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Protein

Disintegrin acostatin-alpha

Gene
N/A
Organism
Agkistrodon contortrix contortrix (Southern copperhead)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits fibrinogen interaction with platelets. Acts by binding to alpha-IIb/beta-3 (ITGA2B/ITGB3) on the platelet surface and inhibits ADP-induced platelet aggregation in human platelet-rich plasma.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: UniProtKB
  • negative regulation of blood coagulation Source: UniProtKB

Keywordsi

Molecular functionCell adhesion impairing toxin, Hemostasis impairing toxin, Platelet aggregation inhibiting toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin acostatin-alpha
Cleaved into the following chain:
OrganismiAgkistrodon contortrix contortrix (Southern copperhead)Imported
Taxonomic identifieri8713 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeAgkistrodon

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000000723621 – 461 PublicationAdd BLAST26
ChainiPRO_000000723747 – 109Disintegrin acostatin-alphaAdd BLAST63
ChainiPRO_000041300848 – 109Disintegrin acostatin-alpha, processed formAdd BLAST62
PropeptideiPRO_0000007238110 – 1112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei48Pyrrolidone carboxylic acid; in Disintegrin acostatin-alpha, processed form2 Publications1
Disulfide bondi53 ↔ 76PROSITE-ProRule annotation1 Publication
Disulfide bondi54Interchain (with C-431 in subunit beta)PROSITE-ProRule annotation1 Publication
Disulfide bondi59Interchain (with C-426 in subunit beta)PROSITE-ProRule annotation1 Publication
Disulfide bondi67 ↔ 73PROSITE-ProRule annotation1 Publication
Disulfide bondi72 ↔ 97PROSITE-ProRule annotation1 Publication
Disulfide bondi85 ↔ 104PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Heterodimer with subunit beta; disulfide-linked.2 Publications

Structurei

Secondary structure

1111
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni56 – 59Combined sources4
Beta strandi68 – 70Combined sources3
Beta strandi84 – 86Combined sources3
Beta strandi89 – 92Combined sources4

3D structure databases

ProteinModelPortaliQ805F7
SMRiQ805F7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ805F7

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 111DisintegrinPROSITE-ProRule annotationAdd BLAST65

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi89 – 91Cell attachment site3

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG051359

Family and domain databases

Gene3Di4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR018358 Disintegrin_CS
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
PfamiView protein in Pfam
PF00200 Disintegrin, 1 hit
PRINTSiPR00289 DISINTEGRIN
SMARTiView protein in SMART
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS00427 DISINTEGRIN_1, 1 hit
PS50214 DISINTEGRIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q805F7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQVLLVTLC LAVFPYQGSS IILESGNVND YEVVYPRKVT ALPKGAIQPK
60 70 80 90 100
NPCCDAATCK LTPGSQCAEG LCCDQCKFIK AGKICRRARG DNPDYRCTGQ
110
SGDCPRKHFY A
Length:111
Mass (Da):12,093
Last modified:June 1, 2003 - v1
Checksum:i5D120A539592659C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB078903 mRNA Translation: BAC55944.1

Similar proteinsi

Entry informationi

Entry nameiDIDA_AGKCO
AccessioniPrimary (citable) accession number: Q805F7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 1, 2003
Last modified: November 22, 2017
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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