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UniProtKB - Q7ZUK1 (Q7ZUK1_DANRE)
Protein
Submitted name:
Ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)
Gene
ube2d2
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 85 | Glycyl thioester intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- ubiquitin conjugating enzyme activity Source: GO_Central
GO - Biological processi
- negative regulation of smoothened signaling pathway Source: ZFIN
- protein polyubiquitination Source: GO_Central
Keywordsi
Molecular function | TransferaseARBA annotation |
Biological process | Ubl conjugation pathwayUniRule annotationARBA annotation |
Ligand | ATP-bindingUniRule annotation, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-DRE-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DRE-201451, Signaling by BMP R-DRE-2173795, Downregulation of SMAD2/3:SMAD4 transcriptional activity R-DRE-8866654, E3 ubiquitin ligases ubiquitinate target proteins R-DRE-8951664, Neddylation R-DRE-9033241, Peroxisomal protein import R-DRE-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Names & Taxonomyi
Protein namesi | Submitted name: Ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)ImportedSubmitted name: Zgc:55886ImportedSubmitted name: Zgc:55886 proteinImported |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-120312-1, ube2d2 |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000043484, Expressed in blastula and 32 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 147 | UBC coreInterPro annotationAdd BLAST | 147 |
Sequence similaritiesi
Belongs to the ubiquitin-conjugating enzyme family.UniRule annotation
Phylogenomic databases
GeneTreei | ENSGT00940000153169 |
HOGENOMi | CLU_030988_13_3_1 |
OMAi | QMDICLL |
OrthoDBi | 1337945at2759 |
TreeFami | TF101108 |
Family and domain databases
CDDi | cd00195, UBCc, 1 hit |
Gene3Di | 3.10.110.10, 1 hit |
InterProi | View protein in InterPro IPR000608, UBQ-conjugat_E2 IPR023313, UBQ-conjugating_AS IPR016135, UBQ-conjugating_enzyme/RWD |
Pfami | View protein in Pfam PF00179, UQ_con, 1 hit |
SUPFAMi | SSF54495, SSF54495, 1 hit |
PROSITEi | View protein in PROSITE PS00183, UBC_1, 1 hit PS50127, UBC_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q7ZUK1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALKRIHKEL HDLGRDPPAQ CSAGPVGDDM FHWQATIMGP NDSPYQGGVF
60 70 80 90 100
FLTIHFPTDY PFKPPKVAFT TRIYHPNINS NGSICLDILR SQWSPALTIS
110 120 130 140
KVLLSICSLL CDPNPDDPLV PEIARIYKTD REKYNRIARE WTQKYAM
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0R4IK31 | A0A0R4IK31_DANRE | Ubiquitin-conjugating enzyme E2D 2 ... | ube2d2 | 29 | Annotation score: | ||
A0A0R4IN97 | A0A0R4IN97_DANRE | Ubiquitin-conjugating enzyme E2D 2 ... | ube2d2 | 46 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU469522 Genomic DNA No translation available. CU570692 Genomic DNA No translation available. LO017652 Genomic DNA No translation available. BC048896 mRNA Translation: AAH48896.1 BC065678 mRNA Translation: AAH65678.1 BC164949 mRNA Translation: AAI64949.1 |
RefSeqi | NP_957253.1, NM_200959.2 |
Genome annotation databases
Ensembli | ENSDART00000063837; ENSDARP00000063836; ENSDARG00000043484 |
GeneIDi | 393934 |
KEGGi | dre:393934 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU469522 Genomic DNA No translation available. CU570692 Genomic DNA No translation available. LO017652 Genomic DNA No translation available. BC048896 mRNA Translation: AAH48896.1 BC065678 mRNA Translation: AAH65678.1 BC164949 mRNA Translation: AAI64949.1 |
RefSeqi | NP_957253.1, NM_200959.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000063836 |
Genome annotation databases
Ensembli | ENSDART00000063837; ENSDARP00000063836; ENSDARG00000043484 |
GeneIDi | 393934 |
KEGGi | dre:393934 |
Organism-specific databases
CTDi | 7322 |
ZFINi | ZDB-GENE-120312-1, ube2d2 |
Phylogenomic databases
GeneTreei | ENSGT00940000153169 |
HOGENOMi | CLU_030988_13_3_1 |
OMAi | QMDICLL |
OrthoDBi | 1337945at2759 |
TreeFami | TF101108 |
Enzyme and pathway databases
Reactomei | R-DRE-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DRE-201451, Signaling by BMP R-DRE-2173795, Downregulation of SMAD2/3:SMAD4 transcriptional activity R-DRE-8866654, E3 ubiquitin ligases ubiquitinate target proteins R-DRE-8951664, Neddylation R-DRE-9033241, Peroxisomal protein import R-DRE-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Gene expression databases
Bgeei | ENSDARG00000043484, Expressed in blastula and 32 other tissues |
Family and domain databases
CDDi | cd00195, UBCc, 1 hit |
Gene3Di | 3.10.110.10, 1 hit |
InterProi | View protein in InterPro IPR000608, UBQ-conjugat_E2 IPR023313, UBQ-conjugating_AS IPR016135, UBQ-conjugating_enzyme/RWD |
Pfami | View protein in Pfam PF00179, UQ_con, 1 hit |
SUPFAMi | SSF54495, SSF54495, 1 hit |
PROSITEi | View protein in PROSITE PS00183, UBC_1, 1 hit PS50127, UBC_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q7ZUK1_DANRE | |
Accessioni | Q7ZUK1Primary (citable) accession number: Q7ZUK1 Secondary accession number(s): F1R981 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 1, 2003 |
Last sequence update: | June 1, 2003 | |
Last modified: | January 19, 2022 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |