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Entry version 42 (03 Jul 2019)
Sequence version 1 (01 Jun 2003)
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Protein

Envelope polyprotein

Gene

GPC

Organism
Andes orthohantavirus
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Envelope polyproteinUniRule annotation
Alternative name(s):
M polyproteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GPCImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAndes orthohantavirusImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1980456 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaNegarnaviricotaPolyploviricotinaEllioviricetesBunyaviralesHantaviridaeMammantavirinaeOrthohantavirus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei485 – 509HelicalSequence analysisAdd BLAST25
Transmembranei630 – 649HelicalSequence analysisAdd BLAST20
Transmembranei1108 – 1129HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, VirionUniRule annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q80DP7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini614 – 637ITAM_2InterPro annotationAdd BLAST24

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the hantavirus envelope glycoprotein family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016402 Envelope_glycoprot_Hantavirus
IPR002534 Hanta_G1
IPR002532 Hanta_G2
IPR012316 ITAM_motif_hantavir-typ

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01567 Hanta_G1, 1 hit
PF01561 Hanta_G2, 1 hit
PF10538 ITAM_Cys-rich, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF003945 M_poly_HantaV, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51056 ITAM_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q80DP7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGWYLVALG ICYTLTLAMP KTTYELKMEC PHTVGLGQGY IIGSTELGLI
60 70 80 90 100
SIEAASDIKL ESSCNFDLHT TSMAQKSFTQ VEWRKKSDTT DTTNAASTTF
110 120 130 140 150
EAQTKTVNLR GTCILAPELY DTLKKVKKTV LCYDLTCNQT HCQPTVYLIA
160 170 180 190 200
PVLTCMSIRS CMARVFTSRI QVIYEKTHCV TGQLIEGQCF NPAHTLTLSQ
210 220 230 240 250
PAHTYDTVTL PISCFFTPKE SEQLKVIKTF EGILTKTGCT ENALQGYYVC
260 270 280 290 300
FLGSHSEPLI VPSLEDIRSA EVVSRMLVHP RGEDHDAIQN SQSHLRIVGP
310 320 330 340 350
ITAKVPSTSS TDTLKGTAFA GVPMYSSLST LVKNADPEFV FSPGIIPESN
360 370 380 390 400
HSVCDKKTVP ITWTGYLPIS GEMEKVTGCT VFCTLAGPGA SCEAYSENGI
410 420 430 440 450
FNISSPTCLV NKVQRFRGSE QKINFICQRV DQDVVVYCNG QKKVILTKTL
460 470 480 490 500
VIGQCIYTFT SLFSLMPDVA HSLAVELCVP GLHGWATVML LSTFCFGWVL
510 520 530 540 550
IPAVTLIILK CLRVLTFSCS HYTNESKFKF ILEKVKVEYQ KTMGSMVCDV
560 570 580 590 600
CHHECETAKE LESHRQSCIN GQCPYCMTIT EATESALQAH YSICKLTGRF
610 620 630 640 650
QEALKKSLKK PEVKKGCYRT LGVFRYKSRC YVGLVWCLLL TCEIVIWAAS
660 670 680 690 700
AETPLMESGW SDTAHGVGEI PMKTDLELDF SLPSSSSYSY RRKLTNPANK
710 720 730 740 750
EESISFHFQM EKQVIHAEIQ PLGHWMDATF NTKTAFHCYG ACQKYSYPWQ
760 770 780 790 800
TSKCFFEKDY QYETGWGCNP GDCPGVGTGC TACGVYLDKL KSVGKAYKII
810 820 830 840 850
SLKYTRKVCI QLGTEQTCKH IDANDCLVTP SVKVCIVGTV SKLQPSDTLL
860 870 880 890 900
FLGPLEQGGV ILKQWCTTSC AFGDPGDIMS TPSGMRCPEH TGSFRKICGF
910 920 930 940 950
ATTPVCEYQG NTISGYKRMM ATKDSFQSFN LTEPHITANK LEWIDPDGNT
960 970 980 990 1000
RDHVNLVLNR DVSFQDLSDN PCKVDLHTQA IEGAWGSGVG FTLTCTVGLT
1010 1020 1030 1040 1050
ECPSFMTSIK ACDLAMCYGS TVANLARGSN TVKVVGKGGH SGSSFKCCHD
1060 1070 1080 1090 1100
TDCSSEGLLA SAPHLERVTG FNQIDSDKVY DDGAPPCTFK CWFTKSGEWL
1110 1120 1130
LGILNGNWIV VVVLVVILIL SIIMFSVLCP RRGHKKTV
Length:1,138
Mass (Da):125,466
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i19E49A866D8DE045
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY228238 Genomic RNA Translation: AAO86638.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY228238 Genomic RNA Translation: AAO86638.1

3D structure databases

SMRiQ80DP7
ModBaseiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR016402 Envelope_glycoprot_Hantavirus
IPR002534 Hanta_G1
IPR002532 Hanta_G2
IPR012316 ITAM_motif_hantavir-typ
PfamiView protein in Pfam
PF01567 Hanta_G1, 1 hit
PF01561 Hanta_G2, 1 hit
PF10538 ITAM_Cys-rich, 1 hit
PIRSFiPIRSF003945 M_poly_HantaV, 1 hit
PROSITEiView protein in PROSITE
PS51056 ITAM_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ80DP7_9VIRU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80DP7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: July 3, 2019
This is version 42 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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