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Protein

Beta-defensin 132

Gene

DEFB132

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has antibacterial activity.Curated

Caution

Was termed (Ref. 2) DEFB133.Curated

GO - Biological processi

  • defense response to bacterium Source: GO_Central
  • defense response to Gram-negative bacterium Source: UniProtKB
  • innate immune response Source: GO_Central
  • killing of cells of other organism Source: UniProtKB

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-HSA-1461957 Beta defensins
R-HSA-1461973 Defensins

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 132
Alternative name(s):
Beta-defensin 32
Short name:
BD-32
Short name:
DEFB-32
Defensin HEL-75
Defensin, beta 132
Gene namesi
Name:DEFB132
Synonyms:DEFB32
ORF Names:UNQ827/PRO1754
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000186458.4
HGNCiHGNC:33806 DEFB132
neXtProtiNX_Q7Z7B7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186458
PharmGKBiPA162383557

Polymorphism and mutation databases

BioMutaiDEFB132
DMDMi61212742

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000700723 – 95Beta-defensin 132Add BLAST73

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 55By similarity
Disulfide bondi35 ↔ 49By similarity
Disulfide bondi39 ↔ 56By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ7Z7B7
PeptideAtlasiQ7Z7B7
PRIDEiQ7Z7B7
ProteomicsDBi69512

Expressioni

Gene expression databases

BgeeiENSG00000186458 Expressed in 33 organ(s), highest expression level in corpus epididymis
CleanExiHS_DEFB132
GenevisibleiQ7Z7B7 HS

Organism-specific databases

HPAiHPA046399

Interactioni

Protein-protein interaction databases

IntActiQ7Z7B7, 1 interactor
STRINGi9606.ENSP00000371813

Structurei

3D structure databases

ProteinModelPortaliQ7Z7B7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JH6I Eukaryota
ENOG41114VH LUCA
GeneTreeiENSGT00390000013860
HOGENOMiHOG000246960
HOVERGENiHBG081411
InParanoidiQ7Z7B7
OMAiGETALFM
OrthoDBiEOG091G10TG
PhylomeDBiQ7Z7B7

Family and domain databases

InterProiView protein in InterPro
IPR025933 Beta_defensin
PANTHERiPTHR15001 PTHR15001, 1 hit
PfamiView protein in Pfam
PF13841 Defensin_beta_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z7B7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFLLLVLAA LGFLTQVIPA SAGGSKCVSN TPGYCRTCCH WGETALFMCN
60 70 80 90
ASRKCCISYS FLPKPDLPQL IGNHWQSRRR NTQRKDKKQQ TTVTS
Length:95
Mass (Da):10,610
Last modified:October 1, 2003 - v1
Checksum:iDEFE657F7DA7A6DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525932 mRNA Translation: AAP47225.1
AY621329 mRNA Translation: AAT51868.1
AY358708 mRNA Translation: AAQ89071.1
EF426755 mRNA Translation: ABR09864.1
AL034548 Genomic DNA No translation available.
BC137292 mRNA Translation: AAI37293.1
BC137293 mRNA Translation: AAI37294.1
CCDSiCCDS12993.1
RefSeqiNP_997352.1, NM_207469.2
UniGeneiHs.516819

Genome annotation databases

EnsembliENST00000382376; ENSP00000371813; ENSG00000186458
GeneIDi400830
KEGGihsa:400830
UCSCiuc002wdb.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525932 mRNA Translation: AAP47225.1
AY621329 mRNA Translation: AAT51868.1
AY358708 mRNA Translation: AAQ89071.1
EF426755 mRNA Translation: ABR09864.1
AL034548 Genomic DNA No translation available.
BC137292 mRNA Translation: AAI37293.1
BC137293 mRNA Translation: AAI37294.1
CCDSiCCDS12993.1
RefSeqiNP_997352.1, NM_207469.2
UniGeneiHs.516819

3D structure databases

ProteinModelPortaliQ7Z7B7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7Z7B7, 1 interactor
STRINGi9606.ENSP00000371813

Polymorphism and mutation databases

BioMutaiDEFB132
DMDMi61212742

Proteomic databases

PaxDbiQ7Z7B7
PeptideAtlasiQ7Z7B7
PRIDEiQ7Z7B7
ProteomicsDBi69512

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382376; ENSP00000371813; ENSG00000186458
GeneIDi400830
KEGGihsa:400830
UCSCiuc002wdb.4 human

Organism-specific databases

CTDi400830
EuPathDBiHostDB:ENSG00000186458.4
GeneCardsiDEFB132
HGNCiHGNC:33806 DEFB132
HPAiHPA046399
neXtProtiNX_Q7Z7B7
OpenTargetsiENSG00000186458
PharmGKBiPA162383557
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JH6I Eukaryota
ENOG41114VH LUCA
GeneTreeiENSGT00390000013860
HOGENOMiHOG000246960
HOVERGENiHBG081411
InParanoidiQ7Z7B7
OMAiGETALFM
OrthoDBiEOG091G10TG
PhylomeDBiQ7Z7B7

Enzyme and pathway databases

ReactomeiR-HSA-1461957 Beta defensins
R-HSA-1461973 Defensins

Miscellaneous databases

GenomeRNAii400830
PROiPR:Q7Z7B7

Gene expression databases

BgeeiENSG00000186458 Expressed in 33 organ(s), highest expression level in corpus epididymis
CleanExiHS_DEFB132
GenevisibleiQ7Z7B7 HS

Family and domain databases

InterProiView protein in InterPro
IPR025933 Beta_defensin
PANTHERiPTHR15001 PTHR15001, 1 hit
PfamiView protein in Pfam
PF13841 Defensin_beta_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDB132_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7B7
Secondary accession number(s): B2RP72, Q4QY40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2003
Last modified: September 12, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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