UniProtKB - Q7ZX64 (2ABD_XENLA)
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
ppp2r2d
Functioni
Miscellaneous
GO - Molecular functioni
- protein phosphatase regulator activity Source: UniProtKB
GO - Biological processi
- cell division Source: UniProtKB-KW
- exit from mitosis Source: UniProtKB
- mitotic cell cycle Source: UniProtKB
Keywordsi
Biological process | Cell cycle, Cell division, Mitosis |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoformAlternative name(s): PP2A subunit B isoform B55-delta PP2A subunit B isoform PR55-delta PP2A subunit B isoform R2-delta PP2A subunit B isoform delta |
Gene namesi | Name:ppp2r2d |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Organism-specific databases
Xenbasei | XB-GENE-940318, ppp2r2d.S |
Subcellular locationi
Other locations
- Cytoplasm By similarity
Nucleus
- nucleoplasm Source: Reactome
Other locations
- cytoplasm Source: UniProtKB-SubCell
- protein phosphatase type 2A complex Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000408325 | 1 – 447 | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoformAdd BLAST | 447 |
Interactioni
Subunit structurei
PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.
Interacts with ensa (when phosphorylated at 'Ser-67') and arpp19 (when phosphorylated at 'Ser-67'), leading to inhibit PP2A activity.
2 PublicationsFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 26 – 65 | WD 1Add BLAST | 40 | |
Repeati | 91 – 132 | WD 2Add BLAST | 42 | |
Repeati | 175 – 213 | WD 3Add BLAST | 39 | |
Repeati | 224 – 264 | WD 4Add BLAST | 41 | |
Repeati | 283 – 321 | WD 5Add BLAST | 39 | |
Repeati | 338 – 379 | WD 6Add BLAST | 42 | |
Repeati | 414 – 447 | WD 7Add BLAST | 34 |
Sequence similaritiesi
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
OMAi | WHPMENI |
OrthoDBi | 810409at2759 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR000009, PP2A_PR55 IPR018067, PP2A_PR55_CS IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR11871, PTHR11871, 1 hit |
PIRSFi | PIRSF037309, PP2A_PR55, 1 hit |
PRINTSi | PR00600, PP2APR55 |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS01024, PR55_1, 1 hit PS01025, PR55_2, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MAGVGGGNDF QWCFSQVKGA IDEDVAEADI ISTVEFNCSG ELLATGDKGG
60 70 80 90 100
RVVIFQREQE NKSRPHSRGE YNVYSTFQSH EPEFDYLKSL EIEEKINKIR
110 120 130 140 150
WLPQQNAANF LLSTNDKTIK LWKISERDKR VEGYNLKDDD GRLRDPFRIT
160 170 180 190 200
SLRVPILKPM DLMVEASPRR IFANAHTYHI NSISVNSDHQ TYLSADDLRV
210 220 230 240 250
NLWHLEITDR SFNIVDIKPA NMEELTEVIT AAEFHPHHCH MFVYSSSKGT
260 270 280 290 300
IRLCDMRDAA LCDRHSKFFE EPEDPSSRSF FSEIISSISD VKFSHSGRYM
310 320 330 340 350
MTRDYLSVKV WDLNMESRPV ETYQVHEYLR SKLCSLYEND CIFDKFECCW
360 370 380 390 400
NGSDSSIMTG SYNNFFRMFD RNTRRDITLE ASRESSKPRA TLKPRKVCTG
410 420 430 440
GKRKKDEINV DSLDFNKKIL HTAWHPTDNI IAVAATNNLY IFQDKVN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC045219 mRNA Translation: AAH45219.1 |
RefSeqi | NP_001079618.1, NM_001086149.1 |
Genome annotation databases
GeneIDi | 379305 |
KEGGi | xla:379305 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC045219 mRNA Translation: AAH45219.1 |
RefSeqi | NP_001079618.1, NM_001086149.1 |
3D structure databases
SMRi | Q7ZX64 |
ModBasei | Search... |
Genome annotation databases
GeneIDi | 379305 |
KEGGi | xla:379305 |
Organism-specific databases
CTDi | 379305 |
Xenbasei | XB-GENE-940318, ppp2r2d.S |
Phylogenomic databases
OMAi | WHPMENI |
OrthoDBi | 810409at2759 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR000009, PP2A_PR55 IPR018067, PP2A_PR55_CS IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR11871, PTHR11871, 1 hit |
PIRSFi | PIRSF037309, PP2A_PR55, 1 hit |
PRINTSi | PR00600, PP2APR55 |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS01024, PR55_1, 1 hit PS01025, PR55_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | 2ABD_XENLA | |
Accessioni | Q7ZX64Primary (citable) accession number: Q7ZX64 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 3, 2011 |
Last sequence update: | June 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 93 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |