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Entry version 145 (02 Jun 2021)
Sequence version 1 (01 Jun 2003)
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Protein
Submitted name:

Notch3

Gene

notch3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi387Calcium 1; via carbonyl oxygenUniRule annotation1
Metal bindingi390Calcium 1; via amide nitrogenUniRule annotation1
Metal bindingi407Calcium 2UniRule annotation1
Metal bindingi410Calcium 2UniRule annotation1
Metal bindingi424Calcium 2UniRule annotation1
Metal bindingi448Calcium 3UniRule annotation1
Metal bindingi462Calcium 3UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivatorARBA annotation, Developmental proteinARBA annotation
Biological processDifferentiationARBA annotation, Notch signaling pathwayARBA annotation, Transcription, Transcription regulationARBA annotation
LigandCalciumUniRule annotation, Metal-bindingUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Notch3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:notch3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-000329-5, notch3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane, NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500429879222 – 2468Sequence analysisAdd BLAST2447

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi44 ↔ 53PROSITE-ProRule annotation
Disulfide bondi85 ↔ 94PROSITE-ProRule annotation
Disulfide bondi122 ↔ 131PROSITE-ProRule annotation
Disulfide bondi161 ↔ 170PROSITE-ProRule annotation
Disulfide bondi200 ↔ 209PROSITE-ProRule annotation
Disulfide bondi238 ↔ 247PROSITE-ProRule annotation
Disulfide bondi278 ↔ 287PROSITE-ProRule annotation
Disulfide bondi316 ↔ 325PROSITE-ProRule annotation
Disulfide bondi336 ↔ 353PROSITE-ProRule annotation
Disulfide bondi355 ↔ 364PROSITE-ProRule annotation
Disulfide bondi371 ↔ 384UniRule annotation
Disulfide bondi378 ↔ 393UniRule annotation
Disulfide bondi395 ↔ 404UniRule annotation
Disulfide bondi411 ↔ 422UniRule annotation
Disulfide bondi416 ↔ 431UniRule annotation
Disulfide bondi433 ↔ 442UniRule annotation
Disulfide bondi449 ↔ 460UniRule annotation
Disulfide bondi454 ↔ 469UniRule annotation
Disulfide bondi471 ↔ 480UniRule annotation
Disulfide bondi509 ↔ 518PROSITE-ProRule annotation
Disulfide bondi525 ↔ 535PROSITE-ProRule annotation
Disulfide bondi546 ↔ 555PROSITE-ProRule annotation
Disulfide bondi584 ↔ 593PROSITE-ProRule annotation
Disulfide bondi600 ↔ 610PROSITE-ProRule annotation
Disulfide bondi621 ↔ 630PROSITE-ProRule annotation
Disulfide bondi659 ↔ 668PROSITE-ProRule annotation
Disulfide bondi675 ↔ 685PROSITE-ProRule annotation
Disulfide bondi696 ↔ 705PROSITE-ProRule annotation
Disulfide bondi734 ↔ 743PROSITE-ProRule annotation
Disulfide bondi772 ↔ 781PROSITE-ProRule annotation
Disulfide bondi793 ↔ 810PROSITE-ProRule annotation
Disulfide bondi812 ↔ 821PROSITE-ProRule annotation
Disulfide bondi850 ↔ 859PROSITE-ProRule annotation
Disulfide bondi888 ↔ 897PROSITE-ProRule annotation
Disulfide bondi926 ↔ 935PROSITE-ProRule annotation
Disulfide bondi964 ↔ 973PROSITE-ProRule annotation
Disulfide bondi1002 ↔ 1011PROSITE-ProRule annotation
Disulfide bondi1041 ↔ 1050PROSITE-ProRule annotation
Disulfide bondi1068 ↔ 1078PROSITE-ProRule annotation
