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Protein

ATPase family AAA domain-containing protein 1-A

Gene

atad1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR). Required for NMDA-stimulated AMPAR internalization in an ATPase-dependent manner (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi136 – 143ATPSequence analysis8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase family AAA domain-containing protein 1-A (EC:3.6.1.3)
Gene namesi
Name:atad1a
ORF Names:si:zc156n3.1, zgc:101570
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 5

Organism-specific databases

ZFINiZDB-GENE-030616-593 atad1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Peroxisome, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000847941 – 380ATPase family AAA domain-containing protein 1-AAdd BLAST380

Proteomic databases

PaxDbiQ7ZZ25

Expressioni

Gene expression databases

BgeeiENSDARG00000023267 Expressed in 19 organ(s), highest expression level in multi-cellular organism
ExpressionAtlasiQ7ZZ25 baseline

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000035974

Structurei

3D structure databases

ProteinModelPortaliQ7ZZ25
SMRiQ7ZZ25
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

eggNOGiKOG0737 Eukaryota
COG0464 LUCA
GeneTreeiENSGT00550000074823
HOGENOMiHOG000225141
HOVERGENiHBG057074
InParanoidiQ7ZZ25
KOiK22530
OMAiMWYGESQ
OrthoDBiEOG091G0CJ6
PhylomeDBiQ7ZZ25
TreeFamiTF105016

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00004 AAA, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q7ZZ25-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSDIPRDAL LRPLTRNEVV GMLVRLTVFG AATYYSIKWV VDALDPTQKQ
60 70 80 90 100
KSQAKKRAEQ LMKQIGVEGV SLTEYEMNIA TLLVDPRSIK VTWRDVAGLD
110 120 130 140 150
EIISEMQDTV ILPFQKRHLF SGSKLLQPPK GVLLYGPPGC GKTLIAKATA
160 170 180 190 200
KASGCRFINL QASTLTDKWY GESQKLTAAV FSLAVKIQPC IIFLDEIDSF
210 220 230 240 250
LRNRSSMDHE ATAMMKAQFM SLWDGLDTGE NSQVMVMGAT NRPQDVDAAI
260 270 280 290 300
LRRMPTAFHV GLPNAAQREE ILRLILSGEN LSNAINLKEI ASQSEGYSGS
310 320 330 340 350
DLKELCRDAA MYRVRDYVRK QQMKQIAQQF QLDEEEEHVD SRQLRPVTQL
360 370 380
DLLFGLDKMR ESKQATATTD PANLREVPLD
Length:380
Mass (Da):42,580
Last modified:September 13, 2005 - v2
Checksum:iECF39E64F9A6CF52
GO
Isoform 2 (identifier: Q7ZZ25-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     330-337: Missing.

Show »
Length:372
Mass (Da):41,560
Checksum:i607580622C781C19
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8RM20A0A2R8RM20_DANRE
ATPase family AAA domain-containing...
atad1a
411Annotation score:
A0A286Y9V2A0A286Y9V2_DANRE
ATPase family AAA domain-containing...
atad1a
382Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015632330 – 337Missing in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772163 Genomic DNA Translation: CAD60864.1
BC081379 mRNA Translation: AAH81379.1
RefSeqiNP_001004640.1, NM_001004640.3 [Q7ZZ25-1]
UniGeneiDr.104656

Genome annotation databases

EnsembliENSDART00000035859; ENSDARP00000035974; ENSDARG00000023267 [Q7ZZ25-1]
GeneIDi368672
KEGGidre:368672

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiATD1A_DANRE
AccessioniPrimary (citable) accession number: Q7ZZ25
Secondary accession number(s): Q66IE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: September 12, 2018
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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