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Protein

Metallothionein-2

Gene

mt2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi4Divalent metal cation; cluster B1
Metal bindingi6Divalent metal cation; cluster B1
Metal bindingi12Divalent metal cation; cluster B1
Metal bindingi14Divalent metal cation; cluster B1
Metal bindingi18Divalent metal cation; cluster B1
Metal bindingi20Divalent metal cation; cluster B1
Metal bindingi23Divalent metal cation; cluster B1
Metal bindingi25Divalent metal cation; cluster B1
Metal bindingi28Divalent metal cation; cluster B1
Metal bindingi32Divalent metal cation; cluster A1
Metal bindingi33Divalent metal cation; cluster A1
Metal bindingi35Divalent metal cation; cluster A1
Metal bindingi36Divalent metal cation; cluster A1
Metal bindingi40Divalent metal cation; cluster A1
Metal bindingi43Divalent metal cation; cluster A1
Metal bindingi47Divalent metal cation; cluster A1
Metal bindingi49Divalent metal cation; cluster A1
Metal bindingi54Divalent metal cation; cluster A1
Metal bindingi58Divalent metal cation; cluster A1
Metal bindingi59Divalent metal cation; cluster A1

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: ZFIN
  • positive regulation of cell migration involved in sprouting angiogenesis Source: ZFIN
  • positive regulation of vascular endothelial growth factor production Source: ZFIN
  • response to cadmium ion Source: ZFIN
  • response to copper ion Source: ZFIN
  • response to metal ion Source: ZFIN
  • response to methylmercury Source: ZFIN
  • response to zinc ion Source: ZFIN

Keywordsi

LigandMetal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-2
Short name:
MT-2
Gene namesi
Name:mt2
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 18

Organism-specific databases

ZFINiZDB-GENE-030131-4174 mt2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001972691 – 60Metallothionein-2Add BLAST60

Proteomic databases

PaxDbiQ7ZSY6
PRIDEiQ7ZSY6

Expressioni

Developmental stagei

Expressed both maternally and zygotically. Expressed ubiquitously during early embryogenesis, but becomes localized to the tail region during segmentation. During early larval development, expressed in discrete areas including the pronephric region, retina and cerebellum.1 Publication

Inductioni

By zinc ions.1 Publication

Gene expression databases

BgeeiENSDARG00000041623
ExpressionAtlasiQ7ZSY6 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000061006

Structurei

3D structure databases

ProteinModelPortaliQ7ZSY6
SMRiQ7ZSY6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 28BetaAdd BLAST28
Regioni29 – 60AlphaAdd BLAST32

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00730000112385
HOVERGENiHBG009063
InParanoidiQ7ZSY6
KOiK14739
OMAiVCKGEEG
OrthoDBiEOG09370XFE

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
IPR018064 Metalthion_vert_metal_BS
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit
PROSITEiView protein in PROSITE
PS00203 METALLOTHIONEIN_VRT, 1 hit

Sequencei

Sequence statusi: Complete.

Q7ZSY6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPCECAKTG TCNCGATCKC TNCQCTTCKK SCCSCCPSGC SKCASGCVCK
60
GNSCGSSCCQ
Length:60
Mass (Da):5,976
Last modified:June 1, 2003 - v1
Checksum:iE5388E7C378BB700
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY305851 Genomic DNA Translation: AAP73739.1
AY514790 mRNA Translation: AAS00513.1
AY514791 Genomic DNA Translation: AAS00514.1
BC049475 mRNA Translation: AAH49475.1
BC051612 mRNA Translation: AAH51612.1
RefSeqiNP_001124525.2, NM_001131053.2
UniGeneiDr.121290

Genome annotation databases

EnsembliENSDART00000061007; ENSDARP00000061006; ENSDARG00000041623
ENSDART00000186782; ENSDARP00000148298; ENSDARG00000113583
GeneIDi100174951
KEGGidre:100174951

Similar proteinsi

Entry informationi

Entry nameiMT2_DANRE
AccessioniPrimary (citable) accession number: Q7ZSY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: June 1, 2003
Last modified: June 20, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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