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UniProtKB - Q802V3 (Q802V3_DANRE)

Entry version 122 (25 May 2022)
Sequence version 1 (01 Jun 2003)
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Protein

Villin-1

Gene

vil1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin cappingARBA annotation, Actin-bindingARBA annotation
LigandCalciumARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Villin-1ARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:vil1Imported
Synonyms:vil1lImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-040426-799, vil1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projectionARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini768 – 834HPInterPro annotationAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni747 – 771DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi747 – 769Polar residuesSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the villin/gelsolin family.ARBA annotation

Keywords - Domaini

RepeatARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...OrthoDBi		1376537at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.950.10, 1 hit
3.40.20.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029006, ADF-H/Gelsolin-like_dom_sf
IPR007123, Gelsolin-like_dom
IPR036180, Gelsolin-like_dom_sf
IPR030007, Villin-1
IPR007122, Villin/Gelsolin
IPR003128, Villin_headpiece
IPR036886, Villin_headpiece_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR11977, PTHR11977, 1 hit
PTHR11977:SF35, PTHR11977:SF35, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00626, Gelsolin, 6 hits
PF02209, VHP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00597, GELSOLIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00262, GEL, 6 hits
SM00153, VHP, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47050, SSF47050, 1 hit
SSF82754, SSF82754, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51089, HP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q802V3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPQEVKTDVP KVLNKTTPGL QIWRVENMEL VPCPSKTFGQ FFEGDSYVIL 
        60         70         80         90        100
YTHKTSNNFS YDIHYWLGKS TSQDEMGAAA IYTTQMDDHL GGVAVQHRET 
       110        120        130        140        150
QGHESATFQG YFKQGIIYKK GGVASGMKQV ETNTYNIRRL LHVKGNKHVV 
       160        170        180        190        200
AGEVEMSWNS FNKGDVFLLD LGSLIIQWNG PKSNRMERLR GMNLAKDIRD 
       210        220        230        240        250
RERGGRAQVA VVEGDDEQSS EEAMKLMKQS LGERPKNIKE AIPDEIVDEK 
       260        270        280        290        300
LKTAIKLYHI SDAQGSLVVQ EVAVKPLTQD LLKTEDCYLL DQGGIKIFIW 
       310        320        330        340        350
KGKKASKAER TESLKMAEAY VKAKGYPVST YIETVSEGAE SSVFKQLFQK 
       360        370        380        390        400
WTDKGQTVGM GTTHNPGKIA KVEQVKFDAT SMHARPDIAA QQKMVDDGSG 
       410        420        430        440        450
EAEVWRIEDN ELAPVDRKWL GHFYGGDCYL ILYKYEVSSK FHYILYMWQG 
       460        470        480        490        500
RHASTAELTA CAYQAVILDQ KYNGEPVQVR VPMGKEPMHL MAIFKGKMIV 
       510        520        530        540        550
YEEGSSREGS SQSRPSVRLF HVHGTNEFNT RATEVPPRSS SLNSNDVFVL 
       560        570        580        590        600
STDKCCYLWY GKGCSGDERE MAKSLADIIS EREKQVIAEG QEPADFWVNL 
       610        620        630        640        650
GGKSQYASNK RLQDENISIT PRLFECSNQT GRFIATEITN FNQDDLDEDD 
       660        670        680        690        700
VMLLDIWDQV YLWIGKGAND TEKREAVVTA QEYLKSHPAG RDLDTPVLVV 
       710        720        730        740        750
KQGFEPPTFT GWFHAWDPQK WSEGKSYDQL KAELGDATDV IKITVDLTQP 
       760        770        780        790        800
SSNQTNSSNS TQGGSMPRPV TQTFPAEKLV NVQTEDLPEG VDPTRKEDYL 
       810        820        830 
SDDDFALAMG ISRMNFYAMP SWKQLNLKKE KGLF
Length:834
Mass (Da):93,937
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2DA88581CFB5907A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC047186 mRNA Translation: AAH47186.1
BC165692 mRNA Translation: AAI65692.1

NCBI Reference Sequences

More...RefSeqi		NP_956532.1, NM_200238.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		393207

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dre:393207

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC047186 mRNA Translation: AAH47186.1
BC165692 mRNA Translation: AAI65692.1
RefSeqiNP_956532.1, NM_200238.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

GeneIDi393207
KEGGidre:393207

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7429
ZFINiZDB-GENE-040426-799, vil1

Phylogenomic databases

OrthoDBi1376537at2759

Family and domain databases

Gene3Di1.10.950.10, 1 hit
3.40.20.10, 6 hits
InterProiView protein in InterPro
IPR029006, ADF-H/Gelsolin-like_dom_sf
IPR007123, Gelsolin-like_dom
IPR036180, Gelsolin-like_dom_sf
IPR030007, Villin-1
IPR007122, Villin/Gelsolin
IPR003128, Villin_headpiece
IPR036886, Villin_headpiece_dom_sf
PANTHERiPTHR11977, PTHR11977, 1 hit
PTHR11977:SF35, PTHR11977:SF35, 1 hit
PfamiView protein in Pfam
PF00626, Gelsolin, 6 hits
PF02209, VHP, 1 hit
PRINTSiPR00597, GELSOLIN
SMARTiView protein in SMART
SM00262, GEL, 6 hits
SM00153, VHP, 1 hit
SUPFAMiSSF47050, SSF47050, 1 hit
SSF82754, SSF82754, 2 hits
PROSITEiView protein in PROSITE
PS51089, HP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ802V3_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q802V3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: May 25, 2022
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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