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Entry version 143 (26 Feb 2020)
Sequence version 1 (01 Oct 2003)
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Protein

Target of Nesh-SH3

Gene

ABI3BP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Target of Nesh-SH3
Short name:
Tarsh
Alternative name(s):
ABI gene family member 3-binding protein
Nesh-binding protein
Short name:
NeshBP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABI3BP
Synonyms:NESHBP, TARSH
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17265 ABI3BP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606279 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z7G0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in ABI3BP has been found in a patient with isolated coloboma, a defect of the eye characterized by the absence of ocular structures due to abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Isolated colobomas may be associated with an abnormally small eye (microphthalmia) or small cornea.1 Publication

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
25890

Open Targets

More...
OpenTargetsi
ENSG00000154175

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134977769

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7Z7G0 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ABI3BP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
50401533

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002247229 – 1075Target of Nesh-SH3Add BLAST1047

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi44N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7Z7G0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7Z7G0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q7Z7G0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7Z7G0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7Z7G0

PeptideAtlas

More...
PeptideAtlasi
Q7Z7G0

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z7G0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69533 [Q7Z7G0-1]
69534 [Q7Z7G0-2]
69535 [Q7Z7G0-3]
69536 [Q7Z7G0-4]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1785

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7Z7G0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z7G0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, heart, lung, liver, pancreas kidney and placenta.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000154175 Expressed in decidua and 196 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7Z7G0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7Z7G0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA044127

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Probably interacts with ABI3.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117399, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q7Z7G0, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000284322

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7Z7G0 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7Z7G0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini123 – 221Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST99
Domaini840 – 933Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST94

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi419 – 756Pro-richAdd BLAST338

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIJU Eukaryota
ENOG410YEIJ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063558

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004059_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7Z7G0

Database of Orthologous Groups

More...
OrthoDBi
46073at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7Z7G0

TreeFam database of animal gene trees

More...
TreeFami
TF331037

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 20 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z7G0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRGGKCNMLS SLGCLLLCGS ITLALGNAQK LPKGKRPNLK VHINTTSDSI
60 70 80 90 100
LLKFLRPSPN VKLEGLLLGY GSNVSPNQYF PLPAEGKFTE AIVDAEPKYL
110 120 130 140 150
IVVRPAPPPS QKKSCSGKTR SRKPLQLVVG TLTPSSVFLS WGFLINPHHD
160 170 180 190 200
WTLPSHCPND RFYTIRYREK DKEKKWIFQI CPATETIVEN LKPNTVYEFG
210 220 230 240 250
VKDNVEGGIW SKIFNHKTVV GSKKVNGKIQ STYDQDHTVP AYVPRKLIPI
260 270 280 290 300
TIIKQVIQNV THKDSAKSPE KAPLGGVILV HLIIPGLNET TVKLPASLMF
310 320 330 340 350
EISDALKTQL AKNETLALPA ESKTPEVEKI SARPTTVTPE TVPRSTKPTT
360 370 380 390 400
SSALDVSETT LASSEKPWIV PTAKISEDSK VLQPQTATYD VFSSPTTSDE
410 420 430 440 450
PEISDSYTAT SDRILDSIPP KTSRTLEQPR ATLAPSETPF VPQKLEIFTS
460 470 480 490 500
PEMQPTTPAP QQTTSIPSTP KRRPRPKPPR TKPERTTSAG TITPKISKSP
510 520 530 540 550
EPTWTTPAPG KTQFISLKPK IPLSPEVTHT KPAPKQTPRA PPKPKTSPRP
560 570 580 590 600
RIPQTQPVPK VPQRVTAKPK TSPSPEVSYT TPAPKDVLLP HKPYPEVSQS
610 620 630 640 650
EPAPLETRGI PFIPMISPSP SQEELQTTLE ETDQSTQEPF TTKIPRTTEL
660 670 680 690 700
AKTTQAPHRF YTTVRPRTSD KPHIRPGVKQ APRPSGADRN VSVDSTHPTK
710 720 730 740 750
KPGTRRPPLP PRPTHPRRKP LPPNNVTGKP GSAGIISSGP ITTPPLRSTP
760 770 780 790 800
RPTGTPLERI ETDIKQPTVP ASGEELENIT DFSSSPTRET DPLGKPRFKG
810 820 830 840 850
PHVRYIQKPD NSPCSITDSV KRFPKEEATE GNATSPPQNP PTNLTVVTVE
860 870 880 890 900
GCPSFVILDW EKPLNDTVTE YEVISRENGS FSGKNKSIQM TNQTFSTVEN
910 920 930 940 950
LKPNTSYEFQ VKPKNPLGEG PVSNTVAFST ESADPRVSEP VSAGRDAIWT
960 970 980 990 1000
ERPFNSDSYS ECKGKQYVKR TWYKKFVGVQ LCNSLRYKIY LSDSLTGKFY
1010 1020 1030 1040 1050
NIGDQRGHGE DHCQFVDSFL DGRTGQQLTS DQLPIKEGYF RAVRQEPVQF
1060 1070
GEIGGHTQIN YVQWYECGTT IPGKW
Length:1,075
Mass (Da):118,642
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i52FF60EE360FA0F1
GO
Isoform 2 (identifier: Q7Z7G0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-614: Missing.
     676-676: P → PVLNRTTTRPTRPKPSGMPSGNGVGT

Show »
Length:486
Mass (Da):53,888
Checksum:i790AEBE657E0D766
GO
Isoform 3 (identifier: Q7Z7G0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-316: Missing.
     317-446: Missing.
     447-531: IFTSPEMQPT...PLSPEVTHTK → MTESLPVSDV...LPSPDEPQTE
     676-676: P → PVLNRTTTRPTRPKPSGMPSGNGVGT

Show »
Length:655
Mass (Da):72,267
Checksum:iBA728A5D1FAC9343
GO
Isoform 4 (identifier: Q7Z7G0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-316: Missing.
     317-530: ALPAESKTPE...IPLSPEVTHT → MTIVPTTDIE...TTPRPEAPES
     676-676: P → PVLNRTTTRPTRPKPSGMPSGNGVGT

Show »
Length:784
Mass (Da):86,789
Checksum:iF981C59445ACC6FF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 20 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JPC9Q5JPC9_HUMAN
ABI gene family, member 3 (NESH) bi...
ABI3BP DKFZp667H216, hCG_2023009
1,005Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YTG3D3YTG3_HUMAN
Target of Nesh-SH3
ABI3BP
1,777Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C556H7C556_HUMAN
Target of Nesh-SH3
ABI3BP
1,229Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y897H0Y897_HUMAN
Target of Nesh-SH3
ABI3BP
1,131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCP4H0YCP4_HUMAN
Target of Nesh-SH3
ABI3BP
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCG4H0YCG4_HUMAN
Target of Nesh-SH3
ABI3BP
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDN0H0YDN0_HUMAN
Target of Nesh-SH3
ABI3BP
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEL2H0YEL2_HUMAN
Target of Nesh-SH3
ABI3BP
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YF18H0YF18_HUMAN
Target of Nesh-SH3
ABI3BP
303Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4N5H7C4N5_HUMAN
Target of Nesh-SH3
ABI3BP
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB56034 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_079855670D → G Found in a patient with isolated coloboma; unknown pathological significance. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0108601 – 614Missing in isoform 2. 2 PublicationsAdd BLAST614
Alternative sequenceiVSP_0108621 – 316Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST316
Alternative sequenceiVSP_010865317 – 530ALPAE…EVTHT → MTIVPTTDIEPVTVRTEATV TTLAPKTSQRTRTRRPRPKH KTTPRPETLQTKLDFGPITP GTSSAPTTTTKRTRRPHPKP KTTPHPEVPQTKLAPKVPQR THRPHPKPKTTLSPEELQTE LVPVTDLGPVTFRTEIPATT LATKTSKRTRPPRPRPKTTP SPQAPETKPVPATVLEPVTL RPEASTTLASKTSQRTRRPR LRTKTTPRPEAPES in isoform 4. 1 PublicationAdd BLAST214
Alternative sequenceiVSP_010863317 – 446Missing in isoform 3. 1 PublicationAdd BLAST130
Alternative sequenceiVSP_010864447 – 531IFTSP…VTHTK → MTESLPVSDVLESVTLSTES PKETIAPAKTDYVYPTAKAP LWPEEPKTEVVESITYVSEP PETTLETSPLPSQSITLPSP DEPQTE in isoform 3. 1 PublicationAdd BLAST85
Alternative sequenceiVSP_010861676P → PVLNRTTTRPTRPKPSGMPS GNGVGT in isoform 2, isoform 3 and isoform 4. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB056106 mRNA Translation: BAB32867.1
AK093861 mRNA Translation: BAG52776.1
AK123737 mRNA Translation: BAC85685.1
AK123748 mRNA Translation: BAC85687.1
CH471052 Genomic DNA Translation: EAW79811.1
BC030221 mRNA Translation: AAH30221.1
AL117664 mRNA Translation: CAB56034.1 Different initiation.

