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Entry version 158 (02 Jun 2021)
Sequence version 1 (01 Jun 2003)
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Protein
Submitted name:

NOD2

Gene

Nod2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
NOD2Imported
Submitted name:
Nucleotide-binding oligomerization domain-containing protein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nod2Imported
Synonyms:Card15Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2429397, Nod2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
334917

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000055994, Expressed in granulocyte and 65 other tissues

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 82CARDInterPro annotationAdd BLAST82
Domaini107 – 178CARDInterPro annotationAdd BLAST72
Domaini266 – 402NACHTInterPro annotationAdd BLAST137

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Leucine-rich repeatARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160934

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011291_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
FWGNKVG

Database of Orthologous Groups

More...
OrthoDBi
88836at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001315, CARD
IPR011029, DEATH-like_dom_sf
IPR018228, DNase_TatD-rel_CS
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf
IPR007111, NACHT_NTPase
IPR041267, NLRP_HD2
IPR041075, NOD2_WH
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00619, CARD, 1 hit
PF13516, LRR_6, 5 hits
PF05729, NACHT, 1 hit
PF17776, NLRC4_HD2, 1 hit
PF17779, NOD2_WH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986, SSF47986, 2 hits
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50209, CARD, 2 hits
PS50837, NACHT, 1 hit
PS01137, TATD_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q80SY9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCSQEEFQAQ RSQLVALLIS GSLEGFESIL DWLLSWDVLS REDYEGLSLP
60 70 80 90 100
GQPLSHSARR LLDTVWNKGV WGCQKLLEAV QEAQANSHTF ELYGSWDTHS
110 120 130 140 150
LHPTRDLQSH RPAIVRRLYN HVEAMLELAR EGGFLSQYEC EEIRLPIFTS
160 170 180 190 200
SQRARRLLDL AAVKANGLAA FLLQHVRELP APLPLPYEAA ECQKFISKLR
210 220 230 240 250
TMVLTQSRFL STYDGSENLC LEDIYTENIL ELQTEVGTAG ALQKSPAILG
260 270 280 290 300
LEDLFDTHGH LNRDADTILV VGEAGSGKST LLQRLHLLWA TGRSFQEFLF
310 320 330 340 350
IFPFSCRQLQ CVAKPLSLRT LLFEHCCWPD VAQDDVFQFL LDHPDRVLLT
360 370 380 390 400
FDGLDEFKFR FTDRERHCSP IDPTSVQTLL FNLLQGNLLK NACKVLTSRP
410 420 430 440 450
DAVSALLRKF VRTELQLKGF SEEGIQLYLR KHHREPGVAD RLIQLIQATS
460 470 480 490 500
ALHGLCHLPV FSWMVSRCHR ELLLQNRGFP TTSTDMYLLI LQHFLLHASP
510 520 530 540 550
PDSSPLGLGP GLLQSRLSTL LHLGHLALRG LAMSCYVFSA QQLQAAQVDS
560 570 580 590 600
DDISLGFLVR AQSSVPGSKA PLEFLHITFQ CFFAAFYLAV SADTSVASLK
610 620 630 640 650
HLFSCGRLGS SLLGRLLPNL CIQGSRVKKG SEAALLQKAE PHNLQITAAF
660 670 680 690 700
LAGLLSQQHR DLLAACQVSE RVLLQRQARA RSCLAHSLRE HFHSIPPAVP
710 720 730 740 750
GETKSMHAMP GFIWLIRSLY EMQEEQLAQE AVRRLDIGHL KLTFCRVGPA
760 770 780 790 800
ECAALAFVLQ HLQRPVALQL DYNSVGDVGV EQLRPCLGVC TALYLRDNNI
810 820 830 840 850
SDRGARTLVE CALRCEQLQK LALFNNKLTD ACACSMAKLL AHKQNFLSLR
860 870 880 890 900
VGNNHITAAG AEVLAQGLKS NTSLKFLGFW GNSVGDKGTQ ALAEVVADHQ
910 920 930 940 950
NLKWLSLVGN NIGSMGAEAL ALMLEKNKSL EELCLEENHI CDEGVYSLAE
960 970 980 990 1000
GLKRNSTLKF LKLSNNGITY RGAEALLQAL SRNSAILEVW LRGNTFSLEE
1010
IQTLSSRDAR LLL
Length:1,013
Mass (Da):112,779
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i459CD3CBE6F66375
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8K3Z0NOD2_MOUSE
Nucleotide-binding oligomerization ...
Nod2 Card15
1,020Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY160220 mRNA Translation: AAN52477.1
AH012069 AY160347 Genomic DNA Translation: AAN57787.1
AH012071 AY160367 Genomic DNA Translation: AAN57789.1
AH012114 AY160567 Genomic DNA Translation: AAN62470.1
AH012115 AY160577 Genomic DNA Translation: AAN62471.1
AH012151 AY160607 Genomic DNA Translation: AAN63034.1
AH012152 AY160617 Genomic DNA Translation: AAN63035.1
AH012156 AY160657 Genomic DNA Translation: AAN63039.1

NCBI Reference Sequences

More...
RefSeqi
NP_665856.2, NM_145857.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000118370; ENSMUSP00000113773; ENSMUSG00000055994

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
257632

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:257632

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY160220 mRNA Translation: AAN52477.1
AH012069 AY160347 Genomic DNA Translation: AAN57787.1
AH012071 AY160367 Genomic DNA Translation: AAN57789.1
AH012114 AY160567 Genomic DNA Translation: AAN62470.1
AH012115 AY160577 Genomic DNA Translation: AAN62471.1
AH012151 AY160607 Genomic DNA Translation: AAN63034.1
AH012152 AY160617 Genomic DNA Translation: AAN63035.1
AH012156 AY160657 Genomic DNA Translation: AAN63039.1
RefSeqiNP_665856.2, NM_145857.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

ProteomicsDBi334917

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
28302, 490 antibodies

The DNASU plasmid repository

More...
DNASUi
257632

Genome annotation databases

EnsembliENSMUST00000118370; ENSMUSP00000113773; ENSMUSG00000055994
GeneIDi257632
KEGGimmu:257632

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64127
MGIiMGI:2429397, Nod2

Phylogenomic databases

GeneTreeiENSGT00940000160934
HOGENOMiCLU_011291_0_0_1
OMAiFWGNKVG
OrthoDBi88836at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
257632, 0 hits in 52 CRISPR screens

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000055994, Expressed in granulocyte and 65 other tissues

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001315, CARD
IPR011029, DEATH-like_dom_sf
IPR018228, DNase_TatD-rel_CS
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf
IPR007111, NACHT_NTPase
IPR041267, NLRP_HD2
IPR041075, NOD2_WH
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00619, CARD, 1 hit
PF13516, LRR_6, 5 hits
PF05729, NACHT, 1 hit
PF17776, NLRC4_HD2, 1 hit
PF17779, NOD2_WH, 1 hit
SUPFAMiSSF47986, SSF47986, 2 hits
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50209, CARD, 2 hits
PS50837, NACHT, 1 hit
PS01137, TATD_1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ80SY9_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80SY9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: June 2, 2021
This is version 158 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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