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UniProtKB - Q803S7 (Q803S7_DANRE)

Entry version 108 (02 Dec 2020)
Sequence version 1 (01 Jun 2003)
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Protein

DNA mismatch repair protein

Gene

msh6

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the post-replicative DNA mismatch repair system (MMR).UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingUniRule annotationARBA annotation
Biological processDNA damage, DNA repairUniRule annotation
LigandATP-bindingUniRule annotationARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA mismatch repair proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:msh6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-020905-3, msh6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		Q803S7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini87 – 138PWWPInterPro annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni17 – 81DisorderedSequence analysisAdd BLAST65
Regioni184 – 366DisorderedSequence analysisAdd BLAST183

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili938 – 958Sequence analysisAdd BLAST21
Coiled coili1012 – 1032Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi194 – 209AcidicSequence analysisAdd BLAST16
Compositional biasi210 – 272PolyampholyteSequence analysisAdd BLAST63
Compositional biasi273 – 293AcidicSequence analysisAdd BLAST21
Compositional biasi333 – 360PolarSequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.UniRule annotationARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Database of Orthologous Groups

More...OrthoDBi		138168at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.420.110, 1 hit
3.40.1170.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007695, DNA_mismatch_repair_MutS-lik_N
IPR017261, DNA_mismatch_repair_MutS/MSH
IPR000432, DNA_mismatch_repair_MutS_C
IPR007861, DNA_mismatch_repair_MutS_clamp
IPR007696, DNA_mismatch_repair_MutS_core
IPR016151, DNA_mismatch_repair_MutS_N
IPR036187, DNA_mismatch_repair_MutS_sf
IPR007860, DNA_mmatch_repair_MutS_con_dom
IPR036678, MutS_con_dom_sf
IPR027417, P-loop_NTPase
IPR000313, PWWP_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01624, MutS_I, 1 hit
PF05188, MutS_II, 1 hit
PF05192, MutS_III, 1 hit
PF05190, MutS_IV, 1 hit
PF00488, MutS_V, 1 hit
PF00855, PWWP, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF037677, DNA_mis_repair_Msh6, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00534, MUTSac, 1 hit
SM00533, MUTSd, 1 hit
SM00293, PWWP, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48334, SSF48334, 1 hit
SSF52540, SSF52540, 1 hit
SSF53150, SSF53150, 1 hit
SSF55271, SSF55271, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00486, DNA_MISMATCH_REPAIR_2, 1 hit
PS50812, PWWP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q803S7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKQSSLFNF FSKSPPLAVK AKSSPSPAEG DAPGRSNTSP KEEAKVNSKK 
        60         70         80         90        100
TPAKPPSKTQ AIAGHAKLFG EKAATTKERK QSPVFSAGSL VWAKMEGHPW 
       110        120        130        140        150
WPCMVVPQPL SGQQMRGRGR DQRLHVHFFD EPPTRGWVNT KYIREYQGSN 
       160        170        180        190        200
SAVAKSGGMF FSGKPVIRKA MELADVAMKD SPEQRLKMPL CMDPSDEEEE 
       210        220        230        240        250
DEEDMEIEKS TVSDAEMSEE EVKEKTKPSR RPPRAAAEKS QKSKRRRIVV 
       260        270        280        290        300
ASDSDDSGEE FDPNKAGGSS DEDKEEEEGV NSGAEEEESE PETEPDSPVK 
       310        320        330        340        350
PIKRKRPTEK PTKSKSKPET PKRAPAALPS VSTDAKSRLS AFSAPDNFDS 
       360        370        380        390        400
QSSANGTEGG STVWDHEKLE WLQDGKRKDA QRKRQSDENY DPTTLYVPED 
       410        420        430        440        450
FLNRTTPGMR RWWQLKSEMF DTVLFYKVGK FYELYHMDAV IGVNELNLTF 
       460        470        480        490        500
MKGTWAHSGF PEIGFGRFSD VLVQKGYKVA RVEQTETPNM MEARCKKLAR 
       510        520        530        540        550
PTKFDKVVKR EVCRIITRGT QTYSVLDGAP SETQSKYLLS IKEKSEEDST 
       560        570        580        590        600
GHGHIYGVCF IDTSVGRFHI GQFQDDRHCS RLRTLVAHYS PAQVIFEKGN 
       610        620        630        640        650
PSIETLKIFK AIVASSLQEG LNAGSQFWDA QKTLKVLAEE DYFKESKDDN 
       660        670        680        690        700
KKASVLPPAL KAMTPECDAL SLTPKTGYEL ALSALGGCMF YLKKCLVDQE 
       710        720        730        740        750
LFSMGNFEEY VPVDVEMEQA GGASCFFAKT NQRMVLDGVT LANLEILQNS 
       760        770        780        790        800
STGGPEGTLL ERLDTCCTPF GKRLLKQWIC APLCNLSSIG DRLDALEDLM 
       810        820        830        840        850
GAPSQTSEVT DLLKKLPDLE RLLSKIHSMG TPLKGQDHPD SRAILYEEVV 
       860        870        880        890        900
YSKRKIADFL AALEGFKVMK EIVSIMEPVG EDLKSKLLRQ VVLLKTENED 
       910        920        930        940        950
GLFPDLSPEL KRWDTAFDHQ KARTTGVITP KAGFDPEYDQ ALNGIKECER 
       960        970        980        990       1000
DLQDYLDRQK KRLGCKNLSY WGTGRNRYQL EVPESVSERS LPEEYEVRST 
      1010       1020       1030       1040       1050
KKGWKRYSTK DIERMFSELQ SWEDKRDAAL KDCMRRLFYN FDKNYKDWQT 
      1060       1070       1080       1090       1100
AVECMAVLDV LLSMCRYSQS ADGSMARPEM ALPGDGSYSA PFLDLRGSRH 
      1110       1120       1130       1140       1150
PCVTKTFFGD DFIPNDIFIG CPGDEEEAQD DTKALAPCVL VTGPNMGGKS 
      1160       1170       1180       1190       1200
TLMRQCGLVV ILAQLGCYVP AESLRLTPVD RVFTRLGASD RIMSGESTFF 
      1210       1220       1230       1240       1250
VELSETASIL LHATNHSLVL LDELGRGTAT YDGTAIASAV VKELSEKICC 
      1260       1270       1280       1290       1300
RTLFSTHYHS LVEDHVQDPA VRLGHMACMV ENECEDPSQE TITFLYKFIR 
      1310       1320       1330       1340       1350
GACPKSYGFN AARLANIPED VIQSGHKKAR DFERSTVSLR IFKKLCSFAE 
      1360 
SPRAEREQLT TLIQTLRNL
Length:1,369
Mass (Da):153,232
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i91E3AF22837071BA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC044350 mRNA Translation: AAH44350.1

NCBI Reference Sequences

More...RefSeqi		NP_878280.1, NM_182860.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		260437

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dre:260437

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC044350 mRNA Translation: AAH44350.1
RefSeqiNP_878280.1, NM_182860.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

PRIDEiQ803S7

Genome annotation databases

GeneIDi260437
KEGGidre:260437

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2956
ZFINiZDB-GENE-020905-3, msh6

Phylogenomic databases

OrthoDBi138168at2759

Family and domain databases

Gene3Di3.30.420.110, 1 hit
3.40.1170.10, 1 hit
InterProiView protein in InterPro
IPR007695, DNA_mismatch_repair_MutS-lik_N
IPR017261, DNA_mismatch_repair_MutS/MSH
IPR000432, DNA_mismatch_repair_MutS_C
IPR007861, DNA_mismatch_repair_MutS_clamp
IPR007696, DNA_mismatch_repair_MutS_core
IPR016151, DNA_mismatch_repair_MutS_N
IPR036187, DNA_mismatch_repair_MutS_sf
IPR007860, DNA_mmatch_repair_MutS_con_dom
IPR036678, MutS_con_dom_sf
IPR027417, P-loop_NTPase
IPR000313, PWWP_dom
PfamiView protein in Pfam
PF01624, MutS_I, 1 hit
PF05188, MutS_II, 1 hit
PF05192, MutS_III, 1 hit
PF05190, MutS_IV, 1 hit
PF00488, MutS_V, 1 hit
PF00855, PWWP, 1 hit
PIRSFiPIRSF037677, DNA_mis_repair_Msh6, 1 hit
SMARTiView protein in SMART
SM00534, MUTSac, 1 hit
SM00533, MUTSd, 1 hit
SM00293, PWWP, 1 hit
SUPFAMiSSF48334, SSF48334, 1 hit
SSF52540, SSF52540, 1 hit
SSF53150, SSF53150, 1 hit
SSF55271, SSF55271, 1 hit
PROSITEiView protein in PROSITE
PS00486, DNA_MISMATCH_REPAIR_2, 1 hit
PS50812, PWWP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ803S7_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q803S7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: December 2, 2020
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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