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Protein

Centromere protein V

Gene

CENPV

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis.1 Publication

GO - Molecular functioni

GO - Biological processi

  • ameboidal-type cell migration Source: MGI
  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • centromere complex assembly Source: UniProtKB
  • metabolic process Source: InterPro
  • pericentric heterochromatin assembly Source: UniProtKB
  • positive regulation of cytokinesis Source: UniProtKB
  • regulation of chromosome organization Source: UniProtKB

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein V
Short name:
CENP-V
Alternative name(s):
Nuclear protein p30
Proline-rich protein 6
Gene namesi
Name:CENPV
Synonyms:PRR6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000166582.9
HGNCiHGNC:29920 CENPV
MIMi608139 gene
neXtProtiNX_Q7Z7K6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi172C → A: Abolishes chromatin hypercondensation phenotype induced by overexpression of wild-type protein; when associated with A-177. 1 Publication1
Mutagenesisi174C → A: Abolishes chromatin hypercondensation phenotype induced by overexpression of wild-type protein. 1 Publication1
Mutagenesisi177C → A: Abolishes chromatin hypercondensation phenotype induced by overexpression of wild-type protein; when associated with A-172. 1 Publication1

Organism-specific databases

DisGeNETi201161
OpenTargetsiENSG00000166582
PharmGKBiPA164717842

Polymorphism and mutation databases

DMDMi74750244

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002443591 – 275Centromere protein VAdd BLAST275

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineCombined sources1
Modified residuei21PhosphoserineCombined sources1
Modified residuei43Omega-N-methylarginineBy similarity1
Modified residuei98PhosphothreonineCombined sources1
Modified residuei101PhosphothreonineCombined sources1
Modified residuei103PhosphothreonineCombined sources1
Modified residuei257PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ7Z7K6
MaxQBiQ7Z7K6
PaxDbiQ7Z7K6
PeptideAtlasiQ7Z7K6
PRIDEiQ7Z7K6
ProteomicsDBi69557
69558 [Q7Z7K6-2]
69559 [Q7Z7K6-3]

PTM databases

iPTMnetiQ7Z7K6
PhosphoSitePlusiQ7Z7K6

Expressioni

Gene expression databases

BgeeiENSG00000166582 Expressed in 176 organ(s), highest expression level in cerebral cortex
CleanExiHS_CENPV
ExpressionAtlasiQ7Z7K6 baseline and differential
GenevisibleiQ7Z7K6 HS

Organism-specific databases

HPAiHPA042529
HPA042616

Interactioni

Protein-protein interaction databases

BioGridi128365, 27 interactors
IntActiQ7Z7K6, 19 interactors
MINTiQ7Z7K6
STRINGi9606.ENSP00000299736

Structurei

3D structure databases

ProteinModelPortaliQ7Z7K6
SMRiQ7Z7K6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini171 – 244GFASequence analysisAdd BLAST74

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi23 – 36Poly-AlaAdd BLAST14
Compositional biasi59 – 102Pro-richAdd BLAST44

Sequence similaritiesi

Belongs to the Gfa family.Curated

Phylogenomic databases

eggNOGiKOG4192 Eukaryota
COG3791 LUCA
GeneTreeiENSGT00390000003183
HOGENOMiHOG000090254
InParanoidiQ7Z7K6
OMAiNGSNWEK
OrthoDBiEOG091G0YXV
PhylomeDBiQ7Z7K6
TreeFamiTF313636

Family and domain databases

InterProiView protein in InterPro
IPR006913 GFA/CENP-V
IPR011057 Mss4-like_sf
PfamiView protein in Pfam
PF04828 GFA, 1 hit
SUPFAMiSSF51316 SSF51316, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z7K6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRRSRSSAAA KLRGQKRSGA SGASAAPAAS AAAALAPSAT RTRRSASQAG
60 70 80 90 100
SKSQAVEKPP SEKPRLRRSS PRAQEEGPGE PPPPELALLP PPPPPPPTPA
110 120 130 140 150
TPTSSASNLD LGEQRERWET FQKRQKLTSE GAAKLLLDTF EYQGLVKHTG
160 170 180 190 200
GCHCGAVRFE VWASADLHIF DCNCSICKKK QNRHFIVPAS RFKLLKGAEH
210 220 230 240 250
ITTYTFNTHK AQHTFCKRCG VQSFYTPRSN PGGFGIAPHC LDEGTVRSMV
260 270
TEEFNGSDWE KAMKEHKTIK NMSKE
Length:275
Mass (Da):29,946
Last modified:October 1, 2003 - v1
Checksum:iE9A69F1F9BA746D8
GO
Isoform 2 (identifier: Q7Z7K6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-173: MRRSRSSAAA...SADLHIFDCN → MQVAAHNLEFALSFCS

Show »
Length:118
Mass (Da):13,415
Checksum:iD2AFAF27CE996704
GO
Isoform 3 (identifier: Q7Z7K6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     18-20: Missing.

