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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

sdha

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.By similarity

Cofactori

FADBy similarity

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (sdha), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (sdhb), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (sdha), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (sdha)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei272FADBy similarity1
Binding sitei293SubstrateBy similarity1
Binding sitei305SubstrateBy similarity1
Active sitei337Proton acceptorBy similarity1
Binding sitei404SubstrateBy similarity1
Binding sitei437FADBy similarity1
Binding sitei448SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 70FADBy similarity6
Nucleotide bindingi88 – 103FADBy similarityAdd BLAST16
Nucleotide bindingi453 – 454FADBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport, Tricarboxylic acid cycle
LigandFAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-DRE-71403 Citric acid cycle (TCA cycle)
UniPathwayi
UPA00223;UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC:1.3.5.1By similarity)
Alternative name(s):
Flavoprotein subunit of complex II
Short name:
Fp
Gene namesi
Name:sdha
ORF Names:si:dkeyp-84f11.2
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 19

Organism-specific databases

ZFINiZDB-GENE-040426-874 sdha

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 39MitochondrionBy similarityAdd BLAST39
ChainiPRO_000034498541 – 661Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialAdd BLAST621

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei96Tele-8alpha-FAD histidineBy similarity1

Proteomic databases

PaxDbiQ7ZVF3
PRIDEiQ7ZVF3

Expressioni

Gene expression databases

BgeeiENSDARG00000016721 Expressed in 37 organ(s), highest expression level in heart
ExpressionAtlasiQ7ZVF3 baseline

Interactioni

Subunit structurei

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000018027

Structurei

3D structure databases

ProteinModelPortaliQ7ZVF3
SMRiQ7ZVF3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2403 Eukaryota
COG1053 LUCA
GeneTreeiENSGT00910000144277
HOGENOMiHOG000160475
HOVERGENiHBG001461
InParanoidiQ7ZVF3
KOiK00234
TreeFamiTF300763

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR003952 FRD_SDH_FAD_BS
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
IPR011281 Succ_DH_flav_su_fwd
IPR014006 Succ_Dhase_FrdA_Gneg
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR01816 sdhA_forward, 1 hit
TIGR01812 sdhA_frdA_Gneg, 1 hit
PROSITEiView protein in PROSITE
PS00504 FRD_SDH_FAD_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7ZVF3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVCAASRV LGTKILSCKS LPAVCQANRQ LHFSIYGKRG DAKISDGVSN
60 70 80 90 100
QYPVVDHEFD AVVVGAGGAG LRAAFGLSEA GFNTACVTKL FPTRSHTVAA
110 120 130 140 150
QGGINAALGN MEQDDWRWHF YDTVKGSDWL GDQDAIHYMT EQAPAAVVEL
160 170 180 190 200
ENFGMPFSRT DDGKIYQRAF GGQSLKFGKG GQAHRCCCVA DRTGHSLLHT
210 220 230 240 250
LYGRSLRYDT SYFVEYFALD LLMEDGECKG VIALCMEDGS IHRFRAKNTV
260 270 280 290 300
IATGGYGRTF FSCTSAHTST GDGNAMVTRA GLPCQDLEFV QFHPTGIYGA
310 320 330 340 350
GCLITEGCRG EGGILINSEG ERFMERYAPN AKDLASRDVV SRSMTIEIRE
360 370 380 390 400
GRGVGPDKDH VHLQLHHLPP QQLAARLPGI SETAMIFAGV DVTKEPIPVL
410 420 430 440 450
PTVHYNMGGI PTNYKGQVIT YKDGQDHVVP GLYACGEAGC ASVHGANRLG
460 470 480 490 500
ANSLLDLVVF GRACALTIAE IDTPGEKLSP LKPNAGEASV ANLDKMRYAN
510 520 530 540 550
GSTRTSEIRL NMQKTMQSHA AVFRTGDVLK EGCVKMESVY KSMDDIKTFD
560 570 580 590 600
RGIVWNTDLV ETLELQNLML NAVQTIVSAE ARKESRGAHA REDFKDRVDE
610 620 630 640 650
YDYSKPLQGQ VKKPFEQHWR KHTLSYVDPE TGKVTLEYRP VIDSSLDAED
660
CAAIPPAIRS Y
Length:661
Mass (Da):72,078
Last modified:July 22, 2008 - v2
Checksum:i636BF993BE55D19B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18C → S in AAH45885 (Ref. 2) Curated1
Sequence conflicti545D → N in AAH45885 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX890617 Genomic DNA Translation: CAK11468.1
BC045885 mRNA Translation: AAH45885.1
RefSeqiNP_957204.1, NM_200910.1
UniGeneiDr.105233

Genome annotation databases

EnsembliENSDART00000015559; ENSDARP00000018027; ENSDARG00000016721
GeneIDi393884
KEGGidre:393884

Similar proteinsi

Entry informationi

Entry nameiSDHA_DANRE
AccessioniPrimary (citable) accession number: Q7ZVF3
Secondary accession number(s): Q1LV99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: September 12, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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