UniProtKB - Q80SY3 (VA0D2_MOUSE)
V-type proton ATPase subunit d 2
Atp6v0d2
Functioni
Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).
May play a role in coupling of proton transport and ATP hydrolysis (PubMed:12963731).
Regulator of osteoclast fusion and bone formation (PubMed:17128270).
By similarity2 PublicationsGO - Molecular functioni
- proton transmembrane transporter activity Source: InterPro
GO - Biological processi
- vacuolar acidification Source: GO_Central
- vacuolar transport Source: GO_Central
Keywordsi
Biological process | Hydrogen ion transport, Ion transport, Transport |
Enzyme and pathway databases
Reactomei | R-MMU-1222556, ROS and RNS production in phagocytes R-MMU-77387, Insulin receptor recycling R-MMU-917977, Transferrin endocytosis and recycling R-MMU-9639288, Amino acids regulate mTORC1 R-MMU-983712, Ion channel transport |
Protein family/group databases
TCDBi | 3.A.2.2.6, the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: V-type proton ATPase subunit d 2Short name: V-ATPase subunit d 2 Alternative name(s): Osteoclast-specific vacuolar ATP synthase Vacuolar proton pump subunit d 2 |
Gene namesi | Name:Atp6v0d2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1924415, Atp6v0d2 |
VEuPathDBi | HostDB:ENSMUSG00000028238 |
Subcellular locationi
Endosome
- early endosome Source: MGI
- endosome Source: MGI
Plasma Membrane
- apical plasma membrane Source: UniProtKB
- plasma membrane proton-transporting V-type ATPase complex Source: GO_Central
Other locations
- membrane Source: MGI
- proton-transporting V-type ATPase, V0 domain Source: InterPro
- vacuolar proton-transporting V-type ATPase complex Source: MGI
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000285658 | 1 – 350 | V-type proton ATPase subunit d 2Add BLAST | 350 |
Proteomic databases
jPOSTi | Q80SY3 |
MaxQBi | Q80SY3 |
PaxDbi | Q80SY3 |
PeptideAtlasi | Q80SY3 |
PRIDEi | Q80SY3 |
ProteomicsDBi | 297906 |
PTM databases
iPTMneti | Q80SY3 |
PhosphoSitePlusi | Q80SY3 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSMUSG00000028238, Expressed in camera-type eye and 107 other tissues |
ExpressionAtlasi | Q80SY3, baseline and differential |
Genevisiblei | Q80SY3, MM |
Interactioni
Subunit structurei
V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR.
By similarityProtein-protein interaction databases
BioGRIDi | 232395, 5 interactors |
STRINGi | 10090.ENSMUSP00000029900 |
Miscellaneous databases
RNActi | Q80SY3, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2957, Eukaryota |
GeneTreei | ENSGT00390000002200 |
HOGENOMi | CLU_051277_0_0_1 |
InParanoidi | Q80SY3 |
OMAi | FCKDHGD |
OrthoDBi | 910004at2759 |
PhylomeDBi | Q80SY3 |
TreeFami | TF300857 |
Family and domain databases
Gene3Di | 1.10.132.50, 1 hit 1.20.1690.10, 2 hits |
InterProi | View protein in InterPro IPR036079, ATPase_su_c/d_sf IPR002843, ATPase_V0-cplx_csu/dsu IPR016727, ATPase_V0-cplx_dsu IPR044911, V-type_ATPase_su_c/d_dom_3 IPR035067, V-type_ATPase_suC/d |
PANTHERi | PTHR11028, PTHR11028, 1 hit |
Pfami | View protein in Pfam PF01992, vATP-synt_AC39, 1 hit |
PIRSFi | PIRSF018497, V-ATP_synth_D, 1 hit |
SUPFAMi | SSF103486, SSF103486, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MLETAELYFN VDHGYLEGLV RGCKASLLTQ QDYVNLVQCE TLEDLKIHLQ
60 70 80 90 100
TTDYGNFLAN ETNPLTVSKI DTEMRKKLCR EFDYFRNHSL EPLSTFLTYM
110 120 130 140 150
TCSYMIDNII LLMNGALQKK SVKEVLAKCH PLGRFTEMEA VNIAETPSDL
160 170 180 190 200
FKAVLVETPL APFFQDCMSE NTLDELNIEL LRNKLYKSYL EAFYKFCKDH
210 220 230 240 250
GDVTADVMCP ILEFEADRRA LIITLNSFGT ELSKEDRETL FPTCGRLYPE
260 270 280 290 300
GLRLLAQAED FEQMKRVADN YGVYKPLFDA VGGSGGKTLE DVFYEREVQM
310 320 330 340 350
NVLAFNRQFH YGVFYAYVKL KEQEMRNIVW IAECISQRHR TKINSYIPIL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketB1AWC2 | B1AWC2_MOUSE | V-type proton ATPase subunit d 2 | Atp6v0d2 | 36 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 309 | F → L in AAN61104 (PubMed:12963731).Curated | 1 | |
Sequence conflicti | 309 | F → L in BAC57951 (PubMed:12527205).Curated | 1 | |
