UniProtKB - Q7Z7K2 (ZN467_HUMAN)
Protein
Zinc finger protein 467
Gene
ZNF467
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence 5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and PPARG. Recruits a histone deacetylase complex (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 160 – 182 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 188 – 210 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 216 – 238 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 244 – 266 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 272 – 294 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 300 – 322 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 355 – 377 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 431 – 453 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 459 – 481 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 487 – 509 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 515 – 537 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 543 – 565 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q7Z7K2 |
Reactomei | R-HSA-381340, Transcriptional regulation of white adipocyte differentiation |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 467 |
Gene namesi | Name:ZNF467 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000181444.12 |
HGNCi | HGNC:23154, ZNF467 |
MIMi | 614040, gene |
neXtProti | NX_Q7Z7K2 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000181444 |
PharmGKBi | PA134886769 |
Miscellaneous databases
Pharosi | Q7Z7K2, Tdark |
Polymorphism and mutation databases
BioMutai | ZNF467 |
DMDMi | 74762444 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000247517 | 1 – 595 | Zinc finger protein 467Add BLAST | 595 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 97 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 368 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
MassIVEi | Q7Z7K2 |
PaxDbi | Q7Z7K2 |
PeptideAtlasi | Q7Z7K2 |
PRIDEi | Q7Z7K2 |
ProteomicsDBi | 69556 |
TopDownProteomicsi | Q7Z7K2 |
PTM databases
iPTMneti | Q7Z7K2 |
PhosphoSitePlusi | Q7Z7K2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000181444, Expressed in blood and 164 other tissues |
ExpressionAtlasi | Q7Z7K2, baseline and differential |
Genevisiblei | Q7Z7K2, HS |
Organism-specific databases
HPAi | ENSG00000181444, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with STAT3. Enhances STAT3 activity by keeping it in the nucleus (By similarity).
By similarityBinary interactionsi
Hide detailsQ7Z7K2
With | #Exp. | IntAct |
---|---|---|
KRTAP12-3 [P60328] | 3 | EBI-11986485,EBI-11953334 |
L3MBTL2 [Q969R5] | 3 | EBI-11986485,EBI-739909 |
LMO4 [P61968] | 3 | EBI-11986485,EBI-2798728 |
TLE5 - isoform 2 [Q08117-2] | 3 | EBI-11986485,EBI-11741437 |
Protein-protein interaction databases
BioGRIDi | 127969, 10 interactors |
IntActi | Q7Z7K2, 4 interactors |
STRINGi | 9606.ENSP00000304769 |
Miscellaneous databases
RNActi | Q7Z7K2, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 160 – 182 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 188 – 210 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 216 – 238 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 244 – 266 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 272 – 294 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 300 – 322 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 355 – 377 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 431 – 453 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 459 – 481 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 487 – 509 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 515 – 537 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 543 – 565 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162497 |
HOGENOMi | CLU_002678_73_2_1 |
InParanoidi | Q7Z7K2 |
OMAi | CSGDEWM |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q7Z7K2 |
TreeFami | TF326846 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 8 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 12 hits |
