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Protein

V-type proton ATPase subunit d 2

Gene

Atp6v0d2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). May play a role in coupling of proton transport and ATP hydrolysis. Regulator of osteoclast fusion and bone formation.By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1222556 ROS, RNS production in phagocytes
R-MMU-77387 Insulin receptor recycling
R-MMU-917977 Transferrin endocytosis and recycling
R-MMU-983712 Ion channel transport

Protein family/group databases

TCDBi3.A.2.2.6 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit d 2
Short name:
V-ATPase subunit d 2
Alternative name(s):
Osteoclast-specific vacuolar ATP synthase
Vacuolar proton pump subunit d 2
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1924415 Atp6v0d2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002856581 – 350V-type proton ATPase subunit d 2Add BLAST350

Proteomic databases

MaxQBiQ80SY3
PaxDbiQ80SY3
PeptideAtlasiQ80SY3
PRIDEiQ80SY3

PTM databases

iPTMnetiQ80SY3
PhosphoSitePlusiQ80SY3

Expressioni

Tissue specificityi

Predominantly expressed in the kidney. Also expressed in the lung, testis, skeletal muscle and heart. Upr-egulated during osteoclast differentiation and is most abundant in mature osteoclasts.3 Publications

Developmental stagei

Strongly expressed at day 7 followed by a disappearance and a gradual recovery to original levels by day 17.1 Publication

Gene expression databases

BgeeiENSMUSG00000028238 Expressed in 69 organ(s), highest expression level in camera-type eye
CleanExiMM_ATP6V0D2
ExpressionAtlasiQ80SY3 baseline and differential
GenevisibleiQ80SY3 MM

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

Protein-protein interaction databases

BioGridi232395, 2 interactors
STRINGi10090.ENSMUSP00000029900

Structurei

3D structure databases

ProteinModelPortaliQ80SY3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase V0D/AC39 subunit family.Curated

Phylogenomic databases

eggNOGiKOG2957 Eukaryota
COG1527 LUCA
GeneTreeiENSGT00390000002200
HOGENOMiHOG000199065
HOVERGENiHBG018065
InParanoidiQ80SY3
KOiK02146
OMAiDCMSENT
OrthoDBiEOG091G09L5
PhylomeDBiQ80SY3
TreeFamiTF300857

Family and domain databases

Gene3Di1.20.1690.10, 2 hits
InterProiView protein in InterPro
IPR036079 ATPase_su_C-like
IPR002843 ATPase_V0-cplx_csu/dsu
IPR016727 ATPase_V0-cplx_dsu
IPR035067 V-type_ATPase_suC
PANTHERiPTHR11028 PTHR11028, 1 hit
PfamiView protein in Pfam
PF01992 vATP-synt_AC39, 1 hit
PIRSFiPIRSF018497 V-ATP_synth_D, 1 hit
SUPFAMiSSF103486 SSF103486, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q80SY3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLETAELYFN VDHGYLEGLV RGCKASLLTQ QDYVNLVQCE TLEDLKIHLQ
60 70 80 90 100
TTDYGNFLAN ETNPLTVSKI DTEMRKKLCR EFDYFRNHSL EPLSTFLTYM
110 120 130 140 150
TCSYMIDNII LLMNGALQKK SVKEVLAKCH PLGRFTEMEA VNIAETPSDL
160 170 180 190 200
FKAVLVETPL APFFQDCMSE NTLDELNIEL LRNKLYKSYL EAFYKFCKDH
210 220 230 240 250
GDVTADVMCP ILEFEADRRA LIITLNSFGT ELSKEDRETL FPTCGRLYPE
260 270 280 290 300
GLRLLAQAED FEQMKRVADN YGVYKPLFDA VGGSGGKTLE DVFYEREVQM
310 320 330 340 350
NVLAFNRQFH YGVFYAYVKL KEQEMRNIVW IAECISQRHR TKINSYIPIL
Length:350
Mass (Da):40,494
Last modified:May 1, 2007 - v2
Checksum:i5CC9BC9D2870943D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AWC2B1AWC2_MOUSE
V-type proton ATPase subunit d 2
Atp6v0d2
36Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti309F → L in AAN61104 (PubMed:12963731).Curated1
Sequence conflicti309F → L in BAC57951 (PubMed:12527205).Curated1
Sequence conflicti315Y → C in BAE41545 (PubMed:16141072).Curated1
Sequence conflicti324E → G in AAH87899 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY145896 mRNA Translation: AAN61104.1
AB088358 mRNA Translation: BAC57951.1
AY517482 mRNA Translation: AAR99405.1
AK075745 mRNA Translation: BAC35925.1
AK089507 mRNA Translation: BAC40907.1
AK170072 mRNA Translation: BAE41545.1
AK170405 mRNA Translation: BAE41772.1
AK170578 mRNA Translation: BAE41890.1
AK170659 mRNA Translation: BAE41942.1
AL732527, AL773599 Genomic DNA Translation: CAM18840.1
AL773599, AL732527 Genomic DNA Translation: CAM20936.1
BC087899 mRNA Translation: AAH87899.1
CCDSiCCDS17994.1
RefSeqiNP_780615.2, NM_175406.3
UniGeneiMm.19298

