UniProtKB - Q7ZTI3 (RARAB_DANRE)
Retinoic acid receptor alpha-B
rarab
Functioni
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity).
Required for hindbrain development and, in lateral plate mesoderm, for specification of the pectoral fins.
By similarity1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 80 – 155 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 76 | |
Zinc fingeri | 83 – 103 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 119 – 138 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 20 |
GO - Molecular functioni
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: ZFIN
- nuclear receptor activity Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: ZFIN
- zinc ion binding Source: InterPro
GO - Biological processi
- cell differentiation Source: GO_Central
- heart development Source: ZFIN
- hormone-mediated signaling pathway Source: GO_Central
- liver development Source: ZFIN
- midbrain-hindbrain boundary development Source: ZFIN
- negative regulation of transcription by RNA polymerase II Source: ZFIN
- pectoral fin development Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- retinoic acid receptor signaling pathway Source: GO_Central
- secondary heart field specification Source: ZFIN
Keywordsi
Molecular function | DNA-binding, Receptor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-DRE-383280, Nuclear Receptor transcription pathway R-DRE-5362517, Signaling by Retinoic Acid |
SignaLinki | Q7ZTI3 |
Names & Taxonomyi
Protein namesi | Recommended name: Retinoic acid receptor alpha-BShort name: RAR-alpha-B Alternative name(s): Nuclear receptor subfamily 1 group B member 1-B Retinoic acid receptor alpha-2.B Short name: RAR-alpha-2.B |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-980526-72, rarab |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000262963 | 1 – 458 | Retinoic acid receptor alpha-BAdd BLAST | 458 |
Proteomic databases
PaxDbi | Q7ZTI3 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSDARG00000034893, Expressed in retina and 72 other tissues |
ExpressionAtlasi | Q7ZTI3, baseline |
Interactioni
Subunit structurei
Heterodimer; with an rxr molecule. Binds DNA preferentially as a rar/rxr heterodimer.
By similarityProtein-protein interaction databases
STRINGi | 7955.ENSDARP00000111644 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 178 – 412 | NR LBDPROSITE-ProRule annotationAdd BLAST | 235 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 79 | ModulatingSequence analysisAdd BLAST | 79 | |
Regioni | 48 – 75 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 156 – 177 | HingeSequence analysisAdd BLAST | 22 | |
Regioni | 411 – 458 | DisorderedSequence analysisAdd BLAST | 48 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 403 – 411 | 9aaTADBy similarity | 9 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 48 – 66 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 440 – 458 | Polar residuesSequence analysisAdd BLAST | 19 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 83 – 103 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 119 – 138 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 20 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000165576 |
InParanoidi | Q7ZTI3 |
OrthoDBi | 1165737at2759 |
PhylomeDBi | Q7ZTI3 |
TreeFami | TF328382 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR003078, Retinoic_acid_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01292, RETNOICACIDR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MYESVDVVGL TPSPNPFLSM DYYHQNRGCL IPDKGLVSGA ARGFRNPHWS
60 70 80 90 100
GSNHSVETQS TSSEEIVPSP PSPPPPPRVY KPCFVCQDKS SGYHYGVSAC
110 120 130 140 150
EGCKGFFRRS IQKNMVYTCH REKSCIINKV TRNRCQYCRL QKCLEVGMSK
160 170 180 190 200
ESVRNDRNKR KKDDKKQECL ENYVLSPDTE KMIEQVRKAH QETFPSLCQL
210 220 230 240 250
GKYTTNNSAD HRVALDVDLW DKFSELSTKC IIKTVEFAKQ LPGFTTLTIA
260 270 280 290 300
DQITLLKAAC LDILILRICT RYTPDQDTMT FSDGLTLNRT QMHNAGFGPL
310 320 330 340 350
TDLVFAFANQ LLPLEMDDAE TGLLSAICLL CGDRQDLEQS DKVDELQEPL
360 370 380 390 400
LEALKIYVRN RRPHKPHMFP KMLMKITDLR SISAKGAERV ITLKMEIPGS
410 420 430 440 450
MPPLIQEMLE NSEGLEGGGS KGAGGGGGGG GGKGAPPGSC SPSLSPSSAH
SSPSAHSP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7EZ95 | E7EZ95_DANRE | Retinoic acid receptor alpha b1 | rarab | 460 | Annotation score: | ||
A0A2R8Q393 | A0A2R8Q393_DANRE | Retinoic acid receptor alpha-B | rarab | 452 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 110 | S → T in AAA50050 (Ref. 1) Curated | 1 | |
Sequence conflicti | 424 | Missing in AAA50050 (Ref. 1) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L03399 mRNA Translation: AAA50050.1 BC049301 mRNA Translation: AAH49301.1 |
RefSeqi | NP_571474.1, NM_131399.1 |
Genome annotation databases
Ensembli | ENSDART00000044677; ENSDARP00000044676; ENSDARG00000034893 ENSDART00000189058; ENSDARP00000146437; ENSDARG00000111757 |
GeneIDi | 555364 |
KEGGi | dre:555364 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L03399 mRNA Translation: AAA50050.1 BC049301 mRNA Translation: AAH49301.1 |
RefSeqi | NP_571474.1, NM_131399.1 |
3D structure databases
SMRi | Q7ZTI3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000111644 |
Proteomic databases
PaxDbi | Q7ZTI3 |
Genome annotation databases
Ensembli | ENSDART00000044677; ENSDARP00000044676; ENSDARG00000034893 ENSDART00000189058; ENSDARP00000146437; ENSDARG00000111757 |
GeneIDi | 555364 |
KEGGi | dre:555364 |
Organism-specific databases
CTDi | 555364 |
ZFINi | ZDB-GENE-980526-72, rarab |
Phylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000165576 |
InParanoidi | Q7ZTI3 |
OrthoDBi | 1165737at2759 |
PhylomeDBi | Q7ZTI3 |
TreeFami | TF328382 |
Enzyme and pathway databases
Reactomei | R-DRE-383280, Nuclear Receptor transcription pathway R-DRE-5362517, Signaling by Retinoic Acid |
SignaLinki | Q7ZTI3 |
Miscellaneous databases
PROi | PR:Q7ZTI3 |
Gene expression databases
Bgeei | ENSDARG00000034893, Expressed in retina and 72 other tissues |
ExpressionAtlasi | Q7ZTI3, baseline |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR003078, Retinoic_acid_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01292, RETNOICACIDR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RARAB_DANRE | |
Accessioni | Q7ZTI3Primary (citable) accession number: Q7ZTI3 Secondary accession number(s): Q90272 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2006 |
Last sequence update: | June 1, 2003 | |
Last modified: | February 23, 2022 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families