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Protein

Calcium-binding mitochondrial carrier protein SCaMC-2

Gene

slc25a25

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Calcium-dependent mitochondrial solute carrier.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi69 – 801PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi105 – 1162PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding mitochondrial carrier protein SCaMC-2
Alternative name(s):
Small calcium-binding mitochondrial carrier protein 2
Solute carrier family 25 member 25
Gene namesi
Name:slc25a25
Synonyms:scamc2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5933262 slc25a25

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 234Mitochondrial intermembraneSequence analysisAdd BLAST234
Transmembranei235 – 252Helical; Name=1Sequence analysisAdd BLAST18
Topological domaini253 – 289Mitochondrial matrixSequence analysisAdd BLAST37
Transmembranei290 – 309Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini310 – 332Mitochondrial intermembraneSequence analysisAdd BLAST23
Transmembranei333 – 346Helical; Name=3Sequence analysisAdd BLAST14
Topological domaini347 – 382Mitochondrial matrixSequence analysisAdd BLAST36
Transmembranei383 – 402Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini403 – 425Mitochondrial intermembraneSequence analysisAdd BLAST23
Transmembranei426 – 443Helical; Name=5Sequence analysisAdd BLAST18
Topological domaini444 – 482Mitochondrial matrixSequence analysisAdd BLAST39
Transmembranei483 – 502Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini503 – 514Mitochondrial intermembraneSequence analysisAdd BLAST12

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003176071 – 514Calcium-binding mitochondrial carrier protein SCaMC-2Add BLAST514

Proteomic databases

PRIDEiQ7ZYD5

Structurei

3D structure databases

ProteinModelPortaliQ7ZYD5
SMRiQ7ZYD5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 91EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini92 – 125EF-hand 2PROSITE-ProRule annotationAdd BLAST34
Domaini123 – 158EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini159 – 194EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Repeati229 – 315Solcar 1Add BLAST87
Repeati323 – 408Solcar 2Add BLAST86
Repeati420 – 508Solcar 3Add BLAST89

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG108464
KOiK14684

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR002167 Graves_DC
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
PF00153 Mito_carr, 3 hits
PRINTSiPR00928 GRAVESDC
PR00926 MITOCARRIER
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF103506 SSF103506, 1 hit
SSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 4 hits
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q7ZYD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARPRSLVSP LLSGVFCQCD TVSGAPHSHE TPASPSLAAA ALAADPCGGL
60 70 80 90 100
LCGGPEHERR LQILFQELDV NKDGAICIND LAVGLKRLGV HRTELELRKI
110 120 130 140 150
VKAGDKDQDG QLDFDEFVHY LRDHEKKLRL VFKSLDKKND GRIDAQEIMQ
160 170 180 190 200
SLRDLGVNIS EQQAEKILKS MDKNGTMTID WNEWRDYHLL HSAENIPEII
210 220 230 240 250
LYWKHSTIFD VGENLLVPDE FTVEEKQTGM WWRHLVAGGG AGAVSRTCTA
260 270 280 290 300
PLDRLKVLMQ VHASRSNNMS ILGGFTHMIR EGGFRSLWRG NGINVIKIAP
310 320 330 340 350
ESAIKFMAYE QIKRIIGSNQ ETLGIHERFV AGSLAGVIAQ SSIYPMEVLK
360 370 380 390 400
TRMALRKTGQ YQGVLDCGKK ILLQEGLSAF YKGYVPNMLG IIPYAGIDLA
410 420 430 440 450
VYETLKNAWL QRYATSSADP GVFVLLACGT VSSTCGQLAS YPLALVRTRM
460 470 480 490 500
QAEASVEGAP QMTMSKLFKH IVKTEGAFGL YRGLAPNFMK VIPAVSISYV
510
VYENLKLTLG VQSR
Length:514
Mass (Da):56,808
Last modified:June 1, 2003 - v1
Checksum:iD8C127DD5A34F888
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC043834 mRNA Translation: AAH43834.1
RefSeqiNP_001080348.1, NM_001086879.1
UniGeneiXl.5805

Genome annotation databases

GeneIDi380040
KEGGixla:380040

Similar proteinsi

Entry informationi

Entry nameiSCMC2_XENLA
AccessioniPrimary (citable) accession number: Q7ZYD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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