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UniProtKB - Q7ZZS9 (VM2J_PROJR)
Protein
Zinc metalloproteinase/disintegrin
Gene
N/A
Organism
Protobothrops jerdonii (Jerdon's pitviper) (Trimeresurus jerdonii)
Status
Functioni
Impairs hemostasis in the envenomed animal.
By similarityInhibits platelet aggregation induced by ADP and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3). Has antitumor-growth activity.
1 PublicationMiscellaneous
The disintegrin belongs to the medium disintegrin subfamily.
Cofactori
Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 200 | CalciumBy similarity | 1 | |
Metal bindingi | 284 | CalciumBy similarity | 1 | |
Metal bindingi | 333 | Zinc; catalyticBy similarity | 1 | |
Active sitei | 334 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 337 | Zinc; catalyticBy similarity | 1 | |
Metal bindingi | 343 | Zinc; catalyticBy similarity | 1 | |
Metal bindingi | 387 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 390 | CalciumBy similarity | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- metalloendopeptidase activity Source: InterPro
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Cell adhesion impairing toxin, Hemostasis impairing toxin, Hydrolase, Metalloprotease, Platelet aggregation inhibiting toxin, Protease, Toxin |
Ligand | Calcium, Metal-binding, Zinc |
Protein family/group databases
MEROPSi | M12.156 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc metalloproteinase/disintegrinCleaved into the following 2 chains: |
Organismi | Protobothrops jerdonii (Jerdon's pitviper) (Trimeresurus jerdonii) |
Taxonomic identifieri | 242841 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Viperidae › Crotalinae › Protobothrops |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
PropeptideiPRO_0000028973 | 21 – 190 | By similarityAdd BLAST | 170 | |
ChainiPRO_0000028974 | 191 – 392 | Snake venom metalloproteinase TJM-1Add BLAST | 202 | |
PropeptideiPRO_0000028975 | 393 – 410 | 1 PublicationAdd BLAST | 18 | |
ChainiPRO_0000028976 | 411 – 481 | Disintegrin jerdoninAdd BLAST | 71 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 293 | N-linked (GlcNAc...) asparagineCurated | 1 | |
Disulfide bondi | 308 ↔ 387 | By similarity | ||
Disulfide bondi | 349 ↔ 371 | By similarity | ||
Disulfide bondi | 351 ↔ 354 | By similarity | ||
Disulfide bondi | 414 ↔ 429 | By similarity | ||
Disulfide bondi | 416 ↔ 424 | By similarity | ||
Disulfide bondi | 423 ↔ 446 | By similarity | ||
Disulfide bondi | 437 ↔ 443 | By similarity | ||
Disulfide bondi | 442 ↔ 467 | By similarity | ||
Disulfide bondi | 455 ↔ 474 | By similarity |
Keywords - PTMi
Disulfide bond, Glycoprotein, ZymogenExpressioni
Tissue specificityi
Expressed by the venom gland.
Interactioni
Subunit structurei
Monomer.
By similarityFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 197 – 392 | Peptidase M12BPROSITE-ProRule annotationAdd BLAST | 196 | |
Domaini | 400 – 481 | DisintegrinPROSITE-ProRule annotationAdd BLAST | 82 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 459 – 461 | Cell attachment site | 3 |
Sequence similaritiesi
Keywords - Domaini
SignalFamily and domain databases
CDDi | cd04269, ZnMc_adamalysin_II_like, 1 hit |
Gene3Di | 3.40.390.10, 1 hit 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR018358, Disintegrin_CS IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N IPR034027, Reprolysin_adamalysin |
Pfami | View protein in Pfam PF00200, Disintegrin, 1 hit PF01562, Pep_M12B_propep, 1 hit PF01421, Reprolysin, 1 hit |
PRINTSi | PR00289, DISINTEGRIN |
SMARTi | View protein in SMART SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS00427, DISINTEGRIN_1, 1 hit PS50214, DISINTEGRIN_2, 1 hit PS00142, ZINC_PROTEASE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q7ZZS9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIQVLLVTIC LAVFPYQGSS IILESGNVDD YEVVYPQKVT ALPKGAVQPK
60 70 80 90 100
YEDAMQYEFK VNGEPVVLHL EKNKGLFSED YSETHYSPDG REITTYPSVE
110 120 130 140 150
DHCYHHGRVH NDADSTASIS ACDGLKGHFK LQGEMYLIEP LELSDSEAHA
160 170 180 190 200
VFKYENVEKE DEAPKMCGVT QNWESDESIK KASQLYLTPE QQRFPQRHIE
210 220 230 240 250
LAIVVDHGMY TKYSSNFKKI RKRVHQMVSN INEMCRPLNI AITLSLLDVW
260 270 280 290 300
SEKDLITVQA DAPTTAGLFG DWRERVLLKK KNHDHAQLLT DINFTGDTIG
310 320 330 340 350
WAYVGGMCNA KYSVGTVKDH SSNVFVVAVT MTHEIGHNLG MEHDDKDKCK
360 370 380 390 400
CEACIMAPVI SDKQSKLFSD CSKDYYQTFL TNKKPQCILN APLRTDTVST
410 420 430 440 450
PISGNEFLEA GEECDCGSPS NPCCDVGTCK LSPGAQCADG LCCDQCRFKK
460 470 480
KGKICRRARG DNPDDRCTGQ SADCPRNGLY G
Mass spectrometryi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY267902 mRNA Translation: AAP23053.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY267902 mRNA Translation: AAP23053.1 |
3D structure databases
SMRi | Q7ZZS9 |
ModBasei | Search... |
Protein family/group databases
MEROPSi | M12.156 |
Family and domain databases
CDDi | cd04269, ZnMc_adamalysin_II_like, 1 hit |
Gene3Di | 3.40.390.10, 1 hit 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR018358, Disintegrin_CS IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N IPR034027, Reprolysin_adamalysin |
Pfami | View protein in Pfam PF00200, Disintegrin, 1 hit PF01562, Pep_M12B_propep, 1 hit PF01421, Reprolysin, 1 hit |
PRINTSi | PR00289, DISINTEGRIN |
SMARTi | View protein in SMART SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS00427, DISINTEGRIN_1, 1 hit PS50214, DISINTEGRIN_2, 1 hit PS00142, ZINC_PROTEASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | VM2J_PROJR | |
Accessioni | Q7ZZS9Primary (citable) accession number: Q7ZZS9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2004 |
Last sequence update: | June 1, 2003 | |
Last modified: | February 23, 2022 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families