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Protein

Schlafen family member 11

Gene

SLFN11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibitor of DNA replication that promotes cell death in response to DNA damage (PubMed:22927417, PubMed:26658330, PubMed:29395061). Acts as a guardian of the genome by killing cells with defective replication (PubMed:29395061). Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death (PubMed:29395061). Acts independently of ATR (PubMed:29395061). Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis (PubMed:23000900). Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner (PubMed:23000900). Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides (PubMed:23000900). The exact inhibition mechanism is unclear: may either sequester tRNAs, prevent their maturation via post-transcriptional processing or may accelerate their deacylation (PubMed:23000900). Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA (PubMed:23000900).4 Publications

Miscellaneous

Dominant determinant of sensitivity to DNA-damaging anticancer drugs: acts by mediating cell death in response to DNA damage induced by anticancer drugs (PubMed:29395061). Down-regulated in a number of chemoresistant tumors (PubMed:26625211, PubMed:28196596, PubMed:27440269, PubMed:28212573).5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi599 – 606ATPSequence analysis8

GO - Molecular functioni

  • ATPase activity Source: UniProtKB
  • ATP binding Source: UniProtKB-KW
  • helicase activity Source: UniProtKB-KW
  • tRNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding, tRNA-binding
Biological processAntiviral defense, DNA damage, Immunity
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Schlafen family member 11Curated (EC:3.6.-.-1 Publication)
Gene namesi
Name:SLFN11Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000172716.16
HGNCiHGNC:26633 SLFN11
MIMi614953 gene
neXtProtiNX_Q7Z7L1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi605K → M: Abolishes ATPase activity without affecting its role in DNA damage response; when associated with A-668. 1 Publication1
Mutagenesisi668D → A: Abolishes ATPase activity without affecting its role in DNA damage response; when associated with M-605. 1 Publication1
Mutagenesisi669E → Q: Abolishes ATPase activity, leading to abolish ability to inhibit DNA replication without affecting subcellular location. 1 Publication1

Organism-specific databases

DisGeNETi91607
OpenTargetsiENSG00000172716
PharmGKBiPA144596358

Polymorphism and mutation databases

BioMutaiSLFN11
DMDMi313104011

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002830911 – 901Schlafen family member 11Add BLAST901

Proteomic databases

EPDiQ7Z7L1
MaxQBiQ7Z7L1
PaxDbiQ7Z7L1
PeptideAtlasiQ7Z7L1
PRIDEiQ7Z7L1
ProteomicsDBi69561

PTM databases

iPTMnetiQ7Z7L1
PhosphoSitePlusiQ7Z7L1

Expressioni

Tissue specificityi

Exhibits a wider expression range in ovarian and colon adenocarcinoma than in their corresponding healthy tissues.1 Publication

Inductioni

Down-regulated in small cell lung cancer (SCLC) cells resistant to PARP inhibitor drugs (PubMed:26625211, PubMed:28196596, PubMed:27440269, PubMed:28212573). Up-regulated by type I interferons, poly-IC and poly-dAdT (PubMed:20956525, PubMed:23000900).6 Publications

Gene expression databases

BgeeiENSG00000172716 Expressed in 157 organ(s), highest expression level in endocervix
CleanExiHS_SLFN11
ExpressionAtlasiQ7Z7L1 baseline and differential
GenevisibleiQ7Z7L1 HS

Organism-specific databases

HPAiHPA023030
HPA062062

Interactioni

Subunit structurei

Interacts with MCM3 (PubMed:29395061). Interacts with DHX9 (PubMed:26625211, PubMed:29395061). Interacts with RPA1 (PubMed:26658330, PubMed:29395061).3 Publications

Protein-protein interaction databases

BioGridi124851, 16 interactors
IntActiQ7Z7L1, 4 interactors
MINTiQ7Z7L1
STRINGi9606.ENSP00000312402

Structurei

3D structure databases

ProteinModelPortaliQ7Z7L1
SMRiQ7Z7L1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Schlafen family. Subgroup III subfamily.Curated

Phylogenomic databases

eggNOGiENOG410IJEW Eukaryota
ENOG410Z5MV LUCA
GeneTreeiENSGT00410000025651
HOGENOMiHOG000049135
HOVERGENiHBG056880
InParanoidiQ7Z7L1
OMAiQHLYIFP
OrthoDBiEOG091G01HZ
PhylomeDBiQ7Z7L1
TreeFamiTF337168

Family and domain databases

Gene3Di3.30.950.30, 1 hit
InterProiView protein in InterPro
IPR018647 DUF2075
IPR027417 P-loop_NTPase
IPR029684 Schlafen
IPR007421 Schlafen_AAA_dom
IPR038461 Schlafen_AAA_dom_sf
IPR029682 SLFN11
PANTHERiPTHR12155 PTHR12155, 1 hit
PTHR12155:SF31 PTHR12155:SF31, 1 hit
PfamiView protein in Pfam
PF04326 AlbA_2, 1 hit
PF09848 DUF2075, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

