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UniProtKB - Q80J95 (Q80J95_9CALI)
Protein
Genome polyprotein
Gene
N/A
Organism
Murine norovirus 1
Status
Functioni
NTPase presumably plays a role in replication. Despite having similarities with helicases, does not seem to display any helicase activity.
ARBA annotationViral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation.
ARBA annotationCaution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 1420 | MagnesiumCombined sources | 1 | |
Metal bindingi | 1524 | MagnesiumCombined sources | 1 | |
Metal bindingi | 1525 | Magnesium; via carbonyl oxygenCombined sources | 1 | |
Metal bindingi | 1569 | Magnesium; via carbonyl oxygenCombined sources | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cysteine-type endopeptidase activity Source: InterPro
- metal ion binding Source: UniProtKB-KW
- nucleoside-triphosphatase activity Source: InterPro
- RNA binding Source: InterPro
- RNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW
- RNA helicase activity Source: InterPro
GO - Biological processi
- transcription, DNA-templated Source: InterPro
- viral RNA genome replication Source: InterPro
Keywordsi
Molecular function | Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymeraseARBA annotation, Thiol proteaseARBA annotation, Transferase |
Biological process | Viral RNA replicationARBA annotation |
Ligand | ATP-bindingARBA annotation, MagnesiumCombined sources, Metal-bindingCombined sources, Nucleotide-binding |
Protein family/group databases
MEROPSi | C37.003 |
Names & Taxonomyi
Protein namesi | Recommended name: Genome polyproteinARBA annotation |
Organismi | Murine norovirus 1Imported |
Taxonomic identifieri | 223997 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Picornavirales › Caliciviridae › Norovirus › |
Proteomesi |
|
PTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 1383 ↔ 1484 | Combined sources | ||
Disulfide bondi | 1482 ↔ 1484 | Combined sources |
Structurei
3D structure databases
SMRi | Q80J95 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q80J95 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 476 – 641 | SF3 helicaseInterPro annotationAdd BLAST | 166 | |
Domaini | 995 – 1172 | Peptidase C37InterPro annotationAdd BLAST | 178 | |
Domaini | 1416 – 1537 | RdRp catalyticInterPro annotationAdd BLAST | 122 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 62 | DisorderedSequence analysisAdd BLAST | 62 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 912 – 932 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 25 – 46 | Polar residuesSequence analysisAdd BLAST | 22 |
Keywords - Domaini
Coiled coilSequence analysisFamily and domain databases
Gene3Di | 2.40.10.10, 2 hits 3.30.70.270, 2 hits 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR043502, DNA/RNA_pol_sf IPR000605, Helicase_SF3_ssDNA/RNA_vir IPR014759, Helicase_SF3_ssRNA_vir IPR001665, Norovirus_pept_C37 IPR027417, P-loop_NTPase IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR043128, Rev_trsase/Diguanyl_cyclase IPR001205, RNA-dir_pol_C IPR007094, RNA-dir_pol_PSvirus IPR013614, Viral_PP_Calicivir_N |
Pfami | View protein in Pfam PF08405, Calici_PP_N, 1 hit PF05416, Peptidase_C37, 1 hit PF00680, RdRP_1, 1 hit PF00910, RNA_helicase, 1 hit |
PRINTSi | PR00917, SRSVCYSPTASE |
SUPFAMi | SSF50494, SSF50494, 1 hit SSF52540, SSF52540, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS51537, NV_3CL_PRO, 1 hit PS50507, RDRP_SSRNA_POS, 1 hit PS51218, SF3_HELICASE_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q80J95-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRMATPSSAP SVRNTEKRKN KKASSKASVS FGAPSPLSSE SEDEINYMTP
60 70 80 90 100
PEQEAQPGAL AALHAEGPLA GLPVTRSDAR VLIFNEWEER KKSDPWLRLD
110 120 130 140 150
MSDKAIFRRY PHLRPKEDRP DAPSHAEDAM DAKEPVIGSI LEQDDHKFYH
160 170 180 190 200
YSVYIGGGLV MGVNNPSAAV CQATIDVEKL HLWWRPVWEP RXPLDSAELR
210 220 230 240 250
KCVGMTVPYV ATTVNCYQVC CWIVGIKDTW LKRAKISRDL PFYSPVQDWN
260 270 280 290 300
VDPQEPFIPS KLRMVSDGIL VALSAVIGRP IKNLLASVKP LNILNIVLSC
310 320 330 340 350
DWTFSGIVNA LILLAELFDI FWTPPDVTNW MISIFGEWQA EGPFDLALDV
360 370 380 390 400
VPTLLGGIGM AFGLTSETIG RKLASTNSAL KAAQEMGKFA IEVFKQIMAW
410 420 430 440 450
IWPSEDPVPA LLSNMEQAII KNECQLENQL TAMLRDRNAG AEFLRSLDEE
460 470 480 490 500
EQEVRKIAAK CGNSATTGTT NALLARISMA RAAFEKARAE QTSRVRPVVI
510 520 530 540 550
MVSGRPGIGK TCFCQNLAKR IAASLGDETS VGIIPRADVD HWDAYKGARV
560 570 580 590 600
VLWDDFGMDN VVKDALRLQM LADTCPVTLN CDRIENKGKM FDSQVIIITT
610 620 630 640 650
NQQTPVPLDY VNLEAVCRRI DFLVYAESPV VDDARARAPG DVNAVKAAMR
660 670 680 690 700
PDYSHINFIL APQGGFDRQG NTPYGKGVTK IIGATALCAR AVALVHERHD
710 720 730 740 750
DFGLQNKVYD FDAGKVTAFK AMAADAGIPW YKMAAIGCKA MGCTCVEEAM
760 770 780 790 800
HLLKDYEVAP CQVIYNGATY NVSCIKGAPM VEKVKEPELP KTLVNCVRRI
810 820 830 840 850
KEARLRCYCR MAADVITSIL QAAGTAFSIY HQIEKRSRPS FYWDXGYTYR
860 870 880 890 900
DGPGSFDIFE DDDDGWYHSE GKKGKNKKGR GRPGVFRTRG LTDEEYDEFK
910 920 930 940 950
KRRESRGGKY SIDDYLADRE REEELLERDE EEAIFGDGFG LKATRRSRKA
960 970 980 990 1000
ERAKLGLVSG GDIRARKPID WNVVGPSWAD DDRQVDYGEK INFEAPVSIW
1010 1020 1030 1040 1050
SRVVQFGTGW GFWVSGHVFI TAKHVAPPKG TEIFGRKPGD FTVTSSGDFL
1060 1070 1080 1090 1100
KYYFTSAVRP DIPAMVLENG CQEGVVASVL VKRASGEMLA LAVRMGSQAA
1110 1120 1130 1140 1150
IKIGSAVVHG QTGMLLTGSN AKAQDLGTIP GDCGCPYVYK KGNTWVVIGV
1160 1170 1180 1190 1200
HVAATRSGNT VIAATHGEPT LEALEFQGPP MLPRPSGTYA GLPIADYGDA
1210 1220 1230 1240 1250
PPLSTKTMFW RTSPEKLPPG AWEPAYLGSK DERVDGPSLQ QVMRDQLKPY
1260 1270 1280 1290 1300
SEPRGLLPPQ EILDAVCDAI ENRLENTLEP QKPWTFKKAC ESLDKNTSSG
1310 1320 1330 1340 1350
YPYHKQKSKD WTGSAFIGDL GDQATHANNM YEMGKSMRPI YTAALKDELV
1360 1370 1380 1390 1400
KPDKIYGKIK KRLLWGSDLG TMIRAARAFG PFCDALKETC IFNPIRVGMS
1410 1420 1430 1440 1450
MNEDGPFIFA RHANFRYHMD ADYTRWDSTQ QRAILKRAGD IMVRLSPEPD
1460 1470 1480 1490 1500
