UniProtKB - Q7Z7G2 (CPLX4_HUMAN)
Protein
Complexin-4
Gene
CPLX4
Organism
Homo sapiens (Human)
Status
Functioni
Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (By similarity). Required for the maintenance of synaptic ultrastructure in the adult retina (By similarity). Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (By similarity). Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca2+ vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca2+ vesicle release (By similarity).By similarity
GO - Molecular functioni
- SNARE binding Source: GO_Central
- syntaxin binding Source: InterPro
GO - Biological processi
- regulation of neurotransmitter secretion Source: GO_Central
- response to stimulus Source: UniProtKB-KW
- synaptic vesicle exocytosis Source: GO_Central
- visual perception Source: UniProtKB-KW
Keywordsi
Biological process | Exocytosis, Neurotransmitter transport, Sensory transduction, Transport, Vision |
Enzyme and pathway databases
PathwayCommonsi | Q7Z7G2 |
Names & Taxonomyi
Protein namesi | Recommended name: Complexin-4Alternative name(s): Complexin IV Short name: CPX IV |
Gene namesi | Name:CPLX4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000166569.8 |
HGNCi | HGNC:24330, CPLX4 |
MIMi | 609586, gene |
neXtProti | NX_Q7Z7G2 |
Subcellular locationi
Plasma membrane
- Cell membrane ; Lipid-anchor By similarity
Other locations
- synapse By similarity
Note: Enriched at the synaptic terminal.By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- SNARE complex Source: GO_Central
- terminal bouton Source: GO_Central
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, SynapsePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000166569 |
PharmGKBi | PA134902350 |
Miscellaneous databases
Pharosi | Q7Z7G2, Tdark |
Polymorphism and mutation databases
BioMutai | CPLX4 |
DMDMi | 74750239 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000240235 | 1 – 157 | Complexin-4Add BLAST | 157 | |
PropeptideiPRO_0000240236 | 158 – 160 | Removed in mature formBy similarity | 3 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 157 | Cysteine methyl esterBy similarity | 1 | |
Lipidationi | 157 | S-farnesyl cysteineBy similarity | 1 |
Post-translational modificationi
Farnesylation mediates presynaptic targeting and is important for function in neurotransmitter release.By similarity
Keywords - PTMi
Lipoprotein, Methylation, PrenylationProteomic databases
MassIVEi | Q7Z7G2 |
PaxDbi | Q7Z7G2 |
PeptideAtlasi | Q7Z7G2 |
PRIDEi | Q7Z7G2 |
ProteomicsDBi | 69540 |
PTM databases
PhosphoSitePlusi | Q7Z7G2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000166569, Expressed in cerebellar hemisphere and 12 other tissues |
ExpressionAtlasi | Q7Z7G2, baseline and differential |
Organism-specific databases
HPAi | ENSG00000166569, Tissue enriched (retina) |
Interactioni
Subunit structurei
Weakly binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.
By similarityBinary interactionsi
Q7Z7G2
GO - Molecular functioni
- SNARE binding Source: GO_Central
- syntaxin binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 130863, 102 interactors |
CORUMi | Q7Z7G2 |
IntActi | Q7Z7G2, 100 interactors |
STRINGi | 9606.ENSP00000299721 |
Miscellaneous databases
RNActi | Q7Z7G2, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the complexin/synaphin family.Curated
Phylogenomic databases
eggNOGi | ENOG502RY7Q, Eukaryota |
GeneTreei | ENSGT00950000182938 |
HOGENOMi | CLU_141096_0_0_1 |
InParanoidi | Q7Z7G2 |
OMAi | MVAEDQV |
OrthoDBi | 1441014at2759 |
PhylomeDBi | Q7Z7G2 |
TreeFami | TF331867 |
Family and domain databases
InterProi | View protein in InterPro IPR008849, Synaphin |
PANTHERi | PTHR16705, PTHR16705, 1 hit |
Pfami | View protein in Pfam PF05835, Synaphin, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q7Z7G2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAFLMKSMIS NQVKNLGFGG GSEENKEEGG ASDPAAAQGM TREEYEEYQK
60 70 80 90 100
QMIEEKMERD AAFTQKKAER ACLRVHLREK YRLPKSEMDE NQIQMAGDDV
110 120 130 140 150
DLPEDLRKMV DEDQEEEEDK DSILGQIQNL QNMDLDTIKE KAQATFTEIK
160
QTAEQKCSVM
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketK7EM04 | K7EM04_HUMAN | Complexin 4, isoform CRA_a | CPLX4 hCG_1776479 | 97 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY286502 mRNA Translation: AAP41128.1 AK123184 mRNA Translation: BAC85549.1 BX640655 mRNA Translation: CAE45797.1 AB593158 mRNA Translation: BAJ84090.1 CH471096 Genomic DNA Translation: EAW63095.1 BC106887 mRNA Translation: AAI06888.1 BC106888 mRNA Translation: AAI06889.1 |
CCDSi | CCDS11973.1 |
RefSeqi | NP_857637.1, NM_181654.3 |
Genome annotation databases
Ensembli | ENST00000299721; ENSP00000299721; ENSG00000166569 |
GeneIDi | 339302 |
KEGGi | hsa:339302 |
UCSCi | uc002lhy.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY286502 mRNA Translation: AAP41128.1 AK123184 mRNA Translation: BAC85549.1 BX640655 mRNA Translation: CAE45797.1 AB593158 mRNA Translation: BAJ84090.1 CH471096 Genomic DNA Translation: EAW63095.1 BC106887 mRNA Translation: AAI06888.1 BC106888 mRNA Translation: AAI06889.1 |
CCDSi | CCDS11973.1 |
RefSeqi | NP_857637.1, NM_181654.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 130863, 102 interactors |
CORUMi | Q7Z7G2 |
IntActi | Q7Z7G2, 100 interactors |
STRINGi | 9606.ENSP00000299721 |
PTM databases
PhosphoSitePlusi | Q7Z7G2 |
Polymorphism and mutation databases
BioMutai | CPLX4 |
DMDMi | 74750239 |
Proteomic databases
MassIVEi | Q7Z7G2 |
PaxDbi | Q7Z7G2 |
PeptideAtlasi | Q7Z7G2 |
PRIDEi | Q7Z7G2 |
ProteomicsDBi | 69540 |
Protocols and materials databases
Antibodypediai | 42122, 62 antibodies |
DNASUi | 339302 |
Genome annotation databases
Ensembli | ENST00000299721; ENSP00000299721; ENSG00000166569 |
GeneIDi | 339302 |
KEGGi | hsa:339302 |
UCSCi | uc002lhy.4, human |
Organism-specific databases
CTDi | 339302 |
EuPathDBi | HostDB:ENSG00000166569.8 |
GeneCardsi | CPLX4 |
HGNCi | HGNC:24330, CPLX4 |
HPAi | ENSG00000166569, Tissue enriched (retina) |
MIMi | 609586, gene |
neXtProti | NX_Q7Z7G2 |
OpenTargetsi | ENSG00000166569 |
PharmGKBi | PA134902350 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RY7Q, Eukaryota |
GeneTreei | ENSGT00950000182938 |
HOGENOMi | CLU_141096_0_0_1 |
InParanoidi | Q7Z7G2 |
OMAi | MVAEDQV |
OrthoDBi | 1441014at2759 |
PhylomeDBi | Q7Z7G2 |
TreeFami | TF331867 |
Enzyme and pathway databases
PathwayCommonsi | Q7Z7G2 |
Miscellaneous databases
BioGRID-ORCSi | 339302, 2 hits in 841 CRISPR screens |
ChiTaRSi | CPLX4, human |
GenomeRNAii | 339302 |
Pharosi | Q7Z7G2, Tdark |
PROi | PR:Q7Z7G2 |
RNActi | Q7Z7G2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000166569, Expressed in cerebellar hemisphere and 12 other tissues |
ExpressionAtlasi | Q7Z7G2, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR008849, Synaphin |
PANTHERi | PTHR16705, PTHR16705, 1 hit |
Pfami | View protein in Pfam PF05835, Synaphin, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CPLX4_HUMAN | |
Accessioni | Q7Z7G2Primary (citable) accession number: Q7Z7G2 Secondary accession number(s): F1T0L6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 13, 2006 |
Last sequence update: | October 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM