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Entry version 168 (17 Jun 2020)
Sequence version 1 (01 Jun 2003)
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Protein

Mitogen-activated protein kinase

Gene

mapk3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by threonine and tyrosine phosphorylation.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-110056 MAPK3 (ERK1) activation
R-DRE-111995 phospho-PLA2 pathway
R-DRE-112409 RAF-independent MAPK1/3 activation
R-DRE-112411 MAPK1 (ERK2) activation
R-DRE-1169408 ISG15 antiviral mechanism
R-DRE-1295596 Spry regulation of FGF signaling
R-DRE-162658 Golgi Cisternae Pericentriolar Stack Reorganization
R-DRE-170968 Frs2-mediated activation
R-DRE-198753 ERK/MAPK targets
R-DRE-202670 ERKs are inactivated
R-DRE-2029482 Regulation of actin dynamics for phagocytic cup formation
R-DRE-2559580 Oxidative Stress Induced Senescence
R-DRE-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-DRE-2559585 Oncogene Induced Senescence
R-DRE-2871796 FCERI mediated MAPK activation
R-DRE-3371453 Regulation of HSF1-mediated heat shock response
R-DRE-375165 NCAM signaling for neurite out-growth
R-DRE-437239 Recycling pathway of L1
R-DRE-445144 Signal transduction by L1
R-DRE-450341 Activation of the AP-1 family of transcription factors
R-DRE-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-DRE-5654726 Negative regulation of FGFR1 signaling
R-DRE-5654727 Negative regulation of FGFR2 signaling
R-DRE-5654732 Negative regulation of FGFR3 signaling
R-DRE-5654733 Negative regulation of FGFR4 signaling
R-DRE-5663213 RHO GTPases Activate WASPs and WAVEs
R-DRE-5668599 RHO GTPases Activate NADPH Oxidases
R-DRE-5673001 RAF/MAP kinase cascade
R-DRE-5674135 MAP2K and MAPK activation
R-DRE-5674499 Negative feedback regulation of MAPK pathway
R-DRE-5675221 Negative regulation of MAPK pathway
R-DRE-6798695 Neutrophil degranulation
R-DRE-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-DRE-73728 RNA Polymerase I Promoter Opening
R-DRE-74749 Signal attenuation
R-DRE-881907 Gastrin-CREB signalling pathway via PKC and MAPK
R-DRE-9634635 Estrogen-stimulated signaling through PRKCZ
R-DRE-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling
R-DRE-982772 Growth hormone receptor signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitogen-activated protein kinaseUniRule annotationSAAS annotation (EC:2.7.11.24UniRule annotationSAAS annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mapk3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-040121-1 mapk3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000070573 Expressed in zone of skin and 38 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000094521

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini56 – 344Protein kinaseInterPro annotationAdd BLAST289

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 47DisorderedSequence analysisAdd BLAST47

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0660 Eukaryota
ENOG410XNY0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160691

KEGG Orthology (KO)

More...
KOi
K04371

Identification of Orthologs from Complete Genome Data

More...
OMAi
RKRKPFA

Database of Orthologous Groups

More...
OrthoDBi
741207at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105097

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR008349 MAPK_ERK1/2
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01770 ERK1ERK2MAPK

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01351 MAPK, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7ZVK8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAESGSSAAA AGAAGSNSSA AGPGGAVAPG GPSGAAGSKP GLESVKGQNF
60 70 80 90 100
DVGPRYTDLQ YIGEGAYGMV CSAFDNVNKI RVAIKKISPF EHQTYCQRTL
110 120 130 140 150
REIKILLRFH HENIIGINDI LRARHIDYMR DVYIVQDLME TDLYKLLKTQ
160 170 180 190 200
QLSNDHICYF LYQILRGLKY IHSANVLHRD LKPSNLLINT TCDLKICDFG
210 220 230 240 250
LARIADPEHD HTGFLTEYVA TRWYRAPEIM LNSKGYTKSI DIWSVGCILA
260 270 280 290 300
EMLSNRPIFP GKHYLDQLNH ILGVLGSPSQ DDLNCIINMK ARNYLQSLPQ
310 320 330 340 350
KPKIPWNKLF PKADNKALDL LDRMLTFNPL KRINVEQALA HPYLEQYYDP
360 370 380 390
SDEPVAEEPF TFNMELDDLP KEKLKELIFE ETARFQANYQ GS
Length:392
Mass (Da):44,099
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC184681E448E5BBE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FP016144 Genomic DNA No translation available.
BC045505 mRNA Translation: AAH45505.1
BC066401 mRNA Translation: AAH66401.1
BC097073 mRNA Translation: AAH97073.1
BC163960 mRNA Translation: AAI63960.1
AY922319 mRNA Translation: AAY57804.1

