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Protein

Calcium/calmodulin-dependent protein kinase II inhibitor 1

Gene

CAMK2N1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potent and specific inhibitor of CaM-kinase II (CAMK2).By similarity1 Publication

GO - Molecular functioni

  • calcium-dependent protein kinase inhibitor activity Source: UniProtKB
  • protein kinase binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionProtein kinase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium/calmodulin-dependent protein kinase II inhibitor 1
Alternative name(s):
CaMKII inhibitory protein alpha
Short name:
CaMKIIN-alpha
Gene namesi
Name:CAMK2N1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162545.5
HGNCiHGNC:24190 CAMK2N1
MIMi614986 gene
neXtProtiNX_Q7Z7J9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse, Synaptosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi55450
OpenTargetsiENSG00000162545
PharmGKBiPA142672209

Polymorphism and mutation databases

BioMutaiCAMK2N1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003383931 – 78Calcium/calmodulin-dependent protein kinase II inhibitor 1Add BLAST78

Proteomic databases

EPDiQ7Z7J9
MaxQBiQ7Z7J9
PaxDbiQ7Z7J9
PeptideAtlasiQ7Z7J9
PRIDEiQ7Z7J9
ProteomicsDBi69554

PTM databases

iPTMnetiQ7Z7J9
PhosphoSitePlusiQ7Z7J9

Expressioni

Tissue specificityi

Widely expressed. Nor detected in skeletal muscle.1 Publication

Developmental stagei

Regulated in a cell cycle-dependent manner: abundant at S and G2/M phases and low in G0/G1 phase.

Gene expression databases

BgeeiENSG00000162545 Expressed in 224 organ(s), highest expression level in postcentral gyrus
CleanExiHS_CAMK2N1
GenevisibleiQ7Z7J9 HS

Interactioni

Subunit structurei

Interacts with CAMK2B; the presence of Ca2+/calmodulin increases the interaction but is not essential (By similarity). Interacts with CAMK2A; this interaction requires CAMK2A activation by Ca2+.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120671, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ7Z7J9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 68CAMK2 inhibitory domainAdd BLAST28

Domaini

CAMK2 inhibitory domain is also called 'conserved inhibitory region' or 27CIR.

Sequence similaritiesi

Belongs to the CAMK2N family.Curated

Phylogenomic databases

eggNOGiENOG410J0PZ Eukaryota
ENOG410YP01 LUCA
GeneTreeiENSGT00390000004940
HOVERGENiHBG104926
InParanoidiQ7Z7J9
OMAiKLGHYGD
OrthoDBiEOG091G15S0
PhylomeDBiQ7Z7J9
TreeFamiTF333175

Family and domain databases

InterProiView protein in InterPro
IPR026779 Camk2n
PANTHERiPTHR31007 PTHR31007, 1 hit
PfamiView protein in Pfam
PF15170 CaM-KIIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q7Z7J9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEVLPYGDE KLSPYGDGGD VGQIFSCRLQ DTNNFFGAGQ NKRPPKLGQI
60 70
GRSKRVVIED DRIDDVLKNM TDKAPPGV
Length:78
Mass (Da):8,553
Last modified:October 1, 2003 - v1
Checksum:i31866C5DA10B606F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY204901 mRNA Translation: AAO49802.1
AL391357 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW94923.1
CCDSiCCDS207.1
RefSeqiNP_061054.2, NM_018584.5
UniGeneiHs.731383

Genome annotation databases

EnsembliENST00000375078; ENSP00000364219; ENSG00000162545
GeneIDi55450
KEGGihsa:55450
UCSCiuc001bdh.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY204901 mRNA Translation: AAO49802.1
AL391357 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW94923.1
CCDSiCCDS207.1
RefSeqiNP_061054.2, NM_018584.5
UniGeneiHs.731383

3D structure databases

ProteinModelPortaliQ7Z7J9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120671, 2 interactors

PTM databases

iPTMnetiQ7Z7J9
PhosphoSitePlusiQ7Z7J9

Polymorphism and mutation databases

BioMutaiCAMK2N1

Proteomic databases

EPDiQ7Z7J9
MaxQBiQ7Z7J9
PaxDbiQ7Z7J9
PeptideAtlasiQ7Z7J9
PRIDEiQ7Z7J9
ProteomicsDBi69554

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375078; ENSP00000364219; ENSG00000162545
GeneIDi55450
KEGGihsa:55450
UCSCiuc001bdh.4 human

Organism-specific databases

CTDi55450
DisGeNETi55450
EuPathDBiHostDB:ENSG00000162545.5
GeneCardsiCAMK2N1
HGNCiHGNC:24190 CAMK2N1
MIMi614986 gene
neXtProtiNX_Q7Z7J9
OpenTargetsiENSG00000162545
PharmGKBiPA142672209
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0PZ Eukaryota
ENOG410YP01 LUCA
GeneTreeiENSGT00390000004940
HOVERGENiHBG104926
InParanoidiQ7Z7J9
OMAiKLGHYGD
OrthoDBiEOG091G15S0
PhylomeDBiQ7Z7J9
TreeFamiTF333175

Miscellaneous databases

ChiTaRSiCAMK2N1 human
GenomeRNAii55450
PROiPR:Q7Z7J9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162545 Expressed in 224 organ(s), highest expression level in postcentral gyrus
CleanExiHS_CAMK2N1
GenevisibleiQ7Z7J9 HS

Family and domain databases

InterProiView protein in InterPro
IPR026779 Camk2n
PANTHERiPTHR31007 PTHR31007, 1 hit
PfamiView protein in Pfam
PF15170 CaM-KIIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCK2N1_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7J9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: October 1, 2003
Last modified: September 12, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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