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UniProtKB - Q7Z7Q0 (Q7Z7Q0_HUMAN)

Entry version 78 (17 Jun 2020)
Sequence version 1 (01 Oct 2003)
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Protein
Submitted name:

APOB protein

Gene

APOB

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
APOB proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:APOBImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA50

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500429694525 – 825Sequence analysisAdd BLAST801

Proteomic databases

PeptideAtlas

More...PeptideAtlasi		Q7Z7Q0

PRoteomics IDEntifications database

More...PRIDEi		Q7Z7Q0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q7Z7Q0 HS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 669VitellogeninInterPro annotationAdd BLAST627

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili598 – 618Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4338 Eukaryota
ENOG411104F LUCA

KEGG Orthology (KO)

More...KOi		K14462

Database of Orthologous Groups

More...OrthoDBi		5350at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR015819 Lipid_transp_b-sht_shell
IPR001747 Lipid_transpt_N
IPR011030 Lipovitellin_superhlx_dom
IPR015255 Vitellinogen_open_b-sht

Pfam protein domain database

More...Pfami		View protein in Pfam
PF09172 DUF1943, 1 hit
PF01347 Vitellogenin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01169 DUF1943, 1 hit
SM00638 LPD_N, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48431 SSF48431, 1 hit
SSF56968 SSF56968, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51211 VITELLOGENIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7Z7Q0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPPRPALLA LPALLLLLLA GARAEEEMLE NVSLVCPKDA TRFKHLRKYT 
        60         70         80         90        100
YNYEAESSSG VPGTADSRSA TRINCKVELE VPQLCSFILK TSQCILKEVY 
       110        120        130        140        150
GFNPEGKALL KKTKNSEEFA AAMSRYELKL AIPEGKQVFL YPEKDEPTYI 
       160        170        180        190        200
LNIKRGIISA LLVPPETEEA KQVLFLDTVY GNCSTHFTVK TRKGNVATEI 
       210        220        230        240        250
STERDLGQCD RFKPIRTGIS PLALIKGMTR PLSTLISSSQ SCQYTLDAKR 
       260        270        280        290        300
KHVAEAICKE QHLFLPFSYK NKYGMVAQVT QTLKLEDTPK INSRFFGEGT 
       310        320        330        340        350
KKMGLAFEST KSTSPPKQAE AVLKTLQELK KLTISEQNIQ RANLFNKLVT 
       360        370        380        390        400
ELRGLSDEAV TSLLPQLIEV SSPITLQALV QCGQPQCSTH ILQWLKRVHA 
       410        420        430        440        450
NPLLIDVVTY LVALIPEPSA QQLREIFNMA RDQRSRATLY ALSHAVNNYH 
       460        470        480        490        500
KTNPTGTQEL LDIANYLMEQ IQDDCTGDED YTYLILRVIG NMGQTMEQLT 
       510        520        530        540        550
PELKSSILKC VQSTKPSLMI QKAAIQALRK MEPKDKDQEV LLQTFLDDAS 
       560        570        580        590        600
PGDKRLAAYL MLMRSPSQAD INKIVQILPW EQNEQVKNFV ASHIANILNS 
       610        620        630        640        650
EELDIQDLKK LVKEALKESQ LPTVMDFRKF SRNYQLYKSV SLPSLDPASA 
       660        670        680        690        700
KIEGNLIFDP NNYLPKESML KTTLTAFGFA SADLIEIGLE GKGFEPTLEA 
       710        720        730        740        750
LFGKQGFFPD SVNKALYWVN GQVPDGVSKV LVDHFGYTKD DKHEQDMVNG 
       760        770        780        790        800
IMLSVEKLIK DLKSKEVPEA RAYLRILGEE LGFASLHDLQ LLGKLLLMDR 
       810        820 
PDSLTIPAAQ ARKDACTFFR DGGLP
Length:825
Mass (Da):92,334
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9004A128F9E6338E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC051278 mRNA Translation: AAH51278.1

NCBI Reference Sequences

More...RefSeqi		NP_000375.2, NM_000384.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		338

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:338

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC051278 mRNA Translation: AAH51278.1
RefSeqiNP_000375.2, NM_000384.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

PeptideAtlasiQ7Z7Q0
PRIDEiQ7Z7Q0

Genome annotation databases

GeneIDi338
KEGGihsa:338

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		338
PharmGKBiPA50

Phylogenomic databases

eggNOGiKOG4338 Eukaryota
ENOG411104F LUCA
KOiK14462
OrthoDBi5350at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		338 1 hit in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		APOB human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		338

Gene expression databases

GenevisibleiQ7Z7Q0 HS

Family and domain databases

Gene3Di1.25.10.20, 1 hit
InterProiView protein in InterPro
IPR015819 Lipid_transp_b-sht_shell
IPR001747 Lipid_transpt_N
IPR011030 Lipovitellin_superhlx_dom
IPR015255 Vitellinogen_open_b-sht
PfamiView protein in Pfam
PF09172 DUF1943, 1 hit
PF01347 Vitellogenin_N, 1 hit
SMARTiView protein in SMART
SM01169 DUF1943, 1 hit
SM00638 LPD_N, 1 hit
SUPFAMiSSF48431 SSF48431, 1 hit
SSF56968 SSF56968, 2 hits
PROSITEiView protein in PROSITE
PS51211 VITELLOGENIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7Z7Q0_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z7Q0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: June 17, 2020
This is version 78 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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