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Protein

Zinc finger and SCAN domain-containing protein 2

Gene

ZSCAN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 244C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri558 – 580C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri586 – 608C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Spermatogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 2
Alternative name(s):
Zinc finger protein 29 homolog
Short name:
Zfp-29
Zinc finger protein 854
Gene namesi
Name:ZSCAN2
Synonyms:ZFP29, ZNF854
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000176371.13
HGNCiHGNC:20994 ZSCAN2
neXtProtiNX_Q7Z7L9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176371
PharmGKBiPA134941325

Polymorphism and mutation databases

BioMutaiZSCAN2
DMDMi296453062

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477491 – 614Zinc finger and SCAN domain-containing protein 2Add BLAST614

Proteomic databases

EPDiQ7Z7L9
MaxQBiQ7Z7L9
PaxDbiQ7Z7L9
PeptideAtlasiQ7Z7L9
PRIDEiQ7Z7L9
ProteomicsDBi69564
69565 [Q7Z7L9-3]
69566 [Q7Z7L9-4]

PTM databases

iPTMnetiQ7Z7L9
PhosphoSitePlusiQ7Z7L9

Expressioni

Gene expression databases

BgeeiENSG00000176371 Expressed in 173 organ(s), highest expression level in female gonad
CleanExiHS_ZSCAN2
ExpressionAtlasiQ7Z7L9 baseline and differential
GenevisibleiQ7Z7L9 HS

Organism-specific databases

HPAiHPA007296
HPA024331

Interactioni

Protein-protein interaction databases

BioGridi120326, 1 interactor
IntActiQ7Z7L9, 1 interactor
STRINGi9606.ENSP00000410198

Structurei

3D structure databases

ProteinModelPortaliQ7Z7L9
SMRiQ7Z7L9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 132SCAN boxPROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 244C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri558 – 580C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri586 – 608C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000148970
HOGENOMiHOG000234619
HOVERGENiHBG066767
InParanoidiQ7Z7L9
KOiK09230
OMAiHRRTHLV
OrthoDBiEOG091G02KC
PhylomeDBiQ7Z7L9
TreeFamiTF337913

Family and domain databases

Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 14 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q7Z7L9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMAADIPRVT TPLSSLVQVP QEEDRQEEEV TTMILEDDSW VQEAVLQEDG
60 70 80 90 100
PESEPFPQSA GKGGPQEEVT RGPQGALGRL RELCRRWLRP EVHTKEQMLT
110 120 130 140 150
MLPKEIQAWL QEHRPESSEE AAALVEDLTQ TLQDSDFEIQ SENGENCNQD
160 170 180 190 200
MFENESRKIF SEMPEGESAQ HSDGESDFER DAGIQRLQGH SPGEDHGEVV
210 220 230 240 250
SQDREVGQLI GLQGTYLGEK PYECPQCGKT FSRKSHLITH ERTHTGEKYY
260 270 280 290 300
KCDECGKSFS DGSNFSRHQT THTGEKPYKC RDCGKSFSRS ANLITHQRIH
310 320 330 340 350
TGEKPFQCAE CGKSFSRSPN LIAHQRTHTG EKPYSCPECG KSFGNRSSLN
360 370 380 390 400
THQGIHTGEK PYECKECGES FSYNSNLIRH QRIHTGEKPY KCTDCGQRFS
410 420 430 440 450
QSSALITHRR THTGEKPYQC SECGKSFSRS SNLATHRRTH MVEKPYKCGV
460 470 480 490 500
CGKSFSQSSS LIAHQGMHTG EKPYECLTCG ESFSWSSNLL KHQRIHTGEK
510 520 530 540 550
PYKCSECGKC FSQRSQLVVH QRTHTGEKPY KCLMCGKSFS RGSILVMHQR
560 570 580 590 600
AHLGDKPYRC PECGKGFSWN SVLIIHQRIH TGEKPYKCPE CGKGFSNSSN
610
FITHQRTHMK EKLY
Length:614
Mass (Da):69,547
Last modified:May 18, 2010 - v2
Checksum:iEF36B0199D575D03
GO
Isoform 3 (identifier: Q7Z7L9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-150: DFEIQSENGENCNQD → AVAVVASLPVEVTSL
     151-614: Missing.

Show »
Length:150
Mass (Da):16,697
Checksum:iE0EBCB4A7672160D
GO
Isoform 4 (identifier: Q7Z7L9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-146: DFEIQSENGEN → ETASCVHGCPV
     147-614: Missing.

Note: No experimental confirmation available.
Show »
Length:146
Mass (Da):16,344
Checksum:iFEA520C6A210B7A2
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DFQ3A0A0C4DFQ3_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN2
613Annotation score:
F5H3F3F5H3F3_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN2
238Annotation score:
F5GZ04F5GZ04_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN2
210Annotation score:
F5GY18F5GY18_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN2
200Annotation score:
F5H4P1F5H4P1_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN2
107Annotation score:
F8W6Y9F8W6Y9_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN2
464Annotation score:
F5H789F5H789_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN2
53Annotation score:
F5H1K4F5H1K4_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN2
32Annotation score:
F5H2D8F5H2D8_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN2
27Annotation score:

Sequence cautioni

The sequence BAC87537 differs from that shown. Reason: Erroneous translation. Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti135 – 136SD → N in AAP36989 (Ref. 1) Curated2
Isoform 3 (identifier: Q7Z7L9-3)
Sequence conflicti140V → F in BAA91283 (PubMed:14702039).Curated1
Sequence conflicti140V → F in AAH41620 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_065095191S → T2 PublicationsCorresponds to variant dbSNP:rs2044502Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011947136 – 150DFEIQ…NCNQD → AVAVVASLPVEVTSL in isoform 3. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_040201136 – 146DFEIQSENGEN → ETASCVHGCPV in isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_040202147 – 614Missing in isoform 4. 1 PublicationAdd BLAST468
Alternative sequenceiVSP_011948151 – 614Missing in isoform 3. 2 PublicationsAdd BLAST464

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY262259 mRNA Translation: AAP36989.1
AK000602 mRNA Translation: BAA91283.1
AK128624 mRNA Translation: BAC87537.1 Sequence problems.
AY279349 mRNA Translation: AAQ62846.1
AC048382 Genomic DNA No translation available.
BC041620 mRNA Translation: AAH41620.1
BC136342 mRNA Translation: AAI36343.1
CCDSiCCDS10329.2 [Q7Z7L9-1]
CCDS32315.1 [Q7Z7L9-4]
CCDS32316.1 [Q7Z7L9-3]
RefSeqiNP_001007073.1, NM_001007072.1 [Q7Z7L9-4]
NP_060364.4, NM_017894.5 [Q7Z7L9-3]
NP_870992.2, NM_181877.3 [Q7Z7L9-1]
UniGeneiHs.594023

Genome annotation databases

EnsembliENST00000334141; ENSP00000333895; ENSG00000176371 [Q7Z7L9-3]
ENST00000379358; ENSP00000368663; ENSG00000176371 [Q7Z7L9-4]
ENST00000448803; ENSP00000410198; ENSG00000176371 [Q7Z7L9-1]
ENST00000540894; ENSP00000441855; ENSG00000176371 [Q7Z7L9-1]
ENST00000546148; ENSP00000445451; ENSG00000176371 [Q7Z7L9-1]
GeneIDi54993
KEGGihsa:54993
UCSCiuc002bkp.4 human [Q7Z7L9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZSCA2_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7L9
Secondary accession number(s): A6NG83
, B2RMQ9, Q6ZQY9, Q9NWU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: May 18, 2010
Last modified: September 12, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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