UniProtKB - Q7ZXB7 (LTR2B_XENLA)
Protein
Ragulator complex protein LAMTOR2-B
Gene
lamtor2-b
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity).By similarity
GO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: InterPro
- molecular adaptor activity Source: InterPro
GO - Biological processi
- cellular protein localization Source: UniProtKB
- cellular response to amino acid stimulus Source: UniProtKB
- positive regulation of TOR signaling Source: UniProtKB
- regulation of cell growth Source: UniProtKB
Names & Taxonomyi
Protein namesi | Recommended name: Ragulator complex protein LAMTOR2-BAlternative name(s): Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2-B Roadblock domain-containing protein 3 |
Gene namesi | Name:lamtor2-b Synonyms:robld3 |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Organism-specific databases
Xenbasei | XB-GENE-6254952, lamtor2.S |
Subcellular locationi
Endosome
- Late endosome membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Lysosome
- Lysosome membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Endosome
- late endosome Source: UniProtKB
- Ragulator complex Source: UniProtKB
Lysosome
- lysosomal membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Endosome, Lysosome, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000365943 | 1 – 125 | Ragulator complex protein LAMTOR2-BAdd BLAST | 125 |
Interactioni
Subunit structurei
Part of the Ragulator complex composed of lamtor1, lamtor2, lamtor3, lamtor4 and lamtor5. The Ragulator complex interacts with slc38a9; the probable amino acid sensor.
Component of the lysosomal folliculin complex (LFC).
By similarityGO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: InterPro
Family & Domainsi
Sequence similaritiesi
Belongs to the GAMAD family.Curated
Phylogenomic databases
OMAi | CECGHVA |
OrthoDBi | 1515483at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR037587, LAMTOR2-like IPR004942, Roadblock/LAMTOR2_dom |
PANTHERi | PTHR13323, PTHR13323, 1 hit |
Pfami | View protein in Pfam PF03259, Robl_LC7, 1 hit |
SMARTi | View protein in SMART SM00960, Robl_LC7, 1 hit |
i Sequence
Sequence statusi: Complete.
Q7ZXB7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRPKALTQV LSQANTGGVQ STLLLNNEGS LLAYSGYGDT DARVTAAIAS
60 70 80 90 100
NIWAAYDKNG HQAFNEDNLK FILMDCMEGR VAITRVSNLL LCMYAKETVG
110 120
FGMLKAKAQA LVHYLEEPLN QVSSS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC045065 mRNA Translation: AAH45065.1 |
RefSeqi | NP_001080049.1, NM_001086580.1 |
Genome annotation databases
GeneIDi | 379741 |
KEGGi | xla:379741 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC045065 mRNA Translation: AAH45065.1 |
RefSeqi | NP_001080049.1, NM_001086580.1 |
3D structure databases
SMRi | Q7ZXB7 |
ModBasei | Search... |
Genome annotation databases
GeneIDi | 379741 |
KEGGi | xla:379741 |
Organism-specific databases
CTDi | 379741 |
Xenbasei | XB-GENE-6254952, lamtor2.S |
Phylogenomic databases
OMAi | CECGHVA |
OrthoDBi | 1515483at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR037587, LAMTOR2-like IPR004942, Roadblock/LAMTOR2_dom |
PANTHERi | PTHR13323, PTHR13323, 1 hit |
Pfami | View protein in Pfam PF03259, Robl_LC7, 1 hit |
SMARTi | View protein in SMART SM00960, Robl_LC7, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LTR2B_XENLA | |
Accessioni | Q7ZXB7Primary (citable) accession number: Q7ZXB7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 3, 2009 |
Last sequence update: | June 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 69 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |