UniProtKB - Q800Z9 (Q800Z9_DANRE)
Protein
Submitted name:
Zinc finger transcription factor detour
Gene
gli1
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- abducens nerve development Source: ZFIN
- abducens nucleus development Source: ZFIN
- adenohypophysis development Source: ZFIN
- adenohypophysis morphogenesis Source: ZFIN
- brain development Source: ZFIN
- cranial nerve development Source: ZFIN
- facial nerve development Source: ZFIN
- facial nucleus development Source: ZFIN
- floor plate formation Source: ZFIN
- generation of neurons Source: ZFIN
- glossopharyngeal nerve development Source: ZFIN
- muscle cell fate specification Source: ZFIN
- neural tube patterning Source: ZFIN
- neuron differentiation Source: ZFIN
- odontogenesis Source: ZFIN
- pituitary gland development Source: ZFIN
- positive regulation of smoothened signaling pathway Source: ZFIN
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of neurogenesis Source: ZFIN
- regulation of transcription, DNA-templated Source: ZFIN
- retinal ganglion cell axon guidance Source: ZFIN
- smoothened signaling pathway Source: ZFIN
- trigeminal motor nucleus development Source: ZFIN
- trigeminal nerve development Source: ZFIN
- vagus nerve development Source: ZFIN
- ventral spinal cord interneuron specification Source: ZFIN
Keywordsi
Molecular function | DNA-bindingARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Zinc finger transcription factor detourImported |
Gene namesi | Name:gli1Imported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Organism-specific databases
ZFINi | ZDB-GENE-030321-1, gli1 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- nucleus Source: GO_Central
Other locations
- Hedgehog signaling complex Source: ZFIN
Keywords - Cellular componenti
NucleusARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 302 – 334 | C2H2-typeInterPro annotationAdd BLAST | 33 | |
Domaini | 340 – 367 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 368 – 397 | C2H2-typeInterPro annotationAdd BLAST | 30 | |
Domaini | 398 – 428 | C2H2-typeInterPro annotationAdd BLAST | 31 | |
Domaini | 429 – 459 | C2H2-typeInterPro annotationAdd BLAST | 31 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 32 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 76 – 115 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 260 – 281 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 442 – 482 | DisorderedSequence analysisAdd BLAST | 41 | |
Regioni | 499 – 536 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 548 – 567 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 644 – 664 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 686 – 723 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 733 – 752 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 792 – 817 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 960 – 994 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 1063 – 1089 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 1129 – 1318 | DisorderedSequence analysisAdd BLAST | 190 | |
Regioni | 1340 – 1368 | DisorderedSequence analysisAdd BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 11 – 32 | PolarSequence analysisAdd BLAST | 22 | |
Compositional biasi | 98 – 115 | PolarSequence analysisAdd BLAST | 18 | |
Compositional biasi | 442 – 469 | PolyampholyteSequence analysisAdd BLAST | 28 | |
Compositional biasi | 503 – 536 | PolarSequence analysisAdd BLAST | 34 | |
Compositional biasi | 648 – 664 | PolarSequence analysisAdd BLAST | 17 | |
Compositional biasi | 698 – 723 | PolarSequence analysisAdd BLAST | 26 | |
Compositional biasi | 1129 – 1193 | PolarSequence analysisAdd BLAST | 65 | |
Compositional biasi | 1208 – 1223 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1247 – 1274 | PolarSequence analysisAdd BLAST | 28 | |
Compositional biasi | 1292 – 1314 | PolarSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Belongs to the GLI C2H2-type zinc-finger protein family.ARBA annotation
Keywords - Domaini
RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
OrthoDBi | 135929at2759 |
PhylomeDBi | Q800Z9 |
Family and domain databases
InterProi | View protein in InterPro IPR043359, GLI-like IPR032850, GLI1 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR45718, PTHR45718, 1 hit PTHR45718:SF2, PTHR45718:SF2, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
i Sequence
Sequence statusi: Complete.