LARVVMDDLL APSLLDVGDY KIVVEEGLPS GCPCTTQLNS LAHWILTLCA
1510 1520 1530 1540 1550
MVEVTRVDPD IVMQESEFSF YGDDEVVSTN LELDMVKYTM ALRRYGLLPT
1560 1570 1580 1590 1600
RADKEEGPLE RRQTLQGISF LRRAIVGDQF GWYGRLDRAS IDRQLLWTKG
1610 1620 1630 1640 1650
PNHQNPFETL PGHAQRPSQL MALLGEAAMH GEKYYRTVAS RVSKEAAQSG
1660 1670 1680
IEMVVPRHRS VLRWVRFGTM DAETPQERSA VFVNEDE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY228235 Genomic RNA Translation: AAO63098.2 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY228235 Genomic RNA Translation: AAO63098.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2M4G | NMR | - | A | 881-955 | [»] | |
2MCD | NMR | - | A | 28-114 | [»] | |
2MCH | NMR | - | A | 58-114 | [»] | |
3NAH | X-ray | 2.75 | A/B/C | 1181-1686 | [»] | |
3NAI | X-ray | 2.56 | A/B/C | 1181-1686 | [»] | |
3QID | X-ray | 2.50 | A/B/C | 1181-1686 | [»] | |
3SFG | X-ray | 2.21 | A/B/C | 1181-1686 | [»] | |
3SFU | X-ray | 2.50 | A/B/C | 1181-1686 | [»] | |
3UPF | X-ray | 2.60 | A/B/C | 1174-1687 | [»] | |
3UQS | X-ray | 2.00 | A/B/C | 1181-1687 | [»] | |
3UR0 | X-ray | 2.45 | A/B/C | 1181-1687 | [»] | |
4ASH | X-ray | 1.58 | A/B | 995-1177 | [»] | |
4NRU | X-ray | 2.30 | A/B/C/D/E/F | 1181-1687 | [»] | |
4O4R | X-ray | 2.40 | A/B/C | 1181-1687 | [»] | |
4X2V | X-ray | 2.30 | A/B/C/D | 995-1178 | [»] | |
E | 1174-1178 | [»] | ||||
4X2W | X-ray | 2.70 | A/B | 997-1175 | [»] | |
4X2X | X-ray | 2.47 | A | 998-1173 | [»] | |
4X2Y | X-ray | 2.42 | A/B | 998-1173 | [»] | |
5Y3D | X-ray | 3.14 | A/B/C/D/E/F | 1181-1686 | [»] | |
SMRi | Q80J95 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Chemistry databases
BindingDBi | Q80J95 |
Protein family/group databases
MEROPSi | C37.003 |
Miscellaneous databases
EvolutionaryTracei | Q80J95 |
Family and domain databases
Gene3Di | 2.40.10.10, 2 hits 3.30.70.270, 2 hits 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR043502, DNA/RNA_pol_sf IPR000605, Helicase_SF3_ssDNA/RNA_vir IPR014759, Helicase_SF3_ssRNA_vir IPR001665, Norovirus_pept_C37 IPR027417, P-loop_NTPase IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR043128, Rev_trsase/Diguanyl_cyclase IPR001205, RNA-dir_pol_C IPR007094, RNA-dir_pol_PSvirus IPR013614, Viral_PP_Calicivir_N |
Pfami | View protein in Pfam PF08405, Calici_PP_N, 1 hit PF05416, Peptidase_C37, 1 hit PF00680, RdRP_1, 1 hit PF00910, RNA_helicase, 1 hit |
PRINTSi | PR00917, SRSVCYSPTASE |
SUPFAMi | SSF50494, SSF50494, 1 hit SSF52540, SSF52540, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS51537, NV_3CL_PRO, 1 hit PS50507, RDRP_SSRNA_POS, 1 hit PS51218, SF3_HELICASE_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q80J95_9CALI | |
Accessioni | Q80J95Primary (citable) accession number: Q80J95 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 1, 2003 |
Last sequence update: | December 6, 2005 | |
Last modified: | January 19, 2022 | |
This is version 116 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |