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Entry version 137 (13 Nov 2019)
Sequence version 2 (30 Nov 2010)
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Protein

Schlafen family member 11

Gene

SLFN11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibitor of DNA replication that promotes cell death in response to DNA damage (PubMed:22927417, PubMed:26658330, PubMed:29395061). Acts as a guardian of the genome by killing cells with defective replication (PubMed:29395061). Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death (PubMed:29395061). Acts independently of ATR (PubMed:29395061). Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis (PubMed:23000900). Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner (PubMed:23000900). Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides (PubMed:23000900). The exact inhibition mechanism is unclear: may either sequester tRNAs, prevent their maturation via post-transcriptional processing or may accelerate their deacylation (PubMed:23000900). Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA (PubMed:23000900).4 Publications

Miscellaneous

Dominant determinant of sensitivity to DNA-damaging anticancer drugs: acts by mediating cell death in response to DNA damage induced by anticancer drugs (PubMed:29395061). Down-regulated in a number of chemoresistant tumors (PubMed:26625211, PubMed:28196596, PubMed:27440269, PubMed:28212573).5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi599 – 606ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding, tRNA-binding
Biological processAntiviral defense, DNA damage, Immunity
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Schlafen family member 11Curated (EC:3.6.-.-1 Publication)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLFN11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:26633 SLFN11

Online Mendelian Inheritance in Man (OMIM)

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MIMi
614953 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z7L1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi605K → M: Abolishes ATPase activity without affecting its role in DNA damage response; when associated with A-668. 1 Publication1
Mutagenesisi668D → A: Abolishes ATPase activity without affecting its role in DNA damage response; when associated with M-605. 1 Publication1
Mutagenesisi669E → Q: Abolishes ATPase activity, leading to abolish ability to inhibit DNA replication without affecting subcellular location. 1 Publication1

Organism-specific databases

DisGeNET

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DisGeNETi
91607

Open Targets

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OpenTargetsi
ENSG00000172716

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA144596358

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q7Z7L1

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
SLFN11

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104011

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002830911 – 901Schlafen family member 11Add BLAST901

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q7Z7L1

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q7Z7L1

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q7Z7L1

MaxQB - The MaxQuant DataBase

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MaxQBi
Q7Z7L1

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q7Z7L1

PeptideAtlas

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PeptideAtlasi
Q7Z7L1

PRoteomics IDEntifications database

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PRIDEi
Q7Z7L1

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
69561

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q7Z7L1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q7Z7L1

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q7Z7L1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Exhibits a wider expression range in ovarian and colon adenocarcinoma than in their corresponding healthy tissues.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated in small cell lung cancer (SCLC) cells resistant to PARP inhibitor drugs (PubMed:26625211, PubMed:28196596, PubMed:27440269, PubMed:28212573). Up-regulated by type I interferons, poly-IC and poly-dAdT (PubMed:20956525, PubMed:23000900).6 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000172716 Expressed in 157 organ(s), highest expression level in endocervix

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q7Z7L1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q7Z7L1 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA023030
HPA062062

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MCM3 (PubMed:29395061).

Interacts with DHX9 (PubMed:26625211, PubMed:29395061).

Interacts with RPA1 (PubMed:26658330, PubMed:29395061).

3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
124851, 19 interactors

Protein interaction database and analysis system

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IntActi
Q7Z7L1, 4 interactors

Molecular INTeraction database

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MINTi
Q7Z7L1

STRING: functional protein association networks

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STRINGi
9606.ENSP00000378067

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q7Z7L1

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Schlafen family. Subgroup III subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IJEW Eukaryota
ENOG410Z5MV LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00410000025651

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000049135

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q7Z7L1

Identification of Orthologs from Complete Genome Data

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OMAi
IYKLPCV

Database of Orthologous Groups

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OrthoDBi
211385at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q7Z7L1

TreeFam database of animal gene trees

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TreeFami
TF337168

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.950.30, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR018647 DUF2075
IPR027417 P-loop_NTPase
IPR029684 Schlafen
IPR007421 Schlafen_AlbA_2_dom
IPR038461 Schlafen_AlbA_2_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR12155 PTHR12155, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04326 AlbA_2, 1 hit
PF09848 DUF2075, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

Q7Z7L1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEANQCPLVV EPSYPDLVIN VGEVTLGEEN RKKLQKIQRD QEKERVMRAA
60 70 80 90 100
CALLNSGGGV IRMAKKVEHP VEMGLDLEQS LRELIQSSDL QAFFETKQQG
110 120 130 140 150
RCFYIFVKSW SSGPFPEDRS VKPRLCSLSS SLYRRSETSV RSMDSREAFC
160 170 180 190 200
FLKTKRKPKI LEEGPFHKIH KGVYQELPNS DPADPNSDPA DLIFQKDYLE
210 220 230 240 250
YGEILPFPES QLVEFKQFST KHFQEYVKRT IPEYVPAFAN TGGGYLFIGV
260 270 280 290 300
DDKSREVLGC AKENVDPDSL RRKIEQAIYK LPCVHFCQPQ RPITFTLKIV
310 320 330 340 350
NVLKRGELYG YACMIRVNPF CCAVFSEAPN SWIVEDKYVC SLTTEKWVGM
360 370 380 390 400
MTDTDPDLLQ LSEDFECQLS LSSGPPLSRP VYSKKGLEHK KELQQLLFSV
410 420 430 440 450
PPGYLRYTPE SLWRDLISEH RGLEELINKQ MQPFFRGILI FSRSWAVDLN
460 470 480 490 500
LQEKPGVICD ALLIAQNSTP ILYTILREQD AEGQDYCTRT AFTLKQKLVN
510 520 530 540 550
MGGYTGKVCV RAKVLCLSPE SSAEALEAAV SPMDYPASYS LAGTQHMEAL
560 570 580 590 600
LQSLVIVLLG FRSLLSDQLG CEVLNLLTAQ QYEIFSRSLR KNRELFVHGL
610 620 630 640 650
PGSGKTIMAM KIMEKIRNVF HCEAHRILYV CENQPLRNFI SDRNICRAET
660 670 680 690 700
RKTFLRENFE HIQHIVIDEA QNFRTEDGDW YGKAKSITRR AKGGPGILWI
710 720 730 740 750
FLDYFQTSHL DCSGLPPLSD QYPREELTRI VRNADPIAKY LQKEMQVIRS
760 770 780 790 800
NPSFNIPTGC LEVFPEAEWS QGVQGTLRIK KYLTVEQIMT CVADTCRRFF
810 820 830 840 850
DRGYSPKDVA VLVSTAKEVE HYKYELLKAM RKKRVVQLSD ACDMLGDHIV
860 870 880 890 900
LDSVRRFSGL ERSIVFGIHP RTADPAILPN VLICLASRAK QHLYIFPWGG

H
Length:901
Mass (Da):102,836
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i514FD89CB7C12E8D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JUT2C9JUT2_HUMAN
Schlafen family member 11
SLFN11
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JDG6C9JDG6_HUMAN
Schlafen family member 11
SLFN11
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJJ3K7EJJ3_HUMAN
Schlafen family member 11
SLFN11
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J902C9J902_HUMAN
Schlafen family member 11
SLFN11
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EIM3K7EIM3_HUMAN
Schlafen family member 11
SLFN11
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ER38K7ER38_HUMAN
Schlafen family member 11
SLFN11
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ES87K7ES87_HUMAN
Schlafen family member 11
SLFN11
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKT7K7EKT7_HUMAN
Schlafen family member 11
SLFN11
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB85010 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti20N → S in BAC03835 (PubMed:14702039).Curated1
Sequence conflicti143M → T in BAC03835 (PubMed:14702039).Curated1
Sequence conflicti324V → M in CAD38606 (PubMed:17974005).Curated1
Sequence conflicti665I → V in BAC03835 (PubMed:14702039).Curated1
Sequence conflicti665I → V in CAD38606 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031492121V → F1 PublicationCorresponds to variant dbSNP:rs12453150Ensembl.1
Natural variantiVAR_031493301N → D4 PublicationsCorresponds to variant dbSNP:rs4796077Ensembl.1
Natural variantiVAR_062186489R → L. Corresponds to variant dbSNP:rs9898983Ensembl.1
Natural variantiVAR_031494822Y → C. Corresponds to variant dbSNP:rs3803860Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK074184 mRNA Translation: BAB85010.1 Frameshift.
AK092241 mRNA Translation: BAC03835.1
AL831964 mRNA Translation: CAD38606.2
AC060766 Genomic DNA No translation available.
CH471147 Genomic DNA Translation: EAW80156.1
CH471147 Genomic DNA Translation: EAW80157.1
CH471147 Genomic DNA Translation: EAW80158.1
BC052586 mRNA Translation: AAH52586.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11294.1

