UniProtKB - Q7Z7L9 (ZSCA2_HUMAN)

BLAST

>sp|Q7Z7L9|ZSCA2_HUMAN Zinc finger and SCAN domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ZSCAN2 PE=2 SV=2
MMAADIPRVTTPLSSLVQVPQEEDRQEEEVTTMILEDDSWVQEAVLQEDGPESEPFPQSA
GKGGPQEEVTRGPQGALGRLRELCRRWLRPEVHTKEQMLTMLPKEIQAWLQEHRPESSEE
AAALVEDLTQTLQDSDFEIQSENGENCNQDMFENESRKIFSEMPEGESAQHSDGESDFER
DAGIQRLQGHSPGEDHGEVVSQDREVGQLIGLQGTYLGEKPYECPQCGKTFSRKSHLITH
ERTHTGEKYYKCDECGKSFSDGSNFSRHQTTHTGEKPYKCRDCGKSFSRSANLITHQRIH
TGEKPFQCAECGKSFSRSPNLIAHQRTHTGEKPYSCPECGKSFGNRSSLNTHQGIHTGEK
PYECKECGESFSYNSNLIRHQRIHTGEKPYKCTDCGQRFSQSSALITHRRTHTGEKPYQC
SECGKSFSRSSNLATHRRTHMVEKPYKCGVCGKSFSQSSSLIAHQGMHTGEKPYECLTCG
ESFSWSSNLLKHQRIHTGEKPYKCSECGKCFSQRSQLVVHQRTHTGEKPYKCLMCGKSFS
RGSILVMHQRAHLGDKPYRCPECGKGFSWNSVLIIHQRIHTGEKPYKCPECGKGFSNSSN
FITHQRTHMKEKLY

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History
Entry version 140 (12 Sep 2018)
Sequence version 2 (18 May 2010)
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Protein

Zinc finger and SCAN domain-containing protein 2

Gene

ZSCAN2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	222 – 244	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	250 – 272	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	278 – 300	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	306 – 328	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	334 – 356	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	362 – 384	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	390 – 412	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	418 – 440	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	446 – 468	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	474 – 496	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	502 – 524	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	530 – 552	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	558 – 580	C2H2-type 13PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	586 – 608	C2H2-type 14PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation Source: UniProtKB-KW
multicellular organism development Source: UniProtKB-KW
spermatogenesis Source: UniProtKB-KW
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Differentiation, Spermatogenesis, Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger and SCAN domain-containing protein 2 Alternative name(s): Zinc finger protein 29 homolog Short name: Zfp-29 Zinc finger protein 854
Gene namesⁱ	Name:ZSCAN2 Synonyms:ZFP29, ZNF854
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000176371.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20994 ZSCAN2
neXtProtⁱ	NX_Q7Z7L9

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000176371
PharmGKBⁱ	PA134941325

Polymorphism and mutation databases

BioMutaⁱ	ZSCAN2
DMDMⁱ	296453062

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047749	1 – 614	Zinc finger and SCAN domain-containing protein 2Add BLAST		614

Proteomic databases

EPDⁱ	Q7Z7L9
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q7Z7L9
PaxDbⁱ	Q7Z7L9
PeptideAtlas More...PeptideAtlasⁱ	Q7Z7L9
PRIDEⁱ	Q7Z7L9
ProteomicsDBⁱ	69564 69565 [Q7Z7L9-3] 69566 [Q7Z7L9-4]

PTM databases

iPTMnetⁱ	Q7Z7L9
PhosphoSitePlusⁱ	Q7Z7L9

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000176371 Expressed in 173 organ(s), highest expression level in female gonad
CleanExⁱ	HS_ZSCAN2
ExpressionAtlasⁱ	Q7Z7L9 baseline and differential
Genevisibleⁱ	Q7Z7L9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA007296 HPA024331

HPAⁱ

HPA007296
HPA024331

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	120326, 1 interactor
IntActⁱ	Q7Z7L9, 1 interactor
STRINGⁱ	9606.ENSP00000410198

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q7Z7L9
SMRⁱ	Q7Z7L9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	59 – 132	SCAN boxPROSITE-ProRule annotationAdd BLAST		74

