UniProtKB - Q805F7 (DIDA_AGKCO)
Protein
Disintegrin acostatin-alpha
Gene
N/A
Organism
Agkistrodon contortrix contortrix (Southern copperhead)
Status
Functioni
Inhibits fibrinogen interaction with platelets. Acts by binding to alpha-IIb/beta-3 (ITGA2B/ITGB3) on the platelet surface and inhibits ADP-induced platelet aggregation in human platelet-rich plasma.1 Publication
GO - Molecular functioni
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- cell adhesion Source: UniProtKB
- negative regulation of blood coagulation Source: UniProtKB
Keywordsi
Molecular function | Cell adhesion impairing toxin, Hemostasis impairing toxin, Platelet aggregation inhibiting toxin, Toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Disintegrin acostatin-alphaCleaved into the following chain: |
Organismi | Agkistrodon contortrix contortrix (Southern copperhead)Imported |
Taxonomic identifieri | 8713 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Viperidae › Crotalinae › Agkistrodon › |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
PropeptideiPRO_0000007236 | 21 – 46 | 1 PublicationAdd BLAST | 26 | |
ChainiPRO_0000007237 | 47 – 109 | Disintegrin acostatin-alphaAdd BLAST | 63 | |
ChainiPRO_0000413008 | 48 – 109 | Disintegrin acostatin-alpha, processed formAdd BLAST | 62 | |
PropeptideiPRO_0000007238 | 110 – 111 | 2 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 48 | Pyrrolidone carboxylic acid; in Disintegrin acostatin-alpha, processed form2 Publications | 1 | |
Disulfide bondi | 53 ↔ 76 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 54 | Interchain (with C-431 in subunit beta)PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 59 | Interchain (with C-426 in subunit beta)PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 67 ↔ 73 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 72 ↔ 97 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 85 ↔ 104 | PROSITE-ProRule annotation1 Publication |
Keywords - PTMi
Disulfide bond, Pyrrolidone carboxylic acidExpressioni
Tissue specificityi
Expressed by the venom gland.
Interactioni
Subunit structurei
Heterodimer with subunit beta; disulfide-linked.2 Publications
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3C05 | X-ray | 1.70 | A/C | 49-109 | [»] | |
ProteinModelPortali | Q805F7 | |||||
SMRi | Q805F7 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q805F7 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 47 – 111 | DisintegrinPROSITE-ProRule annotationAdd BLAST | 65 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 89 – 91 | Cell attachment site | 3 |
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
HOVERGENi | HBG051359 |
Family and domain databases
Gene3Di | 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR018358 Disintegrin_CS IPR001762 Disintegrin_dom IPR036436 Disintegrin_dom_sf |
Pfami | View protein in Pfam PF00200 Disintegrin, 1 hit |
PRINTSi | PR00289 DISINTEGRIN |
SMARTi | View protein in SMART SM00050 DISIN, 1 hit |
SUPFAMi | SSF57552 SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS00427 DISINTEGRIN_1, 1 hit PS50214 DISINTEGRIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q805F7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIQVLLVTLC LAVFPYQGSS IILESGNVND YEVVYPRKVT ALPKGAIQPK
60 70 80 90 100
NPCCDAATCK LTPGSQCAEG LCCDQCKFIK AGKICRRARG DNPDYRCTGQ
110
SGDCPRKHFY A
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB078903 mRNA Translation: BAC55944.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB078903 mRNA Translation: BAC55944.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3C05 | X-ray | 1.70 | A/C | 49-109 | [»] | |
ProteinModelPortali | Q805F7 | |||||
SMRi | Q805F7 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Phylogenomic databases
HOVERGENi | HBG051359 |
Miscellaneous databases
EvolutionaryTracei | Q805F7 |
Family and domain databases
Gene3Di | 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR018358 Disintegrin_CS IPR001762 Disintegrin_dom IPR036436 Disintegrin_dom_sf |
Pfami | View protein in Pfam PF00200 Disintegrin, 1 hit |
PRINTSi | PR00289 DISINTEGRIN |
SMARTi | View protein in SMART SM00050 DISIN, 1 hit |
SUPFAMi | SSF57552 SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS00427 DISINTEGRIN_1, 1 hit PS50214 DISINTEGRIN_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | DIDA_AGKCO | |
Accessioni | Q805F7Primary (citable) accession number: Q805F7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2004 |
Last sequence update: | June 1, 2003 | |
Last modified: | November 22, 2017 | |
This is version 65 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families - PDB cross-references
Index of Protein Data Bank (PDB) cross-references