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Entry version 116 (11 Dec 2019)
Sequence version 2 (16 Aug 2005)
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Protein

WD repeat-containing protein 75

Gene

wdr75

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRibosome biogenesis, rRNA processing, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WD repeat-containing protein 75
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:wdr75
ORF Names:si:dz46i22.2, si:xx-113d7.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030616-5 wdr75

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000514311 – 832WD repeat-containing protein 75Add BLAST832

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7ZVR1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000040730 Expressed in 32 organ(s), highest expression level in tail

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000059666

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati4 – 43WD 1Add BLAST40
Repeati47 – 86WD 2Add BLAST40
Repeati90 – 134WD 3Add BLAST45
Repeati148 – 187WD 4Add BLAST40
Repeati196 – 233WD 5Add BLAST38
Repeati239 – 278WD 6Add BLAST40
Repeati281 – 320WD 7Add BLAST40
Repeati326 – 364WD 8Add BLAST39
Repeati378 – 425WD 9Add BLAST48
Repeati432 – 474WD 10Add BLAST43
Repeati485 – 523WD 11Add BLAST39
Repeati527 – 567WD 12Add BLAST41
Repeati572 – 609WD 13Add BLAST38

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1963 Eukaryota
ENOG410YY9G LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006303

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000043113

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7ZVR1

KEGG Orthology (KO)

More...
KOi
K14552

Database of Orthologous Groups

More...
OrthoDBi
1437651at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7ZVR1

TreeFam database of animal gene trees

More...
TreeFami
TF323469

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011047 Quinoprotein_ADH-like_supfam
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00400 WD40, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit
SSF50998 SSF50998, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7ZVR1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVEKTDIRVV RCGGSKINFR PPIISHDSRF VLCVSGDSVK VYSTRTEEWL
60 70 80 90 100
HNLQGHNNQV TGIAFNPANQ LQVYSCSADG TVKLWDFIDG ILIKTFVIGY
110 120 130 140 150
PLYSLYVSEK HEGVIFLIVS MVTDSNNESF QLVAVHLPKS AEQEVEAKEL
160 170 180 190 200
STVASKISPN PSCTAFGRGG EFIAFSRHLQ LNVYFFRKQK TYSFSLKATD
210 220 230 240 250
KKAGKNAFTC VACHPTDDCI ASGHEDGKIR LWRNFNHKKE YTYSTKHWHH
260 270 280 290 300
DAVNHLCFTP EGSNLLSGGI ESVLVQWQYG DMSKKEFLPR LGGSISHVSA
310 320 330 340 350
SADGQLFCTA HSDNKISIIE SSFKVSGLIQ GLVRGDAVST DLMIDPRSKA
360 370 380 390 400
LVLNGKPGHL QFYSLLRDKH LYNLDIVQQE YIYEAGLDQF EVVKAVFDVK
410 420 430 440 450
GSWLATVEER GHKTSDLEFF LKLWAFDETT QSFVLNTTVT EAHSERITSM
460 470 480 490 500
CFSSSEETTM LVTTALDGQF KAWCQTADAQ QAQNYWSCDF VGSYHNLKPK
510 520 530 540 550
NCCFSADGSI LAVSFQEVLT LWSPETWELL TTLCQPPGEI RDLCFGRLSC
560 570 580 590 600
SKYLLSTTTK NLLCCWNLLT CALEWSTSVD VSRLQSDPLS ENVAAFSFES
610 620 630 640 650
KHTHLFVFKP SEPRPLFSQR YVCLERVDRA VFVPREEPFN SCDESCQWLN
660 670 680 690 700
RSQLYFLTHN MDLLTFSSAT EEDRMLSSSK RLVIDESVAV TPFYLLLGRH
710 720 730 740 750
RKQQHKLNTE TQEPADKPQH TQGSVTIKQL LHTPAHVLPA ASVLCSMFVR
760 770 780 790 800
SLLISNTGVR EEMDSSEQEM DSEKEEEESE EEMEACDGQQ ELRAQGSVDE
810 820 830
QKPKLSKAQE RELKSLRKTD FSWMTSLIDS KP
Length:832
Mass (Da):93,936
Last modified:August 16, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i37CA911EFA18D56B
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAD52129 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAD52133 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAD58775 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAD61075 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti390F → I in CAD52133 (PubMed:23594743).Curated1
Sequence conflicti517E → G in AAH45446 (Ref. 2) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL591593 Genomic DNA Translation: CAD43475.1
AL672118 Genomic DNA Translation: CAD52129.1 Sequence problems.
AL672166 Genomic DNA Translation: CAD52133.1 Sequence problems.
AL672145 Genomic DNA Translation: CAD58775.1 Sequence problems.
AL731861 Genomic DNA Translation: CAD61075.1 Sequence problems.
BC045446 mRNA Translation: AAH45446.1

NCBI Reference Sequences

More...
RefSeqi
NP_956384.1, NM_200090.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000059667; ENSDARP00000059666; ENSDARG00000040730

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
368478

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:368478

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591593 Genomic DNA Translation: CAD43475.1
AL672118 Genomic DNA Translation: CAD52129.1 Sequence problems.
AL672166 Genomic DNA Translation: CAD52133.1 Sequence problems.
AL672145 Genomic DNA Translation: CAD58775.1 Sequence problems.
AL731861 Genomic DNA Translation: CAD61075.1 Sequence problems.
BC045446 mRNA Translation: AAH45446.1
RefSeqiNP_956384.1, NM_200090.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000059666

Proteomic databases

PaxDbiQ7ZVR1

Genome annotation databases

EnsembliENSDART00000059667; ENSDARP00000059666; ENSDARG00000040730
GeneIDi368478
KEGGidre:368478

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84128
ZFINiZDB-GENE-030616-5 wdr75

Phylogenomic databases

eggNOGiKOG1963 Eukaryota
ENOG410YY9G LUCA
GeneTreeiENSGT00390000006303
HOGENOMiHOG000043113
InParanoidiQ7ZVR1
KOiK14552
OrthoDBi1437651at2759
PhylomeDBiQ7ZVR1
TreeFamiTF323469

Enzyme and pathway databases

ReactomeiR-DRE-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q7ZVR1

Gene expression databases

BgeeiENSDARG00000040730 Expressed in 32 organ(s), highest expression level in tail

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR011047 Quinoprotein_ADH-like_supfam
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF50998 SSF50998, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWDR75_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7ZVR1
Secondary accession number(s): Q7ZZ52
, Q8AUI8, Q8AW19, Q8JFV9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: December 11, 2019
This is version 116 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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