UniProtKB - Q7ZV14 (GPX8_DANRE)
Protein
Probable glutathione peroxidase 8
Gene
gpx8
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Caution
Ser-80 is present instead of the conserved Cys/Sec which is expected to be the active site residue.Curated
Catalytic activityi
- EC:1.11.1.9
GO - Molecular functioni
- glutathione peroxidase activity Source: UniProtKB-EC
- peroxidase activity Source: GO_Central
GO - Biological processi
- response to oxidative stress Source: InterPro
Keywordsi
Molecular function | Oxidoreductase, Peroxidase |
Enzyme and pathway databases
Reactomei | R-DRE-3299685, Detoxification of Reactive Oxygen Species |
Names & Taxonomyi
Protein namesi | Recommended name: Probable glutathione peroxidase 8 (EC:1.11.1.9)Short name: GPx-8 Short name: GSHPx-8 |
Gene namesi | Name:gpx8 ORF Names:zgc:56280 |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-040426-965, gpx8 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 13 – 35 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000317758 | 1 – 210 | Probable glutathione peroxidase 8Add BLAST | 210 |
Proteomic databases
PaxDbi | Q7ZV14 |
Family & Domainsi
Sequence similaritiesi
Belongs to the glutathione peroxidase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1651, Eukaryota |
InParanoidi | Q7ZV14 |
OrthoDBi | 1483113at2759 |
PhylomeDBi | Q7ZV14 |
Family and domain databases
CDDi | cd00340, GSH_Peroxidase, 1 hit |
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR013376, Glut_perox_Gpx7 IPR000889, Glutathione_peroxidase IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR11592, PTHR11592, 1 hit |
Pfami | View protein in Pfam PF00255, GSHPx, 1 hit |
PRINTSi | PR01011, GLUTPROXDASE |
SUPFAMi | SSF52833, SSF52833, 1 hit |
TIGRFAMsi | TIGR02540, gpx7, 1 hit |
PROSITEi | View protein in PROSITE PS00014, ER_TARGET, 1 hit PS51355, GLUTATHIONE_PEROXID_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q7ZV14-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEALGGYPSK SSASRAGLFK VLLSVALCMG SLYLLQNKLS KSRKTKDFYS
60 70 80 90 100
YEVKDARGRT VSLEKYRGKV SLVVNVASGS ELTEQSYRAL QELHRELGTS
110 120 130 140 150
HFNVLAFPCS QYGDTESGTS REIEAFAKSN YGVTFPIFNK IKIMGSEAEP
160 170 180 190 200
AFRFLTDSVQ KIPRWNFWKF LVSPEGQVVR FWKPEEPVSD IRKEATTLVR
210
NIILKKRQEL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF1QNX6 | F1QNX6_DANRE | Glutathione peroxidase | gpx8 | 210 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC046044 mRNA Translation: AAH46044.1 |
RefSeqi | NP_956516.1, NM_200222.1 |
Genome annotation databases
GeneIDi | 393191 |
KEGGi | dre:393191 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC046044 mRNA Translation: AAH46044.1 |
RefSeqi | NP_956516.1, NM_200222.1 |
3D structure databases
SMRi | Q7ZV14 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000011955 |
Proteomic databases
PaxDbi | Q7ZV14 |
Genome annotation databases
GeneIDi | 393191 |
KEGGi | dre:393191 |
Organism-specific databases
CTDi | 493869 |
ZFINi | ZDB-GENE-040426-965, gpx8 |
Phylogenomic databases
eggNOGi | KOG1651, Eukaryota |
InParanoidi | Q7ZV14 |
OrthoDBi | 1483113at2759 |
PhylomeDBi | Q7ZV14 |
Enzyme and pathway databases
Reactomei | R-DRE-3299685, Detoxification of Reactive Oxygen Species |
Miscellaneous databases
PROi | PR:Q7ZV14 |
Family and domain databases
CDDi | cd00340, GSH_Peroxidase, 1 hit |
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR013376, Glut_perox_Gpx7 IPR000889, Glutathione_peroxidase IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR11592, PTHR11592, 1 hit |
Pfami | View protein in Pfam PF00255, GSHPx, 1 hit |
PRINTSi | PR01011, GLUTPROXDASE |
SUPFAMi | SSF52833, SSF52833, 1 hit |
TIGRFAMsi | TIGR02540, gpx7, 1 hit |
PROSITEi | View protein in PROSITE PS00014, ER_TARGET, 1 hit PS51355, GLUTATHIONE_PEROXID_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPX8_DANRE | |
Accessioni | Q7ZV14Primary (citable) accession number: Q7ZV14 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | June 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 109 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families