Disulfide bondi1089 ↔ 1098PROSITE-ProRule annotation
Disulfide bondi1127 ↔ 1136PROSITE-ProRule annotation
Disulfide bondi1165 ↔ 1174PROSITE-ProRule annotation
Disulfide bondi1210 ↔ 1219PROSITE-ProRule annotation
Disulfide bondi1231 ↔ 1248PROSITE-ProRule annotation
Disulfide bondi1250 ↔ 1259PROSITE-ProRule annotation
Disulfide bondi1291 ↔ 1300PROSITE-ProRule annotation
Disulfide bondi1328 ↔ 1337PROSITE-ProRule annotation
Disulfide bondi1350 ↔ 1367PROSITE-ProRule annotation
Disulfide bondi1369 ↔ 1378PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationARBA annotation, GlycoproteinARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 54EGF-likeInterPro annotationAdd BLAST35
Domaini55 – 95EGF-likeInterPro annotationAdd BLAST41
Domaini96 – 132EGF-likeInterPro annotationAdd BLAST37
Domaini134 – 171EGF-likeInterPro annotationAdd BLAST38
Domaini173 – 210EGF-likeInterPro annotationAdd BLAST38
Domaini212 – 248EGF-likeInterPro annotationAdd BLAST37
Domaini250 – 288EGF-likeInterPro annotationAdd BLAST39
Domaini290 – 326EGF-likeInterPro annotationAdd BLAST37
Domaini327 – 365EGF-likeInterPro annotationAdd BLAST39
Domaini367 – 405EGF-likeInterPro annotationAdd BLAST39
Domaini407 – 443EGF-likeInterPro annotationAdd BLAST37
Domaini445 – 481EGF-likeInterPro annotationAdd BLAST37
Domaini483 – 519EGF-likeInterPro annotationAdd BLAST37
Domaini521 – 556EGF-likeInterPro annotationAdd BLAST36
Domaini558 – 594EGF-likeInterPro annotationAdd BLAST37
Domaini596 – 631EGF-likeInterPro annotationAdd BLAST36
Domaini633 – 669EGF-likeInterPro annotationAdd BLAST37
Domaini671 – 706EGF-likeInterPro annotationAdd BLAST36
Domaini708 – 744EGF-likeInterPro annotationAdd BLAST37
Domaini746 – 782EGF-likeInterPro annotationAdd BLAST37
Domaini784 – 822EGF-likeInterPro annotationAdd BLAST39
Domaini824 – 860EGF-likeInterPro annotationAdd BLAST37
Domaini862 – 898EGF-likeInterPro annotationAdd BLAST37
Domaini900 – 936EGF-likeInterPro annotationAdd BLAST37
Domaini938 – 974EGF-likeInterPro annotationAdd BLAST37
Domaini976 – 1012EGF-likeInterPro annotationAdd BLAST37
Domaini1014 – 1051EGF-likeInterPro annotationAdd BLAST38
Domaini1064 – 1099EGF-likeInterPro annotationAdd BLAST36
Domaini1101 – 1137EGF-likeInterPro annotationAdd BLAST37
Domaini1139 – 1175EGF-likeInterPro annotationAdd BLAST37
Domaini1177 – 1220EGF-likeInterPro annotationAdd BLAST44
Domaini1222 – 1260EGF-likeInterPro annotationAdd BLAST39
Domaini1262 – 1301EGF-likeInterPro annotationAdd BLAST40
Domaini1302 – 1338EGF-likeInterPro annotationAdd BLAST37
Domaini1341 – 1379EGF-likeInterPro annotationAdd BLAST39
Domaini1392 – 1431LNRInterPro annotationAdd BLAST40
Domaini1432 – 1467LNRInterPro annotationAdd BLAST36
Domaini1469 – 1508LNRInterPro annotationAdd BLAST40
Domaini1822 – 2027ANK_REP_REGIONInterPro annotationAdd BLAST206
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1841 – 1873ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1908 – 1940ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1941 – 1973ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1974 – 2006ANKPROSITE-ProRule annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2036 – 2097DisorderedSequence analysisAdd BLAST62
Regioni2320 – 2468DisorderedSequence analysisAdd BLAST149

