Atp6v0d2

Functionⁱ

Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). May play a role in coupling of proton transport and ATP hydrolysis. Regulator of osteoclast fusion and bone formation.By similarity2 Publications

GO - Molecular functionⁱ

proton-exporting ATPase activity, phosphorylative mechanism
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
proton-transporting ATPase activity, rotational mechanism
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ATP hydrolysis coupled proton transport Source: InterPro
vacuolar acidification
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
vacuolar transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Hydrogen ion transport, Ion transport, Transport

Biological process

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1222556 ROS, RNS production in phagocytes R-MMU-77387 Insulin receptor recycling R-MMU-917977 Transferrin endocytosis and recycling R-MMU-983712 Ion channel transport

Reactomeⁱ

R-MMU-1222556 ROS, RNS production in phagocytes
R-MMU-77387 Insulin receptor recycling
R-MMU-917977 Transferrin endocytosis and recycling
R-MMU-983712 Ion channel transport

Protein family/group databases

TCDBⁱ	3.A.2.2.6 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

TCDBⁱ

3.A.2.2.6 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: V-type proton ATPase subunit d 2 Short name: V-ATPase subunit d 2 Alternative name(s): Osteoclast-specific vacuolar ATP synthase Vacuolar proton pump subunit d 2
Gene namesⁱ	Name:Atp6v0d2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 4

Organism-specific databases

MGIⁱ	MGI:1924415 Atp6v0d2

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000285658	1 – 350	V-type proton ATPase subunit d 2Add BLAST		350

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q80SY3
PaxDbⁱ	Q80SY3
PeptideAtlas More...PeptideAtlasⁱ	Q80SY3
PRIDEⁱ	Q80SY3

PTM databases

iPTMnetⁱ	Q80SY3
PhosphoSitePlusⁱ	Q80SY3

Expressionⁱ

Tissue specificityⁱ

Predominantly expressed in the kidney. Also expressed in the lung, testis, skeletal muscle and heart. Upr-egulated during osteoclast differentiation and is most abundant in mature osteoclasts.3 Publications

Developmental stageⁱ

Strongly expressed at day 7 followed by a disappearance and a gradual recovery to original levels by day 17.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000028238 Expressed in 69 organ(s), highest expression level in camera-type eye
CleanExⁱ	MM_ATP6V0D2
ExpressionAtlasⁱ	Q80SY3 baseline and differential
Genevisibleⁱ	Q80SY3 MM

Interactionⁱ

Subunit structureⁱ

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

Protein-protein interaction databases

BioGridⁱ	232395, 2 interactors
STRINGⁱ	10090.ENSMUSP00000029900

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q80SY3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the V-ATPase V0D/AC39 subunit family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2957 Eukaryota COG1527 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000002200
HOGENOMⁱ	HOG000199065
HOVERGENⁱ	HBG018065
InParanoidⁱ	Q80SY3
KEGG Orthology (KO) More...KOⁱ	K02146
OMAⁱ	DCMSENT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09L5
PhylomeDBⁱ	Q80SY3
TreeFamⁱ	TF300857

Family and domain databases

Gene3Dⁱ	1.20.1690.10, 2 hits
InterProⁱ	View protein in InterPro IPR036079 ATPase_su_C-like IPR002843 ATPase_V0-cplx_csu/dsu IPR016727 ATPase_V0-cplx_dsu IPR035067 V-type_ATPase_suC
PANTHERⁱ	PTHR11028 PTHR11028, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01992 vATP-synt_AC39, 1 hit
PIRSFⁱ	PIRSF018497 V-ATP_synth_D, 1 hit
SUPFAMⁱ	SSF103486 SSF103486, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q80SY3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLETAELYFN VDHGYLEGLV RGCKASLLTQ QDYVNLVQCE TLEDLKIHLQ 
        60         70         80         90        100
TTDYGNFLAN ETNPLTVSKI DTEMRKKLCR EFDYFRNHSL EPLSTFLTYM 
       110        120        130        140        150
TCSYMIDNII LLMNGALQKK SVKEVLAKCH PLGRFTEMEA VNIAETPSDL 
       160        170        180        190        200
FKAVLVETPL APFFQDCMSE NTLDELNIEL LRNKLYKSYL EAFYKFCKDH 
       210        220        230        240        250
GDVTADVMCP ILEFEADRRA LIITLNSFGT ELSKEDRETL FPTCGRLYPE 
       260        270        280        290        300
GLRLLAQAED FEQMKRVADN YGVYKPLFDA VGGSGGKTLE DVFYEREVQM 
       310        320        330        340        350
NVLAFNRQFH YGVFYAYVKL KEQEMRNIVW IAECISQRHR TKINSYIPIL