Sequence conflicti | 315 | Y → C in BAE41545 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 324 | E → G in AAH87899 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY145896 mRNA Translation: AAN61104.1 AB088358 mRNA Translation: BAC57951.1 AY517482 mRNA Translation: AAR99405.1 AK075745 mRNA Translation: BAC35925.1 AK089507 mRNA Translation: BAC40907.1 AK170072 mRNA Translation: BAE41545.1 AK170405 mRNA Translation: BAE41772.1 AK170578 mRNA Translation: BAE41890.1 AK170659 mRNA Translation: BAE41942.1 AL732527 Genomic DNA No translation available. AL773599 Genomic DNA No translation available. BC087899 mRNA Translation: AAH87899.1 |
CCDSi | CCDS17994.1 |
RefSeqi | NP_780615.2, NM_175406.3 |
Genome annotation databases
Ensembli | ENSMUST00000029900; ENSMUSP00000029900; ENSMUSG00000028238 |
GeneIDi | 242341 |
KEGGi | mmu:242341 |
UCSCi | uc008sch.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY145896 mRNA Translation: AAN61104.1 AB088358 mRNA Translation: BAC57951.1 AY517482 mRNA Translation: AAR99405.1 AK075745 mRNA Translation: BAC35925.1 AK089507 mRNA Translation: BAC40907.1 AK170072 mRNA Translation: BAE41545.1 AK170405 mRNA Translation: BAE41772.1 AK170578 mRNA Translation: BAE41890.1 AK170659 mRNA Translation: BAE41942.1 AL732527 Genomic DNA No translation available. AL773599 Genomic DNA No translation available. BC087899 mRNA Translation: AAH87899.1 |
CCDSi | CCDS17994.1 |
RefSeqi | NP_780615.2, NM_175406.3 |
3D structure databases
SMRi | Q80SY3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 232395, 5 interactors |
STRINGi | 10090.ENSMUSP00000029900 |
Protein family/group databases
TCDBi | 3.A.2.2.6, the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily |
PTM databases
iPTMneti | Q80SY3 |
PhosphoSitePlusi | Q80SY3 |
Proteomic databases
jPOSTi | Q80SY3 |
MaxQBi | Q80SY3 |
PaxDbi | Q80SY3 |
PeptideAtlasi | Q80SY3 |
PRIDEi | Q80SY3 |
ProteomicsDBi | 297906 |
Protocols and materials databases
Antibodypediai | 25450, 120 antibodies from 23 providers |
DNASUi | 242341 |
Genome annotation databases
Ensembli | ENSMUST00000029900; ENSMUSP00000029900; ENSMUSG00000028238 |
GeneIDi | 242341 |
KEGGi | mmu:242341 |
UCSCi | uc008sch.2, mouse |
Organism-specific databases
CTDi | 245972 |
MGIi | MGI:1924415, Atp6v0d2 |
VEuPathDBi | HostDB:ENSMUSG00000028238 |
Phylogenomic databases
eggNOGi | KOG2957, Eukaryota |
GeneTreei | ENSGT00390000002200 |
HOGENOMi | CLU_051277_0_0_1 |
InParanoidi | Q80SY3 |
OMAi | FCKDHGD |
OrthoDBi | 910004at2759 |
PhylomeDBi | Q80SY3 |
TreeFami | TF300857 |
Enzyme and pathway databases
Reactomei | R-MMU-1222556, ROS and RNS production in phagocytes R-MMU-77387, Insulin receptor recycling R-MMU-917977, Transferrin endocytosis and recycling R-MMU-9639288, Amino acids regulate mTORC1 R-MMU-983712, Ion channel transport |
Miscellaneous databases
BioGRID-ORCSi | 242341, 0 hits in 63 CRISPR screens |
ChiTaRSi | Atp6v0d2, mouse |
PROi | PR:Q80SY3 |
RNActi | Q80SY3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000028238, Expressed in camera-type eye and 107 other tissues |
ExpressionAtlasi | Q80SY3, baseline and differential |
Genevisiblei | Q80SY3, MM |
Family and domain databases
Gene3Di | 1.10.132.50, 1 hit 1.20.1690.10, 2 hits |
InterProi | View protein in InterPro IPR036079, ATPase_su_c/d_sf IPR002843, ATPase_V0-cplx_csu/dsu IPR016727, ATPase_V0-cplx_dsu IPR044911, V-type_ATPase_su_c/d_dom_3 IPR035067, V-type_ATPase_suC/d |
PANTHERi | PTHR11028, PTHR11028, 1 hit |
Pfami | View protein in Pfam PF01992, vATP-synt_AC39, 1 hit |
PIRSFi | PIRSF018497, V-ATP_synth_D, 1 hit |
SUPFAMi | SSF103486, SSF103486, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | VA0D2_MOUSE | |
Accessioni | Q80SY3Primary (citable) accession number: Q80SY3 Secondary accession number(s): Q3TDQ6 Q8BW16 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 2007 |
Last sequence update: | May 1, 2007 | |
Last modified: | February 23, 2022 | |
This is version 118 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families