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	222 – 244	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	250 – 272	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	278 – 300	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	306 – 328	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	334 – 356	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	362 – 384	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	390 – 412	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	418 – 440	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	446 – 468	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	474 – 496	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	502 – 524	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	530 – 552	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	558 – 580	C2H2-type 13PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	586 – 608	C2H2-type 14PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148970
HOGENOMⁱ	HOG000234619
HOVERGENⁱ	HBG066767
InParanoidⁱ	Q7Z7L9
KEGG Orthology (KO) More...KOⁱ	K09230
OMAⁱ	HRRTHLV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	Q7Z7L9
TreeFamⁱ	TF337913

Family and domain databases

Gene3Dⁱ	1.10.4020.10, 1 hit
InterProⁱ	View protein in InterPro IPR003309 SCAN_dom IPR038269 SCAN_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02023 SCAN, 1 hit
SMARTⁱ	View protein in SMART SM00431 SCAN, 1 hit SM00355 ZnF_C2H2, 14 hits
SUPFAMⁱ	SSF57667 SSF57667, 9 hits
PROSITEⁱ	View protein in PROSITE PS50804 SCAN_BOX, 1 hit PS00028 ZINC_FINGER_C2H2_1, 14 hits PS50157 ZINC_FINGER_C2H2_2, 14 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: Q7Z7L9-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMAADIPRVT TPLSSLVQVP QEEDRQEEEV TTMILEDDSW VQEAVLQEDG 
        60         70         80         90        100
PESEPFPQSA GKGGPQEEVT RGPQGALGRL RELCRRWLRP EVHTKEQMLT 
       110        120        130        140        150
MLPKEIQAWL QEHRPESSEE AAALVEDLTQ TLQDSDFEIQ SENGENCNQD 
       160        170        180        190        200
MFENESRKIF SEMPEGESAQ HSDGESDFER DAGIQRLQGH SPGEDHGEVV 
       210        220        230        240        250
SQDREVGQLI GLQGTYLGEK PYECPQCGKT FSRKSHLITH ERTHTGEKYY 
       260        270        280        290        300
KCDECGKSFS DGSNFSRHQT THTGEKPYKC RDCGKSFSRS ANLITHQRIH 
       310        320        330        340        350
TGEKPFQCAE CGKSFSRSPN LIAHQRTHTG EKPYSCPECG KSFGNRSSLN 
       360        370        380        390        400
THQGIHTGEK PYECKECGES FSYNSNLIRH QRIHTGEKPY KCTDCGQRFS 
       410        420        430        440        450
QSSALITHRR THTGEKPYQC SECGKSFSRS SNLATHRRTH MVEKPYKCGV 
       460        470        480        490        500
CGKSFSQSSS LIAHQGMHTG EKPYECLTCG ESFSWSSNLL KHQRIHTGEK 
       510        520        530        540        550
PYKCSECGKC FSQRSQLVVH QRTHTGEKPY KCLMCGKSFS RGSILVMHQR 
       560        570        580        590        600
AHLGDKPYRC PECGKGFSWN SVLIIHQRIH TGEKPYKCPE CGKGFSNSSN 
       610 
FITHQRTHMK EKLY

Length:614

Mass (Da):69,547

Last modified:May 18, 2010 - v2

Checksum:ⁱEF36B0199D575D03

Isoform 3 (identifier: Q7Z7L9-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
136-150: DFEIQSENGENCNQD → AVAVVASLPVEVTSL
151-614: Missing.

« Hide

        10         20         30         40         50
MMAADIPRVT TPLSSLVQVP QEEDRQEEEV TTMILEDDSW VQEAVLQEDG 
        60         70         80         90        100
PESEPFPQSA GKGGPQEEVT RGPQGALGRL RELCRRWLRP EVHTKEQMLT 
       110        120        130        140        150
MLPKEIQAWL QEHRPESSEE AAALVEDLTQ TLQDSAVAVV ASLPVEVTSL

Show »

Length:150

Mass (Da):16,697

Checksum:ⁱE0EBCB4A7672160D

Isoform 4 (identifier: Q7Z7L9-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
136-146: DFEIQSENGEN → ETASCVHGCPV
147-614: Missing.

« Hide

        10         20         30         40         50
MMAADIPRVT TPLSSLVQVP QEEDRQEEEV TTMILEDDSW VQEAVLQEDG 
        60         70         80         90        100
PESEPFPQSA GKGGPQEEVT RGPQGALGRL RELCRRWLRP EVHTKEQMLT 
       110        120        130        140 
MLPKEIQAWL QEHRPESSEE AAALVEDLTQ TLQDSETASC VHGCPV

Note: No experimental confirmation available.

Show »

Length:146

Mass (Da):16,344

Checksum:ⁱFEA520C6A210B7A2

Computationally mapped potential isoform sequencesⁱ

There are 9 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
A0A0C4DFQ3	A0A0C4DFQ3_HUMAN	Zinc finger and SCAN domain-contain... Zinc finger and SCAN domain-containing protein 2	ZSCAN2	613	Annotation score:
F5H3F3	F5H3F3_HUMAN	Zinc finger and SCAN domain-contain... Zinc finger and SCAN domain-containing protein 2	ZSCAN2	238	Annotation score:
F5GZ04	F5GZ04_HUMAN	Zinc finger and SCAN domain-contain... Zinc finger and SCAN domain-containing protein 2	ZSCAN2	210	Annotation score:
F5GY18	F5GY18_HUMAN	Zinc finger and SCAN domain-contain... Zinc finger and SCAN domain-containing protein 2	ZSCAN2	200	Annotation score:
F5H4P1	F5H4P1_HUMAN	Zinc finger and SCAN domain-contain... Zinc finger and SCAN domain-containing protein 2	ZSCAN2	107	Annotation score:
F8W6Y9	F8W6Y9_HUMAN	Zinc finger and SCAN domain-contain... Zinc finger and SCAN domain-containing protein 2	ZSCAN2	464	Annotation score:
F5H789	F5H789_HUMAN	Zinc finger and SCAN domain-contain... Zinc finger and SCAN domain-containing protein 2	ZSCAN2	53	Annotation score:
F5H1K4	F5H1K4_HUMAN	Zinc finger and SCAN domain-contain... Zinc finger and SCAN domain-containing protein 2	ZSCAN2	32	Annotation score:
F5H2D8	F5H2D8_HUMAN	Zinc finger and SCAN domain-contain... Zinc finger and SCAN domain-containing protein 2	ZSCAN2	27	Annotation score:

Sequence cautionⁱ

The sequence BAC87537 differs from that shown. Reason: Erroneous translation. Aberrant splicing.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	135 – 136	SD → N in AAP36989 (Ref. 1) Curated	2
Isoform 3 (identifier: Q7Z7L9-3)
Sequence conflictⁱ	140	V → F in BAA91283 (PubMed:14702039).Curated	1
Sequence conflictⁱ	140	V → F in AAH41620 (PubMed:15489334).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_065095	191	S → T2 PublicationsCorresponds to variant dbSNP:rs2044502Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_011947	136 – 150	DFEIQ…NCNQD → AVAVVASLPVEVTSL in isoform 3. 2 PublicationsAdd BLAST	15
Alternative sequenceⁱVSP_040201	136 – 146	DFEIQSENGEN → ETASCVHGCPV in isoform 4. 1 PublicationAdd BLAST	11
Alternative sequenceⁱVSP_040202	147 – 614	Missing in isoform 4. 1 PublicationAdd BLAST	468
Alternative sequenceⁱVSP_011948	151 – 614	Missing in isoform 3. 2 PublicationsAdd BLAST	464

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY262259 mRNA Translation: AAP36989.1 AK000602 mRNA Translation: BAA91283.1 AK128624 mRNA Translation: BAC87537.1 Sequence problems. AY279349 mRNA Translation: AAQ62846.1 AC048382 Genomic DNA No translation available. BC041620 mRNA Translation: AAH41620.1 BC136342 mRNA Translation: AAI36343.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10329.2 [Q7Z7L9-1] CCDS32315.1 [Q7Z7L9-4] CCDS32316.1 [Q7Z7L9-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001007073.1, NM_001007072.1 [Q7Z7L9-4] NP_060364.4, NM_017894.5 [Q7Z7L9-3] NP_870992.2, NM_181877.3 [Q7Z7L9-1]
UniGeneⁱ	Hs.594023

Genome annotation databases

Ensemblⁱ	ENST00000334141; ENSP00000333895; ENSG00000176371 [Q7Z7L9-3] ENST00000379358; ENSP00000368663; ENSG00000176371 [Q7Z7L9-4] ENST00000448803; ENSP00000410198; ENSG00000176371 [Q7Z7L9-1] ENST00000540894; ENSP00000441855; ENSG00000176371 [Q7Z7L9-1] ENST00000546148; ENSP00000445451; ENSG00000176371 [Q7Z7L9-1]
GeneIDⁱ	54993
KEGGⁱ	hsa:54993
UCSC genome browser More...UCSCⁱ	uc002bkp.4 human [Q7Z7L9-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q7Z7L9	zinc finger and SCAN domain-containing protein 2		Florida manatee		615	UniRef90_Q7Z7L9
Zinc finger and SCAN domain containing 2		PIG		615
zinc finger and SCAN domain-containing protein 2 isoform X1		TARSY		615
Zinc finger and SCAN domain-containing protein 2		wild yak		615
Zinc finger and SCAN domain containing 2		PROCO		615
+57
Q7Z7L9-3	Zinc finger and SCAN domain containing 2		GORGO		146	UniRef90_A0A2I2ZCF1
Isoform 4 of Zinc finger and SCAN domain-containing protein 2		HUMAN		146
ZSCAN2 isoform 12		PANTR		148
Zinc finger and SCAN domain containing 2		PANPA		148
ZSCAN2 isoform 6		PONAB		148
+9
Q7Z7L9-4	Zinc finger and SCAN domain containing 2		GORGO		146	UniRef90_A0A2I2ZCF1
Zinc finger and SCAN domain containing 2, isoform CRA_b		HUMAN		150
ZSCAN2 isoform 12		PANTR		148
Zinc finger and SCAN domain containing 2		PANPA		148
ZSCAN2 isoform 6		PONAB		148
+9

Protein	Similar proteins		Species	Score	Length	Source
Q7Z7L9	Zinc finger and SCAN domain containing 2		PROCO		615	UniRef50_Q7Z7L9
zinc finger and SCAN domain-containing protein 2 isoform X1		TARSY		615
zinc finger and SCAN domain-containing protein 2		Florida manatee		615
Zinc finger and SCAN domain containing 2		PIG		615
Zinc finger and SCAN domain-containing protein 2		wild yak		615
+73
Q7Z7L9-3	Zinc finger and SCAN domain containing 2		PROCO		148	UniRef50_A0A2K6F1L7
Zinc finger and SCAN domain containing 2		CALJA		146
Zinc finger and SCAN domain containing 2		Cebus capucinus imitator		149
Uncharacterized protein		AOTNA		146
Zinc finger and SCAN domain containing 2		SAIBB		146
+23
Q7Z7L9-4	Zinc finger and SCAN domain containing 2		PROCO		148	UniRef50_A0A2K6F1L7
Zinc finger and SCAN domain containing 2		CALJA		146
Zinc finger and SCAN domain containing 2		Cebus capucinus imitator		149
Uncharacterized protein		AOTNA		146
Zinc finger and SCAN domain containing 2		SAIBB		146
+23

Entry informationⁱ

Entry nameⁱ	ZSCA2_HUMAN
Accessionⁱ	Q7Z7L9Primary (citable) accession number: Q7Z7L9 Secondary accession number(s): A6NG83 , B2RMQ9, Q6ZQY9, Q9NWU4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
	Last sequence update:	May 18, 2010
	Last modified:	September 12, 2018
	This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

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UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - Q7Z7L9 (ZSCA2_HUMAN)

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Zinc finger and SCAN domain-containing protein 2

ZSCAN2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