Length:350

Mass (Da):40,494

Last modified:May 1, 2007 - v2

Checksum:ⁱ5CC9BC9D2870943D

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	B1AWC2	B1AWC2_MOUSE		V-type proton ATPase subunit d 2 V-type proton ATPase subunit d 2	Atp6v0d2	36	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	309	F → L in AAN61104 (PubMed:12963731).Curated	1
Sequence conflictⁱ	309	F → L in BAC57951 (PubMed:12527205).Curated	1
Sequence conflictⁱ	315	Y → C in BAE41545 (PubMed:16141072).Curated	1
Sequence conflictⁱ	324	E → G in AAH87899 (PubMed:15489334).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY145896 mRNA Translation: AAN61104.1 AB088358 mRNA Translation: BAC57951.1 AY517482 mRNA Translation: AAR99405.1 AK075745 mRNA Translation: BAC35925.1 AK089507 mRNA Translation: BAC40907.1 AK170072 mRNA Translation: BAE41545.1 AK170405 mRNA Translation: BAE41772.1 AK170578 mRNA Translation: BAE41890.1 AK170659 mRNA Translation: BAE41942.1 AL732527, AL773599 Genomic DNA Translation: CAM18840.1 AL773599, AL732527 Genomic DNA Translation: CAM20936.1 BC087899 mRNA Translation: AAH87899.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS17994.1
NCBI Reference Sequences More...RefSeqⁱ	NP_780615.2, NM_175406.3
UniGeneⁱ	Mm.19298

Genome annotation databases

Ensemblⁱ	ENSMUST00000029900; ENSMUSP00000029900; ENSMUSG00000028238
GeneIDⁱ	242341
KEGGⁱ	mmu:242341
UCSC genome browser More...UCSCⁱ	uc008sch.2 mouse

Protein	Similar proteins		Species	Score	Length	Source
Q80SY3	V-type proton ATPase subunit d 2 (Fragment)		MOUSE		36	UniRef100_Q80SY3
UPI0007EDC5EA		MOUSE		246

Protein	Similar proteins		Species	Score	Length	Source
Q80SY3	V-type proton ATPase subunit d 2		HUMAN		350	UniRef90_Q8N8Y2
V-type proton ATPase subunit d 2		RAT		350
V-type proton ATPase subunit d 2		PONAB		350
V-type proton ATPase subunit		PANTR		350
V-type proton ATPase subunit		NOMLE		350
+85

Protein	Similar proteins		Species	Score	Length	Source
Q80SY3	V-type proton ATPase subunit d 2		HUMAN		350	UniRef50_Q8N8Y2
V-type proton ATPase subunit d 2		PONAB		350
V-type proton ATPase subunit d 2		RAT		350
V-type proton ATPase subunit d		MANSE		348
V-type proton ATPase subunit d 2		CHICK		351
+395