Q800Z9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPVDMQPHQG LYHYDNTSNQ PSRGLAPSVR SPYSSEASSV CVALSGGQSV
60 70 80 90 100
NSREMYNPSM APGACMEPYM RAPHAPPPHS MMGHRGMPPP EGMSGAPYCN
110 120 130 140 150
QNMMTSHHNL PHNQHTSELM ASGDASCFST PRSMLKLSKK RALSISPLSD
160 170 180 190 200
ASVDLQTVIR TSPNSLVAFV NSRCGPNNPS SYGHLSVGTM SPSLGFSSSI
210 220 230 240 250
NYSRPQGNIY SHPVPSCIGA PARLPPHNPR LHTPAKHTHL KTEPVLGSVM
260 270 280 290 300
DSINIKGLED HSEGDVASPS STGTQDPLLG LLEGRDDLDK EEKPEPEAIY
310 320 330 340 350
ETNCHWESCS KEFDTQEQLV HHINNEHIHG EKKEFVCHWK DCSREQRPFK
360 370 380 390 400
AQYMLVVHMR RHTGEKPHKC TFEGCNKAYS RLENLKTHLR SHTGEKPYVC
410 420 430 440 450
EHEGCNKAFS NASDRAKHQN RTHSNEKPYI CKIPGCTKRY TDPSSLRKHV
460 470 480 490 500
KTVHGPEAHI TKKHRGDTGP RPPGLTTAGQ SSELLIEKEE RNREDCKLLA
510 520 530 540 550
PDNTLKSQPS PGGQSSCSSE RSPLGSANNN DSGVEMNLNA AGSLEDLTTQ
560 570 580 590 600
EDSGNAGVSE SSATISSGGM CMSVQALKRL ENLKIDKLKQ IRRPTPPGRN
610 620 630 640 650
AGNKLPALSA TGEMMSMCAP SPLLSNRRVM ELSAPDMGGV TGMSCPPNDR
660 670 680 690 700
RGSGTSSLSS AYTVSRRSSM VSPYLSSRRS SDVSHCQSVM GGEVPGDPLS
710 720 730 740 750
PQNSQRAGLC QNSGGLPGLP SLTPAQQYSL KAKYAAATGG PPPTPLPNMD
760 770 780 790 800
QAGTPARHVG FLRECQGQPL PPFLQQGGTR RHSANAEYGT GVIYPHQAPG
810 820 830 840 850
NNTRRASDPV RSAADPQGLP KVQRFNSLSN VSLMSRRNAL QQCGSDAALS
860 870 880 890 900
RHMYSPRPPS ITENVMMEAM GMDGNTEGRQ QGNMIPGGDR SYMGYQHNPH
910 920 930 940 950
QASQLSPGQE SLGCIDQVYQ SQMQGQYQRE ESCSTGVMGQ ADIANNLLQQ
960 970 980 990 1000
AEYGMSTCQL SPSGPHYPSQ GDGSGPWGQT NQLHSPGMQY QGAGMQGQHY
1010 1020 1030 1040 1050
TQQGIYDPTS NPNLQRVTVK PEQFHPSMGG SSSCQNTKAL HQNRHNANMQ
1060 1070 1080 1090 1100
TYPLQGQGIM NRSSSASCDF HHSQMGTQPN QGGSFQSGTG INLALAESRR
1110 1120 1130 1140 1150
SQTPMHQMKE MMVRNYVQSQ QALLWEQQQE QSVSEKPDGM DMGQTQMMQH
1160 1170 1180 1190 1200
SPQHQQANQN LYPGNTYQGY PNQNLMSPQQ NRVPGSVKEQ MQSSCYGPDM
1210 1220 1230 1240 1250
IPRPPQVRKS LSRQNSLSQQ AGGAYLGSPP HLSPVHSTAS PRRGVRLPPV
1260 1270 1280 1290 1300
QQQQQQQQQH SENFNNNNNP MYYSGQMHMH HDLEKTPEGP CLAQQHLTSS
1310 1320 1330 1340 1350
DPTTKPTSIS YPDPAPMSNA LEHLDLENAQ IDFTSIIDDQ EPSSYSPINA
1360 1370 1380 1390 1400
PIGHNQCSSQ TSSRLTTPQN SITLPSGLSN MAIGDMSSML TSLAGENKYL
NTLS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY173030 mRNA Translation: AAO43495.1 |
RefSeqi | NP_840081.1, NM_178296.2 |
Genome annotation databases
GeneIDi | 352930 |
KEGGi | dre:352930 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY173030 mRNA Translation: AAO43495.1 |
RefSeqi | NP_840081.1, NM_178296.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
GeneIDi | 352930 |
KEGGi | dre:352930 |
Organism-specific databases
CTDi | 2735 |
ZFINi | ZDB-GENE-030321-1, gli1 |
Phylogenomic databases
OrthoDBi | 135929at2759 |
PhylomeDBi | Q800Z9 |
Family and domain databases
InterProi | View protein in InterPro IPR043359, GLI-like IPR032850, GLI1 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR45718, PTHR45718, 1 hit PTHR45718:SF2, PTHR45718:SF2, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q800Z9_DANRE | |
Accessioni | Q800Z9Primary (citable) accession number: Q800Z9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 1, 2003 |
Last sequence update: | June 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 109 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |