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Entry version 83 (26 Feb 2020)
Sequence version 1 (01 Jun 2003)
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Protein

BRCA2-interacting transcriptional repressor EMSY

Gene

emsy

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Repressor
Biological processDNA damage, DNA repair, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
BRCA2-interacting transcriptional repressor EMSYBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:emsyBy similarity
ORF Names:zgc:56039
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030131-7832 emsy

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000869671 – 1173BRCA2-interacting transcriptional repressor EMSYAdd BLAST1173

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7ZUV7

PRoteomics IDEntifications database

More...
PRIDEi
Q7ZUV7

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000092435

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7ZUV7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 100ENTPROSITE-ProRule annotationAdd BLAST85

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi146 – 214Ser-richAdd BLAST69
Compositional biasi475 – 569Thr-richAdd BLAST95
Compositional biasi897 – 940Ser-richAdd BLAST44

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4675 Eukaryota
ENOG410YF3T LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7ZUV7

Database of Orthologous Groups

More...
OrthoDBi
150416at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7ZUV7

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1240.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033482 EMSY
IPR005491 ENT_dom
IPR036142 ENT_dom-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR16500 PTHR16500, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03735 ENT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01191 ENT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF158639 SSF158639, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51138 ENT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q7ZUV7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVVWPTLLD LSRDECKRIL RKLELEAYAG VISALRAQGD LTKDKKELLG
60 70 80 90 100
ELTRVLSIST ERHRAEVRRA VNDERLTTIA HHMSGPNSSS EWSIEGRRLV
110 120 130 140 150
PLMPRLVPQT AFTVMANAVA NATAHQNASL PLPAETANKE VVVCYSYTST
160 170 180 190 200
TSTPPSASAP SSSSAAVKSP RPASPASNVV VLPSGSTVYV KSVSCSDEDE
210 220 230 240 250
KPRKRRRTSS SSSSPVLLKE VPKVAVTAPG PKTITLPVSG GPKISNLMQS
260 270 280 290 300
IANSLPPHMS PVKITFTKPS TQTTNTTTQK VIIVTTSPSS NFVPNILSKS
310 320 330 340 350
HNYAAVSKLV SSAALTASSQ KQTMVISAGG SSVAPGPGPV AVTTVVSSTP
360 370 380 390 400
SVVMSTVAQA GSAAVKVAST RLPSPKALIG SPSQILQIPK AQQAVLQSAA
410 420 430 440 450
PKALQGSIST AQSTALAAAG PGAKPTIQIK QESGVKIITQ QMQPSKILPK
460 470 480 490 500
PSSAALPSSS SAPIMVVSSN GAIMTTKLVS TPTGSASTYT RPTVSPMGTR
510 520 530 540 550
VATSPAGATY VKTTSGSIIT VVPKALATLG GKIITTSMVS GTTTKITTIP
560 570 580 590 600
MTSKPNVIVV QKTTGKGTTI QGLPGKNVVT TLLNAGGEKT LQAIPGAKPA
610 620 630 640 650
IITASRPITK MIVTQPKSLG AGVQPSTTTK IIPTKIVYGQ QGKTQVLIKP
660 670 680 690 700
KPMAFQTAVV SEQTRQLVSE TLQQVNRSAE NNTTSTHTSA AAAGLENRDD
710 720 730 740 750
THTYTEGSPV PSDSTHDAPP VVHLISSRGQ EWAEQEVSVE SSPALIYQEL
760 770 780 790 800
TAESQSATST IKALLELQQT SVKEKSEAKP RQHTIDLSQM AVPIPVSAEQ
810 820 830 840 850
RESPEPSGQS AAESDAHTEF IPIGKVSKAA EVSASSTPGQ SASAVSAAPH
860 870 880 890 900
VVKISTAAVT TQQVEAQVKP QQEQVLVEEC ELEGDTLDPQ TGLFYRSSPQ
910 920 930 940 950
QQLSRVCEAA SSSSSSSSSS SRRAEPPLTV KILTHRSSSS APATAASANT
960 970 980 990 1000
PHTPQLPRLQ QAPTTHNRPN THTQLSQPPP LQAHHPVGSS KTSSGAQVQQ
1010 1020 1030 1040 1050
PIITQGATVT KITFGAPHVP RAPVSSSSSS EAALKLQAES SSEKPSVPDI
1060 1070 1080 1090 1100
LKISMMEAEI DPGAEPMLVD SSSDCGPLTK APAGPSLISS SKQTLAHGPF
1110 1120 1130 1140 1150
SRKSKELDII QVIPQYSIMP DSSQSNVVVE PSGFLEISDY TSQRLDEEQA
1160 1170
MEQEVDSSND EGAAASPSAD QSQ
Length:1,173
Mass (Da):122,200
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2FBDDAE793CEFCA5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1Q8W2F1Q8W2_DANRE
BRCA2-interacting transcriptional r...
emsy
1,150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4IU34A0A0R4IU34_DANRE
BRCA2-interacting transcriptional r...
emsy
1,173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC047813 mRNA Translation: AAH47813.1

NCBI Reference Sequences

More...
RefSeqi
NP_956278.1, NM_199984.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
335889

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:335889

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC047813 mRNA Translation: AAH47813.1
RefSeqiNP_956278.1, NM_199984.1

3D structure databases

SMRiQ7ZUV7
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000092435

Proteomic databases

PaxDbiQ7ZUV7
PRIDEiQ7ZUV7

Genome annotation databases

GeneIDi335889
KEGGidre:335889

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
56946
ZFINiZDB-GENE-030131-7832 emsy

Phylogenomic databases

eggNOGiKOG4675 Eukaryota
ENOG410YF3T LUCA
InParanoidiQ7ZUV7
OrthoDBi150416at2759
PhylomeDBiQ7ZUV7

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q7ZUV7

Family and domain databases

Gene3Di1.10.1240.40, 1 hit
InterProiView protein in InterPro
IPR033482 EMSY
IPR005491 ENT_dom
IPR036142 ENT_dom-like_sf
PANTHERiPTHR16500 PTHR16500, 2 hits
PfamiView protein in Pfam
PF03735 ENT, 1 hit
SMARTiView protein in SMART
SM01191 ENT, 1 hit
SUPFAMiSSF158639 SSF158639, 1 hit
PROSITEiView protein in PROSITE
PS51138 ENT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEMSY_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7ZUV7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2003
Last modified: February 26, 2020
This is version 83 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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