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY145896 mRNA Translation: AAN61104.1 AB088358 mRNA Translation: BAC57951.1 AY517482 mRNA Translation: AAR99405.1 AK075745 mRNA Translation: BAC35925.1 AK089507 mRNA Translation: BAC40907.1 AK170072 mRNA Translation: BAE41545.1 AK170405 mRNA Translation: BAE41772.1 AK170578 mRNA Translation: BAE41890.1 AK170659 mRNA Translation: BAE41942.1 AL732527, AL773599 Genomic DNA Translation: CAM18840.1 AL773599, AL732527 Genomic DNA Translation: CAM20936.1 BC087899 mRNA Translation: AAH87899.1
CCDSⁱ	CCDS17994.1
RefSeqⁱ	NP_780615.2, NM_175406.3
UniGeneⁱ	Mm.19298

3D structure databases

ProteinModelPortalⁱ	Q80SY3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	232395, 2 interactors
STRINGⁱ	10090.ENSMUSP00000029900

Protein family/group databases

TCDBⁱ	3.A.2.2.6 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

TCDBⁱ

3.A.2.2.6 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

PTM databases

iPTMnetⁱ	Q80SY3
PhosphoSitePlusⁱ	Q80SY3

Proteomic databases

MaxQBⁱ	Q80SY3
PaxDbⁱ	Q80SY3
PeptideAtlasⁱ	Q80SY3
PRIDEⁱ	Q80SY3

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000029900; ENSMUSP00000029900; ENSMUSG00000028238
GeneIDⁱ	242341
KEGGⁱ	mmu:242341
UCSCⁱ	uc008sch.2 mouse

Organism-specific databases

CTDⁱ	245972
MGIⁱ	MGI:1924415 Atp6v0d2

Phylogenomic databases

eggNOGⁱ	KOG2957 Eukaryota COG1527 LUCA
GeneTreeⁱ	ENSGT00390000002200
HOGENOMⁱ	HOG000199065
HOVERGENⁱ	HBG018065
InParanoidⁱ	Q80SY3
KOⁱ	K02146
OMAⁱ	DCMSENT
OrthoDBⁱ	EOG091G09L5
PhylomeDBⁱ	Q80SY3
TreeFamⁱ	TF300857

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1222556 ROS, RNS production in phagocytes R-MMU-77387 Insulin receptor recycling R-MMU-917977 Transferrin endocytosis and recycling R-MMU-983712 Ion channel transport

Reactomeⁱ

R-MMU-1222556 ROS, RNS production in phagocytes
R-MMU-77387 Insulin receptor recycling
R-MMU-917977 Transferrin endocytosis and recycling
R-MMU-983712 Ion channel transport

Miscellaneous databases

ChiTaRSⁱ	Atp6v0d2 mouse
Protein Ontology More...PROⁱ	PR:Q80SY3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000028238 Expressed in 69 organ(s), highest expression level in camera-type eye
CleanExⁱ	MM_ATP6V0D2
ExpressionAtlasⁱ	Q80SY3 baseline and differential
Genevisibleⁱ	Q80SY3 MM

Family and domain databases

Gene3Dⁱ	1.20.1690.10, 2 hits
InterProⁱ	View protein in InterPro IPR036079 ATPase_su_C-like IPR002843 ATPase_V0-cplx_csu/dsu IPR016727 ATPase_V0-cplx_dsu IPR035067 V-type_ATPase_suC
PANTHERⁱ	PTHR11028 PTHR11028, 1 hit
Pfamⁱ	View protein in Pfam PF01992 vATP-synt_AC39, 1 hit
PIRSFⁱ	PIRSF018497 V-ATP_synth_D, 1 hit
SUPFAMⁱ	SSF103486 SSF103486, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	VA0D2_MOUSE
Accessionⁱ	Q80SY3Primary (citable) accession number: Q80SY3 Secondary accession number(s): Q3TDQ6 , Q5I0V5, Q8BTL3, Q8BW16
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
	Last sequence update:	May 1, 2007
	Last modified:	November 7, 2018
	This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - Q80SY3 (VA0D2_MOUSE)

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V-type proton ATPase subunit d 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Plasma Membrane

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