Genome annotation databases

EnsembliENSMUST00000029900; ENSMUSP00000029900; ENSMUSG00000028238
GeneIDi242341
KEGGimmu:242341
UCSCiuc008sch.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY145896 mRNA Translation: AAN61104.1
AB088358 mRNA Translation: BAC57951.1
AY517482 mRNA Translation: AAR99405.1
AK075745 mRNA Translation: BAC35925.1
AK089507 mRNA Translation: BAC40907.1
AK170072 mRNA Translation: BAE41545.1
AK170405 mRNA Translation: BAE41772.1
AK170578 mRNA Translation: BAE41890.1
AK170659 mRNA Translation: BAE41942.1
AL732527, AL773599 Genomic DNA Translation: CAM18840.1
AL773599, AL732527 Genomic DNA Translation: CAM20936.1
BC087899 mRNA Translation: AAH87899.1
CCDSiCCDS17994.1
RefSeqiNP_780615.2, NM_175406.3
UniGeneiMm.19298

3D structure databases

ProteinModelPortaliQ80SY3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232395, 2 interactors
STRINGi10090.ENSMUSP00000029900

Protein family/group databases

TCDBi3.A.2.2.6 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

PTM databases

iPTMnetiQ80SY3
PhosphoSitePlusiQ80SY3

Proteomic databases

MaxQBiQ80SY3
PaxDbiQ80SY3
PeptideAtlasiQ80SY3
PRIDEiQ80SY3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029900; ENSMUSP00000029900; ENSMUSG00000028238
GeneIDi242341
KEGGimmu:242341
UCSCiuc008sch.2 mouse

Organism-specific databases

CTDi245972
MGIiMGI:1924415 Atp6v0d2

Phylogenomic databases

eggNOGiKOG2957 Eukaryota
COG1527 LUCA
GeneTreeiENSGT00390000002200
HOGENOMiHOG000199065
HOVERGENiHBG018065
InParanoidiQ80SY3
KOiK02146
OMAiDCMSENT
OrthoDBiEOG091G09L5
PhylomeDBiQ80SY3
TreeFamiTF300857

Enzyme and pathway databases

ReactomeiR-MMU-1222556 ROS, RNS production in phagocytes
R-MMU-77387 Insulin receptor recycling
R-MMU-917977 Transferrin endocytosis and recycling
R-MMU-983712 Ion channel transport

Miscellaneous databases

ChiTaRSiAtp6v0d2 mouse
PROiPR:Q80SY3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028238 Expressed in 69 organ(s), highest expression level in camera-type eye
CleanExiMM_ATP6V0D2
ExpressionAtlasiQ80SY3 baseline and differential
GenevisibleiQ80SY3 MM

Family and domain databases

Gene3Di1.20.1690.10, 2 hits
InterProiView protein in InterPro
IPR036079 ATPase_su_C-like
IPR002843 ATPase_V0-cplx_csu/dsu
IPR016727 ATPase_V0-cplx_dsu
IPR035067 V-type_ATPase_suC
PANTHERiPTHR11028 PTHR11028, 1 hit
PfamiView protein in Pfam
PF01992 vATP-synt_AC39, 1 hit
PIRSFiPIRSF018497 V-ATP_synth_D, 1 hit
SUPFAMiSSF103486 SSF103486, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVA0D2_MOUSE
AccessioniPrimary (citable) accession number: Q80SY3
Secondary accession number(s): Q3TDQ6
, Q5I0V5, Q8BTL3, Q8BW16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: November 7, 2018
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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