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2053 – 2071Polar residuesSequence analysisAdd BLAST19
Compositional biasi2332 – 2355Pro residuesSequence analysisAdd BLAST24
Compositional biasi2356 – 2399Polar residuesSequence analysisAdd BLAST44
Compositional biasi2428 – 2468Polar residuesSequence analysisAdd BLAST41

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NOTCH family.ARBA annotation

Keywords - Domaini

ANK repeatPROSITE-ProRule annotationARBA annotation, EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, SignalSequence analysis, Transmembrane, Transmembrane helixARBA annotation

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
PQCQHRS

Database of Orthologous Groups

More...
OrthoDBi
7525at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q800E4

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR024600, DUF3454_notch
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR008297, Notch
IPR035993, Notch-like_dom_sf
IPR022331, Notch_3
IPR000800, Notch_dom
IPR010660, Notch_NOD_dom
IPR011656, Notch_NODP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 1 hit
PF11936, DUF3454, 1 hit
PF00008, EGF, 23 hits
PF07645, EGF_CA, 4 hits
PF12661, hEGF, 3 hits
PF06816, NOD, 1 hit
PF07684, NODP, 1 hit
PF00066, Notch, 3 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002279, Notch, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01452, LNOTCHREPEAT
PR01986, NOTCH3

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 6 hits
SM01334, DUF3454, 1 hit
SM00181, EGF, 35 hits
SM00179, EGF_CA, 33 hits
SM00004, NL, 3 hits
SM01338, NOD, 1 hit
SM01339, NODP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit
SSF57184, SSF57184, 7 hits
SSF90193, SSF90193, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits
PS00010, ASX_HYDROXYL, 22 hits
PS00022, EGF_1, 34 hits
PS01186, EGF_2, 30 hits
PS50026, EGF_3, 35 hits
PS01187, EGF_CA, 8 hits
PS50258, LNR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q800E4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNYSLWIFL SILYLVHNSE GLLCVDTHRP CENGGMCIDS RCLCRPGYIG
60 70 80 90 100
SLCQHLDPCH RSPCLNAAAC KSQVANSIPQ YTCVCQRGFR GQDCSLVDAC
110 120 130 140 150
ATSPCANGAR CTNWNNHYNC SCPPGYQGKN CRNDIDECRK PGKCLNGGIC
160 170 180 190 200
MNTHGSFRCE CLTGYSGRTC EVPTQPCAPS QCLNGGTCHQ TGDHTYECAC
210 220 230 240 250
LPGFRGHNCE DNVDDCPGHK CMNNGICVDG VNTYNCQCPP EWTGQYCAED
260 270 280 290 300
VNECLMQPNA CHNGGTCFNT IGGHTCVCVN GWTGDDCSEN IDDCATAVCF
310 320 330 340 350
NGATCHDRVA SFFCECPVGK TGLLCHLDDA CVSNPCNEGA VCDTNPLNGR
360 370 380 390 400
AICTCPAGFV GGACNQDMDE CSIGANPCEH FGKCVNTEGS FQCQCGRGYT
410 420 430 440 450
GPRCEIDINE CLSMPCQNDA TCLDRIGEFT CICMPGYQGK YCEVDIDECE
460 470 480 490 500
SNPCVNDGIC RDMVNGFTCT CQPGFTGTMC QIDIDECAST PCQNGAKCID
510 520 530 540 550
RPNGYECRCA EGFEGRLCES NIDNCKPDPC HHGTCVDGIA SYTCNCEPGY
560 570 580 590 600
TGYRCENQLN ECHSNPCQNG GKCVDLVNKY ICQCQHGTSG TNCEINFDDC
610 620 630 640 650
ASNPCDYGIC KDGINRYECV CKPGFTGPQC KDEIDECQSN PCRNGGTCVD
660 670 680 690 700
DENGFHCQCP EGFHDPYCYS QVDECASNPC LHGTCRDDPN GYRCDCEPGW
710 720 730 740 750
VGKNCDLDRN DCLPSPCQNA GTCFDQLNGF TCKCRQGFRG NLCQVNINEC
760 770 780 790 800
ASSPCLNQGT CVDGVASFTC LCEPPYSGPT CAELLTPCSP NPCANHASCV
810 820 830 840 850
HTPDYLGYQC NCQPGWQGHL CNNDINECTS NPCKNRGTCT NTLGGYVCSC
860 870 880 890 900
RAGYTGPNCE TDINDCSPNP CLNGGSCTDG VNSFRCSCLP GFTGARCATE
910 920 930 940 950
LNECQSVPCK NGGTCTDYVN SYTCTCKPGF TGLLCETNVP DCTESSCFNG
960 970 980 990 1000
GTCTDGINGF KCTCRTGFTG DYCQYEVNEC DSQPCLNGGI CQDAMESYRC
1010 1020 1030 1040 1050
SCPKGYTGPR CQYPVDWCRP SNPCKNGGRC RQKDASFTCD CLGGWSGRYC
1060 1070 1080 1090 1100
DIPGVSCEVA ARQRGRQTDE LCLHGGHCVN TGNTHYCKCP ADYTGSYCES
1110 1120 1130 1140 1150
QFDHCEEKPC LNGATCRSYM GGFTCDCMPG YEGNNCEREV NECQSHPCQN
1160 1170 1180 1190 1200
GGTCIDLVGH YICSCPPGTL GVLCEINEDD CATPSWPRGM PKCQNNGTCV
1210 1220 1230 1240 1250
DRVGGYRCNC PPGFTGERCE GDINECLSNP CNPSNSLDCI QLPNDYQCVC
1260 1270 1280 1290 1300
KPGFTGRGCQ SRFSVCESQP CKNGGVCSLS GSSPPGYSCT CQLGYAGSNC
1310 1320 1330 1340 1350
ERSMNCKELP CYNGGSCTLT TRGARCTCIQ GFGGPLCQHR SNDGCSSKPC
1360 1370 1380 1390 1400
HNGGLCTEET SYPFFHCQCT NGWKGKRCEQ KTGSSAPLPS PCPIADCFSK
1410 1420 1430 1440 1450
ANDGVCDKEC NSLDCRWDGG DCSLAVNPWA RCADPRCWRL FNNSQCDEFC
1460 1470 1480 1490 1500
NNAECLFDNF DCINKEKVCN PIYEAYCTDH YADGLCDQGC NTEECGWDGL
1510 1520 1530 1540 1550
DCARKIPEDL AEDMLVIVVL LPPEELLRTQ TAFLQKLSAI LRTTLRFRLD
1560 1570 1580 1590 1600
RNGDYMIRPY TGRETRIKRE LNPQEVIGSI VYLEIDNRLC SQGSDDCFRN
1610 1620 1630 1640 1650
ADSAAEYLGA LSAREMLRFP YPIKEVTSEK REPSITEIPE WARLLLVGVA
1660 1670 1680 1690 1700
SLFLLVILMV GMLIARRKRE HSTLWFPEGF FLKKETSSNK NRREPVGQDS
1710 1720 1730 1740 1750
LGMKHMPKTV EESLLADHSD QWIDTDCPEA KRLKVEEPSI LSDGEDAVDS
1760 1770 1780 1790 1800
RQWTQHHLAA ADIRMPPSMA LTPPQGEFDS DCMDVNVRGP DGFTPLMLAS
1810 1820 1830 1840 1850
FCGGGLEPEV TEDDDSDESS ANIISDLIYQ GASLAAQTDR TGETALHLAA
1860 1870 1880 1890 1900
RYARADAAKR LLDAGADANA QDNTGRSPLH AAVAADAQGV FQILIRNRAT
1910 1920 1930 1940 1950
DLDARMYDGS TALILAARLA VEGMVEELIT CHADVNAVDE IGKSALHWAA
1960 1970 1980 1990 2000
AVNNVEATIA LLKNGANKDM QDLKEETPLF LAAREGSCEA VKVLLAHFAN
2010 2020 2030 2040 2050
REITDHMDRL PRDIAQERMH HDIVQLLDEY NTVRSPQGHA GAGHHLSGSH
2060 2070 2080 2090 2100
TLSPLMCPPS NFLQGLKSTP QGKKNRRPGA KGIGGQHASG LKDSAKGRNK
2110 2120 2130 2140 2150
RLTLDMQSAL LESSVTLSPV DSLDSPRGGA SNAGYVTNPT SPAAMPSPGL
2160 2170 2180 2190 2200
FHSSMSVPNT PMVHSSILDS TSPFSVSLAQ LSDLGDGGLS MQGRVGMQGG
2210 2220 2230 2240 2250
GVNPGPHNYV MNAGQMSLSM GMVSPVSVPF DWHNRMPPSS QCSQPMISMV
2260 2270 2280 2290 2300
HPVSSQAGML PQTPTLQSSM LLHQQVFRNA QQPILQPTPV SSTPSISPVK
2310 2320 2330 2340 2350
LPPIAEQQPQ QLHSHTLTNP NLSRMATSTP PTPQQAQPPP AFYQPQQPQA
2360 2370 2380 2390 2400
QPPQAPTAPQ ATQAQAIPSQ APPAQVSGST AGPEDYPTPP SQHSYSSAMD
2410 2420 2430 2440 2450
ATPKHYLHVP NEHPYLTPSP ESPEPWSSPS PHCVSDWSDS TPSPAVTAPS
2460
QTQISQVQES NGKMQVFA
Length:2,468
Mass (Da):266,645
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF147966714EF946B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF152001 mRNA Translation: AAF73197.1

