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UniProtKB - Q7ZYA0 (LMBD2_XENLA)
Protein
G-protein coupled receptor-associated protein LMBRD2
Gene
lmbrd2
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
May associate with G-protein coupled receptors and regulate downstream signaling pathways.
By similarityGO - Biological processi
- adrenergic receptor signaling pathway Source: UniProtKB
Names & Taxonomyi
Protein namesi | Recommended name: G-protein coupled receptor-associated protein LMBRD2By similarityAlternative name(s): LMBR1 domain-containing protein 2 |
Gene namesi | Name:lmbrd2 |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Organism-specific databases
Xenbasei | XB-GENE-991218, lmbrd2.L |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 3 | ExtracellularSequence analysis | 3 | |
Transmembranei | 4 – 21 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 22 – 32 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 33 – 53 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 54 – 122 | ExtracellularSequence analysisAdd BLAST | 69 | |
Transmembranei | 123 – 143 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 144 – 167 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 168 – 188 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 189 – 203 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 204 – 224 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 225 – 404 | CytoplasmicSequence analysisAdd BLAST | 180 | |
Transmembranei | 405 – 425 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 426 – 449 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 450 – 470 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 471 – 490 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 491 – 511 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 512 – 538 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 539 – 559 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 560 – 713 | CytoplasmicSequence analysisAdd BLAST | 154 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000299165 | 1 – 713 | G-protein coupled receptor-associated protein LMBRD2Add BLAST | 713 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 76 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 89 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PRIDEi | Q7ZYA0 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 600 – 713 | DisorderedSequence analysisAdd BLAST | 114 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 246 – 314 | Sequence analysisAdd BLAST | 69 | |
Coiled coili | 587 – 620 | Sequence analysisAdd BLAST | 34 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 600 – 633 | Basic and acidic residuesSequence analysisAdd BLAST | 34 | |
Compositional biasi | 634 – 654 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 655 – 670 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 697 – 713 | Polar residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the LIMR family.Curated
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
OrthoDBi | 778022at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR006876, LMBR1-like_membr_prot |
Pfami | View protein in Pfam PF04791, LMBR1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q7ZYA0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGVALGIEI VSVFFLALFL LHRYGDFKKQ HKLVIVGTLL AWYLCFLIVF
60 70 80 90 100
IIPLDVSTTI YNRCVARHAV TPAPSNITVL SPTPGIVSNT TAQNHLPSAD
110 120 130 140 150
KLRSSDNSLE ECSKPWSYIP RGIMPIFWRV VYWTSQFLTW ILMPFMQSYA
160 170 180 190 200
RSGGFSITGK IKTALIENAI YYGTYLLIFG ALLIYVAVNP NLHLEWYQLQ
210 220 230 240 250
TIGIAAANTW GLFLLVLLMG YGLVEIPRSQ WNGAKKGYLL MKTYFKAAKL
260 270 280 290 300
MTEKADAEET LEDVMEEVRK VNECIKYNHP LRKCVDTILK KCPAEYQEKM
310 320 330 340 350
GRNMDDYEDF EEKNISYPSE KTLVKLHKQV IYAVQRHRRT QVQWSILLEQ
360 370 380 390 400
AFHLEDVAKN ETSAAKQFVH TFPHQEPESW IMRRLYTPTI EWYWECLLRP
410 420 430 440 450
WCSRILAVIL ALFSTVVVWS ECTFFSAKPV LSLFAVFIQQ AEQTHNYIYV
460 470 480 490 500
EVVCFLSIFF LSICVYSTVF RIRVFNYYYL ASHHQTDAYS LLFSGMLFCR
510 520 530 540 550
LTPPLCLNFL GLTHMDVSIS HQNIEPTAYT SIMGSLRVLP LIADVFYIYY
560 570 580 590 600
PMLVLILCIA TYFSLGTRCL NLLGFQQFMG DNDMTSDLTD EGKELIKREK
610 620 630 640 650
RKRQRLEDGE TRRREWKERY PTNREDTSRN RSVNSDQKEP TYTEMTTNRS
660 670 680 690 700
SKYTRASNRT ERDRIELLQD AEPLDFNADT FNDDPLDSES GRYQPGGRYL
710
SMSQSNSRIF DDV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC043881 mRNA Translation: AAH43881.1 |
RefSeqi | NP_001080584.1, NM_001087115.1 |
Genome annotation databases
GeneIDi | 380276 |
KEGGi | xla:380276 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC043881 mRNA Translation: AAH43881.1 |
RefSeqi | NP_001080584.1, NM_001087115.1 |
3D structure databases
SMRi | Q7ZYA0 |
ModBasei | Search... |
Proteomic databases
PRIDEi | Q7ZYA0 |
Protocols and materials databases
DNASUi | 380276 |
Genome annotation databases
GeneIDi | 380276 |
KEGGi | xla:380276 |
Organism-specific databases
CTDi | 380276 |
Xenbasei | XB-GENE-991218, lmbrd2.L |
Phylogenomic databases
OrthoDBi | 778022at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR006876, LMBR1-like_membr_prot |
Pfami | View protein in Pfam PF04791, LMBR1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LMBD2_XENLA | |
Accessioni | Q7ZYA0Primary (citable) accession number: Q7ZYA0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 21, 2007 |
Last sequence update: | June 1, 2003 | |
Last modified: | June 2, 2021 | |
This is version 44 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |