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UniProtKB - Q7Z7L9 (ZSCA2_HUMAN)
Protein
Zinc finger and SCAN domain-containing protein 2
Gene
ZSCAN2
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 222 – 244 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 250 – 272 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 278 – 300 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 306 – 328 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 334 – 356 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 362 – 384 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 390 – 412 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 418 – 440 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 446 – 468 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 474 – 496 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 502 – 524 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 530 – 552 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 558 – 580 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 586 – 608 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- regulation of transcription by RNA polymerase II Source: GO_Central
- spermatogenesis Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Differentiation, Spermatogenesis, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q7Z7L9 |
SignaLinki | Q7Z7L9 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger and SCAN domain-containing protein 2Alternative name(s): Zinc finger protein 29 homolog Short name: Zfp-29 Zinc finger protein 854 |
Gene namesi | Name:ZSCAN2 Synonyms:ZFP29, ZNF854 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20994, ZSCAN2 |
neXtProti | NX_Q7Z7L9 |
VEuPathDBi | HostDB:ENSG00000176371 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 54993 |
OpenTargetsi | ENSG00000176371 |
PharmGKBi | PA134941325 |
Miscellaneous databases
Pharosi | Q7Z7L9, Tdark |
Genetic variation databases
BioMutai | ZSCAN2 |
DMDMi | 296453062 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047749 | 1 – 614 | Zinc finger and SCAN domain-containing protein 2Add BLAST | 614 |
Proteomic databases
EPDi | Q7Z7L9 |
jPOSTi | Q7Z7L9 |
MassIVEi | Q7Z7L9 |
MaxQBi | Q7Z7L9 |
PaxDbi | Q7Z7L9 |
PeptideAtlasi | Q7Z7L9 |
PRIDEi | Q7Z7L9 |
ProteomicsDBi | 69564 [Q7Z7L9-1] 69565 [Q7Z7L9-3] 69566 [Q7Z7L9-4] |
PTM databases
GlyGeni | Q7Z7L9, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q7Z7L9 |
PhosphoSitePlusi | Q7Z7L9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000176371, Expressed in female gonad and 190 other tissues |
ExpressionAtlasi | Q7Z7L9, baseline and differential |
Genevisiblei | Q7Z7L9, HS |
Organism-specific databases
HPAi | ENSG00000176371, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 120326, 6 interactors |
IntActi | Q7Z7L9, 2 interactors |
STRINGi | 9606.ENSP00000410198 |
Miscellaneous databases
RNActi | Q7Z7L9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 59 – 132 | SCAN boxPROSITE-ProRule annotationAdd BLAST | 74 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 26 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 43 – 76 | DisorderedSequence analysisAdd BLAST | 34 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 222 – 244 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 250 – 272 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 278 – 300 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 306 – 328 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 334 – 356 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 362 – 384 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 390 – 412 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 418 – 440 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 446 – 468 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 474 – 496 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 502 – 524 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 530 – 552 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 558 – 580 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 586 – 608 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161710 |
HOGENOMi | CLU_002678_49_8_1 |
InParanoidi | Q7Z7L9 |
OMAi | ILLMHQR |
PhylomeDBi | Q7Z7L9 |
TreeFami | TF337913 |
Family and domain databases
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF02023, SCAN, 1 hit PF00096, zf-C2H2, 14 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 14 hits |
SUPFAMi | SSF57667, SSF57667, 9 hits |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 14 hits PS50157, ZINC_FINGER_C2H2_2, 14 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q7Z7L9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMAADIPRVT TPLSSLVQVP QEEDRQEEEV TTMILEDDSW VQEAVLQEDG
60 70 80 90 100
PESEPFPQSA GKGGPQEEVT RGPQGALGRL RELCRRWLRP EVHTKEQMLT
110 120 130 140 150
MLPKEIQAWL QEHRPESSEE AAALVEDLTQ TLQDSDFEIQ SENGENCNQD
160 170 180 190 200
MFENESRKIF SEMPEGESAQ HSDGESDFER DAGIQRLQGH SPGEDHGEVV
210 220 230 240 250
SQDREVGQLI GLQGTYLGEK PYECPQCGKT FSRKSHLITH ERTHTGEKYY
260 270 280 290 300
KCDECGKSFS DGSNFSRHQT THTGEKPYKC RDCGKSFSRS ANLITHQRIH
310 320 330 340 350
TGEKPFQCAE CGKSFSRSPN LIAHQRTHTG EKPYSCPECG KSFGNRSSLN
360 370 380 390 400
THQGIHTGEK PYECKECGES FSYNSNLIRH QRIHTGEKPY KCTDCGQRFS
410 420 430 440 450
QSSALITHRR THTGEKPYQC SECGKSFSRS SNLATHRRTH MVEKPYKCGV
460 470 480 490 500
CGKSFSQSSS LIAHQGMHTG EKPYECLTCG ESFSWSSNLL KHQRIHTGEK
510 520 530 540 550
PYKCSECGKC FSQRSQLVVH QRTHTGEKPY KCLMCGKSFS RGSILVMHQR
560 570 580 590 600
AHLGDKPYRC PECGKGFSWN SVLIIHQRIH TGEKPYKCPE CGKGFSNSSN
610
FITHQRTHMK EKLY
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5GY18 | F5GY18_HUMAN | Zinc finger and SCAN domain-contain... | ZSCAN2 | 200 | Annotation score: | ||
F5H3F3 | F5H3F3_HUMAN | Zinc finger and SCAN domain-contain... | ZSCAN2 | 238 | Annotation score: | ||
F5GZ04 | F5GZ04_HUMAN | Zinc finger and SCAN domain-contain... | ZSCAN2 | 210 | Annotation score: | ||
F5H4P1 | F5H4P1_HUMAN | Zinc finger and SCAN domain-contain... | ZSCAN2 | 107 | Annotation score: | ||
A0A0C4DFQ3 | A0A0C4DFQ3_HUMAN | Zinc finger and SCAN domain-contain... | ZSCAN2 | 613 | Annotation score: | ||
F8W6Y9 | F8W6Y9_HUMAN | Zinc finger and SCAN domain-contain... | ZSCAN2 | 464 | Annotation score: | ||
F5H789 | F5H789_HUMAN | Zinc finger and SCAN domain-contain... | ZSCAN2 | 53 | Annotation score: | ||
F5H1K4 | F5H1K4_HUMAN | Zinc finger and SCAN domain-contain... | ZSCAN2 | 32 | Annotation score: | ||
F5H2D8 | F5H2D8_HUMAN | Zinc finger and SCAN domain-contain... | ZSCAN2 | 27 | Annotation score: |
Sequence cautioni
The sequence BAC87537 differs from that shown. Reason: Erroneous translation. Aberrant splicing.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 135 – 136 | SD → N in AAP36989 (Ref. 1) Curated | 2 | ||
Isoform 3 (identifier: Q7Z7L9-3) | |||||
Sequence conflicti | 140 | V → F in BAA91283 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 140 | V → F in AAH41620 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_065095 | 191 | S → T2 PublicationsCorresponds to variant dbSNP:rs2044502Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_011947 | 136 – 150 | DFEIQ…NCNQD → AVAVVASLPVEVTSL in isoform 3. 2 PublicationsAdd BLAST | 15 | |
Alternative sequenceiVSP_040201 | 136 – 146 | DFEIQSENGEN → ETASCVHGCPV in isoform 4. 1 PublicationAdd BLAST | 11 | |
Alternative sequenceiVSP_040202 | 147 – 614 | Missing in isoform 4. 1 PublicationAdd BLAST | 468 | |
Alternative sequenceiVSP_011948 | 151 – 614 | Missing in isoform 3. 2 PublicationsAdd BLAST | 464 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY262259 mRNA Translation: AAP36989.1 AK000602 mRNA Translation: BAA91283.1 AK128624 mRNA Translation: BAC87537.1 Sequence problems. AY279349 mRNA Translation: AAQ62846.1 AC048382 Genomic DNA No translation available. BC041620 mRNA Translation: AAH41620.1 BC136342 mRNA Translation: AAI36343.1 |
CCDSi | CCDS10329.2 [Q7Z7L9-1] CCDS32315.1 [Q7Z7L9-4] CCDS32316.1 [Q7Z7L9-3] |
