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Entry version 141 (07 Oct 2020)
Sequence version 1 (01 Oct 2003)
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Protein

Transcription initiation factor TFIID subunit 8

Gene

TAF8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity).By similarity1 Publication

Miscellaneous

'Taube nuss' means 'empty nut' in German.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q7Z7C8

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6807505, RNA polymerase II transcribes snRNA genes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 8
Alternative name(s):
Protein taube nuss
TBP-associated factor 43 kDa
TBP-associated factor 8
Transcription initiation factor TFIID 43 kDa subunit
Short name:
TAFII-43
Short name:
TAFII43
Short name:
hTAFII43
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TAF8
Synonyms:TAFII43, TBN
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000137413.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17300, TAF8

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609514, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z7C8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
129685

MalaCards human disease database

More...
MalaCardsi
TAF8

Open Targets

More...
OpenTargetsi
ENSG00000137413

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162405144

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7Z7C8, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TAF8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74723384

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003153962 – 310Transcription initiation factor TFIID subunit 8Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei130PhosphothreonineCombined sources1
Modified residuei271PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7Z7C8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7Z7C8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q7Z7C8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7Z7C8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7Z7C8

PeptideAtlas

More...
PeptideAtlasi
Q7Z7C8

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z7C8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69515 [Q7Z7C8-1]
69516 [Q7Z7C8-2]
69517 [Q7Z7C8-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7Z7C8

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q7Z7C8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z7C8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced with triglyceride accumulation.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137413, Expressed in amniotic fluid and 180 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7Z7C8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7Z7C8, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000137413, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs).

Interacts with TBP, TAF1, TAF6, TAF10, TAF11 and TAF13. Component also of a small TAF complex (SMAT) containing TAF8, TAF10 and SUPT7L.

Forms a heterodimer with TAF10. Interaction with TAF10 is mediated mainly via its histone fold domain while interaction with SUPT7L is via its C-terminal region.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
126205, 35 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-900, SAGA complex
CPX-915, General transcription factor complex TFIID
CPX-930, General transcription factor complex TFIID, TAF4B variant

Database of interacting proteins

More...
DIPi
DIP-60591N

Protein interaction database and analysis system

More...
IntActi
Q7Z7C8, 25 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362068

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7Z7C8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1310
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q7Z7C8

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 102Histone-foldAdd BLAST68

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi294 – 307Nuclear localization signalSequence analysisAdd BLAST14

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Ectopic expression of the histone fold domain acts as a dominant-negative mutant resulting in differentiation inhibition.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TAF8 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4336, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017567

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7Z7C8

KEGG Orthology (KO)

More...
KOi
K14649

Identification of Orthologs from Complete Genome Data

More...
OMAi
FPTEDNM

Database of Orthologous Groups

More...
OrthoDBi
1290064at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7Z7C8

TreeFam database of animal gene trees

More...
TreeFami
TF316311

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08049, TAF8, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006565, BTP
IPR009072, Histone-fold
IPR037818, TAF8
IPR019473, TFIID_su8_C

The PANTHER Classification System

More...
PANTHERi
PTHR46469, PTHR46469, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07524, Bromo_TP, 1 hit
PF10406, TAF8_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00576, BTP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47113, SSF47113, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z7C8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADAAATAGA GGSGTRSGSK QSTNPADNYH LARRRTLQVV VSSLLTEAGF
60 70 80 90 100
ESAEKASVET LTEMLQSYIS EIGRSAKSYC EHTARTQPTL SDIVVTLVEM
110 120 130 140 150
GFNVDTLPAY AKRSQRMVIT APPVTNQPVT PKALTAGQNR PHPPHIPSHF
160 170 180 190 200
PEFPDPHTYI KTPTYREPVS DYQVLREKAA SQRRDVERAL TRFMAKTGET
210 220 230 240 250
QSLFKDDVST FPLIAARPFT IPYLTALLPS ELEMQQMEET DSSEQDEQTD
260 270 280 290 300
TENLALHISM EDSGAEKENT SVLQQNPSLS GSRNGEENII DNPYLRPVKK
310
PKIRRKKSLS
Length:310
Mass (Da):34,262
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0F955828FE9FC0EA
GO
Isoform 2 (identifier: Q7Z7C8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     308-310: SLS → PDTF

Show »
Length:311
Mass (Da):34,436
Checksum:iE54B88DAF8FE9FC0
GO
Isoform 3 (identifier: Q7Z7C8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     261-310: EDSGAEKENT...PKIRRKKSLS → IESRSVTQAG...TSSITLICGR

Show »
Length:338
Mass (Da):37,411
Checksum:iB65123963AA96D63
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DZU5B4DZU5_HUMAN
TBP-associated factor 8
TAF8
234Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MRR3A0A0A0MRR3_HUMAN
TBP-associated factor 8
TAF8
174Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J7M8C9J7M8_HUMAN
Transcription initiation factor TFI...
TAF8
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J856C9J856_HUMAN
Transcription initiation factor TFI...
TAF8
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB71460 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti139N → D in BAB71460 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_030548261 – 310EDSGA…KKSLS → IESRSVTQAGVQWQDLGSLQ PPPPGFKRFSSLSLLSSWNY RRILEPRRRTPLSCSRTPPC RVAGMGRRTSSITLICGR in isoform 3. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_030549308 – 310SLS → PDTF in isoform 2. 1 Publication3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF465841 mRNA Translation: AAP47094.1
AK057383 mRNA Translation: BAB71460.1 Frameshift.
AL513008 Genomic DNA No translation available.
AL512274 Genomic DNA No translation available.
BC119678 mRNA Translation: AAI19679.1
BC119679 mRNA Translation: AAI19680.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43462.1 [Q7Z7C8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_612639.2, NM_138572.2 [Q7Z7C8-1]
XP_011512598.1, XM_011514296.1 [Q7Z7C8-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000372977; ENSP00000362068; ENSG00000137413 [Q7Z7C8-1]
ENST00000372982; ENSP00000362073; ENSG00000137413 [Q7Z7C8-4]
ENST00000456846; ENSP00000411900; ENSG00000137413 [Q7Z7C8-2]
ENST00000494547; ENSP00000417867; ENSG00000137413 [Q7Z7C8-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
129685

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:129685

UCSC genome browser

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UCSCi
uc003ors.4, human [Q7Z7C8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF465841 mRNA Translation: AAP47094.1
AK057383 mRNA Translation: BAB71460.1 Frameshift.
AL513008 Genomic DNA No translation available.
AL512274 Genomic DNA No translation available.
BC119678 mRNA Translation: AAI19679.1
BC119679 mRNA Translation: AAI19680.1
CCDSiCCDS43462.1 [Q7Z7C8-1]
RefSeqiNP_612639.2, NM_138572.2 [Q7Z7C8-1]
XP_011512598.1, XM_011514296.1 [Q7Z7C8-4]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4WV4X-ray1.91B25-120[»]
4WV6X-ray1.75B/C297-310[»]
5FURelectron microscopy8.50L1-310[»]
6MZCelectron microscopy4.50K1-310[»]
6MZLelectron microscopy23.00K1-310[»]
6MZMelectron microscopy7.50K1-310[»]
SMRiQ7Z7C8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi126205, 35 interactors
ComplexPortaliCPX-900, SAGA complex
CPX-915, General transcription factor complex TFIID
CPX-930, General transcription factor complex TFIID, TAF4B variant
DIPiDIP-60591N
IntActiQ7Z7C8, 25 interactors
STRINGi9606.ENSP00000362068

PTM databases

iPTMnetiQ7Z7C8
MetOSiteiQ7Z7C8
PhosphoSitePlusiQ7Z7C8

Polymorphism and mutation databases

BioMutaiTAF8
DMDMi74723384

Proteomic databases

EPDiQ7Z7C8
jPOSTiQ7Z7C8
MassIVEiQ7Z7C8
MaxQBiQ7Z7C8
PaxDbiQ7Z7C8
PeptideAtlasiQ7Z7C8
PRIDEiQ7Z7C8
ProteomicsDBi69515 [Q7Z7C8-1]
69516 [Q7Z7C8-2]
69517 [Q7Z7C8-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
30123, 135 antibodies

Genome annotation databases

EnsembliENST00000372977; ENSP00000362068; ENSG00000137413 [Q7Z7C8-1]
ENST00000372982; ENSP00000362073; ENSG00000137413 [Q7Z7C8-4]
ENST00000456846; ENSP00000411900; ENSG00000137413 [Q7Z7C8-2]
ENST00000494547; ENSP00000417867; ENSG00000137413 [Q7Z7C8-4]
GeneIDi129685
KEGGihsa:129685
UCSCiuc003ors.4, human [Q7Z7C8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
129685
DisGeNETi129685
EuPathDBiHostDB:ENSG00000137413.15

GeneCards: human genes, protein and diseases

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GeneCardsi
TAF8
HGNCiHGNC:17300, TAF8
HPAiENSG00000137413, Low tissue specificity
MalaCardsiTAF8
MIMi609514, gene
neXtProtiNX_Q7Z7C8
OpenTargetsiENSG00000137413
PharmGKBiPA162405144

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4336, Eukaryota
GeneTreeiENSGT00390000017567
InParanoidiQ7Z7C8
KOiK14649
OMAiFPTEDNM
OrthoDBi1290064at2759
PhylomeDBiQ7Z7C8
TreeFamiTF316311

Enzyme and pathway databases

PathwayCommonsiQ7Z7C8
ReactomeiR-HSA-6807505, RNA polymerase II transcribes snRNA genes

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
129685, 530 hits in 879 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TAF8, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TAF8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
129685
PharosiQ7Z7C8, Tbio

Protein Ontology

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PROi
PR:Q7Z7C8
RNActiQ7Z7C8, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000137413, Expressed in amniotic fluid and 180 other tissues
ExpressionAtlasiQ7Z7C8, baseline and differential
GenevisibleiQ7Z7C8, HS

Family and domain databases

CDDicd08049, TAF8, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR006565, BTP
IPR009072, Histone-fold
IPR037818, TAF8
IPR019473, TFIID_su8_C
PANTHERiPTHR46469, PTHR46469, 1 hit
PfamiView protein in Pfam
PF07524, Bromo_TP, 1 hit
PF10406, TAF8_C, 1 hit
SMARTiView protein in SMART
SM00576, BTP, 1 hit
SUPFAMiSSF47113, SSF47113, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTAF8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z7C8
Secondary accession number(s): Q5T0K1, Q8N4R9, Q96M52
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2003
Last modified: October 7, 2020
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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