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Protein

39S ribosomal protein L55, mitochondrial

Gene

MRPL55

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L55, mitochondrial
Short name:
L55mt
Short name:
MRP-L55
Alternative name(s):
Mitochondrial large ribosomal subunit protein bL31m1 Publication
Mitochondrial large ribosomal subunit protein mL551 Publication
Gene namesi
Name:MRPL55
ORF Names:UNQ5835/PRO19675
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162910.18
HGNCiHGNC:16686 MRPL55
MIMi611859 gene
neXtProtiNX_Q7Z7F7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162910
PharmGKBiPA30988

Polymorphism and mutation databases

BioMutaiMRPL55
DMDMi74750237

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 33MitochondrionSequence analysisAdd BLAST33
ChainiPRO_000027309934 – 12839S ribosomal protein L55, mitochondrialAdd BLAST95

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei85PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7Z7F7
MaxQBiQ7Z7F7
PaxDbiQ7Z7F7
PeptideAtlasiQ7Z7F7
PRIDEiQ7Z7F7
ProteomicsDBi69531
69532 [Q7Z7F7-2]
TopDownProteomicsiQ7Z7F7-1 [Q7Z7F7-1]

PTM databases

iPTMnetiQ7Z7F7
PhosphoSitePlusiQ7Z7F7

Expressioni

Gene expression databases

BgeeiENSG00000162910 Expressed in 184 organ(s), highest expression level in liver
CleanExiHS_MRPL55
ExpressionAtlasiQ7Z7F7 baseline and differential
GenevisibleiQ7Z7F7 HS

Organism-specific databases

HPAiHPA027641

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.1 Publication2 Publications

Protein-protein interaction databases

BioGridi126105, 55 interactors
CORUMiQ7Z7F7
IntActiQ7Z7F7, 19 interactors
MINTiQ7Z7F7
STRINGi9606.ENSP00000355692

Structurei

Secondary structure

1128
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ7Z7F7
SMRiQ7Z7F7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4616 Eukaryota
ENOG41124VE LUCA
GeneTreeiENSGT00390000010309
HOGENOMiHOG000006834
HOVERGENiHBG080171
InParanoidiQ7Z7F7
KOiK17436
OMAiFWARTKK
OrthoDBiEOG091G11CW
PhylomeDBiQ7Z7F7
TreeFamiTF320422

Family and domain databases

InterProiView protein in InterPro
IPR018615 Ribosomal_L55_mit
PANTHERiPTHR34095 PTHR34095, 1 hit
PfamiView protein in Pfam
PF09776 Mitoc_L55, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z7F7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAVGSLLGR LRQSTVKATG PALRRLHTSS WRADSSRASL TRVHRQAYAR
60 70 80 90 100
LYPVLLVKQD GSTIHIRYRE PRRMLAMPID LDTLSPEERR ARLRKREAQL
110 120
QSRKEYEQEL SDDLHVERYR QFWTRTKK
Length:128
Mass (Da):15,128
Last modified:October 1, 2003 - v1
Checksum:iA7808C869855C994
GO
Isoform 2 (identifier: Q7Z7F7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     9-9: G → GLAASSWLGGQNASDHSLWLLRKPRGSSCPGTGHQLC

Note: No experimental confirmation available.
Show »
Length:164
Mass (Da):18,903
Checksum:iAC44E758A2D54D49
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6R631X6R631_HUMAN
39S ribosomal protein L55, mitochon...
MRPL55 hCG_42248
55Annotation score:
X6RIW1X6RIW1_HUMAN
39S ribosomal protein L55, mitochon...
MRPL55
76Annotation score:
A0A0A0MST4A0A0A0MST4_HUMAN
39S ribosomal protein L55, mitochon...
MRPL55
43Annotation score:
A0A087X2A2A0A087X2A2_HUMAN
39S ribosomal protein L55, mitochon...
MRPL55
24Annotation score:
A0A0G2JMK5A0A0G2JMK5_HUMAN
39S ribosomal protein L55, mitochon...
MRPL55
8Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03008224R → C. Corresponds to variant dbSNP:rs822730Ensembl.1
Natural variantiVAR_05204542R → H. Corresponds to variant dbSNP:rs35265990Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0224779G → GLAASSWLGGQNASDHSLWL LRKPRGSSCPGTGHQLC in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358771 mRNA Translation: AAQ89131.1
AL136379 Genomic DNA No translation available.
BC052806 mRNA Translation: AAH52806.1
CCDSiCCDS1567.1 [Q7Z7F7-1]
CCDS44325.1 [Q7Z7F7-2]
RefSeqiNP_001308213.1, NM_001321284.1 [Q7Z7F7-1]
NP_852106.1, NM_181441.2 [Q7Z7F7-1]
NP_852119.1, NM_181454.2 [Q7Z7F7-1]
NP_852120.1, NM_181455.2 [Q7Z7F7-1]
NP_852121.1, NM_181456.2 [Q7Z7F7-1]
NP_852127.2, NM_181462.2 [Q7Z7F7-2]
NP_852128.1, NM_181463.2 [Q7Z7F7-1]
NP_852129.1, NM_181464.2 [Q7Z7F7-1]
NP_852130.1, NM_181465.2 [Q7Z7F7-1]
XP_005273116.1, XM_005273059.3 [Q7Z7F7-1]
XP_005273118.1, XM_005273061.4 [Q7Z7F7-1]
XP_005273119.1, XM_005273062.3 [Q7Z7F7-1]
XP_005273120.1, XM_005273063.4 [Q7Z7F7-1]
XP_011542396.1, XM_011544094.2
XP_011542397.1, XM_011544095.2 [Q7Z7F7-1]
UniGeneiHs.63236

Genome annotation databases

EnsembliENST00000295008; ENSP00000295008; ENSG00000162910 [Q7Z7F7-1]
ENST00000336300; ENSP00000337361; ENSG00000162910 [Q7Z7F7-1]
ENST00000336520; ENSP00000337342; ENSG00000162910 [Q7Z7F7-1]
ENST00000348259; ENSP00000338189; ENSG00000162910 [Q7Z7F7-1]
ENST00000366733; ENSP00000355694; ENSG00000162910 [Q7Z7F7-1]
ENST00000366734; ENSP00000355695; ENSG00000162910 [Q7Z7F7-1]
ENST00000366735; ENSP00000355696; ENSG00000162910 [Q7Z7F7-1]
ENST00000366736; ENSP00000355697; ENSG00000162910 [Q7Z7F7-1]
ENST00000366738; ENSP00000355699; ENSG00000162910 [Q7Z7F7-2]
ENST00000366739; ENSP00000355700; ENSG00000162910 [Q7Z7F7-1]
ENST00000366740; ENSP00000355701; ENSG00000162910 [Q7Z7F7-1]
ENST00000366741; ENSP00000355702; ENSG00000162910 [Q7Z7F7-1]
ENST00000366742; ENSP00000355703; ENSG00000162910 [Q7Z7F7-1]
ENST00000366744; ENSP00000355705; ENSG00000162910 [Q7Z7F7-1]
ENST00000366746; ENSP00000355707; ENSG00000162910 [Q7Z7F7-1]
ENST00000366747; ENSP00000355708; ENSG00000162910 [Q7Z7F7-1]
ENST00000391867; ENSP00000375740; ENSG00000162910 [Q7Z7F7-1]
ENST00000430433; ENSP00000403614; ENSG00000162910 [Q7Z7F7-2]
GeneIDi128308
KEGGihsa:128308
UCSCiuc001hrz.5 human [Q7Z7F7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358771 mRNA Translation: AAQ89131.1
AL136379 Genomic DNA No translation available.
BC052806 mRNA Translation: AAH52806.1
CCDSiCCDS1567.1 [Q7Z7F7-1]
CCDS44325.1 [Q7Z7F7-2]
RefSeqiNP_001308213.1, NM_001321284.1 [Q7Z7F7-1]
NP_852106.1, NM_181441.2 [Q7Z7F7-1]
NP_852119.1, NM_181454.2 [Q7Z7F7-1]
NP_852120.1, NM_181455.2 [Q7Z7F7-1]
NP_852121.1, NM_181456.2 [Q7Z7F7-1]
NP_852127.2, NM_181462.2 [Q7Z7F7-2]
NP_852128.1, NM_181463.2 [Q7Z7F7-1]
NP_852129.1, NM_181464.2 [Q7Z7F7-1]
NP_852130.1, NM_181465.2 [Q7Z7F7-1]
XP_005273116.1, XM_005273059.3 [Q7Z7F7-1]
XP_005273118.1, XM_005273061.4 [Q7Z7F7-1]
XP_005273119.1, XM_005273062.3 [Q7Z7F7-1]
XP_005273120.1, XM_005273063.4 [Q7Z7F7-1]
XP_011542396.1, XM_011544094.2
XP_011542397.1, XM_011544095.2 [Q7Z7F7-1]
UniGeneiHs.63236

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50m1-128[»]
5OOLelectron microscopy3.06m1-128[»]
5OOMelectron microscopy3.03m1-128[»]
ProteinModelPortaliQ7Z7F7
SMRiQ7Z7F7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126105, 55 interactors
CORUMiQ7Z7F7
IntActiQ7Z7F7, 19 interactors
MINTiQ7Z7F7
STRINGi9606.ENSP00000355692

PTM databases

iPTMnetiQ7Z7F7
PhosphoSitePlusiQ7Z7F7

Polymorphism and mutation databases

BioMutaiMRPL55
DMDMi74750237

Proteomic databases

EPDiQ7Z7F7
MaxQBiQ7Z7F7
PaxDbiQ7Z7F7
PeptideAtlasiQ7Z7F7
PRIDEiQ7Z7F7
ProteomicsDBi69531
69532 [Q7Z7F7-2]
TopDownProteomicsiQ7Z7F7-1 [Q7Z7F7-1]

Protocols and materials databases

DNASUi128308
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295008; ENSP00000295008; ENSG00000162910 [Q7Z7F7-1]
ENST00000336300; ENSP00000337361; ENSG00000162910 [Q7Z7F7-1]
ENST00000336520; ENSP00000337342; ENSG00000162910 [Q7Z7F7-1]
ENST00000348259; ENSP00000338189; ENSG00000162910 [Q7Z7F7-1]
ENST00000366733; ENSP00000355694; ENSG00000162910 [Q7Z7F7-1]
ENST00000366734; ENSP00000355695; ENSG00000162910 [Q7Z7F7-1]
ENST00000366735; ENSP00000355696; ENSG00000162910 [Q7Z7F7-1]
ENST00000366736; ENSP00000355697; ENSG00000162910 [Q7Z7F7-1]
ENST00000366738; ENSP00000355699; ENSG00000162910 [Q7Z7F7-2]
ENST00000366739; ENSP00000355700; ENSG00000162910 [Q7Z7F7-1]
ENST00000366740; ENSP00000355701; ENSG00000162910 [Q7Z7F7-1]
ENST00000366741; ENSP00000355702; ENSG00000162910 [Q7Z7F7-1]
ENST00000366742; ENSP00000355703; ENSG00000162910 [Q7Z7F7-1]
ENST00000366744; ENSP00000355705; ENSG00000162910 [Q7Z7F7-1]
ENST00000366746; ENSP00000355707; ENSG00000162910 [Q7Z7F7-1]
ENST00000366747; ENSP00000355708; ENSG00000162910 [Q7Z7F7-1]
ENST00000391867; ENSP00000375740; ENSG00000162910 [Q7Z7F7-1]
ENST00000430433; ENSP00000403614; ENSG00000162910 [Q7Z7F7-2]
GeneIDi128308
KEGGihsa:128308
UCSCiuc001hrz.5 human [Q7Z7F7-1]

Organism-specific databases

CTDi128308
EuPathDBiHostDB:ENSG00000162910.18
GeneCardsiMRPL55
HGNCiHGNC:16686 MRPL55
HPAiHPA027641
MIMi611859 gene
neXtProtiNX_Q7Z7F7
OpenTargetsiENSG00000162910
PharmGKBiPA30988
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4616 Eukaryota
ENOG41124VE LUCA
GeneTreeiENSGT00390000010309
HOGENOMiHOG000006834
HOVERGENiHBG080171
InParanoidiQ7Z7F7
KOiK17436
OMAiFWARTKK
OrthoDBiEOG091G11CW
PhylomeDBiQ7Z7F7
TreeFamiTF320422

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSiMRPL55 human
GeneWikiiMRPL55
GenomeRNAii128308
PROiPR:Q7Z7F7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162910 Expressed in 184 organ(s), highest expression level in liver
CleanExiHS_MRPL55
ExpressionAtlasiQ7Z7F7 baseline and differential
GenevisibleiQ7Z7F7 HS

Family and domain databases

InterProiView protein in InterPro
IPR018615 Ribosomal_L55_mit
PANTHERiPTHR34095 PTHR34095, 1 hit
PfamiView protein in Pfam
PF09776 Mitoc_L55, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM55_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7F7
Secondary accession number(s): Q5TBY3, Q5TBY6, Q6UWI8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 1, 2003
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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