NCBI Reference Sequences

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RefSeqi
NP_001098057.1, NM_001104587.1
NP_001098058.1, NM_001104588.1
NP_001098059.1, NM_001104589.1
NP_001098060.1, NM_001104590.1
NP_689483.3, NM_152270.3
XP_005258125.1, XM_005258068.3
XP_006722234.1, XM_006722171.3
XP_011523767.1, XM_011525465.2
XP_016880788.1, XM_017025299.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000308377; ENSP00000312402; ENSG00000172716
ENST00000394566; ENSP00000378067; ENSG00000172716

Database of genes from NCBI RefSeq genomes

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GeneIDi
91607

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:91607

UCSC genome browser

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UCSCi
uc002hjg.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074184 mRNA Translation: BAB85010.1 Frameshift.
AK092241 mRNA Translation: BAC03835.1
AL831964 mRNA Translation: CAD38606.2
AC060766 Genomic DNA No translation available.
CH471147 Genomic DNA Translation: EAW80156.1
CH471147 Genomic DNA Translation: EAW80157.1
CH471147 Genomic DNA Translation: EAW80158.1
BC052586 mRNA Translation: AAH52586.1
CCDSiCCDS11294.1
RefSeqiNP_001098057.1, NM_001104587.1
NP_001098058.1, NM_001104588.1
NP_001098059.1, NM_001104589.1
NP_001098060.1, NM_001104590.1
NP_689483.3, NM_152270.3
XP_005258125.1, XM_005258068.3
XP_006722234.1, XM_006722171.3
XP_011523767.1, XM_011525465.2
XP_016880788.1, XM_017025299.1

3D structure databases

SMRiQ7Z7L1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi124851, 19 interactors
IntActiQ7Z7L1, 4 interactors
MINTiQ7Z7L1
STRINGi9606.ENSP00000378067

PTM databases

iPTMnetiQ7Z7L1
PhosphoSitePlusiQ7Z7L1
SwissPalmiQ7Z7L1

Polymorphism and mutation databases

BioMutaiSLFN11
DMDMi313104011

Proteomic databases

EPDiQ7Z7L1
jPOSTiQ7Z7L1
MassIVEiQ7Z7L1
MaxQBiQ7Z7L1
PaxDbiQ7Z7L1
PeptideAtlasiQ7Z7L1
PRIDEiQ7Z7L1
ProteomicsDBi69561

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
91607

Genome annotation databases

EnsembliENST00000308377; ENSP00000312402; ENSG00000172716
ENST00000394566; ENSP00000378067; ENSG00000172716
GeneIDi91607
KEGGihsa:91607
UCSCiuc002hjg.5 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
91607
DisGeNETi91607

GeneCards: human genes, protein and diseases

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GeneCardsi
SLFN11
HGNCiHGNC:26633 SLFN11
HPAiHPA023030
HPA062062
MIMi614953 gene
neXtProtiNX_Q7Z7L1
OpenTargetsiENSG00000172716
PharmGKBiPA144596358

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IJEW Eukaryota
ENOG410Z5MV LUCA
GeneTreeiENSGT00410000025651
HOGENOMiHOG000049135
InParanoidiQ7Z7L1
OMAiIYKLPCV
OrthoDBi211385at2759
PhylomeDBiQ7Z7L1
TreeFamiTF337168

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLFN11 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLFN11

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
91607
PharosiQ7Z7L1

Protein Ontology

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PROi
PR:Q7Z7L1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000172716 Expressed in 157 organ(s), highest expression level in endocervix
ExpressionAtlasiQ7Z7L1 baseline and differential
GenevisibleiQ7Z7L1 HS

Family and domain databases

Gene3Di3.30.950.30, 1 hit
InterProiView protein in InterPro
IPR018647 DUF2075
IPR027417 P-loop_NTPase
IPR029684 Schlafen
IPR007421 Schlafen_AlbA_2_dom
IPR038461 Schlafen_AlbA_2_dom_sf
PANTHERiPTHR12155 PTHR12155, 1 hit
PfamiView protein in Pfam
PF04326 AlbA_2, 1 hit
PF09848 DUF2075, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSLN11_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z7L1
Secondary accession number(s): E1P643
, Q8N3S8, Q8N762, Q8TEE0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: November 30, 2010
Last modified: November 13, 2019
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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