Q7Z7L1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEANQCPLVV EPSYPDLVIN VGEVTLGEEN RKKLQKIQRD QEKERVMRAA
60 70 80 90 100
CALLNSGGGV IRMAKKVEHP VEMGLDLEQS LRELIQSSDL QAFFETKQQG
110 120 130 140 150
RCFYIFVKSW SSGPFPEDRS VKPRLCSLSS SLYRRSETSV RSMDSREAFC
160 170 180 190 200
FLKTKRKPKI LEEGPFHKIH KGVYQELPNS DPADPNSDPA DLIFQKDYLE
210 220 230 240 250
YGEILPFPES QLVEFKQFST KHFQEYVKRT IPEYVPAFAN TGGGYLFIGV
260 270 280 290 300
DDKSREVLGC AKENVDPDSL RRKIEQAIYK LPCVHFCQPQ RPITFTLKIV
310 320 330 340 350
NVLKRGELYG YACMIRVNPF CCAVFSEAPN SWIVEDKYVC SLTTEKWVGM
360 370 380 390 400
MTDTDPDLLQ LSEDFECQLS LSSGPPLSRP VYSKKGLEHK KELQQLLFSV
410 420 430 440 450
PPGYLRYTPE SLWRDLISEH RGLEELINKQ MQPFFRGILI FSRSWAVDLN
460 470 480 490 500
LQEKPGVICD ALLIAQNSTP ILYTILREQD AEGQDYCTRT AFTLKQKLVN
510 520 530 540 550
MGGYTGKVCV RAKVLCLSPE SSAEALEAAV SPMDYPASYS LAGTQHMEAL
560 570 580 590 600
LQSLVIVLLG FRSLLSDQLG CEVLNLLTAQ QYEIFSRSLR KNRELFVHGL
610 620 630 640 650
PGSGKTIMAM KIMEKIRNVF HCEAHRILYV CENQPLRNFI SDRNICRAET
660 670 680 690 700
RKTFLRENFE HIQHIVIDEA QNFRTEDGDW YGKAKSITRR AKGGPGILWI
710 720 730 740 750
FLDYFQTSHL DCSGLPPLSD QYPREELTRI VRNADPIAKY LQKEMQVIRS
760 770 780 790 800
NPSFNIPTGC LEVFPEAEWS QGVQGTLRIK KYLTVEQIMT CVADTCRRFF
810 820 830 840 850
DRGYSPKDVA VLVSTAKEVE HYKYELLKAM RKKRVVQLSD ACDMLGDHIV
860 870 880 890 900
LDSVRRFSGL ERSIVFGIHP RTADPAILPN VLICLASRAK QHLYIFPWGG

H
Length:901
Mass (Da):102,836
Last modified:November 30, 2010 - v2
Checksum:i514FD89CB7C12E8D
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JUT2C9JUT2_HUMAN
Schlafen family member 11
SLFN11
111Annotation score:
K7ER38K7ER38_HUMAN
Schlafen family member 11
SLFN11
100Annotation score:
K7EJJ3K7EJJ3_HUMAN
Schlafen family member 11
SLFN11
50Annotation score:
C9JDG6C9JDG6_HUMAN
Schlafen family member 11
SLFN11
90Annotation score:
K7EIM3K7EIM3_HUMAN
Schlafen family member 11
SLFN11
123Annotation score:
K7EKT7K7EKT7_HUMAN
Schlafen family member 11
SLFN11
48Annotation score:
C9J902C9J902_HUMAN
Schlafen family member 11
SLFN11
90Annotation score:
K7ES87K7ES87_HUMAN
Schlafen family member 11
SLFN11
80Annotation score:

Sequence cautioni

The sequence BAB85010 differs from that shown. Reason: Frameshift at position 135.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20N → S in BAC03835 (PubMed:14702039).Curated1
Sequence conflicti143M → T in BAC03835 (PubMed:14702039).Curated1
Sequence conflicti324V → M in CAD38606 (PubMed:17974005).Curated1
Sequence conflicti665I → V in BAC03835 (PubMed:14702039).Curated1
Sequence conflicti665I → V in CAD38606 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031492121V → F1 PublicationCorresponds to variant dbSNP:rs12453150Ensembl.1
Natural variantiVAR_031493301N → D4 PublicationsCorresponds to variant dbSNP:rs4796077Ensembl.1
Natural variantiVAR_062186489R → L. Corresponds to variant dbSNP:rs9898983Ensembl.1
Natural variantiVAR_031494822Y → C. Corresponds to variant dbSNP:rs3803860Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074184 mRNA Translation: BAB85010.1 Frameshift.
AK092241 mRNA Translation: BAC03835.1
AL831964 mRNA Translation: CAD38606.2
AC060766 Genomic DNA No translation available.
CH471147 Genomic DNA Translation: EAW80156.1
CH471147 Genomic DNA Translation: EAW80157.1
CH471147 Genomic DNA Translation: EAW80158.1
BC052586 mRNA Translation: AAH52586.1
CCDSiCCDS11294.1
RefSeqiNP_001098057.1, NM_001104587.1
NP_001098058.1, NM_001104588.1
NP_001098059.1, NM_001104589.1
NP_001098060.1, NM_001104590.1
NP_689483.3, NM_152270.3
XP_005258125.1, XM_005258068.3
XP_006722234.1, XM_006722171.3
XP_011523767.1, XM_011525465.2
XP_016880788.1, XM_017025299.1
UniGeneiHs.745059

Genome annotation databases

EnsembliENST00000308377; ENSP00000312402; ENSG00000172716
ENST00000394566; ENSP00000378067; ENSG00000172716
GeneIDi91607
KEGGihsa:91607
UCSCiuc002hjg.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074184 mRNA Translation: BAB85010.1 Frameshift.
AK092241 mRNA Translation: BAC03835.1
AL831964 mRNA Translation: CAD38606.2
AC060766 Genomic DNA No translation available.
CH471147 Genomic DNA Translation: EAW80156.1
CH471147 Genomic DNA Translation: EAW80157.1
CH471147 Genomic DNA Translation: EAW80158.1
BC052586 mRNA Translation: AAH52586.1
CCDSiCCDS11294.1
RefSeqiNP_001098057.1, NM_001104587.1
NP_001098058.1, NM_001104588.1
NP_001098059.1, NM_001104589.1
NP_001098060.1, NM_001104590.1
NP_689483.3, NM_152270.3
XP_005258125.1, XM_005258068.3
XP_006722234.1, XM_006722171.3
XP_011523767.1, XM_011525465.2
XP_016880788.1, XM_017025299.1
UniGeneiHs.745059

3D structure databases

ProteinModelPortaliQ7Z7L1
SMRiQ7Z7L1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124851, 16 interactors
IntActiQ7Z7L1, 4 interactors
MINTiQ7Z7L1
STRINGi9606.ENSP00000312402

PTM databases

iPTMnetiQ7Z7L1
PhosphoSitePlusiQ7Z7L1

Polymorphism and mutation databases

BioMutaiSLFN11
DMDMi313104011

Proteomic databases

EPDiQ7Z7L1
MaxQBiQ7Z7L1
PaxDbiQ7Z7L1
PeptideAtlasiQ7Z7L1
PRIDEiQ7Z7L1
ProteomicsDBi69561

Protocols and materials databases

DNASUi91607
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308377; ENSP00000312402; ENSG00000172716
ENST00000394566; ENSP00000378067; ENSG00000172716
GeneIDi91607
KEGGihsa:91607
UCSCiuc002hjg.5 human

Organism-specific databases

CTDi91607
DisGeNETi91607
EuPathDBiHostDB:ENSG00000172716.16
GeneCardsiSLFN11
H-InvDBiHIX0018885
HGNCiHGNC:26633 SLFN11
HPAiHPA023030
HPA062062
MIMi614953 gene
neXtProtiNX_Q7Z7L1
OpenTargetsiENSG00000172716
PharmGKBiPA144596358
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJEW Eukaryota
ENOG410Z5MV LUCA
GeneTreeiENSGT00410000025651
HOGENOMiHOG000049135
HOVERGENiHBG056880
InParanoidiQ7Z7L1
OMAiQHLYIFP
OrthoDBiEOG091G01HZ
PhylomeDBiQ7Z7L1
TreeFamiTF337168

Miscellaneous databases

ChiTaRSiSLFN11 human
GeneWikiiSLFN11
GenomeRNAii91607
PROiPR:Q7Z7L1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172716 Expressed in 157 organ(s), highest expression level in endocervix
CleanExiHS_SLFN11
ExpressionAtlasiQ7Z7L1 baseline and differential
GenevisibleiQ7Z7L1 HS

Family and domain databases

Gene3Di3.30.950.30, 1 hit
InterProiView protein in InterPro
IPR018647 DUF2075
IPR027417 P-loop_NTPase
IPR029684 Schlafen
IPR007421 Schlafen_AAA_dom
IPR038461 Schlafen_AAA_dom_sf
IPR029682 SLFN11
PANTHERiPTHR12155 PTHR12155, 1 hit
PTHR12155:SF31 PTHR12155:SF31, 1 hit
PfamiView protein in Pfam
PF04326 AlbA_2, 1 hit
PF09848 DUF2075, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSLN11_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7L1
Secondary accession number(s): E1P643
, Q8N3S8, Q8N762, Q8TEE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: November 30, 2010
Last modified: September 12, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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