Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
The new UniProt website is here! Take me to UniProt BETA

UniProtKB - Q80J95 (Q80J95_9CALI)

Entry version 116 (19 Jan 2022)
Sequence version 2 (06 Dec 2005)
Previous versions | rss
Add a publicationFeedback
Protein

Genome polyprotein

Gene
N/A
Organism
Murine norovirus 1
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

NTPase presumably plays a role in replication. Despite having similarities with helicases, does not seem to display any helicase activity.

ARBA annotation

Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation.

ARBA annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1420MagnesiumCombined sources1
Metal bindingi1524MagnesiumCombined sources1
Metal bindingi1525Magnesium; via carbonyl oxygenCombined sources1
Metal bindingi1569Magnesium; via carbonyl oxygenCombined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymeraseARBA annotation, Thiol proteaseARBA annotation, Transferase
Biological processViral RNA replicationARBA annotation
LigandATP-bindingARBA annotation, MagnesiumCombined sources, Metal-bindingCombined sources, Nucleotide-binding

Protein family/group databases

MEROPS protease database

More...MEROPSi		C37.003

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Genome polyproteinARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMurine norovirus 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri223997 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Picornavirales › Caliciviridae › Norovirus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000109015 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1383 ↔ 1484Combined sources
Disulfide bondi1482 ↔ 1484Combined sources

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q80J95

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q80J95

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q80J95

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini476 – 641SF3 helicaseInterPro annotationAdd BLAST166
Domaini995 – 1172Peptidase C37InterPro annotationAdd BLAST178
Domaini1416 – 1537RdRp catalyticInterPro annotationAdd BLAST122

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 62DisorderedSequence analysisAdd BLAST62

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili912 – 932Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi25 – 46Polar residuesSequence analysisAdd BLAST22

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.10.10, 2 hits
3.30.70.270, 2 hits
3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR000605, Helicase_SF3_ssDNA/RNA_vir
IPR014759, Helicase_SF3_ssRNA_vir
IPR001665, Norovirus_pept_C37
IPR027417, P-loop_NTPase
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
IPR013614, Viral_PP_Calicivir_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08405, Calici_PP_N, 1 hit
PF05416, Peptidase_C37, 1 hit
PF00680, RdRP_1, 1 hit
PF00910, RNA_helicase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00917, SRSVCYSPTASE

