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UniProtKB - Q803A0 (JADE1_DANRE)
Protein
Protein Jade-1
Gene
jade1
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation.
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 196 – 246 | PHD-type 1PROSITE-ProRule annotationAdd BLAST | 51 | |
Zinc fingeri | 248 – 282 | C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST | 35 | |
Zinc fingeri | 306 – 362 | PHD-type 2PROSITE-ProRule annotationAdd BLAST | 57 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- histone H3 acetylation Source: GO_Central
- histone H4-K5 acetylation Source: GO_Central
- histone H4-K8 acetylation Source: GO_Central
- regulation of canonical Wnt signaling pathway Source: ZFIN
Keywordsi
Molecular function | Activator |
Biological process | Apoptosis, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-DRE-3214847, HATs acetylate histones |
Names & Taxonomyi
Protein namesi | Recommended name: Protein Jade-1Alternative name(s): Jade family PHD finger protein 1 PHD finger protein 17 |
Gene namesi | Name:jade1 Synonyms:phf17 ORF Names:zgc:55323 |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-030131-5648, jade1 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytoskeleton
- cilium basal body By similarity
Other locations
- Chromosome By similarity
Note: Localizes to the ciliary transition zone.By similarity
Cytoskeleton
- cytoskeleton Source: UniProtKB-KW
Nucleus
- histone acetyltransferase complex Source: GO_Central
Other locations
- cell projection Source: UniProtKB-KW
- chromosome Source: UniProtKB-SubCell
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell projection, Chromosome, Cytoplasm, Cytoskeleton, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000253531 | 1 – 829 | Protein Jade-1Add BLAST | 829 |
Proteomic databases
PaxDbi | Q803A0 |
PRIDEi | Q803A0 |
Interactioni
Subunit structurei
Component of the HBO1 complex composed.
By similarityProtein-protein interaction databases
BioGRIDi | 84576, 1 interactor |
STRINGi | 7955.ENSDARP00000042059 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 40 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 368 – 408 | DisorderedSequence analysisAdd BLAST | 41 | |
Regioni | 556 – 651 | DisorderedSequence analysisAdd BLAST | 96 | |
Regioni | 697 – 829 | DisorderedSequence analysisAdd BLAST | 133 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 10 – 28 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 368 – 390 | Basic and acidic residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 391 – 405 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 566 – 584 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 608 – 624 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 625 – 651 | Basic and acidic residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 697 – 720 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 734 – 754 | Basic and acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 755 – 780 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 781 – 801 | Basic and acidic residuesSequence analysisAdd BLAST | 21 |
Domaini
The 2 PHD-type zinc fingers are required for transcriptional activity.By similarity
Sequence similaritiesi
Belongs to the JADE family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 196 – 246 | PHD-type 1PROSITE-ProRule annotationAdd BLAST | 51 | |
Zinc fingeri | 248 – 282 | C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST | 35 | |
Zinc fingeri | 306 – 362 | PHD-type 2PROSITE-ProRule annotationAdd BLAST | 57 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG0954, Eukaryota |
InParanoidi | Q803A0 |
OrthoDBi | 1235709at2759 |
PhylomeDBi | Q803A0 |
Family and domain databases
CDDi | cd15679, PHD_JADE1, 1 hit |
Gene3Di | 3.30.40.10, 2 hits |
InterProi | View protein in InterPro IPR019542, Enhancer_polycomb-like_N IPR034732, EPHD IPR039546, Jade-1_PHD IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF10513, EPL1, 1 hit |
SMARTi | View protein in SMART SM00249, PHD, 2 hits |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS51805, EPHD, 1 hit PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q803A0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKRSRVPSTS EDSDNGSNST SWSQHSNSKH RKQSGKRPSE VFRTDLITAM
60 70 80 90 100
KLHDSHQLNP EDYYELADPW RQEWEKGVQV PVSPESIPQC AVRTVAEKST
110 120 130 140 150
APLFIKPKKL IRSSESSMLG YVGIQTLADG MCRYDLNEED VAWLQITNEE
160 170 180 190 200
FSKMGMQPLD ELTMERVMEE FERRCYDNMS HAMETEEGLG IEYDEDVVCD
210 220 230 240 250
VCQSPDGEDG NEMVFCDKCN ICVHQACYGI LKVPEGSWLC RTCALGIFPK
260 270 280 290 300
CHLCPKKGGA MKPTRSGTKW VHVSCALWIP EVSIGNPEKM EPITNVSHIP
310 320 330 340 350
SNRWALICCL CKEKTGACIQ CSAKSCRVAF HVTCGLHCGL KMNTILTEAD
360 370 380 390 400
EVKFKSFCPK HSGLDWNEEE GDDDRPVKVP TREDRSRNRG IDFSASSQTR
410 420 430 440 450
LSQNPEETRL SERKLRVQQL EDEFYRFVAA DEVAEHLQLP LEMVDILFQY
460 470 480 490 500
WKLKRKVNFN QPLIMPKKEE EDSLARREQE VLLRRLRLFT HLRQDLERVR
510 520 530 540 550
NLTYMVSRRE RIKRTLCRVQ EQIFHHHVRL LEQGRVTGVS STRRLEEAMF
560 570 580 590 600
YFRTTPPVPA SPQPLKGHCG QNSTLSSSEK GSNSYRSSKH IEADKPAKML
610 620 630 640 650
MDGVPSSGDS VRSETVMSAS SRRSEGRTRS GESHRKEEES ERPLEDRRRK
660 670 680 690 700
SKLWDQVSIK DKLRHAKSME DTLSSETELD TMDDRLLLSH TNANSVATAP
710 720 730 740 750
NMYSGSPRKT NASHQGKLVP NGTSGRHLKN WGSFRIPKRS ERTSAGRQTE
760 770 780 790 800
RQEADNTADQ NSSLKTFSTS PSSPQIRTRL RTGSENRRHL EESDLGQSEQ
810 820
GKRCHTQRLP SPMTRRYGSD VIQRGVLAS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF1QA19 | F1QA19_DANRE | Protein Jade-1 | jade1 phf17 | 829 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC046874 mRNA Translation: AAH46874.1 BN000276 mRNA Translation: CAE30491.1 |
RefSeqi | NP_956099.1, NM_199805.1 |
Genome annotation databases
GeneIDi | 327437 |
KEGGi | dre:327437 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC046874 mRNA Translation: AAH46874.1 BN000276 mRNA Translation: CAE30491.1 |
RefSeqi | NP_956099.1, NM_199805.1 |
3D structure databases
SMRi | Q803A0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 84576, 1 interactor |
STRINGi | 7955.ENSDARP00000042059 |
Proteomic databases
PaxDbi | Q803A0 |
PRIDEi | Q803A0 |
Genome annotation databases
GeneIDi | 327437 |
KEGGi | dre:327437 |
Organism-specific databases
CTDi | 79960 |
ZFINi | ZDB-GENE-030131-5648, jade1 |
Phylogenomic databases
eggNOGi | KOG0954, Eukaryota |
InParanoidi | Q803A0 |
OrthoDBi | 1235709at2759 |
PhylomeDBi | Q803A0 |
Enzyme and pathway databases
Reactomei | R-DRE-3214847, HATs acetylate histones |
Miscellaneous databases
PROi | PR:Q803A0 |
Family and domain databases
CDDi | cd15679, PHD_JADE1, 1 hit |
Gene3Di | 3.30.40.10, 2 hits |
InterProi | View protein in InterPro IPR019542, Enhancer_polycomb-like_N IPR034732, EPHD IPR039546, Jade-1_PHD IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF10513, EPL1, 1 hit |
SMARTi | View protein in SMART SM00249, PHD, 2 hits |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS51805, EPHD, 1 hit PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | JADE1_DANRE | |
Accessioni | Q803A0Primary (citable) accession number: Q803A0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 17, 2006 |
Last sequence update: | June 1, 2003 | |
Last modified: | September 29, 2021 | |
This is version 104 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families