RefSeqi | NP_001007073.1, NM_001007072.1 [Q7Z7L9-4] NP_060364.4, NM_017894.5 [Q7Z7L9-3] NP_870992.2, NM_181877.3 [Q7Z7L9-1] |
Genome annotation databases
Ensembli | ENST00000334141; ENSP00000333895; ENSG00000176371 [Q7Z7L9-3] ENST00000379358; ENSP00000368663; ENSG00000176371 [Q7Z7L9-4] ENST00000448803; ENSP00000410198; ENSG00000176371 ENST00000540894; ENSP00000441855; ENSG00000176371 ENST00000546148; ENSP00000445451; ENSG00000176371 |
GeneIDi | 54993 |
KEGGi | hsa:54993 |
MANE-Selecti | ENST00000546148.6; ENSP00000445451.1; NM_181877.4; NP_870992.2 |
UCSCi | uc002bkp.4, human [Q7Z7L9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY262259 mRNA Translation: AAP36989.1 AK000602 mRNA Translation: BAA91283.1 AK128624 mRNA Translation: BAC87537.1 Sequence problems. AY279349 mRNA Translation: AAQ62846.1 AC048382 Genomic DNA No translation available. BC041620 mRNA Translation: AAH41620.1 BC136342 mRNA Translation: AAI36343.1 |
CCDSi | CCDS10329.2 [Q7Z7L9-1] CCDS32315.1 [Q7Z7L9-4] CCDS32316.1 [Q7Z7L9-3] |
RefSeqi | NP_001007073.1, NM_001007072.1 [Q7Z7L9-4] NP_060364.4, NM_017894.5 [Q7Z7L9-3] NP_870992.2, NM_181877.3 [Q7Z7L9-1] |
3D structure databases
SMRi | Q7Z7L9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120326, 6 interactors |
IntActi | Q7Z7L9, 2 interactors |
STRINGi | 9606.ENSP00000410198 |
PTM databases
GlyGeni | Q7Z7L9, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q7Z7L9 |
PhosphoSitePlusi | Q7Z7L9 |
Genetic variation databases
BioMutai | ZSCAN2 |
DMDMi | 296453062 |
Proteomic databases
EPDi | Q7Z7L9 |
jPOSTi | Q7Z7L9 |
MassIVEi | Q7Z7L9 |
MaxQBi | Q7Z7L9 |
PaxDbi | Q7Z7L9 |
PeptideAtlasi | Q7Z7L9 |
PRIDEi | Q7Z7L9 |
ProteomicsDBi | 69564 [Q7Z7L9-1] 69565 [Q7Z7L9-3] 69566 [Q7Z7L9-4] |
Protocols and materials databases
Antibodypediai | 1841, 135 antibodies from 23 providers |
DNASUi | 54993 |
Genome annotation databases
Ensembli | ENST00000334141; ENSP00000333895; ENSG00000176371 [Q7Z7L9-3] ENST00000379358; ENSP00000368663; ENSG00000176371 [Q7Z7L9-4] ENST00000448803; ENSP00000410198; ENSG00000176371 ENST00000540894; ENSP00000441855; ENSG00000176371 ENST00000546148; ENSP00000445451; ENSG00000176371 |
GeneIDi | 54993 |
KEGGi | hsa:54993 |
MANE-Selecti | ENST00000546148.6; ENSP00000445451.1; NM_181877.4; NP_870992.2 |
UCSCi | uc002bkp.4, human [Q7Z7L9-1] |
Organism-specific databases
CTDi | 54993 |
DisGeNETi | 54993 |
GeneCardsi | ZSCAN2 |
HGNCi | HGNC:20994, ZSCAN2 |
HPAi | ENSG00000176371, Low tissue specificity |
neXtProti | NX_Q7Z7L9 |
OpenTargetsi | ENSG00000176371 |
PharmGKBi | PA134941325 |
VEuPathDBi | HostDB:ENSG00000176371 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161710 |
HOGENOMi | CLU_002678_49_8_1 |
InParanoidi | Q7Z7L9 |
OMAi | ILLMHQR |
PhylomeDBi | Q7Z7L9 |
TreeFami | TF337913 |
Enzyme and pathway databases
PathwayCommonsi | Q7Z7L9 |
SignaLinki | Q7Z7L9 |
Miscellaneous databases
BioGRID-ORCSi | 54993, 10 hits in 1067 CRISPR screens |
ChiTaRSi | ZSCAN2, human |
GenomeRNAii | 54993 |
Pharosi | Q7Z7L9, Tdark |
PROi | PR:Q7Z7L9 |
RNActi | Q7Z7L9, protein |
Gene expression databases
Bgeei | ENSG00000176371, Expressed in female gonad and 190 other tissues |
ExpressionAtlasi | Q7Z7L9, baseline and differential |
Genevisiblei | Q7Z7L9, HS |
Family and domain databases
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF02023, SCAN, 1 hit PF00096, zf-C2H2, 14 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 14 hits |
SUPFAMi | SSF57667, SSF57667, 9 hits |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 14 hits PS50157, ZINC_FINGER_C2H2_2, 14 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZSCA2_HUMAN | |
Accessioni | Q7Z7L9Primary (citable) accession number: Q7Z7L9 Secondary accession number(s): A6NG83 Q9NWU4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 23, 2004 |
Last sequence update: | May 18, 2010 | |
Last modified: | February 23, 2022 | |
This is version 161 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families