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Protein

Pre-mRNA-splicing factor 38B

Gene

Prpf38b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be required for pre-mRNA splicing.Curated

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor 38B
Gene namesi
Name:Prpf38b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1914171 Prpf38b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002872362 – 542Pre-mRNA-splicing factor 38BAdd BLAST541

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei5PhosphoserineBy similarity1
Modified residuei228N6-acetyllysineCombined sources1
Modified residuei289PhosphoserineBy similarity1
Modified residuei291PhosphoserineBy similarity1
Modified residuei319PhosphoserineBy similarity1
Modified residuei321PhosphoserineBy similarity1
Modified residuei445PhosphoserineBy similarity1
Modified residuei470PhosphoserineBy similarity1
Modified residuei472PhosphoserineBy similarity1
Modified residuei478PhosphoserineBy similarity1
Modified residuei523PhosphoserineBy similarity1
Modified residuei525PhosphoserineBy similarity1
Modified residuei530PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ80SY5
MaxQBiQ80SY5
PaxDbiQ80SY5
PeptideAtlasiQ80SY5
PRIDEiQ80SY5

PTM databases

iPTMnetiQ80SY5
PhosphoSitePlusiQ80SY5

Expressioni

Gene expression databases

BgeeiENSMUSG00000027881 Expressed in 288 organ(s), highest expression level in spleen
ExpressionAtlasiQ80SY5 baseline and differential
GenevisibleiQ80SY5 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029480

Structurei

3D structure databases

ProteinModelPortaliQ80SY5
SMRiQ80SY5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili293 – 322Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi254 – 506Arg-richAdd BLAST253

Sequence similaritiesi

Belongs to the PRP38 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2888 Eukaryota
ENOG410XS5N LUCA
GeneTreeiENSGT00730000111145
HOGENOMiHOG000115682
InParanoidiQ80SY5
KOiK12850
OMAiHGPSFDR
OrthoDBiEOG091G0EEY
TreeFamiTF313626

Family and domain databases

InterProiView protein in InterPro
IPR005037 PRP38
PANTHERiPTHR23142 PTHR23142, 1 hit
PfamiView protein in Pfam
PF03371 PRP38, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q80SY5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANNSPALTG NSQPQHQAAA AVTQQQQQCG GGGGATKPAV SGKQGNVLPL
60 70 80 90 100
WGNEKTMNLN PMILTNILSS PYFKVQLYEL KTYHEVVDEI YFKVTHVEPW
110 120 130 140 150
EKGSRKTAGQ TGMCGGVRGV GTGGIVSTAF CLLYKLFTLK LTRKQVMGLI
160 170 180 190 200
THTDSPYIRA LGFMYIRYTQ PPTDLWDWFE SFLDDEEDLD VKAGGGCVMT
210 220 230 240 250
IGEMLRSFLT KLEWFSTLFP RIPVPVQKNI DQQIKTRPRK IKKDGKEGIE
260 270 280 290 300
EIDRHVERRR SRSPRRSLSP RRSPRRSRSR SHHREGHGSS SFDRELEREK
310 320 330 340 350
ERQRLEREAK EREKERRRSR SIDRGLDRRR SRSRERHRSR SRSRDRKGDR
360 370 380 390 400
RDRDREREKE NERGRRRDRD YDKERGSDRE RDRERSRERS KEQRSRGDGE
410 420 430 440 450
EKKHKEDKED RRHRDDKKES KKKHSRSRSR ERKHRSRSRN AGKRSRSRSK
460 470 480 490 500
DKSSRHKNES KEKANKRSRS GSQGRTGSVE KRKREHSPSR EKSRKRSRSQ
510 520 530 540
DRSHKREHND SKDQSDRQDH QSSQSGEPES QEKEHKSKDE TV
Length:542
Mass (Da):63,753
Last modified:June 1, 2003 - v1
Checksum:i5A7FE888FB4443AF
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JGW4A0A0G2JGW4_MOUSE
Pre-mRNA-splicing factor 38B
Prpf38b
94Annotation score:
A0A0G2JEW4A0A0G2JEW4_MOUSE
Pre-mRNA-splicing factor 38B
Prpf38b
182Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti348G → W in BAB23062 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003895 mRNA Translation: BAB23062.1
AK015938 mRNA Translation: BAB30042.1
AK018126 mRNA Translation: BAB31082.1
AL671894 Genomic DNA No translation available.
BC050900 mRNA Translation: AAH50900.1
BC052077 mRNA Translation: AAH52077.1
CCDSiCCDS17770.1
RefSeqiNP_080121.1, NM_025845.2
UniGeneiMm.51049

Genome annotation databases

EnsembliENSMUST00000029480; ENSMUSP00000029480; ENSMUSG00000027881
GeneIDi66921
KEGGimmu:66921
UCSCiuc008qzx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003895 mRNA Translation: BAB23062.1
AK015938 mRNA Translation: BAB30042.1
AK018126 mRNA Translation: BAB31082.1
AL671894 Genomic DNA No translation available.
BC050900 mRNA Translation: AAH50900.1
BC052077 mRNA Translation: AAH52077.1
CCDSiCCDS17770.1
RefSeqiNP_080121.1, NM_025845.2
UniGeneiMm.51049

3D structure databases

ProteinModelPortaliQ80SY5
SMRiQ80SY5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029480

PTM databases

iPTMnetiQ80SY5
PhosphoSitePlusiQ80SY5

Proteomic databases

EPDiQ80SY5
MaxQBiQ80SY5
PaxDbiQ80SY5
PeptideAtlasiQ80SY5
PRIDEiQ80SY5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029480; ENSMUSP00000029480; ENSMUSG00000027881
GeneIDi66921
KEGGimmu:66921
UCSCiuc008qzx.1 mouse

Organism-specific databases

CTDi55119
MGIiMGI:1914171 Prpf38b

Phylogenomic databases

eggNOGiKOG2888 Eukaryota
ENOG410XS5N LUCA
GeneTreeiENSGT00730000111145
HOGENOMiHOG000115682
InParanoidiQ80SY5
KOiK12850
OMAiHGPSFDR
OrthoDBiEOG091G0EEY
TreeFamiTF313626

Miscellaneous databases

ChiTaRSiPrpf38b mouse
PROiPR:Q80SY5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027881 Expressed in 288 organ(s), highest expression level in spleen
ExpressionAtlasiQ80SY5 baseline and differential
GenevisibleiQ80SY5 MM

Family and domain databases

InterProiView protein in InterPro
IPR005037 PRP38
PANTHERiPTHR23142 PTHR23142, 1 hit
PfamiView protein in Pfam
PF03371 PRP38, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPR38B_MOUSE
AccessioniPrimary (citable) accession number: Q80SY5
Secondary accession number(s): Q9CTD9, Q9CU48, Q9CUI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 2003
Last modified: September 12, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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