SUPFAMi | SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 12 hits PS50157, ZINC_FINGER_C2H2_2, 12 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q7Z7K2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRETLEALSS LGFSVGQPEM APQSEPREGS HNAQEQMSSS REERALGVCS
60 70 80 90 100
GHEAPTPEEG AHTEQAEAPC RGQACSAQKA QPVGTCPGEE WMIRKVKVED
110 120 130 140 150
EDQEAEEEVE WPQHLSLLPS PFPAPDLGHL AAAYKLEPGA PGALSGLALS
160 170 180 190 200
GWGPMPEKPY GCGECERRFR DQLTLRLHQR LHRGEGPCAC PDCGRSFTQR
210 220 230 240 250
AHMLLHQRSH RGERPFPCSE CDKRFSKKAH LTRHLRTHTG ERPYPCAECG
260 270 280 290 300
KRFSQKIHLG SHQKTHTGER PFPCTECEKR FRKKTHLIRH QRIHTGERPY
310 320 330 340 350
QCAQCARSFT HKQHLVRHQR VHQTAGPARP SPDSSASPHS TAPSPTPSFP
360 370 380 390 400
GPKPFACSDC GLSFGWKKNL ATHQCLHRSE GRPFGCDECA LGATVDAPAA
410 420 430 440 450
KPLASAPGGP GCGPGSDPVV PQRAPSGERS FFCPDCGRGF SHGQHLARHP
460 470 480 490 500
RVHTGERPFA CTQCDRRFGS RPNLVAHSRA HSGARPFACA QCGRRFSRKS
510 520 530 540 550
HLGRHQAVHT GSRPHACAVC ARSFSSKTNL VRHQAIHTGS RPFSCPQCGK
560 570 580 590
SFSRKTHLVR HQLIHGEAAH AAPDAALAAP AWSAPPEVAP PPLFF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9JAX3 | C9JAX3_HUMAN | Zinc finger protein 467 | ZNF467 | 146 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052835 | 324 | T → A. Corresponds to variant dbSNP:rs6965332Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC052625 mRNA Translation: AAH52625.1 |
CCDSi | CCDS5899.1 |
RefSeqi | NP_997219.1, NM_207336.2 XP_005250016.1, XM_005249959.4 XP_005250017.1, XM_005249960.4 XP_005250018.1, XM_005249961.4 XP_011514160.1, XM_011515858.1 |
Genome annotation databases
Ensembli | ENST00000302017; ENSP00000304769; ENSG00000181444 |
GeneIDi | 168544 |
KEGGi | hsa:168544 |
UCSCi | uc003wgd.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC052625 mRNA Translation: AAH52625.1 |
CCDSi | CCDS5899.1 |
RefSeqi | NP_997219.1, NM_207336.2 XP_005250016.1, XM_005249959.4 XP_005250017.1, XM_005249960.4 XP_005250018.1, XM_005249961.4 XP_011514160.1, XM_011515858.1 |
3D structure databases
SMRi | Q7Z7K2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127969, 10 interactors |
IntActi | Q7Z7K2, 4 interactors |
STRINGi | 9606.ENSP00000304769 |
PTM databases
iPTMneti | Q7Z7K2 |
PhosphoSitePlusi | Q7Z7K2 |
Polymorphism and mutation databases
BioMutai | ZNF467 |
DMDMi | 74762444 |
Proteomic databases
MassIVEi | Q7Z7K2 |
PaxDbi | Q7Z7K2 |
PeptideAtlasi | Q7Z7K2 |
PRIDEi | Q7Z7K2 |
ProteomicsDBi | 69556 |
TopDownProteomicsi | Q7Z7K2 |
Protocols and materials databases
Antibodypediai | 51657, 12 antibodies |
Genome annotation databases
Ensembli | ENST00000302017; ENSP00000304769; ENSG00000181444 |
GeneIDi | 168544 |
KEGGi | hsa:168544 |
UCSCi | uc003wgd.3, human |
Organism-specific databases
CTDi | 168544 |
EuPathDBi | HostDB:ENSG00000181444.12 |
GeneCardsi | ZNF467 |
HGNCi | HGNC:23154, ZNF467 |
HPAi | ENSG00000181444, Low tissue specificity |
MIMi | 614040, gene |
neXtProti | NX_Q7Z7K2 |
OpenTargetsi | ENSG00000181444 |
PharmGKBi | PA134886769 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162497 |
HOGENOMi | CLU_002678_73_2_1 |
InParanoidi | Q7Z7K2 |
OMAi | CSGDEWM |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q7Z7K2 |
TreeFami | TF326846 |
Enzyme and pathway databases
PathwayCommonsi | Q7Z7K2 |
Reactomei | R-HSA-381340, Transcriptional regulation of white adipocyte differentiation |
Miscellaneous databases
BioGRID-ORCSi | 168544, 4 hits in 867 CRISPR screens |
GenomeRNAii | 168544 |
Pharosi | Q7Z7K2, Tdark |
PROi | PR:Q7Z7K2 |
RNActi | Q7Z7K2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000181444, Expressed in blood and 164 other tissues |
ExpressionAtlasi | Q7Z7K2, baseline and differential |
Genevisiblei | Q7Z7K2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 8 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 12 hits |
SUPFAMi | SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 12 hits PS50157, ZINC_FINGER_C2H2_2, 12 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN467_HUMAN | |
Accessioni | Q7Z7K2Primary (citable) accession number: Q7Z7K2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 25, 2006 |
Last sequence update: | October 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations