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Entry version 122 (22 Apr 2020)
Sequence version 1 (01 Oct 2003)
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Protein

Complexin-4

Gene

CPLX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (By similarity). Required for the maintenance of synaptic ultrastructure in the adult retina (By similarity). Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (By similarity). Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca2+ vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca2+ vesicle release (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis, Neurotransmitter transport, Sensory transduction, Transport, Vision

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Complexin-4
Alternative name(s):
Complexin IV
Short name:
CPX IV
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CPLX4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:24330 CPLX4

Online Mendelian Inheritance in Man (OMIM)

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MIMi
609586 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z7G2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
339302

Open Targets

More...
OpenTargetsi
ENSG00000166569

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134902350

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7Z7G2 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CPLX4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74750239

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002402351 – 157Complexin-4Add BLAST157
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000240236158 – 160Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei157Cysteine methyl esterBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi157S-farnesyl cysteineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Farnesylation mediates presynaptic targeting and is important for function in neurotransmitter release.By similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q7Z7G2

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q7Z7G2

PeptideAtlas

More...
PeptideAtlasi
Q7Z7G2

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z7G2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69540

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z7G2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166569 Expressed in cerebellar hemisphere and 9 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7Z7G2 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000166569 Tissue enriched (retina)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Weakly binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q7Z7G2
With#Exp.IntAct
ADIPOQ [Q15848]3EBI-18013275,EBI-10827839
AGTRAP - isoform 2 [Q6RW13-2]3EBI-18013275,EBI-11522760
AIG1 - isoform 2 [Q9NVV5-2]3EBI-18013275,EBI-11957045
AOC3 [Q16853]3EBI-18013275,EBI-3921628
APOD [P05090]3EBI-18013275,EBI-715495
AQP1 [P29972]3EBI-18013275,EBI-745213
AQP9 [O43315]3EBI-18013275,EBI-17444777
ASGR1 [P07306]3EBI-18013275,EBI-1172335
ATP6V0C [P27449]3EBI-18013275,EBI-721179
BNIP2 [Q12982]3EBI-18013275,EBI-752094
C5 [P01031]3EBI-18013275,EBI-8558308
CACNG1 [Q06432]3EBI-18013275,EBI-9686780
CCL4L2 [Q8NHW4]3EBI-18013275,EBI-10271156
CD81 [P60033]3EBI-18013275,EBI-712921
CDIPT [O14735]3EBI-18013275,EBI-358858
CDS2 [O95674]3EBI-18013275,EBI-3913685
CLDND2 [Q8NHS1]3EBI-18013275,EBI-11959453
CLEC4G [Q6UXB4]3EBI-18013275,EBI-2114729
CLN6 [Q9NWW5]3EBI-18013275,EBI-6165897
CMTM5 - isoform 2 [Q96DZ9-2]3EBI-18013275,EBI-11522780
CNIH1 [O95406]3EBI-18013275,EBI-12172273
CTXN3 [Q4LDR2]3EBI-18013275,EBI-12019274
CYB5B [O43169]3EBI-18013275,EBI-1058710
CYBC1 [Q9BQA9]3EBI-18013275,EBI-2680384
CYP4F2 [P78329]3EBI-18013275,EBI-1752413
DEFB127 [Q9H1M4]3EBI-18013275,EBI-10305240
EMD [P50402]3EBI-18013275,EBI-489887
GAD2 [Q05329]3EBI-18013275,EBI-9304251
GIMAP1 [Q8WWP7]3EBI-18013275,EBI-11991950
GRM2 [Q14416]3EBI-18013275,EBI-10232876
HACD1 [B0YJ81]3EBI-18013275,EBI-12051643
HHATL [Q9HCP6]3EBI-18013275,EBI-5916693
HMOX1 [P09601]3EBI-18013275,EBI-2806151
INSIG2 [Q9Y5U4]3EBI-18013275,EBI-8503746
LPAR3 [Q9UBY5]3EBI-18013275,EBI-12033434
MAL [P21145]3EBI-18013275,EBI-3932027
MALL [Q13021]3EBI-18013275,EBI-750078
MAN2B2 [Q9Y2E5]3EBI-18013275,EBI-12243024
MGAM [O43451]3EBI-18013275,EBI-2829774
NINJ2 [Q9NZG7]3EBI-18013275,EBI-10317425
NRAC [Q8N912]3EBI-18013275,EBI-12051377
NRM [Q8IXM6]3EBI-18013275,EBI-10262547
ORMDL1 [Q9P0S3]3EBI-18013275,EBI-1054848
PGAP2 - isoform 5 [Q9UHJ9-5]3EBI-18013275,EBI-12092917
PLN [P26678]3EBI-18013275,EBI-692836
PLP2 [Q04941]3EBI-18013275,EBI-608347
PLPP4 [Q5VZY2]3EBI-18013275,EBI-10485931
PNLIPRP1 [P54315]3EBI-18013275,EBI-8652812
PPGB [Q59EV6]3EBI-18013275,EBI-14210385
PTPN9 [P43378]3EBI-18013275,EBI-742898
RTP2 [Q5QGT7]3EBI-18013275,EBI-10244780
SEC22B [O75396]3EBI-18013275,EBI-1058865
SELENOK [Q9Y6D0]3EBI-18013275,EBI-9679163
SFTPC [P11686]3EBI-18013275,EBI-10197617
SLC30A2 [Q9BRI3]3EBI-18013275,EBI-8644112
SLC30A8 [Q8IWU4]3EBI-18013275,EBI-10262251
SLC35A1 [P78382]3EBI-18013275,EBI-12870360
SLC35A4 [Q96G79]3EBI-18013275,EBI-12363689
SLC35B4 [Q969S0]3EBI-18013275,EBI-10281213
SLC38A7 [Q9NVC3]3EBI-18013275,EBI-10314552
SLC39A9 [Q9NUM3]3EBI-18013275,EBI-2823239
SMCO4 [Q9NRQ5]3EBI-18013275,EBI-8640191
STX3 [Q13277]3EBI-18013275,EBI-1394295
STX8 [Q9UNK0]3EBI-18013275,EBI-727240
SYNJ2BP [P57105]3EBI-18013275,EBI-1049004
TF [P02787]3EBI-18013275,EBI-714319
TMEM120B [A0PK00]3EBI-18013275,EBI-10171534
TMEM14A [Q9Y6G1]3EBI-18013275,EBI-2800360
TMEM14B [Q9NUH8]3EBI-18013275,EBI-8638294
TMEM19 [Q96HH6]3EBI-18013275,EBI-741829
TMEM201 - isoform 2 [Q5SNT2-2]3EBI-18013275,EBI-11994282
TMEM203 [Q969S6]3EBI-18013275,EBI-12274070
TMEM218 [A2RU14]3EBI-18013275,EBI-10173151
TMEM229B [Q8NBD8]3EBI-18013275,EBI-12195227
TMEM243 [Q9BU79]3EBI-18013275,EBI-12887458
TMEM254 [Q8TBM7]3EBI-18013275,EBI-11956809
TMEM267 [Q0VDI3]3EBI-18013275,EBI-17555467
TMEM60 [Q9H2L4]3EBI-18013275,EBI-2852148
TMEM79 [Q9BSE2]3EBI-18013275,EBI-8649725
TMEM86A [Q8N2M4]3EBI-18013275,EBI-12015604
TMEM97 [Q5BJF2]3EBI-18013275,EBI-12111910
TRAF3IP3 [Q9Y228]3EBI-18013275,EBI-765817
TSPO2 [Q5TGU0]3EBI-18013275,EBI-12195249
TTMP [Q5BVD1]3EBI-18013275,EBI-10243654
UBIAD1 [Q9Y5Z9]3EBI-18013275,EBI-2819725
VAMP4 [O75379]3EBI-18013275,EBI-744953
VAMP5 [O95183]3EBI-18013275,EBI-10191195
VKORC1 [Q9BQB6]3EBI-18013275,EBI-6256462
WFDC2 [Q14508]3EBI-18013275,EBI-723529
YIPF6 [Q96EC8]3EBI-18013275,EBI-751210
ZFPL1 [O95159]3EBI-18013275,EBI-718439

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
130863, 10 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q7Z7G2

Protein interaction database and analysis system

More...
IntActi
Q7Z7G2, 100 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000299721

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7Z7G2 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the complexin/synaphin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IGJR Eukaryota
ENOG4111JE6 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000182938

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_141096_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q7Z7G2

KEGG Orthology (KO)

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KOi
K15295

Identification of Orthologs from Complete Genome Data

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OMAi
MKSMLSN

Database of Orthologous Groups

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OrthoDBi
1441014at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q7Z7G2

TreeFam database of animal gene trees

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TreeFami
TF331867

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR008849 Synaphin

The PANTHER Classification System

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PANTHERi
PTHR16705 PTHR16705, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05835 Synaphin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q7Z7G2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFLMKSMIS NQVKNLGFGG GSEENKEEGG ASDPAAAQGM TREEYEEYQK
60 70 80 90 100
QMIEEKMERD AAFTQKKAER ACLRVHLREK YRLPKSEMDE NQIQMAGDDV
110 120 130 140 150
DLPEDLRKMV DEDQEEEEDK DSILGQIQNL QNMDLDTIKE KAQATFTEIK
160
QTAEQKCSVM
Length:160
Mass (Da):18,336
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE812EE05BD47E179
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EM04K7EM04_HUMAN
Complexin 4, isoform CRA_a
CPLX4 hCG_1776479
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY286502 mRNA Translation: AAP41128.1
AK123184 mRNA Translation: BAC85549.1
BX640655 mRNA Translation: CAE45797.1
AB593158 mRNA Translation: BAJ84090.1
CH471096 Genomic DNA Translation: EAW63095.1
BC106887 mRNA Translation: AAI06888.1
BC106888 mRNA Translation: AAI06889.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11973.1

NCBI Reference Sequences

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RefSeqi
NP_857637.1, NM_181654.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000299721; ENSP00000299721; ENSG00000166569

Database of genes from NCBI RefSeq genomes

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GeneIDi
339302

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:339302

UCSC genome browser

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UCSCi
uc002lhy.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY286502 mRNA Translation: AAP41128.1
AK123184 mRNA Translation: BAC85549.1
BX640655 mRNA Translation: CAE45797.1
AB593158 mRNA Translation: BAJ84090.1
CH471096 Genomic DNA Translation: EAW63095.1
BC106887 mRNA Translation: AAI06888.1
BC106888 mRNA Translation: AAI06889.1
CCDSiCCDS11973.1
RefSeqiNP_857637.1, NM_181654.3

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi130863, 10 interactors
CORUMiQ7Z7G2
IntActiQ7Z7G2, 100 interactors
STRINGi9606.ENSP00000299721

PTM databases

PhosphoSitePlusiQ7Z7G2

Polymorphism and mutation databases

BioMutaiCPLX4
DMDMi74750239

Proteomic databases

MassIVEiQ7Z7G2
PaxDbiQ7Z7G2
PeptideAtlasiQ7Z7G2
PRIDEiQ7Z7G2
ProteomicsDBi69540

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
42122 62 antibodies

The DNASU plasmid repository

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DNASUi
339302

Genome annotation databases

EnsembliENST00000299721; ENSP00000299721; ENSG00000166569
GeneIDi339302
KEGGihsa:339302
UCSCiuc002lhy.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
339302
DisGeNETi339302

GeneCards: human genes, protein and diseases

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GeneCardsi
CPLX4
HGNCiHGNC:24330 CPLX4
HPAiENSG00000166569 Tissue enriched (retina)
MIMi609586 gene
neXtProtiNX_Q7Z7G2
OpenTargetsiENSG00000166569
PharmGKBiPA134902350

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IGJR Eukaryota
ENOG4111JE6 LUCA
GeneTreeiENSGT00950000182938
HOGENOMiCLU_141096_0_0_1
InParanoidiQ7Z7G2
KOiK15295
OMAiMKSMLSN
OrthoDBi1441014at2759
PhylomeDBiQ7Z7G2
TreeFamiTF331867

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CPLX4 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
339302
PharosiQ7Z7G2 Tdark

Protein Ontology

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PROi
PR:Q7Z7G2
RNActiQ7Z7G2 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000166569 Expressed in cerebellar hemisphere and 9 other tissues
ExpressionAtlasiQ7Z7G2 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR008849 Synaphin
PANTHERiPTHR16705 PTHR16705, 1 hit
PfamiView protein in Pfam
PF05835 Synaphin, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCPLX4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z7G2
Secondary accession number(s): F1T0L6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 1, 2003
Last modified: April 22, 2020
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
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