPSTP VSSSNPDSSV
2760 2770 2780 2790 2800
SSPPSHPGTC SLQEEEHQIT YQGCVANVTL TRCQGFCASS VSFNKDTLQL
2810 2820 2830 2840 2850
ESSCGCCQPL STYKKQLSLP CPDPDAPGQQ LTLTLQVFSS CVCSPLQCKN
Length:2,850
Mass (Da):300,401
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9CD95F0845C79C9D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WIM6F8WIM6_MOUSE
Mucin-6
Muc6
2,853Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WR59A0A087WR59_MOUSE
Mucin-6
Muc6
2,918Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q0VAV1Q0VAV1_MOUSE
Muc6 protein
Muc6
1,437Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1436 – 1446DITKTQNLFST → ILHRRTSTSTS in CAD54411 (PubMed:14984930).CuratedAdd BLAST11
Sequence conflicti2793Missing in CAD54411 (PubMed:14984930).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY184388
, AY184385, AY184387, AY184386 Genomic DNA Translation: AAO47735.1
AJ511869 Genomic DNA Translation: CAD54411.1

Genome annotation databases

UCSC genome browser

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UCSCi
uc009klu.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY184388
, AY184385, AY184387, AY184386 Genomic DNA Translation: AAO47735.1
AJ511869 Genomic DNA Translation: CAD54411.1

3D structure databases

SMRiQ80T03
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000140483

Protein family/group databases

MEROPSiI08.952

PTM databases

iPTMnetiQ80T03
PhosphoSitePlusiQ80T03

Proteomic databases

MaxQBiQ80T03
PaxDbiQ80T03
PRIDEiQ80T03

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc009klu.2 mouse

Organism-specific databases

MGIiMGI:2663233 Muc6

Phylogenomic databases

eggNOGiKOG1216 Eukaryota
ENOG410XNSK LUCA
HOGENOMiHOG000170714
InParanoidiQ80T03
PhylomeDBiQ80T03

Enzyme and pathway databases

ReactomeiR-MMU-913709 O-linked glycosylation of mucins
R-MMU-977068 Termination of O-glycan biosynthesis

Miscellaneous databases

Protein Ontology

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PROi
PR:Q80T03

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Family and domain databases

InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR030124 MUC6
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR014853 Unchr_dom_Cys-rich
IPR001007 VWF_dom
IPR001846 VWF_type-D
PANTHERiPTHR11339:SF264 PTHR11339:SF264, 8 hits
PfamiView protein in Pfam
PF08742 C8, 3 hits
PF01826 TIL, 2 hits
PF00094 VWD, 4 hits
SMARTiView protein in SMART
SM00832 C8, 3 hits
SM00215 VWC_out, 2 hits
SM00216 VWD, 3 hits
SUPFAMiSSF57567 SSF57567, 3 hits
PROSITEiView protein in PROSITE
PS01225 CTCK_2, 1 hit
PS51233 VWFD, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMUC6_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80T03
Secondary accession number(s): Q80Z22
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2003
Last modified: May 8, 2019
This is version 84 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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