NCBI Reference Sequences

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RefSeqi
NP_571624.2, NM_131549.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
58066

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:58066

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152001 mRNA Translation: AAF73197.1
RefSeqiNP_571624.2, NM_131549.2

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
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Genome annotation databases

GeneIDi58066
KEGGidre:58066

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4854
ZFINiZDB-GENE-000329-5, notch3

Phylogenomic databases

OMAiPQCQHRS
OrthoDBi7525at2759
PhylomeDBiQ800E4

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR024600, DUF3454_notch
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR008297, Notch
IPR035993, Notch-like_dom_sf
IPR022331, Notch_3
IPR000800, Notch_dom
IPR010660, Notch_NOD_dom
IPR011656, Notch_NODP_dom
PfamiView protein in Pfam
PF12796, Ank_2, 1 hit
PF11936, DUF3454, 1 hit
PF00008, EGF, 23 hits
PF07645, EGF_CA, 4 hits
PF12661, hEGF, 3 hits
PF06816, NOD, 1 hit
PF07684, NODP, 1 hit
PF00066, Notch, 3 hits
PIRSFiPIRSF002279, Notch, 2 hits
PRINTSiPR01452, LNOTCHREPEAT
PR01986, NOTCH3
SMARTiView protein in SMART
SM00248, ANK, 6 hits
SM01334, DUF3454, 1 hit
SM00181, EGF, 35 hits
SM00179, EGF_CA, 33 hits
SM00004, NL, 3 hits
SM01338, NOD, 1 hit
SM01339, NODP, 1 hit
SUPFAMiSSF48403, SSF48403, 1 hit
SSF57184, SSF57184, 7 hits
SSF90193, SSF90193, 3 hits
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits
PS00010, ASX_HYDROXYL, 22 hits
PS00022, EGF_1, 34 hits
PS01186, EGF_2, 30 hits
PS50026, EGF_3, 35 hits
PS01187, EGF_CA, 8 hits
PS50258, LNR, 3 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ800E4_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q800E4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: June 2, 2021
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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