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51537, NV_3CL_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit
PS51218, SF3_HELICASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q80J95-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRMATPSSAP SVRNTEKRKN KKASSKASVS FGAPSPLSSE SEDEINYMTP 
        60         70         80         90        100
PEQEAQPGAL AALHAEGPLA GLPVTRSDAR VLIFNEWEER KKSDPWLRLD 
       110        120        130        140        150
MSDKAIFRRY PHLRPKEDRP DAPSHAEDAM DAKEPVIGSI LEQDDHKFYH 
       160        170        180        190        200
YSVYIGGGLV MGVNNPSAAV CQATIDVEKL HLWWRPVWEP RXPLDSAELR 
       210        220        230        240        250
KCVGMTVPYV ATTVNCYQVC CWIVGIKDTW LKRAKISRDL PFYSPVQDWN 
       260        270        280        290        300
VDPQEPFIPS KLRMVSDGIL VALSAVIGRP IKNLLASVKP LNILNIVLSC 
       310        320        330        340        350
DWTFSGIVNA LILLAELFDI FWTPPDVTNW MISIFGEWQA EGPFDLALDV 
       360        370        380        390        400
VPTLLGGIGM AFGLTSETIG RKLASTNSAL KAAQEMGKFA IEVFKQIMAW 
       410        420        430        440        450
IWPSEDPVPA LLSNMEQAII KNECQLENQL TAMLRDRNAG AEFLRSLDEE 
       460        470        480        490        500
EQEVRKIAAK CGNSATTGTT NALLARISMA RAAFEKARAE QTSRVRPVVI 
       510        520        530        540        550
MVSGRPGIGK TCFCQNLAKR IAASLGDETS VGIIPRADVD HWDAYKGARV 
       560        570        580        590        600
VLWDDFGMDN VVKDALRLQM LADTCPVTLN CDRIENKGKM FDSQVIIITT 
       610        620        630        640        650
NQQTPVPLDY VNLEAVCRRI DFLVYAESPV VDDARARAPG DVNAVKAAMR 
       660        670        680        690        700
PDYSHINFIL APQGGFDRQG NTPYGKGVTK IIGATALCAR AVALVHERHD 
       710        720        730        740        750
DFGLQNKVYD FDAGKVTAFK AMAADAGIPW YKMAAIGCKA MGCTCVEEAM 
       760        770        780        790        800
HLLKDYEVAP CQVIYNGATY NVSCIKGAPM VEKVKEPELP KTLVNCVRRI 
       810        820        830        840        850
KEARLRCYCR MAADVITSIL QAAGTAFSIY HQIEKRSRPS FYWDXGYTYR 
       860        870        880        890        900
DGPGSFDIFE DDDDGWYHSE GKKGKNKKGR GRPGVFRTRG LTDEEYDEFK 
       910        920        930        940        950
KRRESRGGKY SIDDYLADRE REEELLERDE EEAIFGDGFG LKATRRSRKA 
       960        970        980        990       1000
ERAKLGLVSG GDIRARKPID WNVVGPSWAD DDRQVDYGEK INFEAPVSIW 
      1010       1020       1030       1040       1050
SRVVQFGTGW GFWVSGHVFI TAKHVAPPKG TEIFGRKPGD FTVTSSGDFL 
      1060       1070       1080       1090       1100
KYYFTSAVRP DIPAMVLENG CQEGVVASVL VKRASGEMLA LAVRMGSQAA 
      1110       1120       1130       1140       1150
IKIGSAVVHG QTGMLLTGSN AKAQDLGTIP GDCGCPYVYK KGNTWVVIGV 
      1160       1170       1180       1190       1200
HVAATRSGNT VIAATHGEPT LEALEFQGPP MLPRPSGTYA GLPIADYGDA 
      1210       1220       1230       1240       1250
PPLSTKTMFW RTSPEKLPPG AWEPAYLGSK DERVDGPSLQ QVMRDQLKPY 
      1260       1270       1280       1290       1300
SEPRGLLPPQ EILDAVCDAI ENRLENTLEP QKPWTFKKAC ESLDKNTSSG 
      1310       1320       1330       1340       1350
YPYHKQKSKD WTGSAFIGDL GDQATHANNM YEMGKSMRPI YTAALKDELV 
      1360       1370       1380       1390       1400
KPDKIYGKIK KRLLWGSDLG TMIRAARAFG PFCDALKETC IFNPIRVGMS 
      1410       1420       1430       1440       1450
MNEDGPFIFA RHANFRYHMD ADYTRWDSTQ QRAILKRAGD IMVRLSPEPD 
      1460       1470       1480       1490       1500
LARVVMDDLL APSLLDVGDY KIVVEEGLPS GCPCTTQLNS LAHWILTLCA 
      1510       1520       1530       1540       1550
MVEVTRVDPD IVMQESEFSF YGDDEVVSTN LELDMVKYTM ALRRYGLLPT 
      1560       1570       1580       1590       1600
RADKEEGPLE RRQTLQGISF LRRAIVGDQF GWYGRLDRAS IDRQLLWTKG 
      1610       1620       1630       1640       1650
PNHQNPFETL PGHAQRPSQL MALLGEAAMH GEKYYRTVAS RVSKEAAQSG 
      1660       1670       1680 
IEMVVPRHRS VLRWVRFGTM DAETPQERSA VFVNEDE
Length:1,687
Mass (Da):187,473
Last modified:December 6, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEA493276296FDB23
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY228235 Genomic RNA Translation: AAO63098.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY228235 Genomic RNA Translation: AAO63098.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M4GNMR-A881-955[»]
2MCDNMR-A28-114[»]
2MCHNMR-A58-114[»]
3NAHX-ray2.75A/B/C1181-1686[»]
3NAIX-ray2.56A/B/C1181-1686[»]
3QIDX-ray2.50A/B/C1181-1686[»]
3SFGX-ray2.21A/B/C1181-1686[»]
3SFUX-ray2.50A/B/C1181-1686[»]
3UPFX-ray2.60A/B/C1174-1687[»]
3UQSX-ray2.00A/B/C1181-1687[»]
3UR0X-ray2.45A/B/C1181-1687[»]
4ASHX-ray1.58A/B995-1177[»]
4NRUX-ray2.30A/B/C/D/E/F1181-1687[»]
4O4RX-ray2.40A/B/C1181-1687[»]
4X2VX-ray2.30A/B/C/D995-1178[»]
E1174-1178[»]
4X2WX-ray2.70A/B997-1175[»]
4X2XX-ray2.47A998-1173[»]
4X2YX-ray2.42A/B998-1173[»]
5Y3DX-ray3.14A/B/C/D/E/F1181-1686[»]
SMRiQ80J95
ModBaseiSearch...
PDBe-KBiSearch...

Chemistry databases

BindingDBiQ80J95

Protein family/group databases

MEROPSiC37.003

Miscellaneous databases

EvolutionaryTraceiQ80J95

Family and domain databases

Gene3Di2.40.10.10, 2 hits
3.30.70.270, 2 hits
3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR000605, Helicase_SF3_ssDNA/RNA_vir
IPR014759, Helicase_SF3_ssRNA_vir
IPR001665, Norovirus_pept_C37
IPR027417, P-loop_NTPase
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
IPR013614, Viral_PP_Calicivir_N
PfamiView protein in Pfam
PF08405, Calici_PP_N, 1 hit
PF05416, Peptidase_C37, 1 hit
PF00680, RdRP_1, 1 hit
PF00910, RNA_helicase, 1 hit
PRINTSiPR00917, SRSVCYSPTASE
SUPFAMiSSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51537, NV_3CL_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit
PS51218, SF3_HELICASE_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ80J95_9CALI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80J95
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: December 6, 2005
Last modified: January 19, 2022
This is version 116 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again