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Protein

Zygote arrest protein 1

Gene

Zar1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Essential for female fertility. May play a role in the oocyte-to-embryo transition.1 Publication

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Zygote arrest protein 1
Alternative name(s):
Oocyte-specific maternal effect factor
Gene namesi
Name:Zar1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2180337 Zar1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001870121 – 361Zygote arrest protein 1Add BLAST361

Proteomic databases

PaxDbiQ80SU3
PRIDEiQ80SU3

PTM databases

iPTMnetiQ80SU3
PhosphoSitePlusiQ80SU3

Expressioni

Tissue specificityi

Ovary. Expressed in primary oocytes (from primary through antral follicle stages) and during the progression from Meiosis I to Meiosis II. The mRNA is detected in growing oocytes (early primary follicle, type 3a) through fully grown oocytes (antral follicle, type 8).2 Publications

Developmental stagei

Expressed in zygote at the one-cell embryo, markedly less abundant at the two-cell embryo.1 Publication

Gene expression databases

BgeeiENSMUSG00000063935 Expressed in 115 organ(s), highest expression level in embryo
CleanExiMM_ZAR1
ExpressionAtlasiQ80SU3 baseline and differential
GenevisibleiQ80SU3 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073221

Structurei

3D structure databases

ProteinModelPortaliQ80SU3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ZAR1 family.Curated

Phylogenomic databases

eggNOGiENOG410IEKQ Eukaryota
ENOG4110E36 LUCA
GeneTreeiENSGT00390000012305
HOGENOMiHOG000108874
HOVERGENiHBG050367
InParanoidiQ80SU3
KOiK18762
OMAiCKECNIR
OrthoDBiEOG091G090Z
PhylomeDBiQ80SU3
TreeFamiTF331383

Family and domain databases

InterProiView protein in InterPro
IPR026775 Zar1
IPR027377 Znf-3CxxC
PANTHERiPTHR31054 PTHR31054, 1 hit
PfamiView protein in Pfam
PF13695 zf-3CxxC, 1 hit
SMARTiView protein in SMART
SM01328 zf-3CxxC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q80SU3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFPASTFHPC PHPYPQATKA GDGWRFGARG CRPAPPSFLP GYRQLMAAEY
60 70 80 90 100
VDSHQRAQLM ALLSRMGPRS VSSRDAAVQV NPRRDASVQC SLGRRTLQPA
110 120 130 140 150
GCRASPDARS GSCQPRGHAG AGRSPRSWQT VAPFSSVTFC GLSSSLEVAG
160 170 180 190 200
GRQTPTKGEG SPASSGTREP EPREVAARKA VPQPRSEEGD VQAAGQAGWE
210 220 230 240 250
QQPPPEDRNS VAAMQSEPGS EEPCPAAEMA QDPGDSDAPR DQASPQSTEQ
260 270 280 290 300
DKERLRFQFL EQKYGYYHCK DCKIRWESAY VWCVQGTSKV YFKQFCRVCE
310 320 330 340 350
KSYNPYRVED ITCQSCKRTR CACPVRLRHV DPKRPHRQDL CGRCKDKRLS
360
CDSTFSFKYI I
Length:361
Mass (Da):39,986
Last modified:June 1, 2003 - v1
Checksum:iC34AE85F76839242
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YU98A0A0J9YU98_MOUSE
Zygote arrest protein 1
Zar1
204Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY191415 mRNA Translation: AAO24706.1
AY193889 Genomic DNA Translation: AAO24708.1
BC099399 mRNA Translation: AAH99399.1
CCDSiCCDS19331.1
RefSeqiNP_777366.1, NM_174877.3
UniGeneiMm.11934

Genome annotation databases

EnsembliENSMUST00000073528; ENSMUSP00000073221; ENSMUSG00000063935
GeneIDi317755
KEGGimmu:317755
UCSCiuc008xrp.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY191415 mRNA Translation: AAO24706.1
AY193889 Genomic DNA Translation: AAO24708.1
BC099399 mRNA Translation: AAH99399.1
CCDSiCCDS19331.1
RefSeqiNP_777366.1, NM_174877.3
UniGeneiMm.11934

3D structure databases

ProteinModelPortaliQ80SU3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073221

PTM databases

iPTMnetiQ80SU3
PhosphoSitePlusiQ80SU3

Proteomic databases

PaxDbiQ80SU3
PRIDEiQ80SU3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073528; ENSMUSP00000073221; ENSMUSG00000063935
GeneIDi317755
KEGGimmu:317755
UCSCiuc008xrp.1 mouse

Organism-specific databases

CTDi326340
MGIiMGI:2180337 Zar1

Phylogenomic databases

eggNOGiENOG410IEKQ Eukaryota
ENOG4110E36 LUCA
GeneTreeiENSGT00390000012305
HOGENOMiHOG000108874
HOVERGENiHBG050367
InParanoidiQ80SU3
KOiK18762
OMAiCKECNIR
OrthoDBiEOG091G090Z
PhylomeDBiQ80SU3
TreeFamiTF331383

Miscellaneous databases

PROiPR:Q80SU3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063935 Expressed in 115 organ(s), highest expression level in embryo
CleanExiMM_ZAR1
ExpressionAtlasiQ80SU3 baseline and differential
GenevisibleiQ80SU3 MM

Family and domain databases

InterProiView protein in InterPro
IPR026775 Zar1
IPR027377 Znf-3CxxC
PANTHERiPTHR31054 PTHR31054, 1 hit
PfamiView protein in Pfam
PF13695 zf-3CxxC, 1 hit
SMARTiView protein in SMART
SM01328 zf-3CxxC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZAR1_MOUSE
AccessioniPrimary (citable) accession number: Q80SU3
Secondary accession number(s): Q4FZK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 2003
Last modified: September 12, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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