Show »
Length:272
Mass (Da):29,731
Checksum:i3E3A33B9CEBFDB3E
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0M3HER2A0A0M3HER2_HUMAN
Centromere protein V
CENPV
175Annotation score:
K7ERN6K7ERN6_HUMAN
Centromere protein V
CENPV
14Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0195491 – 173MRRSR…IFDCN → MQVAAHNLEFALSFCS in isoform 2. 1 PublicationAdd BLAST173
Alternative sequenceiVSP_01955018 – 20Missing in isoform 3. 2 Publications3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY382899 mRNA Translation: AAR24368.1
BC052604 mRNA Translation: AAH52604.1
BC137486 mRNA Translation: AAI37487.1
BC137487 mRNA Translation: AAI37488.1
AF514992 mRNA Translation: AAM76703.1
CCDSiCCDS32575.1 [Q7Z7K6-3]
RefSeqiNP_859067.2, NM_181716.2 [Q7Z7K6-3]
UniGeneiHs.433422

Genome annotation databases

EnsembliENST00000299736; ENSP00000299736; ENSG00000166582 [Q7Z7K6-3]
GeneIDi201161
KEGGihsa:201161
UCSCiuc002gpw.4 human [Q7Z7K6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY382899 mRNA Translation: AAR24368.1
BC052604 mRNA Translation: AAH52604.1
BC137486 mRNA Translation: AAI37487.1
BC137487 mRNA Translation: AAI37488.1
AF514992 mRNA Translation: AAM76703.1
CCDSiCCDS32575.1 [Q7Z7K6-3]
RefSeqiNP_859067.2, NM_181716.2 [Q7Z7K6-3]
UniGeneiHs.433422

3D structure databases

ProteinModelPortaliQ7Z7K6
SMRiQ7Z7K6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128365, 27 interactors
IntActiQ7Z7K6, 19 interactors
MINTiQ7Z7K6
STRINGi9606.ENSP00000299736

PTM databases

iPTMnetiQ7Z7K6
PhosphoSitePlusiQ7Z7K6

Polymorphism and mutation databases

DMDMi74750244

Proteomic databases

EPDiQ7Z7K6
MaxQBiQ7Z7K6
PaxDbiQ7Z7K6
PeptideAtlasiQ7Z7K6
PRIDEiQ7Z7K6
ProteomicsDBi69557
69558 [Q7Z7K6-2]
69559 [Q7Z7K6-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299736; ENSP00000299736; ENSG00000166582 [Q7Z7K6-3]
GeneIDi201161
KEGGihsa:201161
UCSCiuc002gpw.4 human [Q7Z7K6-1]

Organism-specific databases

CTDi201161
DisGeNETi201161
EuPathDBiHostDB:ENSG00000166582.9
GeneCardsiCENPV
H-InvDBiHIX0027142
HGNCiHGNC:29920 CENPV
HPAiHPA042529
HPA042616
MIMi608139 gene
neXtProtiNX_Q7Z7K6
OpenTargetsiENSG00000166582
PharmGKBiPA164717842
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4192 Eukaryota
COG3791 LUCA
GeneTreeiENSGT00390000003183
HOGENOMiHOG000090254
InParanoidiQ7Z7K6
OMAiNGSNWEK
OrthoDBiEOG091G0YXV
PhylomeDBiQ7Z7K6
TreeFamiTF313636

Miscellaneous databases

ChiTaRSiCENPV human
GenomeRNAii201161
PROiPR:Q7Z7K6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166582 Expressed in 176 organ(s), highest expression level in cerebral cortex
CleanExiHS_CENPV
ExpressionAtlasiQ7Z7K6 baseline and differential
GenevisibleiQ7Z7K6 HS

Family and domain databases

InterProiView protein in InterPro
IPR006913 GFA/CENP-V
IPR011057 Mss4-like_sf
PfamiView protein in Pfam
PF04828 GFA, 1 hit
SUPFAMiSSF51316 SSF51316, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCENPV_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7K6
Secondary accession number(s): B2RPK2, Q3L8N5, Q8NFH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2003
Last modified: October 10, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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