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Entry version 67 (12 Aug 2020)
Sequence version 1 (01 Jun 2003)
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Protein

HEAT repeat-containing protein 6

Gene

heatr6

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HEAT repeat-containing protein 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:heatr6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-5772487, heatr6.S

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003371781 – 1174HEAT repeat-containing protein 6Add BLAST1174

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
Q7ZY56

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati168 – 207HEAT 1Add BLAST40
Repeati460 – 498HEAT 2Add BLAST39
Repeati523 – 560HEAT 3Add BLAST38
Repeati566 – 603HEAT 4Add BLAST38

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Repeat

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

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OMAi
DYGCLTG

Database of Orthologous Groups

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OrthoDBi
106835at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR025283, DUF4042
IPR000357, HEAT

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13251, DUF4042, 1 hit
PF02985, HEAT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7ZY56-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAQEDRLDS FGMQHGILLS SSPSLQPPYN HQEYAWDFQR YLNKLQSLRP
60 70 80 90 100
SDSESFRTEI NLLLDQLISQ DYTPGVTGIG QEEVCAILVQ ACRLVQHNQE
110 120 130 140 150
HLVSKVCQLV HYLLNRLQVI VDEQNLDFLL AFSISALKQC SSWTHADVLH
160 170 180 190 200
ALAALVYNNG SKCQKYLNEL LGPTGILVNL CDPSQPDPEL WREAIHCMAN
210 220 230 240 250
LCLGVPGHPY LDEPYRMTCF KNFLTVLQTP KPNIVDDIAV CTLLQNALKG
260 270 280 290 300
IQSLLNGSKI KLLETGQLGS LLAVLKKYMF HGLPGLSIEM PTVLYPTPLA
310 320 330 340 350
QYDGRSPTKP EQPEAAVNQP TWSKKKRKAG KQKKGHQGEE SKEELKNEIG
360 370 380 390 400
AEINKDLEKM KLCSGEAQHS LYLGPQKSPL DPHQGQVGKD HFSPQVQRYK
410 420 430 440 450
KINSSDSEYS DAEGSLQNKI RSFQAKVRQG ALSCFLSTIK SIEKKVLYGY
460 470 480 490 500
WSAFVPDISG IGSPQSVSLM TIALKDSSPK TRACALQVLS AILDGSKQFL
510 520 530 540 550
SVADDASDHK RAFTPLSVTL ASSIRELHRC LLLAIVAESS AQTLTQIIKC
560 570 580 590 600
LANLVSNAPY HRLKPGLLTR VWNQIKPYIR NKDVNVRVSS LTLLGAIVSA
610 620 630 640 650
QVSLPEVQLL LQQPLYSLSQ NSGSATPSDP ESNRKESMLE GGKKNGLHSE
660 670 680 690 700
HSQSCWLIRL CITLVVEPRE DSYSDSEPSS TPAVMYEPSP VRLEALQVLA
710 720 730 740 750
CLVKGCFNMA QSYLIELGEV ACKCMQETDA SIQLHGAKLL EELGTGIVQQ
760 770 780 790 800
QKPDSIVPIN LMVPINQAVT FWNMILNGPL PAALQNEQHP TLQTSACDAL
810 820 830 840 850
SSVLPEAFSN LPNDRQILCI TLLLGLNHSE NPLVKAAAAR ALGVYILFPC
860 870 880 890 900
LRQDVMFVAD TANAILMCLS DRSPNVRAKA AWSLGNLTDS LIVNMEAMGQ
910 920 930 940 950
SFQEEFSDML LLKMLWAATE ASKDKDKVKS NAVRALGNLL HFLQPYHIVK
960 970 980 990 1000
PRFCESIECA IQALVSTVLG DGTMKVKWNA CYALGNVFKN TALPLGKATW
1010 1020 1030 1040 1050
TAAAYNALTT VVKACKNFKV RIKSAMALSI PFSREQYGST EQYCDIWNAL
1060 1070 1080 1090 1100
VTALQKSEDT EDFLEFKYSA SLREQICQAL IHLLSLASQE DLPRIRKTLL
1110 1120 1130 1140 1150
EKGDSIRNYV LHYVKSEVQG DESQREHQDR GKMLQRAIEH IRGFEELPGS
1160 1170
NKGLIEVAYF EAILVSCDKE MEAL
Length:1,174
Mass (Da):130,049
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i413FEF48DC195CDD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC043967 mRNA Translation: AAH43967.1

NCBI Reference Sequences

More...
RefSeqi
NP_001079513.1, NM_001086044.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
379200

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:379200

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC043967 mRNA Translation: AAH43967.1
RefSeqiNP_001079513.1, NM_001086044.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

MaxQBiQ7ZY56

Genome annotation databases

GeneIDi379200
KEGGixla:379200

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
379200
XenbaseiXB-GENE-5772487, heatr6.S

Phylogenomic databases

OMAiDYGCLTG
OrthoDBi106835at2759

Family and domain databases

Gene3Di1.25.10.10, 3 hits
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR025283, DUF4042
IPR000357, HEAT
PfamiView protein in Pfam
PF13251, DUF4042, 1 hit
PF02985, HEAT, 1 hit
SUPFAMiSSF48371, SSF48371, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHEAT6_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7ZY56
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 1, 2003
Last modified: August 12, 2020
This is version 67 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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