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UniProtKB - Q804H4 (Q804H4_CHICK)
Protein
Pro-interleukin-16
Gene
IL16
Organism
Gallus gallus (Chicken)
Status
Functioni
Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
UniRule annotationARBA annotationGO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
GO - Biological processi
- chemotaxis Source: UniProtKB-KW
Keywordsi
Molecular function | CytokineUniRule annotationARBA annotation |
Biological process | ChemotaxisUniRule annotationARBA annotation, Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Pro-interleukin-16UniRule annotationCleaved into the following chain: Interleukin-16UniRule annotation Short name: IL-16UniRule annotation Alternative name(s): Lymphocyte chemoattractant factorUniRule annotation Short name: LCFUniRule annotation |
Gene namesi | Name:IL16UniRule annotation |
Organismi | Gallus gallus (Chicken)Imported |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Subcellular locationi
Extracellular region or secreted
- extracellular space Source: UniProtKB-KW
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmUniRule annotation, NucleusUniRule annotation, SecretedUniRule annotationInteractioni
Subunit structurei
Homotetramer.
UniRule annotationGO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 389 – 474 | PDZInterPro annotationAdd BLAST | 86 | |
Domaini | 509 – 594 | PDZInterPro annotationAdd BLAST | 86 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 156 | DisorderedSequence analysisAdd BLAST | 156 | |
Regioni | 173 – 208 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 296 – 319 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 333 – 356 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 472 – 500 | DisorderedSequence analysisAdd BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 39 – 53 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 78 – 124 | Polar residuesSequence analysisAdd BLAST | 47 | |
Compositional biasi | 482 – 500 | Polar residuesSequence analysisAdd BLAST | 19 |
Family and domain databases
Gene3Di | 2.30.42.10, 2 hits |
InterProi | View protein in InterPro IPR020450, IL-16 IPR001478, PDZ IPR036034, PDZ_sf |
Pfami | View protein in Pfam PF00595, PDZ, 2 hits |
PRINTSi | PR01931, INTRLEUKIN16 |
SMARTi | View protein in SMART SM00228, PDZ, 2 hits |
SUPFAMi | SSF50156, SSF50156, 2 hits |
PROSITEi | View protein in PROSITE PS50106, PDZ, 2 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q804H4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSEDNSHLDL QPGIDANEGH ENRSSSEAVL QKSESEIVSS KVLKSDENDA
60 70 80 90 100
VKKGPPVAPK PVWFRQSLKG LRKANSDLKP QADQSPSDLQ SVSTKELQSS
110 120 130 140 150
LSRLPSRGSS IKQRISSFES LSAPQSPEKV HRRLSPKPSV QKEQSPSAKW
160 170 180 190 200
SEGAPDHFSQ TFLQCSENSQ QQSKSSVVMG TKSLDRSSCP KDTLTASSEK
210 220 230 240 250
SNDANTENPP ALLTAEAIAT SHVAPVAKVH NLRSRSFPLT ATQSCEMMKT
260 270 280 290 300
FDEKYSKIYS ISNQVSSALM KSLLCLPQSP VPSGNTAWEA VDTLSQTSVE
310 320 330 340 350
EDGTSLPPSS ENHHPDTGFS LNLSELREYT VSLADSEKEE EKQEQGSPQA
360 370 380 390 400
SAVSGQSVIS LLSPEELAKL IEEVKSLDEA TLKELDDIHV TILHKEENTG
410 420 430 440 450
LGFSLAGGAD LENKVITVHK VFPNGLASQE GTIQKGDEVL SINGKSFKGA
460 470 480 490 500
THNDASVIMR QARQPRQAVV VTRKAKDGEK SHNVSIGSST SSVASDASQE
510 520 530 540 550
STTEETICTI TLDKTAAGLG FSLEGGKGSI HGDKPIIINR IFKGTSLEQS
560 570 580 590 600
SPVQPGDELL QVHTTALQGL TRFEAWNIIK ALPDGPITAI IKRKNPSSVT
KKASETL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY177426 mRNA Translation: AAO18640.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY177426 mRNA Translation: AAO18640.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family and domain databases
Gene3Di | 2.30.42.10, 2 hits |
InterProi | View protein in InterPro IPR020450, IL-16 IPR001478, PDZ IPR036034, PDZ_sf |
Pfami | View protein in Pfam PF00595, PDZ, 2 hits |
PRINTSi | PR01931, INTRLEUKIN16 |
SMARTi | View protein in SMART SM00228, PDZ, 2 hits |
SUPFAMi | SSF50156, SSF50156, 2 hits |
PROSITEi | View protein in PROSITE PS50106, PDZ, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | Q804H4_CHICK | |
Accessioni | Q804H4Primary (citable) accession number: Q804H4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 1, 2003 |
Last sequence update: | June 1, 2003 | |
Last modified: | January 19, 2022 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |