Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Developmental pluripotency-associated protein 2

Gene

DPPA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes.By similarity

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Developmental pluripotency-associated protein 2
Alternative name(s):
Pluripotent embryonic stem cell-related gene 1 protein
Gene namesi
Name:DPPA2
Synonyms:PESCRG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163530.4
HGNCiHGNC:19197 DPPA2
MIMi614445 gene
neXtProtiNX_Q7Z7J5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi151871
OpenTargetsiENSG00000163530
PharmGKBiPA134944028

Polymorphism and mutation databases

BioMutaiDPPA2
DMDMi116241341

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002392631 – 298Developmental pluripotency-associated protein 2Add BLAST298

Proteomic databases

EPDiQ7Z7J5
MaxQBiQ7Z7J5
PaxDbiQ7Z7J5
PeptideAtlasiQ7Z7J5
PRIDEiQ7Z7J5
ProteomicsDBi69552

PTM databases

iPTMnetiQ7Z7J5
PhosphoSitePlusiQ7Z7J5
SwissPalmiQ7Z7J5

Expressioni

Tissue specificityi

Expressed in embryonic stem cells. No expression is seen in 5 months embryo, mesenchymal stem cells, embryonic fibrocytes and adult tissues.1 Publication

Gene expression databases

BgeeiENSG00000163530 Expressed in 19 organ(s), highest expression level in testis
CleanExiHS_DPPA2
GenevisibleiQ7Z7J5 HS

Organism-specific databases

HPAiHPA036134

Interactioni

Subunit structurei

Interacts with DPPA4.By similarity

Protein-protein interaction databases

BioGridi127407, 21 interactors
IntActiQ7Z7J5, 17 interactors
STRINGi9606.ENSP00000417710

Structurei

3D structure databases

ProteinModelPortaliQ7Z7J5
SMRiQ7Z7J5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 126SAPPROSITE-ProRule annotationAdd BLAST35

Phylogenomic databases

eggNOGiENOG410IJEN Eukaryota
ENOG4111ADR LUCA
GeneTreeiENSGT00390000004871
HOGENOMiHOG000060113
HOVERGENiHBG095578
InParanoidiQ7Z7J5
OMAiTLRDWCQ
OrthoDBiEOG091G0QL3
PhylomeDBiQ7Z7J5
TreeFamiTF338129

Family and domain databases

InterProiView protein in InterPro
IPR025891 Dppa2/4_C_dom
IPR025892 Dppa2/4_central_dom
IPR003034 SAP_dom
PfamiView protein in Pfam
PF14047 DCR, 1 hit
PF14049 Dppa2_A, 1 hit
PROSITEiView protein in PROSITE
PS50800 SAP, 1 hit

Sequencei

Sequence statusi: Complete.

Q7Z7J5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDANLDSSK KNFLEGEVDD EESVILTLVP VKDDANMEQM EPSVSSTSDV
60 70 80 90 100
KLEKPKKYNP GHLLQTNEQF TAPQKARCKI PALPLPTILP PINKVCRDTL
110 120 130 140 150
RDWCQQLGLS TNGKKIEVYL RLHRHAYPEQ RQDMPEMSQE TRLQRCSRKR
160 170 180 190 200
KAVTKRARLQ RSYEMNERAE ETNTVEVITS APGAMLASWA RIAARAVQPK
210 220 230 240 250
ALNSCSIPVS VEAFLMQASG VRWCVVHGRL LSADTKGWVR LQFHAGQAWV
260 270 280 290
PTTHRRMISL FLLPACIFPS PGIEDNMLCP DCAKRNKKMM KRLMTVEK
Length:298
Mass (Da):33,784
Last modified:October 17, 2006 - v2
Checksum:i87FBCCCF52E88B5D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89L → S in AAP37285 (PubMed:15583978).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028087131R → Q. Corresponds to variant dbSNP:rs9809030Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY283672 mRNA Translation: AAP37285.1
BC018070 mRNA Translation: AAH18070.1
CCDSiCCDS2956.1
RefSeqiNP_620170.3, NM_138815.3
XP_011510746.1, XM_011512444.2
XP_011510747.1, XM_011512445.2
UniGeneiHs.351113

Genome annotation databases

EnsembliENST00000478945; ENSP00000417710; ENSG00000163530
GeneIDi151871
KEGGihsa:151871
UCSCiuc003dxo.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY283672 mRNA Translation: AAP37285.1
BC018070 mRNA Translation: AAH18070.1
CCDSiCCDS2956.1
RefSeqiNP_620170.3, NM_138815.3
XP_011510746.1, XM_011512444.2
XP_011510747.1, XM_011512445.2
UniGeneiHs.351113

3D structure databases

ProteinModelPortaliQ7Z7J5
SMRiQ7Z7J5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127407, 21 interactors
IntActiQ7Z7J5, 17 interactors
STRINGi9606.ENSP00000417710

PTM databases

iPTMnetiQ7Z7J5
PhosphoSitePlusiQ7Z7J5
SwissPalmiQ7Z7J5

Polymorphism and mutation databases

BioMutaiDPPA2
DMDMi116241341

Proteomic databases

EPDiQ7Z7J5
MaxQBiQ7Z7J5
PaxDbiQ7Z7J5
PeptideAtlasiQ7Z7J5
PRIDEiQ7Z7J5
ProteomicsDBi69552

Protocols and materials databases

DNASUi151871
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000478945; ENSP00000417710; ENSG00000163530
GeneIDi151871
KEGGihsa:151871
UCSCiuc003dxo.3 human

Organism-specific databases

CTDi151871
DisGeNETi151871
EuPathDBiHostDB:ENSG00000163530.4
GeneCardsiDPPA2
HGNCiHGNC:19197 DPPA2
HPAiHPA036134
MIMi614445 gene
neXtProtiNX_Q7Z7J5
OpenTargetsiENSG00000163530
PharmGKBiPA134944028
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJEN Eukaryota
ENOG4111ADR LUCA
GeneTreeiENSGT00390000004871
HOGENOMiHOG000060113
HOVERGENiHBG095578
InParanoidiQ7Z7J5
OMAiTLRDWCQ
OrthoDBiEOG091G0QL3
PhylomeDBiQ7Z7J5
TreeFamiTF338129

Miscellaneous databases

GeneWikiiDevelopmental_pluripotency_associated_2
GenomeRNAii151871
PROiPR:Q7Z7J5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163530 Expressed in 19 organ(s), highest expression level in testis
CleanExiHS_DPPA2
GenevisibleiQ7Z7J5 HS

Family and domain databases

InterProiView protein in InterPro
IPR025891 Dppa2/4_C_dom
IPR025892 Dppa2/4_central_dom
IPR003034 SAP_dom
PfamiView protein in Pfam
PF14047 DCR, 1 hit
PF14049 Dppa2_A, 1 hit
PROSITEiView protein in PROSITE
PS50800 SAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDPPA2_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7J5
Secondary accession number(s): Q8WVF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: October 17, 2006
Last modified: September 12, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again