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Entry version 70 (31 Jul 2019)
Sequence version 1 (01 Jun 2003)
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Protein
Submitted name:

Dag1-prov protein

Gene

dag1

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S72.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Dag1-prov proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dag1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-17341576 dag1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei740 – 766HelicalSequence analysisAdd BLAST27

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500429578328 – 886Sequence analysisAdd BLAST859

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini591 – 701Peptidase S72InterPro annotationAdd BLAST111

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni344 – 365DisorderedSequence analysisAdd BLAST22
Regioni407 – 486DisorderedSequence analysisAdd BLAST80
Regioni814 – 886DisorderedSequence analysisAdd BLAST73

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi344 – 360Pro-richSequence analysisAdd BLAST17
Compositional biasi410 – 443PolarSequence analysisAdd BLAST34
Compositional biasi461 – 485PolarSequence analysisAdd BLAST25
Compositional biasi849 – 864Pro-richSequence analysisAdd BLAST16

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

KEGG Orthology (KO)

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KOi
K06265

Database of Orthologous Groups

More...
OrthoDBi
163609at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.30.70.1040, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027468 Alpha-dystroglycan_domain_2
IPR041631 Alpha_DG1_N2
IPR006644 Cadg
IPR015919 Cadherin-like_sf
IPR008465 DAG1_C
IPR013783 Ig-like_fold
IPR030398 SEA_DG_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18424 a_DG1_N2, 1 hit
PF05454 DAG1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00736 CADG, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111006 SSF111006, 1 hit
SSF49313 SSF49313, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51699 SEA_DG, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7ZX16-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDIRCAALSF PMLRTIMVLL MASSAWSVWP SDPTEVAQDW DNQLEASMHS
60 70 80 90 100
LFPEIKETVA PMAGIPDSSA VVGRPFKIHI PAEFLASNGE TIKISEVGKD
110 120 130 140 150
TLPSWLHWEA NFLQGLPLDG DKGVYEISVA SLQLAPNGSY VPQTTDVFSV
160 170 180 190 200
EVHPEDHNEP QSVRVAGQET TEATPFLCGT DEPVTILTVI LDADLTKMTT
210 220 230 240 250
KQRVDLLNRM RDFSEVELFH MKLVPVVNNR LFDMSAFMAG PGNAKKVVEN
260 270 280 290 300
GALLSWKLGC GMDQNTVPNI RSVEVPAKEG TMSAQLGYPV VGWHIANKKP
310 320 330 340 350
QMPKRIRRQI YATPTPVTAI GPPTTAIHEP PERIVPTPTS PAIAPPTDTT
360 370 380 390 400
APPVREPIPL PGKPTVTIRT RGAIIHTPTL GPIHPTRIIE TTSIVRPTMT
410 420 430 440 450
RPIYVEPTAA VTPPSTTTKR PRVTTIKSAT PPTTDSSTTT TKKPTKKPRP
460 470 480 490 500
RPPKPLATTK APTTKVETTS TTRPRTSTSG VPNTDPELKN HIDKVVAWVG
510 520 530 540 550
TYFEVKIPPD TFYDREDGTT DNLQLTLVPR IKASTGEKMW VMLNSTSQVM
560 570 580 590 600
YGMPDYIHIG DHEYYLRAAD KAGRTAVDAL EIQVRNLFQK QPSPVKFHAK
610 620 630 640 650
FHGDHNAVIN DINKKILLVK KLAFAFGDRN SSSITLHNIT KGSVVVDWTN
660 670 680 690 700
NTFPTEPCPV EQVEGVGKKI YDERGNPRQH FVNAVEPEFK LLNISLSFTG
710 720 730 740 750
SCKHKNFRYI PMRPEEPIPT AVAPTLAEER NPEKSSEDDV YLHTVIPAVV
760 770 780 790 800
VAAILLIAGI IAMICYRKKR KGKLTIEDQA TFIKKGVPII FADELDDSKP
810 820 830 840 850
PPSSSMPLIL KEEKAPLPPP EYPNQNVPET IPLNQDTFGE YMPLRDEDPN
860 870 880
APPYQPPPPF TTPMEGKGSR PKNMTPYRSP PPYVPP
Length:886
Mass (Da):97,791
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i913DEDDC93F9B40F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC046260 mRNA Translation: AAH46260.1

NCBI Reference Sequences

More...
RefSeqi
NP_001080755.1, NM_001087286.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
380447

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:380447

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC046260 mRNA Translation: AAH46260.1
RefSeqiNP_001080755.1, NM_001087286.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiS72.001

Genome annotation databases

GeneIDi380447
KEGGixla:380447

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
380447
XenbaseiXB-GENE-17341576 dag1

Phylogenomic databases

KOiK06265
OrthoDBi163609at2759

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.70.1040, 1 hit
InterProiView protein in InterPro
IPR027468 Alpha-dystroglycan_domain_2
IPR041631 Alpha_DG1_N2
IPR006644 Cadg
IPR015919 Cadherin-like_sf
IPR008465 DAG1_C
IPR013783 Ig-like_fold
IPR030398 SEA_DG_dom
PfamiView protein in Pfam
PF18424 a_DG1_N2, 1 hit
PF05454 DAG1, 1 hit
SMARTiView protein in SMART
SM00736 CADG, 2 hits
SUPFAMiSSF111006 SSF111006, 1 hit
SSF49313 SSF49313, 2 hits
PROSITEiView protein in PROSITE
PS51699 SEA_DG, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7ZX16_XENLA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7ZX16
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: July 31, 2019
This is version 70 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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