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UniProtKB - Q803A0 (JADE1_DANRE)

Entry version 104 (29 Sep 2021)
Sequence version 1 (01 Jun 2003)
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Protein

Protein Jade-1

Gene

jade1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation.

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri196 – 246PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri248 – 282C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST35
Zinc fingeri306 – 362PHD-type 2PROSITE-ProRule annotationAdd BLAST57

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processApoptosis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DRE-3214847, HATs acetylate histones

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein Jade-1
Alternative name(s):
Jade family PHD finger protein 1
PHD finger protein 17
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:jade1
Synonyms:phf17
ORF Names:zgc:55323
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-030131-5648, jade1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Chromosome, Cytoplasm, Cytoskeleton, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002535311 – 829Protein Jade-1Add BLAST829

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q803A0

PRoteomics IDEntifications database

More...PRIDEi		Q803A0

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the HBO1 complex composed.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		84576, 1 interactor

STRING: functional protein association networks

More...STRINGi		7955.ENSDARP00000042059

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q803A0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 40DisorderedSequence analysisAdd BLAST40
Regioni368 – 408DisorderedSequence analysisAdd BLAST41
Regioni556 – 651DisorderedSequence analysisAdd BLAST96
Regioni697 – 829DisorderedSequence analysisAdd BLAST133

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi10 – 28Polar residuesSequence analysisAdd BLAST19
Compositional biasi368 – 390Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi391 – 405Polar residuesSequence analysisAdd BLAST15
Compositional biasi566 – 584Polar residuesSequence analysisAdd BLAST19
Compositional biasi608 – 624Polar residuesSequence analysisAdd BLAST17
Compositional biasi625 – 651Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi697 – 720Polar residuesSequence analysisAdd BLAST24
Compositional biasi734 – 754Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi755 – 780Polar residuesSequence analysisAdd BLAST26
Compositional biasi781 – 801Basic and acidic residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The 2 PHD-type zinc fingers are required for transcriptional activity.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the JADE family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri196 – 246PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri248 – 282C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST35
Zinc fingeri306 – 362PHD-type 2PROSITE-ProRule annotationAdd BLAST57

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0954, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q803A0

Database of Orthologous Groups

More...OrthoDBi		1235709at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q803A0

Family and domain databases

Conserved Domains Database

More...CDDi		cd15679, PHD_JADE1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR019542, Enhancer_polycomb-like_N
IPR034732, EPHD
IPR039546, Jade-1_PHD
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10513, EPL1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00249, PHD, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51805, EPHD, 1 hit
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q803A0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRSRVPSTS EDSDNGSNST SWSQHSNSKH RKQSGKRPSE VFRTDLITAM 
        60         70         80         90        100
KLHDSHQLNP EDYYELADPW RQEWEKGVQV PVSPESIPQC AVRTVAEKST 
       110        120        130        140        150
APLFIKPKKL IRSSESSMLG YVGIQTLADG MCRYDLNEED VAWLQITNEE 
       160        170        180        190        200
FSKMGMQPLD ELTMERVMEE FERRCYDNMS HAMETEEGLG IEYDEDVVCD 
       210        220        230        240        250
VCQSPDGEDG NEMVFCDKCN ICVHQACYGI LKVPEGSWLC RTCALGIFPK 
       260        270        280        290        300
CHLCPKKGGA MKPTRSGTKW VHVSCALWIP EVSIGNPEKM EPITNVSHIP 
       310        320        330        340        350
SNRWALICCL CKEKTGACIQ CSAKSCRVAF HVTCGLHCGL KMNTILTEAD 
       360        370        380        390        400
EVKFKSFCPK HSGLDWNEEE GDDDRPVKVP TREDRSRNRG IDFSASSQTR 
       410        420        430        440        450
LSQNPEETRL SERKLRVQQL EDEFYRFVAA DEVAEHLQLP LEMVDILFQY 
       460        470        480        490        500
WKLKRKVNFN QPLIMPKKEE EDSLARREQE VLLRRLRLFT HLRQDLERVR 
       510        520        530        540        550
NLTYMVSRRE RIKRTLCRVQ EQIFHHHVRL LEQGRVTGVS STRRLEEAMF 
       560        570        580        590        600
YFRTTPPVPA SPQPLKGHCG QNSTLSSSEK GSNSYRSSKH IEADKPAKML 
       610        620        630        640        650
MDGVPSSGDS VRSETVMSAS SRRSEGRTRS GESHRKEEES ERPLEDRRRK 
       660        670        680        690        700
SKLWDQVSIK DKLRHAKSME DTLSSETELD TMDDRLLLSH TNANSVATAP 
       710        720        730        740        750
NMYSGSPRKT NASHQGKLVP NGTSGRHLKN WGSFRIPKRS ERTSAGRQTE 
       760        770        780        790        800
RQEADNTADQ NSSLKTFSTS PSSPQIRTRL RTGSENRRHL EESDLGQSEQ 
       810        820 
GKRCHTQRLP SPMTRRYGSD VIQRGVLAS
Length:829
Mass (Da):94,548
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4AF7760FC43DB54C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1QA19F1QA19_DANRE
Protein Jade-1
jade1 phf17
829Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC046874 mRNA Translation: AAH46874.1
BN000276 mRNA Translation: CAE30491.1

NCBI Reference Sequences

More...RefSeqi		NP_956099.1, NM_199805.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		327437

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dre:327437

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC046874 mRNA Translation: AAH46874.1
BN000276 mRNA Translation: CAE30491.1
RefSeqiNP_956099.1, NM_199805.1

3D structure databases

SMRiQ803A0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi84576, 1 interactor
STRINGi7955.ENSDARP00000042059

Proteomic databases

PaxDbiQ803A0
PRIDEiQ803A0

Genome annotation databases

GeneIDi327437
KEGGidre:327437

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79960
ZFINiZDB-GENE-030131-5648, jade1

Phylogenomic databases

eggNOGiKOG0954, Eukaryota
InParanoidiQ803A0
OrthoDBi1235709at2759
PhylomeDBiQ803A0

Enzyme and pathway databases

ReactomeiR-DRE-3214847, HATs acetylate histones

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q803A0

Family and domain databases

CDDicd15679, PHD_JADE1, 1 hit
Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR019542, Enhancer_polycomb-like_N
IPR034732, EPHD
IPR039546, Jade-1_PHD
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF10513, EPL1, 1 hit
SMARTiView protein in SMART
SM00249, PHD, 2 hits
SUPFAMiSSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51805, EPHD, 1 hit
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJADE1_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q803A0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 1, 2003
Last modified: September 29, 2021
This is version 104 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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