NCBI Reference Sequences

More...
RefSeqi
NP_958915.1, NM_201507.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000103746; ENSDARP00000094521; ENSDARG00000070573

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
399480

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:399480

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP016144 Genomic DNA No translation available.
BC045505 mRNA Translation: AAH45505.1
BC066401 mRNA Translation: AAH66401.1
BC097073 mRNA Translation: AAH97073.1
BC163960 mRNA Translation: AAI63960.1
AY922319 mRNA Translation: AAY57804.1
RefSeqiNP_958915.1, NM_201507.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000094521

Genome annotation databases

EnsembliENSDART00000103746; ENSDARP00000094521; ENSDARG00000070573
GeneIDi399480
KEGGidre:399480

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5595
ZFINiZDB-GENE-040121-1 mapk3

Phylogenomic databases

eggNOGiKOG0660 Eukaryota
ENOG410XNY0 LUCA
GeneTreeiENSGT00940000160691
KOiK04371
OMAiRKRKPFA
OrthoDBi741207at2759
TreeFamiTF105097

Enzyme and pathway databases

ReactomeiR-DRE-110056 MAPK3 (ERK1) activation
R-DRE-111995 phospho-PLA2 pathway
R-DRE-112409 RAF-independent MAPK1/3 activation
R-DRE-112411 MAPK1 (ERK2) activation
R-DRE-1169408 ISG15 antiviral mechanism
R-DRE-1295596 Spry regulation of FGF signaling
R-DRE-162658 Golgi Cisternae Pericentriolar Stack Reorganization
R-DRE-170968 Frs2-mediated activation
R-DRE-198753 ERK/MAPK targets
R-DRE-202670 ERKs are inactivated
R-DRE-2029482 Regulation of actin dynamics for phagocytic cup formation
R-DRE-2559580 Oxidative Stress Induced Senescence
R-DRE-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-DRE-2559585 Oncogene Induced Senescence
R-DRE-2871796 FCERI mediated MAPK activation
R-DRE-3371453 Regulation of HSF1-mediated heat shock response
R-DRE-375165 NCAM signaling for neurite out-growth
R-DRE-437239 Recycling pathway of L1
R-DRE-445144 Signal transduction by L1
R-DRE-450341 Activation of the AP-1 family of transcription factors
R-DRE-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-DRE-5654726 Negative regulation of FGFR1 signaling
R-DRE-5654727 Negative regulation of FGFR2 signaling
R-DRE-5654732 Negative regulation of FGFR3 signaling
R-DRE-5654733 Negative regulation of FGFR4 signaling
R-DRE-5663213 RHO GTPases Activate WASPs and WAVEs
R-DRE-5668599 RHO GTPases Activate NADPH Oxidases
R-DRE-5673001 RAF/MAP kinase cascade
R-DRE-5674135 MAP2K and MAPK activation
R-DRE-5674499 Negative feedback regulation of MAPK pathway
R-DRE-5675221 Negative regulation of MAPK pathway
R-DRE-6798695 Neutrophil degranulation
R-DRE-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-DRE-73728 RNA Polymerase I Promoter Opening
R-DRE-74749 Signal attenuation
R-DRE-881907 Gastrin-CREB signalling pathway via PKC and MAPK
R-DRE-9634635 Estrogen-stimulated signaling through PRKCZ
R-DRE-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling
R-DRE-982772 Growth hormone receptor signaling

Gene expression databases

BgeeiENSDARG00000070573 Expressed in zone of skin and 38 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR008349 MAPK_ERK1/2
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PRINTSiPR01770 ERK1ERK2MAPK
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01351 MAPK, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7ZVK8_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7ZVK8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: June 17, 2020
This is version 168 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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