Protein sequence database of the Protein Information Resource

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PIRi
T17344

NCBI Reference Sequences

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RefSeqi
NP_056244.2, NM_015429.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000284322; ENSP00000284322; ENSG00000154175 [Q7Z7G0-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
25890

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:25890

UCSC genome browser

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UCSCi
uc003dun.4 human [Q7Z7G0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB056106 mRNA Translation: BAB32867.1
AK093861 mRNA Translation: BAG52776.1
AK123737 mRNA Translation: BAC85685.1
AK123748 mRNA Translation: BAC85687.1
CH471052 Genomic DNA Translation: EAW79811.1
BC030221 mRNA Translation: AAH30221.1
AL117664 mRNA Translation: CAB56034.1 Different initiation.
PIRiT17344
RefSeqiNP_056244.2, NM_015429.3

3D structure databases

SMRiQ7Z7G0
ModBaseiSearch...

Protein-protein interaction databases

BioGridi117399, 9 interactors
IntActiQ7Z7G0, 7 interactors
STRINGi9606.ENSP00000284322

PTM databases

GlyConnecti1785
iPTMnetiQ7Z7G0
PhosphoSitePlusiQ7Z7G0

Polymorphism and mutation databases

BioMutaiABI3BP
DMDMi50401533

Proteomic databases

EPDiQ7Z7G0
jPOSTiQ7Z7G0
MassIVEiQ7Z7G0
MaxQBiQ7Z7G0
PaxDbiQ7Z7G0
PeptideAtlasiQ7Z7G0
PRIDEiQ7Z7G0
ProteomicsDBi69533 [Q7Z7G0-1]
69534 [Q7Z7G0-2]
69535 [Q7Z7G0-3]
69536 [Q7Z7G0-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
25890

Genome annotation databases

EnsembliENST00000284322; ENSP00000284322; ENSG00000154175 [Q7Z7G0-1]
GeneIDi25890
KEGGihsa:25890
UCSCiuc003dun.4 human [Q7Z7G0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
25890
DisGeNETi25890

GeneCards: human genes, protein and diseases

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GeneCardsi
ABI3BP
HGNCiHGNC:17265 ABI3BP
HPAiHPA044127
MIMi606279 gene
neXtProtiNX_Q7Z7G0
OpenTargetsiENSG00000154175
PharmGKBiPA134977769

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IIJU Eukaryota
ENOG410YEIJ LUCA
GeneTreeiENSGT00530000063558
HOGENOMiCLU_004059_0_0_1
InParanoidiQ7Z7G0
OrthoDBi46073at2759
PhylomeDBiQ7Z7G0
TreeFamiTF331037

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ABI3BP human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
25890
PharosiQ7Z7G0 Tbio

Protein Ontology

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PROi
PR:Q7Z7G0
RNActiQ7Z7G0 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000154175 Expressed in decidua and 196 other tissues
ExpressionAtlasiQ7Z7G0 baseline and differential
GenevisibleiQ7Z7G0 HS

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00041 fn3, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SUPFAMiSSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTARSH_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z7G0
Secondary accession number(s): B3KSL4
, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2003
Last modified: February 26, 2020
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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