UniProtKB - Q7ZTH9 (Q7ZTH9_DANRE)
Protein
Butyryl-CoA dehydrogenase
Gene
ivd
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Catalytic activityi
- 3-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]ARBA annotationEC:1.3.8.4ARBA annotation
- butanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]ARBA annotationEC:1.3.8.1ARBA annotation
Cofactori
FADUniRule annotationARBA annotation
: L-leucine degradation Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA.ARBA annotationProteins known to be involved in the 3 steps of the subpathway in this organism are:
- Butyryl-CoA dehydrogenase (ivd), Butyryl-CoA dehydrogenase (ivd), Butyryl-CoA dehydrogenase (ivd), Butyryl-CoA dehydrogenase (ivd)
- no protein annotated in this organism
- no protein annotated in this organism
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA, the pathway L-leucine degradation and in Amino-acid degradation.
GO - Molecular functioni
- butyryl-CoA dehydrogenase activity Source: UniProtKB-EC
- flavin adenine dinucleotide binding Source: UniProtKB-UniRule
- isovaleryl-CoA dehydrogenase activity Source: GO_Central
GO - Biological processi
- leucine catabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | OxidoreductaseUniRule annotationARBA annotation |
Ligand | FADUniRule annotationARBA annotation, Flavoprotein |
Enzyme and pathway databases
UniPathwayi | UPA00363;UER00860 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ivdImported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Organism-specific databases
ZFINi | ZDB-GENE-030616-262, ivd |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 40 – 154 | Acyl-CoA_dh_NInterPro annotationAdd BLAST | 115 | |
Domaini | 158 – 253 | Acyl-CoA_dh_MInterPro annotationAdd BLAST | 96 | |
Domaini | 265 – 412 | Acyl-CoA_dh_1InterPro annotationAdd BLAST | 148 |
Sequence similaritiesi
Keywords - Domaini
Transit peptideARBA annotationPhylogenomic databases
OrthoDBi | 589058at2759 |
Family and domain databases
CDDi | cd01156, IVD, 1 hit |
Gene3Di | 1.10.540.10, 1 hit |
InterProi | View protein in InterPro IPR006089, Acyl-CoA_DH_CS IPR006091, Acyl-CoA_Oxase/DH_cen-dom IPR036250, AcylCo_DH-like_C IPR009075, AcylCo_DH/oxidase_C IPR013786, AcylCoA_DH/ox_N IPR037069, AcylCoA_DH/ox_N_sf IPR009100, AcylCoA_DH/oxidase_NM_dom IPR034183, IVD |
Pfami | View protein in Pfam PF00441, Acyl-CoA_dh_1, 1 hit PF02770, Acyl-CoA_dh_M, 1 hit PF02771, Acyl-CoA_dh_N, 1 hit |
SUPFAMi | SSF47203, SSF47203, 1 hit SSF56645, SSF56645, 1 hit |
PROSITEi | View protein in PROSITE PS00072, ACYL_COA_DH_1, 1 hit PS00073, ACYL_COA_DH_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q7ZTH9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFAVRRALRV CQGVVKVSAG VSRRGCAGAV PVDDIVNGLT EEQIQLRQTV
60 70 80 90 100
QRFFQEKLAP YADEIDKKNE FPQMREFWKE MGDLGLLGVT APVEFGGTGL
110 120 130 140 150
GYLDHVIIME EISRVSAAIG LSYGAHSNLC VNQMVRHGNQ KQKEKYMPKL
160 170 180 190 200
LTGEHVGALA MSESNSGSDV VSMKLTAKKQ GDHYVLNGNK FWITNGSDAD
210 220 230 240 250
VLIVYAKTDP EAVARGITAF IVEKGMPGFS SAQKLDKLGM RGSSTCELVF
260 270 280 290 300
EDCKIPEENV LGPLNKGVYV LMSGLDLERL VLASGPVGIM QAVLDHAIPY
310 320 330 340 350
LHVREAFGQK IGHFQLMQGK MADMYTRLSS CRQYLYNVAR ACDKGHFSAK
360 370 380 390 400
DCAGVILYCA ENATQVALDG IQCLGGNGYI NDYPMGRFLR DAKLYEIGAG
410
TSEIRRIIIG RSSNAMFK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC045426 mRNA Translation: AAH45426.1 BC164520 mRNA Translation: AAI64520.1 |
RefSeqi | NP_958899.1, NM_201491.1 |
Genome annotation databases
GeneIDi | 368775 |
KEGGi | dre:368775 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC045426 mRNA Translation: AAH45426.1 BC164520 mRNA Translation: AAI64520.1 |
RefSeqi | NP_958899.1, NM_201491.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
GeneIDi | 368775 |
KEGGi | dre:368775 |
Organism-specific databases
CTDi | 3712 |
ZFINi | ZDB-GENE-030616-262, ivd |
Phylogenomic databases
OrthoDBi | 589058at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00363;UER00860 |
Family and domain databases
CDDi | cd01156, IVD, 1 hit |
Gene3Di | 1.10.540.10, 1 hit |
InterProi | View protein in InterPro IPR006089, Acyl-CoA_DH_CS IPR006091, Acyl-CoA_Oxase/DH_cen-dom IPR036250, AcylCo_DH-like_C IPR009075, AcylCo_DH/oxidase_C IPR013786, AcylCoA_DH/ox_N IPR037069, AcylCoA_DH/ox_N_sf IPR009100, AcylCoA_DH/oxidase_NM_dom IPR034183, IVD |
Pfami | View protein in Pfam PF00441, Acyl-CoA_dh_1, 1 hit PF02770, Acyl-CoA_dh_M, 1 hit PF02771, Acyl-CoA_dh_N, 1 hit |
SUPFAMi | SSF47203, SSF47203, 1 hit SSF56645, SSF56645, 1 hit |
PROSITEi | View protein in PROSITE PS00072, ACYL_COA_DH_1, 1 hit PS00073, ACYL_COA_DH_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q7ZTH9_DANRE | |
Accessioni | Q7ZTH9Primary (citable) accession number: Q7ZTH9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 1, 2003 |
Last sequence update: | June 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |