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UniProtKB - Q7Z7F0 (KHDC4_HUMAN)

Entry version 141 (07 Apr 2021)
Sequence version 1 (01 Oct 2003)
Previous versions | rss
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Protein

KH homology domain-containing protein 4

Gene

KHDC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein involved in pre-mRNA splicing (PubMed:19641227). Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome (PubMed:19641227). Involved in regulating splice site selection (PubMed:19641227). Binds preferentially RNA with A/C rich sequences and poly-C stretches (PubMed:23144703).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q7Z7F0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
KH homology domain-containing protein 4Imported
Alternative name(s):
Brings lots of money 71 Publication
Pre-mRNA splicing factor protein KHDC4Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KHDC4Imported
Synonyms:BLOM71 Publication, KIAA0907, SNORA80EHGImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29145, KHDC4

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q7Z7F0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000132680.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		22889

Open Targets

More...OpenTargetsi		ENSG00000132680

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671618

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q7Z7F0, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KHDC4

Domain mapping of disease mutations (DMDM)

More...DMDMi		74750236

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002966691 – 614KH homology domain-containing protein 4Add BLAST614

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei571PhosphoserineCombined sources1
Modified residuei572PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q7Z7F0

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q7Z7F0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q7Z7F0

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q7Z7F0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q7Z7F0

PeptideAtlas

More...PeptideAtlasi		Q7Z7F0

PRoteomics IDEntifications database

More...PRIDEi		Q7Z7F0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		69525 [Q7Z7F0-1]
69526 [Q7Z7F0-2]
69527 [Q7Z7F0-3]
69528 [Q7Z7F0-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q7Z7F0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q7Z7F0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Expressed at high level in skeletal muscle, kidney, heart, brain and liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000132680, Expressed in endometrium and 247 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q7Z7F0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000132680, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PRPF19 (PubMed:19641227).

1 Publication

Interacts with U2AF65 (PubMed:19641227).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116555, 45 interactors

Protein interaction database and analysis system

More...IntActi		Q7Z7F0, 40 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000357304

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q7Z7F0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1614
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q7Z7F0

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q7Z7F0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini100 – 180KH 11 PublicationAdd BLAST81
Domaini235 – 317KH 21 PublicationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni480 – 549Required for nuclear retention1 PublicationAdd BLAST70

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi335 – 457Pro-richAdd BLAST123

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal part is necessary for the interaction with the PRP19C/Prp19 complex/NTC/Nineteen complex.1 Publication
The KH domains mediate RNA-binding.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the KHDC4 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1960, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00510000047412

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_032219_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q7Z7F0

Identification of Orthologs from Complete Genome Data

More...OMAi		MSFCGTQ

Database of Orthologous Groups

More...OrthoDBi		633868at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q7Z7F0

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.1370.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036612, KH_dom_type_1_sf
IPR031121, RIK/BLOM7

The PANTHER Classification System

More...PANTHERi		PTHR15744, PTHR15744, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54791, SSF54791, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q7Z7F0-1) [UniParc]FASTAAdd to basket
Also known as: Alpha, Blom7alpha1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAGSATHPG AGGRRSKWDQ PAPAPLLFLP PAAPGGEVTS SGGSPGGTTA 
        60         70         80         90        100
APSGALDAAA AVAAKINAML MAKGKLKPTQ NASEKLQAPG KGLTSNKSKD 
       110        120        130        140        150
DLVVAEVEIN DVPLTCRNLL TRGQTQDEIS RLSGAAVSTR GRFMTTEEKA 
       160        170        180        190        200
KVGPGDRPLY LHVQGQTREL VDRAVNRIKE IITNGVVKAA TGTSPTFNGA 
       210        220        230        240        250
TVTVYHQPAP IAQLSPAVSQ KPPFQSGMHY VQDKLFVGLE HAVPTFNVKE 
       260        270        280        290        300
KVEGPGCSYL QHIQIETGAK VFLRGKGSGC IEPASGREAF EPMYIYISHP 
       310        320        330        340        350
KPEGLAAAKK LCENLLQTVH AEYSRFVNQI NTAVPLPGYT QPSAISSVPP 
       360        370        380        390        400
QPPYYPSNGY QSGYPVVPPP QQPVQPPYGV PSIVPPAVSL APGVLPALPT 
       410        420        430        440        450
GVPPVPTQYP ITQVQPPAST GQSPMGGPFI PAAPVKTALP AGPQPQPQPQ 
       460        470        480        490        500
PPLPSQPQAQ KRRFTEELPD ERESGLLGYQ HGPIHMTNLG TGFSSQNEIE 
       510        520        530        540        550
GAGSKPASSS GKERERDRQL MPPPAFPVTG IKTESDERNG SGTLTGSHDY 
       560        570        580        590        600
PAKKMKTTEK GFGLVAYAAD SSDEEEEHGG HKNASSFPQG WSLGYQYPSS 
       610 
QPRAKQQMPF WMAP
Length:614
Mass (Da):64,845
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i61968993DA061561
GO
Isoform 2 (identifier: Q7Z7F0-2) [UniParc]FASTAAdd to basket
Also known as: Beta, KIAA09071 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     549-564: DYPAKKMKTTEKGFGL → GECDIAGGTGEWLRLV
     565-614: Missing.

Note: Interacts with U2AF65.1 Publication
Show »
Length:564
Mass (Da):59,138
Checksum:i6CAEC61BE66BB4CE
GO
Isoform 3 (identifier: Q7Z7F0-3) [UniParc]FASTAAdd to basket
Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     338-378: GYTQPSAISS...PPQQPVQPPY → AASSTSLRST...IPDNTSAASS
     379-614: Missing.

Show »
Length:384
Mass (Da):40,283
Checksum:i55E581185DDDD64D
GO
Isoform 4 (identifier: Q7Z7F0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     228-241: MHYVQDKLFVGLEH → VCFGEGSLIALSFL
     242-614: Missing.

Show »
Length:241
Mass (Da):24,732
Checksum:iD707FA95D343AD55
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA74930 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_027238228 – 241MHYVQ…VGLEH → VCFGEGSLIALSFL in isoform 4. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_027239242 – 614Missing in isoform 4. 1 PublicationAdd BLAST373
Alternative sequenceiVSP_027240338 – 378GYTQP…VQPPY → AASSTSLRSTKHSATSCFIS TWSLAGITYWSPTCANTIPD NTSAASS in isoform 3. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_027241379 – 614Missing in isoform 3. 1 PublicationAdd BLAST236
Alternative sequenceiVSP_027242549 – 564DYPAK…KGFGL → GECDIAGGTGEWLRLV in isoform 2. 2 PublicationsAdd BLAST16
Alternative sequenceiVSP_027243565 – 614Missing in isoform 2. 2 PublicationsAdd BLAST50

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY112680 mRNA Translation: AAM51855.1
AY112681 mRNA Translation: AAM51856.1
AY112682 mRNA Translation: AAM51857.1
AB020714 mRNA Translation: BAA74930.2 Different initiation.
AL355388 Genomic DNA No translation available.
BC027182 mRNA Translation: AAH27182.1
BC062637 mRNA Translation: AAH62637.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS30885.1 [Q7Z7F0-1]

NCBI Reference Sequences

More...RefSeqi		NP_055764.2, NM_014949.3 [Q7Z7F0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000368319; ENSP00000357302; ENSG00000132680 [Q7Z7F0-3]
ENST00000368320; ENSP00000357303; ENSG00000132680 [Q7Z7F0-2]
ENST00000368321; ENSP00000357304; ENSG00000132680 [Q7Z7F0-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		22889

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:22889

UCSC genome browser

More...UCSCi		uc001fmi.2, human [Q7Z7F0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY112680 mRNA Translation: AAM51855.1
AY112681 mRNA Translation: AAM51856.1
AY112682 mRNA Translation: AAM51857.1
AB020714 mRNA Translation: BAA74930.2 Different initiation.
AL355388 Genomic DNA No translation available.
BC027182 mRNA Translation: AAH27182.1
BC062637 mRNA Translation: AAH62637.1
CCDSiCCDS30885.1 [Q7Z7F0-1]
RefSeqiNP_055764.2, NM_014949.3 [Q7Z7F0-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YQRNMR-A227-338[»]
SMRiQ7Z7F0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116555, 45 interactors
IntActiQ7Z7F0, 40 interactors
STRINGi9606.ENSP00000357304

PTM databases

iPTMnetiQ7Z7F0
PhosphoSitePlusiQ7Z7F0

Genetic variation databases

BioMutaiKHDC4
DMDMi74750236

Proteomic databases

EPDiQ7Z7F0
jPOSTiQ7Z7F0
MassIVEiQ7Z7F0
MaxQBiQ7Z7F0
PaxDbiQ7Z7F0
PeptideAtlasiQ7Z7F0
PRIDEiQ7Z7F0
ProteomicsDBi69525 [Q7Z7F0-1]
69526 [Q7Z7F0-2]
69527 [Q7Z7F0-3]
69528 [Q7Z7F0-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1657, 83 antibodies

The DNASU plasmid repository

More...DNASUi		22889

Genome annotation databases

EnsembliENST00000368319; ENSP00000357302; ENSG00000132680 [Q7Z7F0-3]
ENST00000368320; ENSP00000357303; ENSG00000132680 [Q7Z7F0-2]
ENST00000368321; ENSP00000357304; ENSG00000132680 [Q7Z7F0-1]
GeneIDi22889
KEGGihsa:22889
UCSCiuc001fmi.2, human [Q7Z7F0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		22889
DisGeNETi22889

GeneCards: human genes, protein and diseases

More...GeneCardsi		KHDC4
HGNCiHGNC:29145, KHDC4
HPAiENSG00000132680, Low tissue specificity
neXtProtiNX_Q7Z7F0
OpenTargetsiENSG00000132680
PharmGKBiPA142671618
VEuPathDBiHostDB:ENSG00000132680.10

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1960, Eukaryota
GeneTreeiENSGT00510000047412
HOGENOMiCLU_032219_1_0_1
InParanoidiQ7Z7F0
OMAiMSFCGTQ
OrthoDBi633868at2759
PhylomeDBiQ7Z7F0

Enzyme and pathway databases

PathwayCommonsiQ7Z7F0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		22889, 31 hits in 999 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		KIAA0907, human
EvolutionaryTraceiQ7Z7F0

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		22889
PharosiQ7Z7F0, Tdark

Protein Ontology

More...PROi		PR:Q7Z7F0
RNActiQ7Z7F0, protein

Gene expression databases

BgeeiENSG00000132680, Expressed in endometrium and 247 other tissues
GenevisibleiQ7Z7F0, HS

Family and domain databases

Gene3Di3.30.1370.10, 2 hits
InterProiView protein in InterPro
IPR036612, KH_dom_type_1_sf
IPR031121, RIK/BLOM7
PANTHERiPTHR15744, PTHR15744, 1 hit
SUPFAMiSSF54791, SSF54791, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKHDC4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z7F0
Secondary accession number(s): O94981
, Q7L7Q2, Q7Z7E9, Q8TBQ0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: October 1, 2003
Last modified: April 7, 2021
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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