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Protein

Cyanide hydratase

Gene

CyhAB

Organism
Alternaria brassicicola (Dark leaf spot agent)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the hydration of cyanide to formamide. Degradation of cyanide may be important for plant pathogenic fungi in infection of cyanogenic plants.UniRule annotation

Catalytic activityi

Formamide = cyanide + H2O.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei46Proton acceptorPROSITE-ProRule annotation1
Active sitei128PROSITE-ProRule annotation1
Active sitei163NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Lyase

Names & Taxonomyi

Protein namesi
Recommended name:
Cyanide hydrataseUniRule annotation (EC:4.2.1.66UniRule annotation)
Short name:
CHTUniRule annotation
Alternative name(s):
Cyanide-degrading nitrilaseUniRule annotation
Formamide hydrolyaseUniRule annotation
Gene namesi
Name:CyhAB
OrganismiAlternaria brassicicola (Dark leaf spot agent)
Taxonomic identifieri29001 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaeAlternaria

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004400291 – 363Cyanide hydrataseAdd BLAST363

Expressioni

Inductioni

By cyanide (By similarity). Expressed on the host leaf surface in late stages of fungal infection.UniRule annotation1 Publication

Interactioni

Subunit structurei

Oligomer of dimers, forming left-handed helical fibers.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ7Z8M6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 285CN hydrolasePROSITE-ProRule annotationAdd BLAST280

Sequence similaritiesi

Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.UniRule annotation

Family and domain databases

Gene3Di3.60.110.10, 1 hit
HAMAPiMF_03224 CN_hydrolase, 1 hit
InterProiView protein in InterPro
IPR003010 C-N_Hydrolase
IPR036526 C-N_Hydrolase_sf
IPR037544 CN_hydrolase
IPR000132 Nitrilase/CN_hydratase_CS
PfamiView protein in Pfam
PF00795 CN_hydrolase, 1 hit
SUPFAMiSSF56317 SSF56317, 1 hit
PROSITEiView protein in PROSITE
PS50263 CN_HYDROLASE, 1 hit
PS00920 NITRIL_CHT_1, 1 hit
PS00921 NITRIL_CHT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7Z8M6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLTKYKAAC VTSEPCWFDL EAGVQKTINF INEAGAAGCK LIAFPEVWIP
60 70 80 90 100
GYPYWMWKIN YQQSLPMLKS YRENSLPMDS EEFRRIRRAA RDNQIYVSLG
110 120 130 140 150
FSEIDHATLY LAQALIGPTG EVINHRRKIK PTHVEKLVYG DGAGDTFKSV
160 170 180 190 200
TQTELGRLGQ LNCWENMNPF LKALNVSEGE QIHIAAWPVY PGKETLKYPD
210 220 230 240 250
PATNVADPAS DLVTPAYAIE TGTWTLAPFQ RLSVEGLKKT TPEGVEPETD
260 270 280 290 300
PSTYNGHARI YKPDGTLVCK PDKDFDGLLF VDIDLNECHL AKALADFSGH
310 320 330 340 350
YMRPDLIRLL VDTRRKELIT EADTNGGIAT YTTRERLGLN IPLDAQAPKQ
360
KATAADVPSS SVM
Length:363
Mass (Da):40,469
Last modified:October 1, 2003 - v1
Checksum:i6D7E25334506C010
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY325811 mRNA Translation: AAP88966.1

Similar proteinsi

Entry informationi

Entry nameiCHT_ALTBR
AccessioniPrimary (citable) accession number: Q7Z8M6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2017
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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