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Entry version 111 (16 Oct 2019)
Sequence version 1 (01 Jun 2003)
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Protein
Submitted name:

Envelope protein US28

Gene

US28

Organism
Human cytomegalovirus (HHV-5) (Human herpesvirus 5)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptorUniRule annotation, Receptor, Transducer

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Envelope protein US28Imported
Submitted name:
US28 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:US28Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHuman cytomegalovirus (HHV-5) (Human herpesvirus 5)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10359 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei37 – 58HelicalSequence analysisAdd BLAST22
Transmembranei70 – 94HelicalSequence analysisAdd BLAST25
Transmembranei100 – 123HelicalSequence analysisAdd BLAST24
Transmembranei144 – 166HelicalSequence analysisAdd BLAST23
Transmembranei186 – 209HelicalSequence analysisAdd BLAST24
Transmembranei229 – 250HelicalSequence analysisAdd BLAST22
Transmembranei272 – 294HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Viral envelope proteinImported, Virion

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini50 – 291G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST242

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

KEGG Orthology (KO)

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KOi
K22781

Database of Orthologous Groups

More...
OrthoDBi
5438at10239

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00657 CCCHEMOKINER
PR00237 GPCRRHODOPSN

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q80KM9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTPTTTTAEL TTEFDYDEDA TPCVFTDVLN QSKPVTLFLY GVVFLFGSIG
60 70 80 90 100
NFLVIFTITW RRRIQCSGDV YFINLAAADL LFVCTLPLWM QYLLDHNSLA
110 120 130 140 150
SVPCTLLTAC FYVAMFASLC FITEIALDRY YAIVYMRYRP VKQACLFSIF
160 170 180 190 200
WWIFAVIIAI PHFMVVTKKD NQCMTDYDYL EVSYPIILNV ELMLGAFVIP
210 220 230 240 250
LSVISYCYYR ISRIVAVSQS RHKGRIVRVL IAVVLVFIIF WLPYHLTLFV
260 270 280 290 300
DTLKLLKWIS SSCEFERSLK RALILTESLA FCHCCLNPLL YVFVGTKFRQ
310 320 330 340 350
ELHCLLAEFR QRLFSRDVSW YHSMSFSRRG SPSRRETSSD TLSDEVCRVS

QIIP
Length:354
Mass (Da):41,034
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3C1B7B7C54DF7AAD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY174275 Genomic DNA Translation: AAO22965.1
GU179001 Genomic DNA Translation: ACZ72907.1
GU179289 Genomic DNA Translation: ACZ80075.1
GU179290 Genomic DNA Translation: ACZ80240.1
JX512199 Genomic DNA Translation: AFR54982.1
KJ361953 Genomic DNA Translation: AHJ83221.1
KJ361963 Genomic DNA Translation: AHJ84904.1
KJ361967 Genomic DNA Translation: AHJ85581.1
KM192298 Genomic DNA Translation: AII79597.1
KM192299 Genomic DNA Translation: AII79764.1
KM192300 Genomic DNA Translation: AII79921.1
KM192301 Genomic DNA Translation: AII80088.1
KM192302 Genomic DNA Translation: AII80254.1
KP973623 Genomic DNA Translation: AJY54824.1
KP973624 Genomic DNA Translation: AJY54990.1
KP973625 Genomic DNA Translation: AJY55157.1
KP973626 Genomic DNA Translation: AJY55324.1
KP973627 Genomic DNA Translation: AJY55491.1
KP973628 Genomic DNA Translation: AJY55658.1
KP973629 Genomic DNA Translation: AJY55825.1
KP973630 Genomic DNA Translation: AJY55992.1
KP973631 Genomic DNA Translation: AJY56159.1
KP973632 Genomic DNA Translation: AJY56326.1
KP973633 Genomic DNA Translation: AJY56493.1
KP973634 Genomic DNA Translation: AJY56660.1
KP973635 Genomic DNA Translation: AJY56827.1
KP973636 Genomic DNA Translation: AJY56994.1
KP973637 Genomic DNA Translation: AJY57161.1
KP973638 Genomic DNA Translation: AJY57328.1
KP973639 Genomic DNA Translation: AJY57495.1
KP973640 Genomic DNA Translation: AJY57662.1
KP973641 Genomic DNA Translation: AJY57829.1
KP973642 Genomic DNA Translation: AJY57995.1
KP745647 Genomic DNA Translation: AKI10060.1
KP745662 Genomic DNA Translation: AKI12561.1
KP745679 Genomic DNA Translation: AKI15406.1
KP745684 Genomic DNA Translation: AKI16239.1
KR534207 Genomic DNA Translation: AKI25649.1
KU221090 Genomic DNA Translation: ALT14744.1
KU221091 Genomic DNA Translation: ALT14909.1
KU221092 Genomic DNA Translation: ALT15074.1
KU221093 Genomic DNA Translation: ALT15239.1
KU221094 Genomic DNA Translation: ALT15404.1
KU221095 Genomic DNA Translation: ALT15569.1
KU221096 Genomic DNA Translation: ALT15734.1
KU221097 Genomic DNA Translation: ALT15899.1
KU221098 Genomic DNA Translation: ALT16055.1
KU221099 Genomic DNA Translation: ALT16220.1
KU221100 Genomic DNA Translation: ALT16385.1
KT726952 Genomic DNA Translation: AMJ54692.1
MF084223 Genomic DNA Translation: ARX80377.1

NCBI Reference Sequences

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RefSeqi
YP_081612.1, NC_006273.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
3077536

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:3077536

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY174275 Genomic DNA Translation: AAO22965.1
GU179001 Genomic DNA Translation: ACZ72907.1
GU179289 Genomic DNA Translation: ACZ80075.1
GU179290 Genomic DNA Translation: ACZ80240.1
JX512199 Genomic DNA Translation: AFR54982.1
KJ361953 Genomic DNA Translation: AHJ83221.1
KJ361963 Genomic DNA Translation: AHJ84904.1
KJ361967 Genomic DNA Translation: AHJ85581.1
KM192298 Genomic DNA Translation: AII79597.1
KM192299 Genomic DNA Translation: AII79764.1
KM192300 Genomic DNA Translation: AII79921.1
KM192301 Genomic DNA Translation: AII80088.1
KM192302 Genomic DNA Translation: AII80254.1
KP973623 Genomic DNA Translation: AJY54824.1
KP973624 Genomic DNA Translation: AJY54990.1
KP973625 Genomic DNA Translation: AJY55157.1
KP973626 Genomic DNA Translation: AJY55324.1
KP973627 Genomic DNA Translation: AJY55491.1
KP973628 Genomic DNA Translation: AJY55658.1
KP973629 Genomic DNA Translation: AJY55825.1
KP973630 Genomic DNA Translation: AJY55992.1
KP973631 Genomic DNA Translation: AJY56159.1
KP973632 Genomic DNA Translation: AJY56326.1
KP973633 Genomic DNA Translation: AJY56493.1
KP973634 Genomic DNA Translation: AJY56660.1
KP973635 Genomic DNA Translation: AJY56827.1
KP973636 Genomic DNA Translation: AJY56994.1
KP973637 Genomic DNA Translation: AJY57161.1
KP973638 Genomic DNA Translation: AJY57328.1
KP973639 Genomic DNA Translation: AJY57495.1
KP973640 Genomic DNA Translation: AJY57662.1
KP973641 Genomic DNA Translation: AJY57829.1
KP973642 Genomic DNA Translation: AJY57995.1
KP745647 Genomic DNA Translation: AKI10060.1
KP745662 Genomic DNA Translation: AKI12561.1
KP745679 Genomic DNA Translation: AKI15406.1
KP745684 Genomic DNA Translation: AKI16239.1
KR534207 Genomic DNA Translation: AKI25649.1
KU221090 Genomic DNA Translation: ALT14744.1
KU221091 Genomic DNA Translation: ALT14909.1
KU221092 Genomic DNA Translation: ALT15074.1
KU221093 Genomic DNA Translation: ALT15239.1
KU221094 Genomic DNA Translation: ALT15404.1
KU221095 Genomic DNA Translation: ALT15569.1
KU221096 Genomic DNA Translation: ALT15734.1
KU221097 Genomic DNA Translation: ALT15899.1
KU221098 Genomic DNA Translation: ALT16055.1
KU221099 Genomic DNA Translation: ALT16220.1
KU221100 Genomic DNA Translation: ALT16385.1
KT726952 Genomic DNA Translation: AMJ54692.1
MF084223 Genomic DNA Translation: ARX80377.1
RefSeqiYP_081612.1, NC_006273.2

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

Genome annotation databases

GeneIDi3077536
KEGGivg:3077536

Phylogenomic databases

KOiK22781
OrthoDBi5438at10239

Family and domain databases

InterProiView protein in InterPro
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00657 CCCHEMOKINER
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ80KM9_HCMV
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80KM9
Secondary accession number(s): A0A076JXF1, Q6SVX9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: October 16, 2019
This is version 111 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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