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Protein
Submitted name:

Polyprotein

Gene
N/A
Organism
Murine norovirus 1
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1420MagnesiumCombined sources1
Metal bindingi1524MagnesiumCombined sources1
Metal bindingi1525Magnesium; via carbonyl oxygenCombined sources1
Metal bindingi1569Magnesium; via carbonyl oxygenCombined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymeraseSAAS annotation, Thiol proteaseSAAS annotation, Transferase
Biological processViral RNA replicationSAAS annotation
LigandATP-bindingSAAS annotation, MagnesiumCombined sources, Metal-bindingCombined sources, Nucleotide-binding

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C37.003

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
PolyproteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMurine norovirus 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri223997 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageCaliciviridaeNorovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000109015 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1383 ↔ 1484Combined sources
Disulfide bondi1482 ↔ 1484Combined sources

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q80J95

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q80J95

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q80J95

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini476 – 641SF3 helicaseInterPro annotationAdd BLAST166
Domaini995 – 1172Peptidase C37InterPro annotationAdd BLAST178
Domaini1416 – 1537RdRp catalyticInterPro annotationAdd BLAST122

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili912 – 932Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000605 Helicase_SF3_ssDNA/RNA_vir
IPR014759 Helicase_SF3_ssRNA_vir
IPR001665 Norovirus_pept_C37
IPR027417 P-loop_NTPase
IPR009003 Peptidase_S1_PA
IPR001205 RNA-dir_pol_C
IPR007094 RNA-dir_pol_PSvirus
IPR013614 Viral_PP_Calicivir_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08405 Calici_PP_N, 1 hit
PF05416 Peptidase_C37, 1 hit
PF00680 RdRP_1, 1 hit
PF00910 RNA_helicase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00917 SRSVCYSPTASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494 SSF50494, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51537 NV_3CL_PRO, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit
PS51218 SF3_HELICASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q80J95-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRMATPSSAP SVRNTEKRKN KKASSKASVS FGAPSPLSSE SEDEINYMTP
60 70 80 90 100
PEQEAQPGAL AALHAEGPLA GLPVTRSDAR VLIFNEWEER KKSDPWLRLD
110 120 130 140 150
MSDKAIFRRY PHLRPKEDRP DAPSHAEDAM DAKEPVIGSI LEQDDHKFYH
160 170 180 190 200
YSVYIGGGLV MGVNNPSAAV CQATIDVEKL HLWWRPVWEP RXPLDSAELR
210 220 230 240 250
KCVGMTVPYV ATTVNCYQVC CWIVGIKDTW LKRAKISRDL PFYSPVQDWN
260 270 280 290 300
VDPQEPFIPS KLRMVSDGIL VALSAVIGRP IKNLLASVKP LNILNIVLSC
310 320 330 340 350
DWTFSGIVNA LILLAELFDI FWTPPDVTNW MISIFGEWQA EGPFDLALDV
360 370 380 390 400
VPTLLGGIGM AFGLTSETIG RKLASTNSAL KAAQEMGKFA IEVFKQIMAW
410 420 430 440 450
IWPSEDPVPA LLSNMEQAII KNECQLENQL TAMLRDRNAG AEFLRSLDEE
460 470 480 490 500
EQEVRKIAAK CGNSATTGTT NALLARISMA RAAFEKARAE QTSRVRPVVI
510 520 530 540 550
MVSGRPGIGK TCFCQNLAKR IAASLGDETS VGIIPRADVD HWDAYKGARV
560 570 580 590 600
VLWDDFGMDN VVKDALRLQM LADTCPVTLN CDRIENKGKM FDSQVIIITT
610 620 630 640 650
NQQTPVPLDY VNLEAVCRRI DFLVYAESPV VDDARARAPG DVNAVKAAMR
660 670 680 690 700
PDYSHINFIL APQGGFDRQG NTPYGKGVTK IIGATALCAR AVALVHERHD
710 720 730 740 750
DFGLQNKVYD FDAGKVTAFK AMAADAGIPW YKMAAIGCKA MGCTCVEEAM
760 770 780 790 800
HLLKDYEVAP CQVIYNGATY NVSCIKGAPM VEKVKEPELP KTLVNCVRRI
810 820 830 840 850
KEARLRCYCR MAADVITSIL QAAGTAFSIY HQIEKRSRPS FYWDXGYTYR
860 870 880 890 900
DGPGSFDIFE DDDDGWYHSE GKKGKNKKGR GRPGVFRTRG LTDEEYDEFK
910 920 930 940 950
KRRESRGGKY SIDDYLADRE REEELLERDE EEAIFGDGFG LKATRRSRKA
960 970 980 990 1000
ERAKLGLVSG GDIRARKPID WNVVGPSWAD DDRQVDYGEK INFEAPVSIW
1010 1020 1030 1040 1050
SRVVQFGTGW GFWVSGHVFI TAKHVAPPKG TEIFGRKPGD FTVTSSGDFL
1060 1070 1080 1090 1100
KYYFTSAVRP DIPAMVLENG CQEGVVASVL VKRASGEMLA LAVRMGSQAA
1110 1120 1130 1140 1150
IKIGSAVVHG QTGMLLTGSN AKAQDLGTIP GDCGCPYVYK KGNTWVVIGV
1160 1170 1180 1190 1200
HVAATRSGNT VIAATHGEPT LEALEFQGPP MLPRPSGTYA GLPIADYGDA
1210 1220 1230 1240 1250
PPLSTKTMFW RTSPEKLPPG AWEPAYLGSK DERVDGPSLQ QVMRDQLKPY
1260 1270 1280 1290 1300
SEPRGLLPPQ EILDAVCDAI ENRLENTLEP QKPWTFKKAC ESLDKNTSSG
1310 1320 1330 1340 1350
YPYHKQKSKD WTGSAFIGDL GDQATHANNM YEMGKSMRPI YTAALKDELV
1360 1370 1380 1390 1400
KPDKIYGKIK KRLLWGSDLG TMIRAARAFG PFCDALKETC IFNPIRVGMS
1410 1420 1430 1440 1450
MNEDGPFIFA RHANFRYHMD ADYTRWDSTQ QRAILKRAGD IMVRLSPEPD
1460 1470 1480 1490 1500
LARVVMDDLL APSLLDVGDY KIVVEEGLPS GCPCTTQLNS LAHWILTLCA
1510 1520 1530 1540 1550
MVEVTRVDPD IVMQESEFSF YGDDEVVSTN LELDMVKYTM ALRRYGLLPT
1560 1570 1580 1590 1600
RADKEEGPLE RRQTLQGISF LRRAIVGDQF GWYGRLDRAS IDRQLLWTKG
1610 1620 1630 1640 1650
PNHQNPFETL PGHAQRPSQL MALLGEAAMH GEKYYRTVAS RVSKEAAQSG
1660 1670 1680
IEMVVPRHRS VLRWVRFGTM DAETPQERSA VFVNEDE
Length:1,687
Mass (Da):187,473
Last modified:December 6, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEA493276296FDB23
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY228235 Genomic RNA Translation: AAO63098.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY228235 Genomic RNA Translation: AAO63098.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M4GNMR-A881-955[»]
2MCDNMR-A28-114[»]
2MCHNMR-A58-114[»]
3NAHX-ray2.75A/B/C1181-1686[»]
3NAIX-ray2.56A/B/C1181-1686[»]
3QIDX-ray2.50A/B/C1181-1686[»]
3SFGX-ray2.21A/B/C1181-1686[»]
3SFUX-ray2.50A/B/C1181-1686[»]
3UPFX-ray2.60A/B/C1174-1687[»]
3UQSX-ray2.00A/B/C1181-1687[»]
3UR0X-ray2.45A/B/C1181-1687[»]
4ASHX-ray1.58A/B995-1177[»]
4NRUX-ray2.30A/B/C/D/E/F1181-1687[»]
4O4RX-ray2.40A/B/C1181-1687[»]
4X2VX-ray2.30A/B/C/D995-1178[»]
E1174-1178[»]
4X2WX-ray2.70A/B997-1175[»]
4X2XX-ray2.47A998-1173[»]
4X2YX-ray2.42A/B998-1173[»]
5Y3DX-ray3.14A/B/C/D/E/F1181-1686[»]
ProteinModelPortaliQ80J95
SMRiQ80J95
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiC37.003

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ80J95

Family and domain databases

InterProiView protein in InterPro
IPR000605 Helicase_SF3_ssDNA/RNA_vir
IPR014759 Helicase_SF3_ssRNA_vir
IPR001665 Norovirus_pept_C37
IPR027417 P-loop_NTPase
IPR009003 Peptidase_S1_PA
IPR001205 RNA-dir_pol_C
IPR007094 RNA-dir_pol_PSvirus
IPR013614 Viral_PP_Calicivir_N
PfamiView protein in Pfam
PF08405 Calici_PP_N, 1 hit
PF05416 Peptidase_C37, 1 hit
PF00680 RdRP_1, 1 hit
PF00910 RNA_helicase, 1 hit
PRINTSiPR00917 SRSVCYSPTASE
SUPFAMiSSF50494 SSF50494, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51537 NV_3CL_PRO, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit
PS51218 SF3_HELICASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ80J95_9CALI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80J95
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: December 6, 2005
Last modified: December 5, 2018
This is version 102 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported
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