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Protein

Interferon-induced GTP-binding protein MxE

Gene

mxe

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi50 – 57GTPSequence analysis8
Nucleotide bindingi151 – 155GTPSequence analysis5
Nucleotide bindingi220 – 223GTPSequence analysis4

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW
  • microtubule binding Source: GO_Central

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DRE-1169408 ISG15 antiviral mechanism

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced GTP-binding protein MxE
Alternative name(s):
IFN-inducible antiviral protein MxE
Interferon-inducible MxE protein
Gene namesi
Name:mxe
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 9

Organism-specific databases

ZFINiZDB-GENE-030131-9609 mxe

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002928701 – 625Interferon-induced GTP-binding protein MxEAdd BLAST625

Proteomic databases

PaxDbiQ800G5
PRIDEiQ800G5

Expressioni

Inductioni

By interferons.

Gene expression databases

BgeeiENSDARG00000014427 Expressed in 14 organ(s), highest expression level in spleen

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000118741

Structurei

3D structure databases

ProteinModelPortaliQ800G5
SMRiQ800G5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 313Dynamin-type GPROSITE-ProRule annotationAdd BLAST274
Domaini536 – 625GEDPROSITE-ProRule annotationAdd BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni50 – 57G1 motifPROSITE-ProRule annotation8
Regioni75 – 77G2 motifPROSITE-ProRule annotation3
Regioni151 – 154G3 motifPROSITE-ProRule annotation4
Regioni220 – 223G4 motifPROSITE-ProRule annotation4
Regioni252 – 255G5 motifPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0446 Eukaryota
COG0699 LUCA
GeneTreeiENSGT00760000119213
HOGENOMiHOG000063238
HOVERGENiHBG008788
InParanoidiQ800G5
PhylomeDBiQ800G5
TreeFamiTF331484

Family and domain databases

CDDicd08771 DLP_1, 1 hit
InterProiView protein in InterPro
IPR000375 Dynamin_central
IPR001401 Dynamin_GTPase
IPR019762 Dynamin_GTPase_CS
IPR022812 Dynamin_SF
IPR030381 G_DYNAMIN_dom
IPR003130 GED
IPR020850 GED_dom
IPR027417 P-loop_NTPase
PANTHERiPTHR11566 PTHR11566, 1 hit
PfamiView protein in Pfam
PF01031 Dynamin_M, 1 hit
PF00350 Dynamin_N, 1 hit
PF02212 GED, 1 hit
PRINTSiPR00195 DYNAMIN
SMARTiView protein in SMART
SM00053 DYNc, 1 hit
SM00302 GED, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00410 G_DYNAMIN_1, 1 hit
PS51718 G_DYNAMIN_2, 1 hit
PS51388 GED, 1 hit

Sequencei

Sequence statusi: Complete.

Q800G5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPSGSTKGE SSGLNQHYEE KVRPCIDLVD SLRALGVEKD LNLPAIAVIG
60 70 80 90 100
DQSSGKSSVL EALSGVALPR GTGIVTRCPL VLKLKKITKD KSWHGLLTYN
110 120 130 140 150
DKIRELKDPA KIEKAVLNAQ TALAGIGEGI SHEMITLEIQ SCDVPDLTLI
160 170 180 190 200
DLPGIARVAT GNQPEDIEKQ IKSLIEKFIK RQETISLVVV PANIDIATTE
210 220 230 240 250
ALKMASTVDP TGQRTLGILT KPDLVDRGME DTVVRTVNNE VIPLKKGYMI
260 270 280 290 300
VKCRGQQDIN DKLGLVEALE KERRFFDENV HFRSLLEDRK ATIPLLAERL
310 320 330 340 350
TKELVEHIAK NLPQLQNQLE MKLEKTSADL RGLGDGVPLD KNEKSNFLIM
360 370 380 390 400
KIRQFNDVLE RVQMAEEDVE KPNTRVFSKI RSEFVKWKRI LDSKAIKTEE
410 420 430 440 450
TLRDEVQEYV KTRRGKELPG FVNYRTFENI VKKHIAELHE PALKLLKDVT
460 470 480 490 500
DIVHSSVDHI VNAHFSSFSP LMRAAKDPTE DFLHEQFQRA EEKIHSQFRM
510 520 530 540 550
EKIVYSQDDL YSDQLTTAKN TLRGYGLQSP NVSADVREMA YHLTSYLTIA
560 570 580 590 600
CERLANQIPL IVQYHMLNQY ISQLQNAMLG LIGKNSPGML LCEDSGVARK
610 620
RKDLKERLER LKSAGRVLSK FVHSA
Length:625
Mass (Da):70,395
Last modified:June 1, 2003 - v1
Checksum:i3AB63E70B41B4ED6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ544827 mRNA Translation: CAD67759.1
RefSeqiNP_878287.1, NM_182867.1
UniGeneiDr.26920

Genome annotation databases

EnsembliENSDART00000142227; ENSDARP00000118741; ENSDARG00000014427
GeneIDi337663
KEGGidre:337663

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ544827 mRNA Translation: CAD67759.1
RefSeqiNP_878287.1, NM_182867.1
UniGeneiDr.26920

3D structure databases

ProteinModelPortaliQ800G5
SMRiQ800G5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000118741

Proteomic databases

PaxDbiQ800G5
PRIDEiQ800G5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000142227; ENSDARP00000118741; ENSDARG00000014427
GeneIDi337663
KEGGidre:337663

Organism-specific databases

CTDi337663
ZFINiZDB-GENE-030131-9609 mxe

Phylogenomic databases

eggNOGiKOG0446 Eukaryota
COG0699 LUCA
GeneTreeiENSGT00760000119213
HOGENOMiHOG000063238
HOVERGENiHBG008788
InParanoidiQ800G5
PhylomeDBiQ800G5
TreeFamiTF331484

Enzyme and pathway databases

ReactomeiR-DRE-1169408 ISG15 antiviral mechanism

Miscellaneous databases

PROiPR:Q800G5

Gene expression databases

BgeeiENSDARG00000014427 Expressed in 14 organ(s), highest expression level in spleen

Family and domain databases

CDDicd08771 DLP_1, 1 hit
InterProiView protein in InterPro
IPR000375 Dynamin_central
IPR001401 Dynamin_GTPase
IPR019762 Dynamin_GTPase_CS
IPR022812 Dynamin_SF
IPR030381 G_DYNAMIN_dom
IPR003130 GED
IPR020850 GED_dom
IPR027417 P-loop_NTPase
PANTHERiPTHR11566 PTHR11566, 1 hit
PfamiView protein in Pfam
PF01031 Dynamin_M, 1 hit
PF00350 Dynamin_N, 1 hit
PF02212 GED, 1 hit
PRINTSiPR00195 DYNAMIN
SMARTiView protein in SMART
SM00053 DYNc, 1 hit
SM00302 GED, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00410 G_DYNAMIN_1, 1 hit
PS51718 G_DYNAMIN_2, 1 hit
PS51388 GED, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMXE_DANRE
AccessioniPrimary (citable) accession number: Q800G5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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